DK594084A - Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning - Google Patents

Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning Download PDF

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Publication number
DK594084A
DK594084A DK594084A DK594084A DK594084A DK 594084 A DK594084 A DK 594084A DK 594084 A DK594084 A DK 594084A DK 594084 A DK594084 A DK 594084A DK 594084 A DK594084 A DK 594084A
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DK
Denmark
Prior art keywords
extra
chromosomal
gene
bacteria
stabilized
Prior art date
Application number
DK594084A
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English (en)
Other versions
DK594084D0 (da
Inventor
Boerge Krag Diderichsen
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK594084A priority Critical patent/DK594084A/da
Publication of DK594084D0 publication Critical patent/DK594084D0/da
Priority to US06/807,483 priority patent/US4920048A/en
Priority to AU51081/85A priority patent/AU592542B2/en
Priority to DE8585309020T priority patent/DE3579133D1/de
Priority to CA000497395A priority patent/CA1292197C/en
Priority to EP85309020A priority patent/EP0185512B1/en
Priority to AT85309020T priority patent/ATE55413T1/de
Priority to NO854966A priority patent/NO172063C/no
Priority to FI854893A priority patent/FI85876C/fi
Priority to JP60278850A priority patent/JP2576970B2/ja
Priority to DK571985A priority patent/DK159282C/da
Publication of DK594084A publication Critical patent/DK594084A/da
Priority to JP5184932A priority patent/JP2571338B2/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Discharge Heating (AREA)
  • Saccharide Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Mushroom Cultivation (AREA)
DK594084A 1984-12-12 1984-12-12 Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning DK594084A (da)

Priority Applications (12)

Application Number Priority Date Filing Date Title
DK594084A DK594084A (da) 1984-12-12 1984-12-12 Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning
US06/807,483 US4920048A (en) 1984-12-12 1985-12-10 Method for stabilizing extra-chromosomal elements in bacteria during cultivation
DK571985A DK159282C (da) 1984-12-12 1985-12-11 Fremgangsmaade til stabilisering af extra-kromosomale elementer i en vaekstbakterie under dyrkning, transformerede bakterier samt en fremgangsmaade til fremstilling af et oensket produkt i saadanne transformerede bakterier
CA000497395A CA1292197C (en) 1984-12-12 1985-12-11 Method for stabilizing extra-chromosomal elements in bacteria during cultivation
DE8585309020T DE3579133D1 (de) 1984-12-12 1985-12-11 Verfahren zur stabilisierung extrachromosomaler elemente in bakterien waehrend deren zuechtung, extrachromosomale elemente, transformierte bakterien und verfahren zur herstellung eines gewuenschten produktes in transformierten bakterien.
AU51081/85A AU592542B2 (en) 1984-12-12 1985-12-11 Method for stabilizing extra-chromosomal elements in bacteria during cultivation
EP85309020A EP0185512B1 (en) 1984-12-12 1985-12-11 Method for stabilizing extra-chromosomal elements in bacteria during cultivation, extra-chromosomal elements, transformed bacteria and a method of producing a desired product in transformed bacteria
AT85309020T ATE55413T1 (de) 1984-12-12 1985-12-11 Verfahren zur stabilisierung extrachromosomaler elemente in bakterien waehrend deren zuechtung, extrachromosomale elemente, transformierte bakterien und verfahren zur herstellung eines gewuenschten produktes in transformierten bakterien.
NO854966A NO172063C (no) 1984-12-12 1985-12-11 Fremgangsmaate ved stabilisering av ekstra-kromosomale elementer i bakterier under dyrking og fremgangsmaate for fremstilling av et oensket produkt i transformerte bakterier
FI854893A FI85876C (fi) 1984-12-12 1985-12-11 Foerfarande foer stabilisering av plasmider i bakterier under kultivering.
JP60278850A JP2576970B2 (ja) 1984-12-12 1985-12-11 形質転換された細菌による所望産物の製造方法
JP5184932A JP2571338B2 (ja) 1984-12-12 1993-07-27 形質転換された細菌

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK594084A DK594084A (da) 1984-12-12 1984-12-12 Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning

Publications (2)

Publication Number Publication Date
DK594084D0 DK594084D0 (da) 1984-12-12
DK594084A true DK594084A (da) 1986-06-13

Family

ID=8146313

Family Applications (1)

Application Number Title Priority Date Filing Date
DK594084A DK594084A (da) 1984-12-12 1984-12-12 Fremgangsmaade til stabilisering af extra-chromosomale elementer i bakterier under dyrkning

Country Status (10)

Country Link
US (1) US4920048A (da)
EP (1) EP0185512B1 (da)
JP (2) JP2576970B2 (da)
AT (1) ATE55413T1 (da)
AU (1) AU592542B2 (da)
CA (1) CA1292197C (da)
DE (1) DE3579133D1 (da)
DK (1) DK594084A (da)
FI (1) FI85876C (da)
NO (1) NO172063C (da)

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ES2079348T3 (es) * 1986-08-05 1996-01-16 Transgene Sa Procedimiento de estabilizacion de un plasmido contenido en una cepa bacteriana y cepa obtenida.
FR2618159B2 (fr) * 1987-07-15 1990-02-02 Transgene Sa Procede de stabilisation d'un plasmide contenu dans une souche bacterienne et souche obtenue
FR2602792B1 (fr) * 1986-08-05 1989-10-20 Transgene Sa Procede de stabilisation d'un plasmide contenu dans une souche bacterienne et souche obtenue
US5198343A (en) * 1986-08-05 1993-03-30 Transgene, S.A. Method for expressing a heterologous protein in a dapD- mutant of E. coli and the strain obtained
JPH04501351A (ja) * 1987-10-07 1992-03-12 ワシントン ユニバーシティ 細胞の遺伝的集団において所望の組換え遺伝子を維持する方法
HU200796B (en) * 1988-07-14 1990-08-28 Richter Gedeon Vegyeszet Process for producing expression vectors ensuring insertion of nucleotide sequences into e. coli chromosome
RU2099418C1 (ru) * 1991-11-21 1997-12-20 Лонца Аг Фрагмент днк, обеспечивающий использование бетаина, рекомбинантная плазмидная днк с фрагментом днк, обеспечивающим использование бетаина, штамм бактерий rhizobium/agrobacterium, предназначенный для стабильного хранения плазмиды с фрагментом днк, способ получения штамма бактерий
HU219819B (hu) * 1992-08-18 2001-08-28 Dimminaco Ag/Sa/Ltd. Izolált polinukleotidok, ezeket tartalmazó Bordetella bronchiseptica törzs, és Bordetella bronchiseptica elleni vakcina
US5714375A (en) * 1995-06-05 1998-02-03 Nobl Laboratories, Inc. Ileal symbiont intracellularis propagation in suspended host cells
US5885823A (en) * 1995-06-05 1999-03-23 Nobl Laboratories, Inc. Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
US6743780B1 (en) 1995-09-08 2004-06-01 Cobra Biologics Limited Plasmid stabilization
GB9518395D0 (en) * 1995-09-08 1995-11-08 Therexsys Ltd Plasmid stabilization
US5922583A (en) * 1995-10-17 1999-07-13 Biostar Inc. Methods for production of recombinant plasmids
US6291245B1 (en) 1998-07-15 2001-09-18 Roche Diagnostics Gmbh Host-vector system
EP0972838B1 (en) * 1998-07-15 2004-09-15 Roche Diagnostics GmbH Escherichia coli host/vector system based on antibiotic-free selection by complementation of an auxotrophy
JP3958884B2 (ja) 1998-09-11 2007-08-15 株式会社林原生物化学研究所 非還元性糖質生成酵素及びトレハロース遊離酵素ならびに該酵素を用いる糖質の製造方法
WO2002000907A1 (en) * 2000-06-23 2002-01-03 Novozymes A/S Method for stable chromosomal multi-copy integration of genes
DK1297170T3 (da) * 2000-06-23 2016-03-14 Novozymes As Fremgangsmåde til stabil kromosomal integrering af flere kopier af gener
WO2005052151A1 (en) * 2003-11-19 2005-06-09 Dow Global Technologies Inc. Improved protein expression systems
JP2006067884A (ja) * 2004-09-01 2006-03-16 Kao Corp 組換えバチルス属細菌
JP2006067883A (ja) * 2004-09-01 2006-03-16 Kao Corp 組換えバチルス属細菌
US7923231B2 (en) * 2004-12-17 2011-04-12 Cargill, Incorporated Production of glucuronic acid using myo-inositol oxygenase from cryptococcus neoformans
US8834891B2 (en) * 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
US8398994B2 (en) * 2005-07-15 2013-03-19 Boehringer Ingelheim Vetmedica, Inc. Lawsonia vaccine and methods of use thereof
US8268594B2 (en) * 2005-10-06 2012-09-18 Advanced Accelerator Applications S.A. pyrC as a selection marker in Escherichia coli
US8470336B2 (en) * 2006-05-25 2013-06-25 Boehringer Ingelheim Vetmedica, Inc. Vaccination of young animals against Lawsonia intracellularis infections
DE102007021001A1 (de) 2007-05-04 2008-11-06 Ab Enzymes Gmbh Expressionssystem zur antibiotikafreien Produktion von Polypeptiden
US8398970B2 (en) * 2007-09-17 2013-03-19 Boehringer Ingelheim Vetmedica, Inc. Method of preventing early Lawsonia intracellularis infections
AU2010247938B2 (en) 2009-05-11 2016-02-18 Pelican Technology Holdings, Inc. Production of recombinant proteins utilizing non-antibiotic selection methods and the incorporation of non-natural amino acids therein
EP3556847B1 (de) 2015-12-11 2021-03-03 Wacker Chemie AG Mikroorganismenstamm und verfahren zur antibiotikafreien, fermentativen herstellung von niedermolekularen substanzen und proteinen
DE18305781T1 (de) 2018-06-20 2020-09-17 Eligo Bioscience Bakterielles freisetzungsvehikel, verfahren zur herstellung und verwendungen davon
US11746352B2 (en) 2019-12-30 2023-09-05 Eligo Bioscience Microbiome modulation of a host by delivery of DNA payloads with minimized spread
US12098372B2 (en) 2019-12-30 2024-09-24 Eligo Bioscience Microbiome modulation of a host by delivery of DNA payloads with minimized spread
WO2022144381A1 (en) 2020-12-30 2022-07-07 Eligo Bioscience Microbiome modulation of a host by delivery of dna payloads with minimized spread
JP2024520940A (ja) 2021-05-12 2024-05-27 エリゴ・バイオサイエンス 産生細菌細胞及び産生方法におけるその使用
GB202304540D0 (en) 2023-03-28 2023-05-10 Univ Tartu Method of biosynthesis

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FI792481A (fi) * 1978-08-11 1980-02-12 Univ California Syntes av enkaroytiskt protein genom anvaendning av mikro-organismer
US4506013A (en) * 1980-10-03 1985-03-19 Eli Lilly And Company Stabilizing and selecting recombinant DNA host cells
US4436815A (en) * 1981-11-27 1984-03-13 Eli Lilly And Company Method for stabilizing and selecting recombinant DNA containing host cells
DK410783D0 (da) * 1982-09-16 1983-09-09 Benzon A Salfred Fremgangsmade til stabilisering af plasmider
US4595660A (en) * 1983-03-02 1986-06-17 University Of Delaware Molecular cloning with bifunctional plasmid vectors in Bacillus subtilis, mutants and substantially stably transformed mutants of Bacillus subtilis, and methods for utilizing the transformed mutants
JPS59205983A (ja) * 1983-04-28 1984-11-21 ジエネツクス・コ−ポレイシヨン 異種遺伝子を原核微生物で発現させる方法
AU600885B2 (en) * 1984-05-25 1990-08-30 Zymogenetics Inc. Stable DNA constructs

Also Published As

Publication number Publication date
ATE55413T1 (de) 1990-08-15
NO172063C (no) 1993-06-02
US4920048A (en) 1990-04-24
JP2576970B2 (ja) 1997-01-29
NO172063B (no) 1993-02-22
JPS61139392A (ja) 1986-06-26
DK594084D0 (da) 1984-12-12
AU592542B2 (en) 1990-01-18
JP2571338B2 (ja) 1997-01-16
NO854966L (no) 1986-06-13
CA1292197C (en) 1991-11-19
EP0185512B1 (en) 1990-08-08
FI854893A0 (fi) 1985-12-11
JPH0686669A (ja) 1994-03-29
FI85876C (fi) 1992-06-10
AU5108185A (en) 1986-06-19
EP0185512A1 (en) 1986-06-25
DE3579133D1 (de) 1990-09-13
FI854893A (fi) 1986-06-13
FI85876B (fi) 1992-02-28

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