DE69606337D1 - Trizyklische Derivate, ihre Herstellung, ihre Verwendung zur Herstellung von optisch aktivem oder racemischem Colchizin, Thiocolchizin, dessen Analoge oder Derivate, und Intermediate - Google Patents

Trizyklische Derivate, ihre Herstellung, ihre Verwendung zur Herstellung von optisch aktivem oder racemischem Colchizin, Thiocolchizin, dessen Analoge oder Derivate, und Intermediate

Info

Publication number
DE69606337D1
DE69606337D1 DE69606337T DE69606337T DE69606337D1 DE 69606337 D1 DE69606337 D1 DE 69606337D1 DE 69606337 T DE69606337 T DE 69606337T DE 69606337 T DE69606337 T DE 69606337T DE 69606337 D1 DE69606337 D1 DE 69606337D1
Authority
DE
Germany
Prior art keywords
derivatives
alkyl
thiocolchicine
analogs
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69606337T
Other languages
English (en)
Other versions
DE69606337T2 (de
Inventor
Francis Brion
Bernadette Chappert
Christian Diolez
Christian Marie
Alain Mazurie
Michel Middendorp
Didier Pronine
Edmond Toromanoff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Hoechst Marion Roussel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel filed Critical Hoechst Marion Roussel
Application granted granted Critical
Publication of DE69606337D1 publication Critical patent/DE69606337D1/de
Publication of DE69606337T2 publication Critical patent/DE69606337T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/543—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69606337T 1995-03-03 1996-02-28 Trizyklische Derivate, ihre Herstellung, ihre Verwendung zur Herstellung von optisch aktivem oder racemischem Colchizin, Thiocolchizin, dessen Analoge oder Derivate, und Intermediate Expired - Lifetime DE69606337T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9502480A FR2731217B1 (fr) 1995-03-03 1995-03-03 Nouveaux derives tricycliques, leur preparation, leur application a la preparation de la colchicine et de la thiocolchicine optiquement actives ou racemiques et d'analogues ou derives et intermediaires

Publications (2)

Publication Number Publication Date
DE69606337D1 true DE69606337D1 (de) 2000-03-02
DE69606337T2 DE69606337T2 (de) 2000-08-10

Family

ID=9476700

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69606337T Expired - Lifetime DE69606337T2 (de) 1995-03-03 1996-02-28 Trizyklische Derivate, ihre Herstellung, ihre Verwendung zur Herstellung von optisch aktivem oder racemischem Colchizin, Thiocolchizin, dessen Analoge oder Derivate, und Intermediate

Country Status (18)

Country Link
US (3) US5705704A (de)
EP (1) EP0729933B1 (de)
JP (1) JP3831445B2 (de)
KR (2) KR100415038B1 (de)
CN (2) CN1067044C (de)
AT (1) ATE189203T1 (de)
AU (1) AU717153B2 (de)
CA (1) CA2170806C (de)
DE (1) DE69606337T2 (de)
DK (1) DK0729933T3 (de)
EA (1) EA000093B1 (de)
ES (1) ES2141445T3 (de)
FR (1) FR2731217B1 (de)
GR (1) GR3033123T3 (de)
HU (1) HUP9600517A3 (de)
MX (1) MX9600816A (de)
PT (1) PT729933E (de)
ZA (1) ZA961694B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP806A (en) * 1996-03-20 2000-01-28 Aventis Pharma Sa Tricyclic compounds having activity specific for integrins, particularly avB3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same.
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
US6459001B1 (en) * 1997-03-20 2002-10-01 Aventis Pharma S.A. Tricyclic compounds, their preparation process and the intermediates of this process, their use as medicaments and the pharmaceutical compositions containing them
FR2768736B1 (fr) * 1997-09-24 2000-05-26 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2768734B1 (fr) * 1997-09-24 2000-01-28 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
EP1236713A4 (de) * 1999-11-18 2004-10-13 Ajinomoto Kk Neue zwischenstufen für süssstoffe mit hoher süssigkeit und verfahren zu deren herstellung
IT1318436B1 (it) * 2000-03-31 2003-08-25 Enichem Spa Ciclopentadieni sostituiti policiclici e metodo per la loropreparazione.
US7210997B2 (en) * 2001-09-28 2007-05-01 Igt Gaming device having a mechanical award indicator
DK2470499T3 (da) * 2009-08-26 2019-09-23 Alberta Health Services Nye colchicin-derivativer, fremgangsmåder og anvendelse deraf

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5426224A (en) * 1993-03-18 1995-06-20 The University Of North Carolina At Chapel Hill Mammalian DNA topoisomerase II inhibitor and method

Also Published As

Publication number Publication date
CN1143622A (zh) 1997-02-26
AU4585096A (en) 1996-09-12
KR100414622B1 (ko) 2004-01-13
EA000093B1 (ru) 1998-06-25
GR3033123T3 (en) 2000-08-31
DE69606337T2 (de) 2000-08-10
CA2170806C (fr) 2009-12-01
CN1310171A (zh) 2001-08-29
JP3831445B2 (ja) 2006-10-11
ES2141445T3 (es) 2000-03-16
FR2731217B1 (fr) 1997-06-13
JPH0967326A (ja) 1997-03-11
EA199600007A2 (ru) 1996-10-01
ATE189203T1 (de) 2000-02-15
EP0729933A1 (de) 1996-09-04
MX9600816A (es) 1997-02-28
US6268520B1 (en) 2001-07-31
HU9600517D0 (en) 1996-04-29
EP0729933B1 (de) 2000-01-26
DK0729933T3 (da) 2000-07-17
CA2170806A1 (fr) 1996-09-04
US5705704A (en) 1998-01-06
KR100415038B1 (ko) 2004-04-13
US5959146A (en) 1999-09-28
EA199600007A3 (ru) 1996-12-30
PT729933E (pt) 2000-05-31
ZA961694B (en) 1997-03-03
FR2731217A1 (fr) 1996-09-06
HUP9600517A2 (en) 1997-01-28
CN1067044C (zh) 2001-06-13
HUP9600517A3 (en) 1998-07-28
KR960034153A (ko) 1996-10-22
AU717153B2 (en) 2000-03-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS PHARMA S.A., ANTONY, FR

8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC