ES2061779T3 - Nuevas 6-fenoximetil-4-hidroxitetrahidropiran-2-onas y 6-tiofenoximetil-4-hidroxitetrahidropiran-2-onas, asi como los correspondientes derivados de acidos dihidroxicarboxilicos, sales y esteres, procedimiento para la preparacion de estos compuestos, su utilizacion como medicament - Google Patents

Nuevas 6-fenoximetil-4-hidroxitetrahidropiran-2-onas y 6-tiofenoximetil-4-hidroxitetrahidropiran-2-onas, asi como los correspondientes derivados de acidos dihidroxicarboxilicos, sales y esteres, procedimiento para la preparacion de estos compuestos, su utilizacion como medicament

Info

Publication number
ES2061779T3
ES2061779T3 ES89108378T ES89108378T ES2061779T3 ES 2061779 T3 ES2061779 T3 ES 2061779T3 ES 89108378 T ES89108378 T ES 89108378T ES 89108378 T ES89108378 T ES 89108378T ES 2061779 T3 ES2061779 T3 ES 2061779T3
Authority
ES
Spain
Prior art keywords
southeast
hidroxitetrahidropiran
onas
well
thiofenoximetil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89108378T
Other languages
English (en)
Inventor
Heiner Dr Jendralla
Gunther Dr Wess
Wilhelm Prof Dr Bartmann
Gerhard Dr Beck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE3816388A external-priority patent/DE3816388A1/de
Priority claimed from DE19883819999 external-priority patent/DE3819999A1/de
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2061779T3 publication Critical patent/ES2061779T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/09—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)

Abstract

SE DESCRIBEN NUEVOS COMPUESTOS DE FORMULA GENERAL I, ASI COMO LOS CORRESPONDIENTES ACIDOS DIHIDROXICARBOXILICOS DE CADENA ABIERTA DE FORMULA II, DONDE X, Y Y Z TIENEN LA SIGNIFICACION CITADA, ASI COMO SUS SALES FARMACOLOGICAMENTE COMPATIBLES CON BASES Y SUS ESTERES FARMACOLOGICAMENTE COMPATIBLES, PROCESO DE OBTENCION DE ESTE COMPUESTO, SU USO COMO MEDICAMENTO, ASI COMO PREPARADOS FARMACEUTICOS. ADEMAS SE DESCRIBEN NUEVOS FENOLES Y TIOFENOLES DE FORMULA II, DONDE X, Y Y Z TIENEN LA SIGNIFICACION DADA.
ES89108378T 1988-05-13 1989-05-10 Nuevas 6-fenoximetil-4-hidroxitetrahidropiran-2-onas y 6-tiofenoximetil-4-hidroxitetrahidropiran-2-onas, asi como los correspondientes derivados de acidos dihidroxicarboxilicos, sales y esteres, procedimiento para la preparacion de estos compuestos, su utilizacion como medicament Expired - Lifetime ES2061779T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3816388A DE3816388A1 (de) 1988-05-13 1988-05-13 Neue-6-phenoxymethyl-4-hydroxytetrahydropyran-2-one und 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-one, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und neue phenole sowie thiophenole
DE19883819999 DE3819999A1 (de) 1988-06-11 1988-06-11 Neue 6-phenoxymethyl-4-hydroxytetrahydropyran-2-one und 6-thiphenoxymethyl-4-hydroxytetrahydropyran-2 -one, sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zur herstellung dieser verbindung, ihre verwendung als arzneimittel, pharmazeutische praeparate und neue phenole sowie thiophenole

Publications (1)

Publication Number Publication Date
ES2061779T3 true ES2061779T3 (es) 1994-12-16

Family

ID=25868078

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89108378T Expired - Lifetime ES2061779T3 (es) 1988-05-13 1989-05-10 Nuevas 6-fenoximetil-4-hidroxitetrahidropiran-2-onas y 6-tiofenoximetil-4-hidroxitetrahidropiran-2-onas, asi como los correspondientes derivados de acidos dihidroxicarboxilicos, sales y esteres, procedimiento para la preparacion de estos compuestos, su utilizacion como medicament

Country Status (16)

Country Link
EP (1) EP0341681B1 (es)
JP (1) JP2833779B2 (es)
KR (1) KR900018062A (es)
AU (1) AU615060B2 (es)
CA (1) CA1338018C (es)
DE (1) DE58906520D1 (es)
DK (1) DK235389A (es)
ES (1) ES2061779T3 (es)
FI (1) FI96684C (es)
HU (1) HU206312B (es)
IE (1) IE63298B1 (es)
IL (1) IL90249A (es)
NO (1) NO172538C (es)
NZ (1) NZ229083A (es)
PH (1) PH26257A (es)
PT (1) PT90532B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929913A1 (de) * 1989-09-08 1991-04-04 Hoechst Ag 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte
EP0643054A3 (en) * 1993-08-09 1995-05-03 Fujirebio Kk Process for the preparation of carbonic acid ester derivatives and intermediates.
US9045684B2 (en) * 2012-07-30 2015-06-02 Jnc Corporation Liquid crystal composition, antioxidant and liquid crystal display device

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0216127B1 (de) * 1985-08-29 1990-09-26 Hoechst Aktiengesellschaft 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-one, Verfahren zu ihrer Herstellung, ihre Verwendung als Arzneimittel, pharmazeutische Präparate und Zwischenprodukte
DE3530798A1 (de) * 1985-08-29 1987-03-05 Hoechst Ag 6-phenoxymethyl-4-hydroxytetrahydropyran-2-one, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
DE3632893A1 (de) * 1986-09-27 1988-04-07 Hoechst Ag 4-(r)-hydroxy-6(s)-arylthiomethyl-tetrahydropyran-2-one, deren entsprechende sulfoxide und sulfone, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate und zwischenprodukte
DE3929913A1 (de) * 1989-09-08 1991-04-04 Hoechst Ag 4-hydroxytetrahydropyran-2-one sowie die entsprechenden dihydroxycarbonsaeurederivate, salze und ester, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, pharmazeutische praeparate sowie vorprodukte

Also Published As

Publication number Publication date
FI892291A (fi) 1989-11-14
DK235389A (da) 1989-11-14
NO891937D0 (no) 1989-05-12
IE891554L (en) 1989-11-13
AU615060B2 (en) 1991-09-19
IL90249A0 (en) 1989-12-15
PT90532A (pt) 1989-11-30
FI96684C (fi) 1996-08-12
EP0341681A3 (en) 1990-05-16
NO172538C (no) 1993-08-04
PH26257A (en) 1992-04-01
NZ229083A (en) 1990-12-21
IE63298B1 (en) 1995-04-05
DK235389D0 (da) 1989-05-12
NO891937L (no) 1989-11-14
PT90532B (pt) 1994-11-30
NO172538B (no) 1993-04-26
DE58906520D1 (de) 1994-02-10
HU206312B (en) 1992-10-28
JPH01319472A (ja) 1989-12-25
JP2833779B2 (ja) 1998-12-09
IL90249A (en) 1994-01-25
EP0341681A2 (de) 1989-11-15
HUT58309A (en) 1992-02-28
AU3471589A (en) 1989-12-21
CA1338018C (en) 1996-01-30
EP0341681B1 (de) 1993-12-29
FI96684B (fi) 1996-04-30
FI892291A0 (fi) 1989-05-11
KR900018062A (ko) 1990-12-20

Similar Documents

Publication Publication Date Title
ES2054860T5 (es) Derivados de 9-halogeno-(z)-prostaglandinas, procedimiento para su preparacion y su utilizacion como medicamentos.
ES2119762T3 (es) Tratamiento de la catarata con la ayuda de derivados 15-ceto-prostaglandinas.
AR004498A1 (es) Compuestos de aminofosfonato y composiciones farmaceuticas que los contienen, el uso de los mismos, y un procedimiento para su preparacion
ES2080739T3 (es) Nitro-compuestos insecticidamente activos.
SE8602723L (sv) Tiazoler, deras framstellning och farmaceutiska kompositioner innehallande dem
PT83647B (pt) Processo para a preparacao de novos derivados de benzimidazole com actividade farmacologica e de composicoes farmaceuticas que os contem
ATE269089T1 (de) Verwendung von vitamin d derivaten zur verstärkung der wirkung von zytotoxischen stoffen
ES557835A0 (es) Un procedimiento para preparar una formulacion farmaceutica que contiene 3'-azido-3'-desoxitimidina o uno de sus derivados farmaceuticamente aceptables.
ES2062310T3 (es) Un procedimiento para fabricar un preparado farmaceutico acuoso estabilizado.
AR011116A1 (es) Compuesto derivado de n-hidroxi-beta-sulfonil propionamida y composicion farmaceutica que lo contiene
AR011846A1 (es) Una composicion farmaceutica, y el procedimiento para prepararla
FI865233A (fi) Pyrazolinderivat, deras framstaellning och anvaendning som medel med insekticid och akaricid verkan.
BR0014818A (pt) Imidazo-3-il-aminas bicìclicas procedimento de preparação e medicamentos que contém como substância ativa pelo menos uma imidazo-3-il-amina bicìclica
DK249389D0 (da) 2-acylamino-benzothiazol-forbindelser og deres anvendelse til fremstilling af laegemidler til behandling af tumorer
ES2052028T3 (es) Un metodo para preparar compuestos diarilicos anti-ateroscleroticos.
ES2058149T3 (es) 3,4-dihidro-2h-benzopiranos sustiuidos, procedimiento para su preparacion, su empleo, asi como preparados farmaceuticos a base de estos compuestos.
AR002265A1 (es) Soluciones para inyeccion o infusion que comprenden enrofloxaxin y su procedimiento de preparacion
ES2059625T3 (es) Un procedimiento para preparar un derivado de hidroxialquilcisteina.
NL175882B (nl) Farmaceutisch preparaat, dat een verbinding met ontstekingtegengaande werking bevat.
ES2061779T3 (es) Nuevas 6-fenoximetil-4-hidroxitetrahidropiran-2-onas y 6-tiofenoximetil-4-hidroxitetrahidropiran-2-onas, asi como los correspondientes derivados de acidos dihidroxicarboxilicos, sales y esteres, procedimiento para la preparacion de estos compuestos, su utilizacion como medicament
ES2052850T3 (es) Un procedimiento para preparar un compuesto de hidrazona.
BR9806193A (pt) Composição bi-aromáticos ligados por um radical heteroetinileno e composições farmacêuticas e cosméticas que os contêm
MX9301235A (es) DERIVADOS 1,4-DIOXINO(2,3-B)PIRIDINA. á
BR9507381A (pt) Composto uso de um composto processo para o tratamento de um manifero composição famacèutica e processo para a preparação de compostos
ES2078256T3 (es) Formula farmaceutica para uso topico que contiene diclofenaco sodico.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 341681

Country of ref document: ES