CY1106450T1 - Υποκατεστημενα με παλλαδιο βακτηριοχλωροφυλλικα παραγωγα και χρηση τους - Google Patents
Υποκατεστημενα με παλλαδιο βακτηριοχλωροφυλλικα παραγωγα και χρηση τουςInfo
- Publication number
- CY1106450T1 CY1106450T1 CY20071100207T CY071100207T CY1106450T1 CY 1106450 T1 CY1106450 T1 CY 1106450T1 CY 20071100207 T CY20071100207 T CY 20071100207T CY 071100207 T CY071100207 T CY 071100207T CY 1106450 T1 CY1106450 T1 CY 1106450T1
- Authority
- CY
- Cyprus
- Prior art keywords
- derivatives
- bacteriochlorofoil
- palladium
- ch2oh
- substituted
- Prior art date
Links
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical group [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 title 2
- 229910052763 palladium Inorganic materials 0.000 title 1
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- DSJXIQQMORJERS-AGGZHOMASA-M bacteriochlorophyll a Chemical class C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@H](CC)[C@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 DSJXIQQMORJERS-AGGZHOMASA-M 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 238000002428 photodynamic therapy Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Υποκατεστημένα με παλλάδιο Βακτηριοχλωροφυλλικά παράγωγα του τύπου (I), όπου το Α αντιπροσωπεύει OH, OR1, -O-(CH2)n-Y, -S-(CH2)n-Y, -NH-(CH2)n-Y, -O-(CH2)2-NH2, -O-(CH2)2-OH, -NH-(CH2)n- +N o, X-, -NH-(CH2)2-NH=BOC ή -N-(CH2-CH=CH2)2- όπου το R1 αντιπροσωπεύει Na+, K+, (Ca2+)0.5, (Mg2+)0.5, Li+, NH4+, +NH3-C(CH2OH)3, +NH3-CH2-(CHOH)4-CH2OH, +NH2(CH3)-CH2-(CHOH)4-CH2OH ή +N(Cn’H2n’+1)4˙ το R2 αντιπροσωπεύει Η, OH ή COOR4, όπου το R4 είναι C1-C12 αλκύλιο ή C3-C12 κυκλοαλκύλιο˙ το R3 αντιπροσωπεύει Η, ΟΗ ή C1-C12 αλκύλιο ή αλκοξυ˙ το n είναι 1, 2, 3, 4, 5 ή 6, το Υ είναι -NR'1R'2 ή -+NR'1R'2R'3,Χ― όπου τα R'1, R'2 και R'3 ανεξάρτητα το ένα από το άλλο αντιπροσωπεύουν -CH3 ή -C2H5˙ το Χ είναι F, CI, Br ή I, το n' είναι 1, 2, 3 ή 4 και οι οξειδωμένες τους μορφές, είναι χρήσιμα στο πεδίο της φωτοδυναμικής θεραπείας (PDT).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98403110 | 1998-12-09 | ||
EP99958470A EP1137411B1 (en) | 1998-12-09 | 1999-12-09 | Palladium-substituted bacteriochlorophyll derivatives and use thereof |
PCT/IL1999/000673 WO2000033833A1 (en) | 1998-12-09 | 1999-12-09 | Palladium-substituted bacteriochlorophyll derivatives and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106450T1 true CY1106450T1 (el) | 2011-10-12 |
Family
ID=8235584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100207T CY1106450T1 (el) | 1998-12-09 | 2007-02-15 | Υποκατεστημενα με παλλαδιο βακτηριοχλωροφυλλικα παραγωγα και χρηση τους |
Country Status (22)
Country | Link |
---|---|
US (1) | US6569846B1 (el) |
EP (1) | EP1137411B1 (el) |
JP (1) | JP4796227B2 (el) |
CN (1) | CN1160069C (el) |
AT (1) | ATE347554T1 (el) |
AU (1) | AU771292B2 (el) |
BR (1) | BRPI9916096B8 (el) |
CA (1) | CA2353554C (el) |
CY (1) | CY1106450T1 (el) |
DE (1) | DE69934328T2 (el) |
DK (1) | DK1137411T3 (el) |
ES (1) | ES2277454T3 (el) |
HK (1) | HK1040638B (el) |
HU (1) | HU228208B1 (el) |
IL (1) | IL143591A0 (el) |
NO (1) | NO331426B1 (el) |
NZ (1) | NZ512093A (el) |
PL (1) | PL201172B1 (el) |
PT (1) | PT1137411E (el) |
RU (1) | RU2234508C2 (el) |
SI (1) | SI1137411T1 (el) |
WO (1) | WO2000033833A1 (el) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7897140B2 (en) * | 1999-12-23 | 2011-03-01 | Health Research, Inc. | Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents |
EP1318807A4 (en) * | 2000-08-11 | 2008-02-20 | Ceramoptec Gmbh | LIGHT-SENSITIVE OINTMENT |
EP1277470A1 (fr) * | 2001-07-17 | 2003-01-22 | Steba Biotech N.V. | Formulation galénique injectable pour utilisation dans un diagnostic ou une thérapie photodynamique et son procédé de préparation |
BR0304716A (pt) * | 2002-05-08 | 2004-07-13 | Yeda Res & Dev | Método para formação de imagens de mri-bold on line, sensibilizada |
JP4529344B2 (ja) * | 2002-06-03 | 2010-08-25 | ニプロ株式会社 | 腫瘍組織の酸素濃度を上昇させるためのポルフィリン酸素輸液製剤 |
EP1517684B1 (en) | 2002-06-27 | 2009-07-22 | Health Research, Inc. | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy |
AU2003249742A1 (en) * | 2002-07-02 | 2004-01-23 | Health Research, Inc. | Efficient synthesis of pyropheophorbide a and its derivatives |
IL152900A0 (en) * | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
KR101191700B1 (ko) * | 2004-06-07 | 2012-10-16 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 양이온성 박테리오클로로필 유도체 및 이의 용도 |
US20060222592A1 (en) * | 2005-04-05 | 2006-10-05 | Clemens Burda | Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications |
US20110040170A1 (en) * | 2008-01-28 | 2011-02-17 | Yeda Research And Development Co., Ltd. | Endoscopic imaging photodynamic therapy system and methods of use |
DK2257309T3 (da) | 2008-02-27 | 2020-01-20 | Yeda Res And Development Company Ltd | Rgd-(bakterie)chlorophyl-konjugater til anvendelse ved diagnose af tumorer, der omfatter nekrotiske domæner |
US20120034155A1 (en) * | 2010-08-03 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Artificial cells |
GB0819594D0 (en) | 2008-10-24 | 2008-12-03 | Univ Coimbrra | Process |
EP2425873A1 (fr) | 2010-09-07 | 2012-03-07 | Steba Maor SA | Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement |
CN103405769A (zh) * | 2013-03-07 | 2013-11-27 | 北京亿仁赛博医疗科技研发中心有限公司 | 光敏剂在制备治疗疾病的病毒灭活药物中的应用 |
DK2971026T3 (da) | 2013-03-11 | 2021-02-15 | Tookad Ip Sarl | Fremgangsmåde til produktion af bakterieklorofyl a |
CN105377862B (zh) | 2013-03-15 | 2019-09-13 | 希瑞·安·麦克法兰 | 用作光动力化合物的金属基配合物及其用途 |
AU2017250732B2 (en) | 2016-04-10 | 2022-11-10 | Memorial Sloan-Kettering Cancer Center | Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative |
US10933134B2 (en) | 2017-03-16 | 2021-03-02 | Memorial Sloan Kettering Cancer Center | Combination therapies for treatment of cancer |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5002962A (en) * | 1988-07-20 | 1991-03-26 | Health Research, Inc. | Photosensitizing agents |
US5171741A (en) * | 1989-04-21 | 1992-12-15 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
IL102645A (en) | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
IL116126A0 (en) * | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
-
1999
- 1999-12-09 EP EP99958470A patent/EP1137411B1/en not_active Expired - Lifetime
- 1999-12-09 BR BRPI9916096A patent/BRPI9916096B8/pt not_active IP Right Cessation
- 1999-12-09 DE DE69934328T patent/DE69934328T2/de not_active Expired - Lifetime
- 1999-12-09 SI SI9930949T patent/SI1137411T1/sl unknown
- 1999-12-09 PT PT99958470T patent/PT1137411E/pt unknown
- 1999-12-09 AU AU15834/00A patent/AU771292B2/en not_active Expired
- 1999-12-09 JP JP2000586326A patent/JP4796227B2/ja not_active Expired - Lifetime
- 1999-12-09 US US09/857,772 patent/US6569846B1/en not_active Expired - Lifetime
- 1999-12-09 IL IL14359199A patent/IL143591A0/xx active IP Right Grant
- 1999-12-09 CN CNB99816058XA patent/CN1160069C/zh not_active Expired - Lifetime
- 1999-12-09 ES ES99958470T patent/ES2277454T3/es not_active Expired - Lifetime
- 1999-12-09 PL PL348201A patent/PL201172B1/pl unknown
- 1999-12-09 HU HU0105411A patent/HU228208B1/hu unknown
- 1999-12-09 RU RU2001118842/04A patent/RU2234508C2/ru active
- 1999-12-09 DK DK99958470T patent/DK1137411T3/da active
- 1999-12-09 AT AT99958470T patent/ATE347554T1/de active
- 1999-12-09 WO PCT/IL1999/000673 patent/WO2000033833A1/en active IP Right Grant
- 1999-12-09 CA CA2353554A patent/CA2353554C/en not_active Expired - Lifetime
- 1999-12-09 NZ NZ512093A patent/NZ512093A/xx unknown
-
2001
- 2001-06-07 NO NO20012807A patent/NO331426B1/no not_active IP Right Cessation
-
2002
- 2002-03-28 HK HK02102403.5A patent/HK1040638B/zh unknown
-
2007
- 2007-02-15 CY CY20071100207T patent/CY1106450T1/el unknown
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