ATE189203T1 - Trizyklische derivate, ihre herstellung, ihre verwendung zur herstellung von optisch aktivem oder racemischem colchizin, thiocolchizin, dessen analoge oder derivate, und intermediate - Google Patents

Trizyklische derivate, ihre herstellung, ihre verwendung zur herstellung von optisch aktivem oder racemischem colchizin, thiocolchizin, dessen analoge oder derivate, und intermediate

Info

Publication number
ATE189203T1
ATE189203T1 AT96400417T AT96400417T ATE189203T1 AT E189203 T1 ATE189203 T1 AT E189203T1 AT 96400417 T AT96400417 T AT 96400417T AT 96400417 T AT96400417 T AT 96400417T AT E189203 T1 ATE189203 T1 AT E189203T1
Authority
AT
Austria
Prior art keywords
derivatives
alkyl
thiocolchicine
analogues
intermediates
Prior art date
Application number
AT96400417T
Other languages
English (en)
Inventor
Francis Brion
Bernadette Chappert
Christian Diolez
Christian Marie
Alain Mazurie
Michel Middendorp
Didier Pronine
Edmond Toromanoff
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ATE189203T1 publication Critical patent/ATE189203T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/543Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings to a six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63Esters of sulfonic acids
    • C07C309/72Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96400417T 1995-03-03 1996-02-28 Trizyklische derivate, ihre herstellung, ihre verwendung zur herstellung von optisch aktivem oder racemischem colchizin, thiocolchizin, dessen analoge oder derivate, und intermediate ATE189203T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9502480A FR2731217B1 (fr) 1995-03-03 1995-03-03 Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires

Publications (1)

Publication Number Publication Date
ATE189203T1 true ATE189203T1 (de) 2000-02-15

Family

ID=9476700

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96400417T ATE189203T1 (de) 1995-03-03 1996-02-28 Trizyklische derivate, ihre herstellung, ihre verwendung zur herstellung von optisch aktivem oder racemischem colchizin, thiocolchizin, dessen analoge oder derivate, und intermediate

Country Status (18)

Country Link
US (3) US5705704A (de)
EP (1) EP0729933B1 (de)
JP (1) JP3831445B2 (de)
KR (2) KR100415038B1 (de)
CN (2) CN1067044C (de)
AT (1) ATE189203T1 (de)
AU (1) AU717153B2 (de)
CA (1) CA2170806C (de)
DE (1) DE69606337T2 (de)
DK (1) DK0729933T3 (de)
EA (1) EA000093B1 (de)
ES (1) ES2141445T3 (de)
FR (1) FR2731217B1 (de)
GR (1) GR3033123T3 (de)
HU (1) HUP9600517A3 (de)
MX (1) MX9600816A (de)
PT (1) PT729933E (de)
ZA (1) ZA961694B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA002271B1 (ru) * 1996-03-20 2002-02-28 Хехст Марион Руссель ТРИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ В ОТНОШЕНИИ ИНТЕГРИНОВ, В ЧАСТНОСТИ В ОТНОШЕНИИ ИНТЕГРИНА АЛЬФАvБЕТА 3, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, ИСПОЛЬЗУЕМЫЕ В ЭТОМ СПОСОБЕ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МЕДИКАМЕНТОВ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US6459001B1 (en) * 1997-03-20 2002-10-01 Aventis Pharma S.A. Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them
FR2768734B1 (fr) * 1997-09-24 2000-01-28 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2768736B1 (fr) * 1997-09-24 2000-05-26 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
EP1236713A4 (de) * 1999-11-18 2004-10-13 Ajinomoto Kk Neue zwischenstufen für süssstoffe mit hoher süssigkeit und verfahren zu deren herstellung
IT1318436B1 (it) * 2000-03-31 2003-08-25 Enichem Spa Ciclopentadieni sostituiti policiclici e metodo per la loropreparazione.
US7204754B2 (en) * 2001-09-28 2007-04-17 Igt Gaming device having a mechanical award indicator
PL2470499T3 (pl) 2009-08-26 2019-11-29 Alberta Health Services Nowe pochodne kolchicyny, sposoby i ich zastosowania

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5426224A (en) * 1993-03-18 1995-06-20 The University Of North Carolina At Chapel Hill Mammalian DNA topoisomerase II inhibitor and method

Also Published As

Publication number Publication date
CA2170806C (fr) 2009-12-01
HUP9600517A2 (en) 1997-01-28
DE69606337T2 (de) 2000-08-10
ZA961694B (en) 1997-03-03
CN1067044C (zh) 2001-06-13
DK0729933T3 (da) 2000-07-17
EA000093B1 (ru) 1998-06-25
FR2731217A1 (fr) 1996-09-06
EA199600007A3 (ru) 1996-12-30
JP3831445B2 (ja) 2006-10-11
EP0729933B1 (de) 2000-01-26
EP0729933A1 (de) 1996-09-04
CA2170806A1 (fr) 1996-09-04
AU4585096A (en) 1996-09-12
KR100414622B1 (ko) 2004-01-13
CN1143622A (zh) 1997-02-26
DE69606337D1 (de) 2000-03-02
ES2141445T3 (es) 2000-03-16
AU717153B2 (en) 2000-03-16
GR3033123T3 (en) 2000-08-31
CN1310171A (zh) 2001-08-29
HUP9600517A3 (en) 1998-07-28
KR100415038B1 (ko) 2004-04-13
US5959146A (en) 1999-09-28
US5705704A (en) 1998-01-06
MX9600816A (es) 1997-02-28
FR2731217B1 (fr) 1997-06-13
KR960034153A (ko) 1996-10-22
US6268520B1 (en) 2001-07-31
JPH0967326A (ja) 1997-03-11
PT729933E (pt) 2000-05-31
EA199600007A2 (ru) 1996-10-01
HU9600517D0 (en) 1996-04-29

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee