DK1137411T3 - Palladium-substituerede bakteriechlorophyl-derivater og anvendelsen deraf - Google Patents
Palladium-substituerede bakteriechlorophyl-derivater og anvendelsen derafInfo
- Publication number
- DK1137411T3 DK1137411T3 DK99958470T DK99958470T DK1137411T3 DK 1137411 T3 DK1137411 T3 DK 1137411T3 DK 99958470 T DK99958470 T DK 99958470T DK 99958470 T DK99958470 T DK 99958470T DK 1137411 T3 DK1137411 T3 DK 1137411T3
- Authority
- DK
- Denmark
- Prior art keywords
- palladium
- chlorophyll derivatives
- substituted
- bacterial chlorophyll
- ch2oh
- Prior art date
Links
- 230000001580 bacterial effect Effects 0.000 title 1
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 title 1
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- DSJXIQQMORJERS-AGGZHOMASA-M bacteriochlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@H](CC)[C@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 DSJXIQQMORJERS-AGGZHOMASA-M 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98403110 | 1998-12-09 | ||
| PCT/IL1999/000673 WO2000033833A1 (en) | 1998-12-09 | 1999-12-09 | Palladium-substituted bacteriochlorophyll derivatives and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1137411T3 true DK1137411T3 (da) | 2007-03-26 |
Family
ID=8235584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99958470T DK1137411T3 (da) | 1998-12-09 | 1999-12-09 | Palladium-substituerede bakteriechlorophyl-derivater og anvendelsen deraf |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6569846B1 (enExample) |
| EP (1) | EP1137411B1 (enExample) |
| JP (1) | JP4796227B2 (enExample) |
| CN (1) | CN1160069C (enExample) |
| AT (1) | ATE347554T1 (enExample) |
| AU (1) | AU771292B2 (enExample) |
| BR (1) | BRPI9916096B8 (enExample) |
| CA (1) | CA2353554C (enExample) |
| CY (1) | CY1106450T1 (enExample) |
| DE (1) | DE69934328T2 (enExample) |
| DK (1) | DK1137411T3 (enExample) |
| ES (1) | ES2277454T3 (enExample) |
| HK (1) | HK1040638B (enExample) |
| HU (1) | HU228208B1 (enExample) |
| IL (1) | IL143591A0 (enExample) |
| NO (1) | NO331426B1 (enExample) |
| NZ (1) | NZ512093A (enExample) |
| PL (1) | PL201172B1 (enExample) |
| PT (1) | PT1137411E (enExample) |
| RU (1) | RU2234508C2 (enExample) |
| SI (1) | SI1137411T1 (enExample) |
| WO (1) | WO2000033833A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7897140B2 (en) * | 1999-12-23 | 2011-03-01 | Health Research, Inc. | Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents |
| WO2002013820A1 (en) * | 2000-08-11 | 2002-02-21 | Ceramoptec Industries, Inc. | Photosensitizing ointment |
| EP1277470A1 (fr) * | 2001-07-17 | 2003-01-22 | Steba Biotech N.V. | Formulation galénique injectable pour utilisation dans un diagnostic ou une thérapie photodynamique et son procédé de préparation |
| CA2485224A1 (en) | 2002-05-08 | 2003-11-20 | Yeda Research And Development Co. Ltd. | Sensitized online bold-mri imaging method |
| JP4529344B2 (ja) * | 2002-06-03 | 2010-08-25 | ニプロ株式会社 | 腫瘍組織の酸素濃度を上昇させるためのポルフィリン酸素輸液製剤 |
| AU2003248747A1 (en) | 2002-06-27 | 2004-01-19 | Health Research, Inc. | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy |
| EP1606291A2 (en) * | 2002-07-02 | 2005-12-21 | Health Research, Inc. | Efficient synthesis of pyropheophorbide a and its dervatives |
| IL152900A0 (en) | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
| RU2257898C1 (ru) * | 2004-03-22 | 2005-08-10 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Фотосенсибилизатор, липосомальная форма фотосенсибилизатора и способ проведения фотодинамической терапии |
| CN1980661B (zh) | 2004-06-07 | 2011-09-28 | 耶达研究及发展有限公司 | 阳离子细菌叶绿素衍生物及其用途 |
| GB2415372A (en) * | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
| US20060222592A1 (en) * | 2005-04-05 | 2006-10-05 | Clemens Burda | Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications |
| EP2244787A1 (en) * | 2008-01-28 | 2010-11-03 | Yeda Research And Development Company Ltd. | Endoscopic imaging photodynamic therapy system and methods of use |
| MX2010009530A (es) | 2008-02-27 | 2010-11-30 | Yeda Res & Dev | Conjugados de rgd-(bacterio) clorofila para terapia fotodinámica y formación de imágenes de tumores necróticos. |
| US20120034155A1 (en) * | 2010-08-03 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Artificial cells |
| GB0819594D0 (en) | 2008-10-24 | 2008-12-03 | Univ Coimbrra | Process |
| EP2425873A1 (fr) | 2010-09-07 | 2012-03-07 | Steba Maor SA | Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement |
| CN103405769A (zh) * | 2013-03-07 | 2013-11-27 | 北京亿仁赛博医疗科技研发中心有限公司 | 光敏剂在制备治疗疾病的病毒灭活药物中的应用 |
| CN105358702B (zh) | 2013-03-11 | 2020-12-29 | Tookad Ip有限责任公司 | 细菌叶绿素a的生产方法 |
| RU2682674C2 (ru) | 2013-03-15 | 2019-03-20 | Шерри Энн МАКФАРЛЭНД | Координационные комплексы на основе металлов в качестве фотодинамических соединений и их применение |
| EP3442582A1 (en) | 2016-04-10 | 2019-02-20 | Yeda Research and Development Co. Ltd | Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative |
| US10933134B2 (en) | 2017-03-16 | 2021-03-02 | Memorial Sloan Kettering Cancer Center | Combination therapies for treatment of cancer |
| IL311461A (en) * | 2024-03-13 | 2025-10-01 | Impact Biotech Ltd | Process for preparing bacteriophophorbid derivatives and their alkali metal salts |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002962A (en) * | 1988-07-20 | 1991-03-26 | Health Research, Inc. | Photosensitizing agents |
| US5171741A (en) * | 1989-04-21 | 1992-12-15 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
| IL102645A (en) * | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| RU2063971C1 (ru) * | 1993-11-05 | 1996-07-20 | Московская государственная академия тонкой химической технологии им.М.В.Ломоносова | Способ получения производного гематопорфирина |
| IL115744A (en) * | 1994-10-27 | 2000-07-16 | Akzo Nobel Nv | Peptides comprising a subsequence of human cartilage glycoprotein - 39 |
| IL116126A0 (en) * | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
-
1999
- 1999-12-09 PT PT99958470T patent/PT1137411E/pt unknown
- 1999-12-09 JP JP2000586326A patent/JP4796227B2/ja not_active Expired - Lifetime
- 1999-12-09 CA CA2353554A patent/CA2353554C/en not_active Expired - Lifetime
- 1999-12-09 US US09/857,772 patent/US6569846B1/en not_active Expired - Lifetime
- 1999-12-09 AU AU15834/00A patent/AU771292B2/en not_active Expired
- 1999-12-09 RU RU2001118842/04A patent/RU2234508C2/ru active
- 1999-12-09 HU HU0105411A patent/HU228208B1/hu unknown
- 1999-12-09 CN CNB99816058XA patent/CN1160069C/zh not_active Expired - Lifetime
- 1999-12-09 WO PCT/IL1999/000673 patent/WO2000033833A1/en not_active Ceased
- 1999-12-09 EP EP99958470A patent/EP1137411B1/en not_active Expired - Lifetime
- 1999-12-09 SI SI9930949T patent/SI1137411T1/sl unknown
- 1999-12-09 BR BRPI9916096A patent/BRPI9916096B8/pt not_active IP Right Cessation
- 1999-12-09 NZ NZ512093A patent/NZ512093A/xx unknown
- 1999-12-09 ES ES99958470T patent/ES2277454T3/es not_active Expired - Lifetime
- 1999-12-09 PL PL348201A patent/PL201172B1/pl unknown
- 1999-12-09 HK HK02102403.5A patent/HK1040638B/en unknown
- 1999-12-09 IL IL14359199A patent/IL143591A0/xx active IP Right Grant
- 1999-12-09 AT AT99958470T patent/ATE347554T1/de active
- 1999-12-09 DE DE69934328T patent/DE69934328T2/de not_active Expired - Lifetime
- 1999-12-09 DK DK99958470T patent/DK1137411T3/da active
-
2001
- 2001-06-07 NO NO20012807A patent/NO331426B1/no not_active IP Right Cessation
-
2007
- 2007-02-15 CY CY20071100207T patent/CY1106450T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1137411T3 (da) | Palladium-substituerede bakteriechlorophyl-derivater og anvendelsen deraf | |
| FI863121A0 (fi) | Indenanaloger av mevalonolaktoner och deras derivater. | |
| ES2174551T3 (es) | Utilizacion de alcanos semifluorados como agentes dermatologicos. | |
| ES2053094T3 (es) | Agentes ansioliticos y antidepresivos bis-aza-biciclicos. | |
| SE7700777L (sv) | Forfarande for framstellning av substituerade fenylamidiner | |
| ES2062558T3 (es) | Compuestos contra el cancer. | |
| ES557756A0 (es) | Un procedimiento para preparar 1-naftoles-2-sustituidos | |
| DE69432542D1 (de) | Tetraderivate, ihre Herstellung und Verwendung | |
| FI872555A0 (fi) | Antiallergiska och antiinflammatoriska aemnen. | |
| GB2001960A (en) | Pharmaceutically Active alpha -Halomethyl Derivatives of alpha -Amino Acids | |
| DK0888379T3 (da) | Forbindelser tilhørende amidinium-familien, farmaceutiske præparater indeholdende disse forbindelser og anvendelsen deraf | |
| DK113183D0 (da) | Kroneetherforbindelser, deres fremstilling og anvendelse | |
| ATE188217T1 (de) | 1,2,3,4,10,14b-hexahydrodibenzo-c,f)pyrazino-1, - a)azepino-derivate | |
| DK221490D0 (da) | Beta-carbonyl-carboxyamider af 1,3-thiazolidiner | |
| DK37580A (da) | 4,5-dihydro-4-oxofuran-2-carboxylsyrederivater samt deres fremstilling og anvendelse | |
| SE7906507L (sv) | Fenyl-1-piperazinderivat | |
| NO964269L (no) | 2,3-dihydroksypropyl 2-(1-oksoalkyl)amino-2-deoksogluco-pyranosider, deres fremstilling og anvendelse | |
| SE8304545D0 (sv) | Benzamide derivatives | |
| SE7903672L (sv) | Nytt antibiotikum neplanocin | |
| DE3783279D1 (de) | Substituierte furazane. | |
| DE3874487D1 (de) | (6-(hetero)aryloxy-naphthalin-2-yl-oxy)-alkancarbonsaeure-derivate. | |
| ES464483A1 (es) | Procedimiento para la obtencion de ortoaminoacetofenonas. | |
| JPS56131571A (en) | Novel hetero ring substituted carboxyamide and methyl amine compound | |
| DK17785D0 (da) | Propanolderivater | |
| ATE15201T1 (de) | Organophosphat-derivate. |