DE69934328T2 - Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung - Google Patents

Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung Download PDF

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Publication number
DE69934328T2
DE69934328T2 DE69934328T DE69934328T DE69934328T2 DE 69934328 T2 DE69934328 T2 DE 69934328T2 DE 69934328 T DE69934328 T DE 69934328T DE 69934328 T DE69934328 T DE 69934328T DE 69934328 T2 DE69934328 T2 DE 69934328T2
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DE
Germany
Prior art keywords
bpheid
compound
formula
preparation
cells
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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DE69934328T
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German (de)
English (en)
Other versions
DE69934328D1 (de
Inventor
Avigdor Scherz
Yoram Salomon
Alexander Brandis
Hugo Scheer
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Yeda Research and Development Co Ltd
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Yeda Research and Development Co Ltd
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Publication of DE69934328D1 publication Critical patent/DE69934328D1/de
Application granted granted Critical
Publication of DE69934328T2 publication Critical patent/DE69934328T2/de
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Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE69934328T 1998-12-09 1999-12-09 Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung Expired - Lifetime DE69934328T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98403110 1998-12-09
EP98403110 1998-12-09
PCT/IL1999/000673 WO2000033833A1 (en) 1998-12-09 1999-12-09 Palladium-substituted bacteriochlorophyll derivatives and use thereof

Publications (2)

Publication Number Publication Date
DE69934328D1 DE69934328D1 (de) 2007-01-18
DE69934328T2 true DE69934328T2 (de) 2007-07-19

Family

ID=8235584

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69934328T Expired - Lifetime DE69934328T2 (de) 1998-12-09 1999-12-09 Palladiumsubstituierte bakteriochlorophyllderivate und deren verwendung

Country Status (22)

Country Link
US (1) US6569846B1 (enExample)
EP (1) EP1137411B1 (enExample)
JP (1) JP4796227B2 (enExample)
CN (1) CN1160069C (enExample)
AT (1) ATE347554T1 (enExample)
AU (1) AU771292B2 (enExample)
BR (1) BRPI9916096B8 (enExample)
CA (1) CA2353554C (enExample)
CY (1) CY1106450T1 (enExample)
DE (1) DE69934328T2 (enExample)
DK (1) DK1137411T3 (enExample)
ES (1) ES2277454T3 (enExample)
HK (1) HK1040638B (enExample)
HU (1) HU228208B1 (enExample)
IL (1) IL143591A0 (enExample)
NO (1) NO331426B1 (enExample)
NZ (1) NZ512093A (enExample)
PL (1) PL201172B1 (enExample)
PT (1) PT1137411E (enExample)
RU (1) RU2234508C2 (enExample)
SI (1) SI1137411T1 (enExample)
WO (1) WO2000033833A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
WO2002013820A1 (en) * 2000-08-11 2002-02-21 Ceramoptec Industries, Inc. Photosensitizing ointment
EP1277470A1 (fr) * 2001-07-17 2003-01-22 Steba Biotech N.V. Formulation galénique injectable pour utilisation dans un diagnostic ou une thérapie photodynamique et son procédé de préparation
US7715901B2 (en) * 2002-05-08 2010-05-11 Yeda Research And Development Co. Ltd. Sensitized online BOLD-MRI imaging method
JP4529344B2 (ja) * 2002-06-03 2010-08-25 ニプロ株式会社 腫瘍組織の酸素濃度を上昇させるためのポルフィリン酸素輸液製剤
AU2003248747A1 (en) 2002-06-27 2004-01-19 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
WO2004005289A2 (en) * 2002-07-02 2004-01-15 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
RU2257898C1 (ru) * 2004-03-22 2005-08-10 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Фотосенсибилизатор, липосомальная форма фотосенсибилизатора и способ проведения фотодинамической терапии
CN1980661B (zh) * 2004-06-07 2011-09-28 耶达研究及发展有限公司 阳离子细菌叶绿素衍生物及其用途
GB2415372A (en) * 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
US20060222592A1 (en) * 2005-04-05 2006-10-05 Clemens Burda Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications
CN101925382A (zh) * 2008-01-28 2010-12-22 耶达研究及发展有限公司 内窥镜成像光动力学治疗系统及其使用方法
DK2257309T3 (da) 2008-02-27 2020-01-20 Yeda Res And Development Company Ltd Rgd-(bakterie)chlorophyl-konjugater til anvendelse ved diagnose af tumorer, der omfatter nekrotiske domæner
US20120034155A1 (en) * 2010-08-03 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Artificial cells
GB0819594D0 (en) 2008-10-24 2008-12-03 Univ Coimbrra Process
EP2425873A1 (fr) 2010-09-07 2012-03-07 Steba Maor SA Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement
CN103405769A (zh) * 2013-03-07 2013-11-27 北京亿仁赛博医疗科技研发中心有限公司 光敏剂在制备治疗疾病的病毒灭活药物中的应用
JP6517158B2 (ja) 2013-03-11 2019-05-22 トーカド イーペー エスアーエールエル バクテリオクロロフィルａの生成方法
WO2014145428A2 (en) 2013-03-15 2014-09-18 Mcfarland Sherri Ann Metal-based coordination complexes as photodynamic compounds and their use
EP3442582A1 (en) 2016-04-10 2019-02-20 Yeda Research and Development Co. Ltd Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative
US10933134B2 (en) 2017-03-16 2021-03-02 Memorial Sloan Kettering Cancer Center Combination therapies for treatment of cancer
IL311461B2 (en) * 2024-03-13 2026-05-01 Impact Biotech Ltd Process for preparing palladium-bacteriophophorbide derivatives and their alkali metal salts

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002962A (en) * 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US5171741A (en) * 1989-04-21 1992-12-15 Health Research, Inc. Bacteriochlorophyll-a derivatives useful in photodynamic therapy
IL102645A (en) 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
RU2063971C1 (ru) * 1993-11-05 1996-07-20 Московская государственная академия тонкой химической технологии им.М.В.Ломоносова Способ получения производного гематопорфирина
IL115744A (en) * 1994-10-27 2000-07-16 Akzo Nobel Nv Peptides comprising a subsequence of human cartilage glycoprotein - 39
IL116126A0 (en) * 1995-11-24 1996-01-31 Yeda Res & Dev Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
HK1040638A1 (en) 2002-06-21
CN1334728A (zh) 2002-02-06
DE69934328D1 (de) 2007-01-18
DK1137411T3 (da) 2007-03-26
EP1137411A1 (en) 2001-10-04
PL201172B1 (pl) 2009-03-31
BRPI9916096B8 (pt) 2021-05-25
ATE347554T1 (de) 2006-12-15
NO331426B1 (no) 2011-12-27
HUP0105411A2 (hu) 2002-04-29
IL143591A0 (en) 2002-04-21
CY1106450T1 (el) 2011-10-12
NO20012807L (no) 2001-08-08
US6569846B1 (en) 2003-05-27
ES2277454T3 (es) 2007-07-01
BR9916096A (pt) 2001-11-13
NZ512093A (en) 2003-04-29
RU2234508C2 (ru) 2004-08-20
WO2000033833A1 (en) 2000-06-15
AU1583400A (en) 2000-06-26
HUP0105411A3 (en) 2003-12-29
AU771292B2 (en) 2004-03-18
CN1160069C (zh) 2004-08-04
BR9916096B1 (pt) 2013-11-19
HK1040638B (en) 2007-06-15
EP1137411B1 (en) 2006-12-06
HU228208B1 (en) 2013-01-28
CA2353554C (en) 2011-04-26
PL348201A1 (en) 2002-05-06
SI1137411T1 (sl) 2007-10-31
EP1137411A4 (en) 2003-04-23
JP4796227B2 (ja) 2011-10-19
NO20012807D0 (no) 2001-06-07
PT1137411E (pt) 2007-02-28
CA2353554A1 (en) 2000-06-15
JP2002531497A (ja) 2002-09-24

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