HK1040638A1 - Palladium-substituted bacteriochlorophyll derivatives and use thereof - Google Patents

Palladium-substituted bacteriochlorophyll derivatives and use thereof

Info

Publication number
HK1040638A1
HK1040638A1 HK02102403A HK02102403A HK1040638A1 HK 1040638 A1 HK1040638 A1 HK 1040638A1 HK 02102403 A HK02102403 A HK 02102403A HK 02102403 A HK02102403 A HK 02102403A HK 1040638 A1 HK1040638 A1 HK 1040638A1
Authority
HK
Hong Kong
Prior art keywords
palladium
bacteriochlorophyll derivatives
ch2oh
substituted
substituted bacteriochlorophyll
Prior art date
Application number
HK02102403A
Other versions
HK1040638B (en
Inventor
Avigdor Scherz
Yoram Salomon
Alexander Brandis
Hugo Scheer
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of HK1040638A1 publication Critical patent/HK1040638A1/en
Publication of HK1040638B publication Critical patent/HK1040638B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Palladium-substituted Bacteriochlorophyll derivatives of formula (I), wherein A represents OH, OR1, -O-(CH2)n-Y, -S-(CH2)n-Y, -NH-(CH2)n-Y, -O-(CH2)2-NH2, -O-(CH2)2-OH, -NH-(CH2)n-+N o, X-, -NH0(CH2)2-NH=BOC or -N-(CH2-CH=CH2)2; wherein R1 represents Na+, K+, (Ca2+)0, 5, (Mg2+)0, 5, Li+, NH4+, NH3-C(CH2OH)3 +NH3-CH2-(CHOH)4-CH2OH, +NH2(CH3)-CH2-(CHOH)4-CH2OH or +N(CN'H2n'+1)4; R2 represents H, OH or COOR4, wherein R4 is C1-C12 alkyl or C3-C12 cycloalkl; R3 represents H, OH or C1-C12 alkyl or alkoxy; n is 1, 2, 3, 4, 5 or 6, Y is -NR'1R'2R'3, X-wherein R'1, R'2 and R'3 independently from each other represent -CH3 or -C2H5; X is F, Cl, Br or 1, n' is 1, 2, 3 or 4 and their oxidized forms, are usefu
HK02102403.5A 1998-12-09 2002-03-28 Palladium-substituted bacteriochlorophyll derivatives and use thereof HK1040638B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98403110 1998-12-09
PCT/IL1999/000673 WO2000033833A1 (en) 1998-12-09 1999-12-09 Palladium-substituted bacteriochlorophyll derivatives and use thereof

Publications (2)

Publication Number Publication Date
HK1040638A1 true HK1040638A1 (en) 2002-06-21
HK1040638B HK1040638B (en) 2007-06-15

Family

ID=8235584

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02102403.5A HK1040638B (en) 1998-12-09 2002-03-28 Palladium-substituted bacteriochlorophyll derivatives and use thereof

Country Status (22)

Country Link
US (1) US6569846B1 (en)
EP (1) EP1137411B1 (en)
JP (1) JP4796227B2 (en)
CN (1) CN1160069C (en)
AT (1) ATE347554T1 (en)
AU (1) AU771292B2 (en)
BR (1) BRPI9916096B8 (en)
CA (1) CA2353554C (en)
CY (1) CY1106450T1 (en)
DE (1) DE69934328T2 (en)
DK (1) DK1137411T3 (en)
ES (1) ES2277454T3 (en)
HK (1) HK1040638B (en)
HU (1) HU228208B1 (en)
IL (1) IL143591A0 (en)
NO (1) NO331426B1 (en)
NZ (1) NZ512093A (en)
PL (1) PL201172B1 (en)
PT (1) PT1137411E (en)
RU (1) RU2234508C2 (en)
SI (1) SI1137411T1 (en)
WO (1) WO2000033833A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
EP1318807A4 (en) * 2000-08-11 2008-02-20 Ceramoptec Gmbh Photosensitizing ointment
EP1277470A1 (en) * 2001-07-17 2003-01-22 Steba Biotech N.V. Injectable galenical formulation for use in photodynamic diagnostic or therapy and process of manufacturing it
BR0304716A (en) * 2002-05-08 2004-07-13 Yeda Res & Dev Sensitized mri-bold online imaging method
JP4529344B2 (en) * 2002-06-03 2010-08-25 ニプロ株式会社 Porphyrin oxygen infusion formulation to increase oxygen concentration in tumor tissue
EP1517684B1 (en) 2002-06-27 2009-07-22 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
AU2003249742A1 (en) * 2002-07-02 2004-01-23 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
KR101191700B1 (en) * 2004-06-07 2012-10-16 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 Cationic bacteriochlorophyll derivatives and uses thereof
US20060222592A1 (en) * 2005-04-05 2006-10-05 Clemens Burda Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications
US20110040170A1 (en) * 2008-01-28 2011-02-17 Yeda Research And Development Co., Ltd. Endoscopic imaging photodynamic therapy system and methods of use
DK2257309T3 (en) 2008-02-27 2020-01-20 Yeda Res And Development Company Ltd RGD (BACTERY) CHLOROPHYL CONJUGATES USED FOR THE DIAGNOSIS OF TUMORS CONTAINING NECROTIC DOMAINS
US20120034155A1 (en) * 2010-08-03 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Artificial cells
GB0819594D0 (en) 2008-10-24 2008-12-03 Univ Coimbrra Process
EP2425873A1 (en) 2010-09-07 2012-03-07 Steba Maor SA Modelling of the action of optical fibre in a treatment by photodynamic therapy, and assistance in planning such a treatment
CN103405769A (en) * 2013-03-07 2013-11-27 北京亿仁赛博医疗科技研发中心有限公司 Application of photosensitizer to preparation of virus inactivated medicines for treating diseases
DK2971026T3 (en) 2013-03-11 2021-02-15 Tookad Ip Sarl PROCEDURE FOR PRODUCTION OF BACTERIAL CHLOROPHYL A
CN105377862B (en) 2013-03-15 2019-09-13 希瑞·安·麦克法兰 Metal Substrate complex as photodynamic compound and application thereof
AU2017250732B2 (en) 2016-04-10 2022-11-10 Memorial Sloan-Kettering Cancer Center Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative
US10933134B2 (en) 2017-03-16 2021-03-02 Memorial Sloan Kettering Cancer Center Combination therapies for treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002962A (en) * 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US5171741A (en) * 1989-04-21 1992-12-15 Health Research, Inc. Bacteriochlorophyll-a derivatives useful in photodynamic therapy
IL102645A (en) 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
IL116126A0 (en) * 1995-11-24 1996-01-31 Yeda Res & Dev Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
AU1583400A (en) 2000-06-26
NO331426B1 (en) 2011-12-27
HUP0105411A3 (en) 2003-12-29
AU771292B2 (en) 2004-03-18
EP1137411A4 (en) 2003-04-23
IL143591A0 (en) 2002-04-21
CN1160069C (en) 2004-08-04
BR9916096A (en) 2001-11-13
CA2353554A1 (en) 2000-06-15
HK1040638B (en) 2007-06-15
NO20012807L (en) 2001-08-08
CY1106450T1 (en) 2011-10-12
JP2002531497A (en) 2002-09-24
US6569846B1 (en) 2003-05-27
WO2000033833A1 (en) 2000-06-15
CN1334728A (en) 2002-02-06
DK1137411T3 (en) 2007-03-26
PT1137411E (en) 2007-02-28
RU2234508C2 (en) 2004-08-20
BR9916096B1 (en) 2013-11-19
JP4796227B2 (en) 2011-10-19
CA2353554C (en) 2011-04-26
HUP0105411A2 (en) 2002-04-29
EP1137411B1 (en) 2006-12-06
NO20012807D0 (en) 2001-06-07
ATE347554T1 (en) 2006-12-15
BRPI9916096B8 (en) 2021-05-25
SI1137411T1 (en) 2007-10-31
PL348201A1 (en) 2002-05-06
DE69934328D1 (en) 2007-01-18
PL201172B1 (en) 2009-03-31
EP1137411A1 (en) 2001-10-04
NZ512093A (en) 2003-04-29
ES2277454T3 (en) 2007-07-01
DE69934328T2 (en) 2007-07-19
HU228208B1 (en) 2013-01-28

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