DE3856387T2 - 1,2,3,4,10,14b-HEXAHYDRODIBENZO-c,f]PYRAZINO-1,2-a]AZEPINO-DERIVATE - Google Patents

1,2,3,4,10,14b-HEXAHYDRODIBENZO-c,f]PYRAZINO-1,2-a]AZEPINO-DERIVATE

Info

Publication number
DE3856387T2
DE3856387T2 DE3856387T DE3856387T DE3856387T2 DE 3856387 T2 DE3856387 T2 DE 3856387T2 DE 3856387 T DE3856387 T DE 3856387T DE 3856387 T DE3856387 T DE 3856387T DE 3856387 T2 DE3856387 T2 DE 3856387T2
Authority
DE
Germany
Prior art keywords
pct
lower alkyl
alkyl
hexahydrodibenzo
azepino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3856387T
Other languages
English (en)
Other versions
DE3856387D1 (de
Inventor
Frederick Copp
Alan Boura
William Jackson
John Cullen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
POLYCHIP ELECTRONICS Pty Ltd
Monash University
Original Assignee
POLYCHIP ELECTRONICS Pty Ltd
Monash University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by POLYCHIP ELECTRONICS Pty Ltd, Monash University filed Critical POLYCHIP ELECTRONICS Pty Ltd
Publication of DE3856387D1 publication Critical patent/DE3856387D1/de
Application granted granted Critical
Publication of DE3856387T2 publication Critical patent/DE3856387T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE3856387T 1987-04-10 1988-03-31 1,2,3,4,10,14b-HEXAHYDRODIBENZO-c,f]PYRAZINO-1,2-a]AZEPINO-DERIVATE Expired - Fee Related DE3856387T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPI136387 1987-04-10
PCT/AU1988/000095 WO1988007997A1 (en) 1987-04-10 1988-03-31 1,2,3,4,10,14b-HEXAHYDRODIBENZO[c,f]PYRAZINO-[1,2-a]AZEPINO DERIVATIVES AND 10-AZA, 10-OXA AND 10-THIA ANALOGUES

Publications (2)

Publication Number Publication Date
DE3856387D1 DE3856387D1 (de) 2000-02-03
DE3856387T2 true DE3856387T2 (de) 2000-05-11

Family

ID=3772107

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3856387T Expired - Fee Related DE3856387T2 (de) 1987-04-10 1988-03-31 1,2,3,4,10,14b-HEXAHYDRODIBENZO-c,f]PYRAZINO-1,2-a]AZEPINO-DERIVATE

Country Status (7)

Country Link
US (1) US5049637A (de)
EP (1) EP0379483B1 (de)
JP (1) JP2865255B2 (de)
AT (1) ATE188217T1 (de)
CA (1) CA1336773C (de)
DE (1) DE3856387T2 (de)
WO (1) WO1988007997A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2026925A1 (en) * 1989-10-05 1991-04-06 Hiroshi Fukumi Tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use
JPH04211071A (ja) * 1990-03-05 1992-08-03 Hokuriku Seiyaku Co Ltd 多環式化合物
EP0539164A1 (de) * 1991-10-23 1993-04-28 Sankyo Company Limited Stickstoff enthaltende tetracyclische Verbindungen mit antiallergischen und antiasthmatischen Wirkungen, ihre Herstellung und Verwendung
EP1017695A4 (de) * 1997-09-26 2002-01-16 Univ Monash Trennung von optisch aktiven verbindungen
WO1999047524A1 (en) * 1998-03-17 1999-09-23 Novo Nordisk A/S Novel heterocyclic compounds
US6187770B1 (en) 1998-03-17 2001-02-13 Novo Nordisk A/S N-substituted azaheterocyclic compounds
AU2002951965A0 (en) * 2002-10-09 2002-10-24 Monash University Amidine compounds
ITMI20042230A1 (it) * 2004-11-19 2005-02-19 Farchemia Srl Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide
ES2568262T3 (es) * 2009-04-23 2016-04-28 Abbvie Inc. Moduladores de receptores de 5-HT y sus métodos de uso
US8546377B2 (en) 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8518933B2 (en) * 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129434C (de) * 1966-03-12
EP0126343A1 (de) * 1983-05-18 1984-11-28 Beecham Group Plc Behandlung der Diarrhöe

Also Published As

Publication number Publication date
EP0379483A1 (de) 1990-08-01
ATE188217T1 (de) 2000-01-15
DE3856387D1 (de) 2000-02-03
EP0379483A4 (en) 1991-10-09
JPH02503670A (ja) 1990-11-01
WO1988007997A1 (en) 1988-10-20
EP0379483B1 (de) 1999-12-29
US5049637A (en) 1991-09-17
CA1336773C (en) 1995-08-22
JP2865255B2 (ja) 1999-03-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee