BR9806193A - Composição bi-aromáticos ligados por um radical heteroetinileno e composições farmacêuticas e cosméticas que os contêm - Google Patents
Composição bi-aromáticos ligados por um radical heteroetinileno e composições farmacêuticas e cosméticas que os contêmInfo
- Publication number
- BR9806193A BR9806193A BR9806193-3A BR9806193A BR9806193A BR 9806193 A BR9806193 A BR 9806193A BR 9806193 A BR9806193 A BR 9806193A BR 9806193 A BR9806193 A BR 9806193A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical
- compositions containing
- cosmetic compositions
- aromatic composition
- heteroethynylene
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C391/00—Compounds containing selenium
- C07C391/02—Compounds containing selenium having selenium atoms bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Abstract
Patente de Invenção: <B>''COMPOSTOS Bl-AROMáTICOS LIGADOS POR UM RADICAL HETEROETINILENO E COMPOSIçõES FARMACêUTICAS E COSMéTICAS QUE OS CONTêM''<D>. A invenção se refere a compostos de fórmula (I) nos quais: Ar representa um radical selecionado dentre as fórmulas (a) a (c). Z sendo O, S ou N-R~ 6~; R~ 1~, representa em particular um átomo de halogênio, -CH~ 3~, ou carboxila; R~ 2~ e R~ 3~ representam em particular H, alquila, cicloalquila; ou R~ 2~ e R~ 3~ juntos formam um ciclo com 5 ou 6 cadeias; R~ 4~ e R~ 5~ representam em particular H ou um átomo de halogênio; R~ 6~ representa em particular H ou alquila; X representa um radical Y-C<sym>C-; Y representa O, <sym>S(O)~ n?~, ou Se(O)~ n'~, n sendo 0, 1 ou 2, e os sais dos compostos da fórmula (I). Os referidos compostos podem ser usados em particular para o tratamento de moléstias dermatológicas relacionadas a uma desordem de queratinização, e para lutar contra o envelhecimento da pele.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9710554A FR2767526B1 (fr) | 1997-08-21 | 1997-08-21 | Composes bi-aromatiques relies par un radical heteroethynylene et compositions pharmaceutiques et cosmetiques les contenant |
PCT/FR1998/001835 WO1999010322A1 (fr) | 1997-08-21 | 1998-08-21 | Composes bi-aromatiques relies par un radical heteroethynylene et compositions pharmaceutiques et cosmetiques les contenant |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9806193A true BR9806193A (pt) | 1999-11-16 |
Family
ID=9510427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9806193-3A BR9806193A (pt) | 1997-08-21 | 1998-08-21 | Composição bi-aromáticos ligados por um radical heteroetinileno e composições farmacêuticas e cosméticas que os contêm |
Country Status (21)
Country | Link |
---|---|
US (2) | US6201019B1 (pt) |
EP (1) | EP0952975B1 (pt) |
KR (1) | KR100399992B1 (pt) |
CN (1) | CN1184200C (pt) |
AT (1) | ATE220393T1 (pt) |
AU (1) | AU737628B2 (pt) |
BR (1) | BR9806193A (pt) |
CA (1) | CA2268796C (pt) |
DE (1) | DE69806465T2 (pt) |
DK (1) | DK0952975T3 (pt) |
ES (1) | ES2179529T3 (pt) |
FR (1) | FR2767526B1 (pt) |
ID (1) | ID21353A (pt) |
IL (1) | IL129359A0 (pt) |
NO (1) | NO991867L (pt) |
NZ (1) | NZ335083A (pt) |
PL (1) | PL332964A1 (pt) |
PT (1) | PT952975E (pt) |
RU (1) | RU2185373C2 (pt) |
TR (1) | TR199900872T1 (pt) |
WO (1) | WO1999010322A1 (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2767526B1 (fr) | 1997-08-21 | 2002-10-04 | Galderma Rech Dermatologique | Composes bi-aromatiques relies par un radical heteroethynylene et compositions pharmaceutiques et cosmetiques les contenant |
US6818666B2 (en) * | 1919-08-21 | 2004-11-16 | Galderma Research & Development | Bi-aromatic compounds linked via a heteroethylene radical, and pharmaceutical and cosmetic compositions using them |
DE10004724A1 (de) | 2000-02-03 | 2001-08-09 | Bayer Ag | Rohrleitung mit ultraphober Innenwand |
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
EP1609460A1 (en) * | 2004-06-24 | 2005-12-28 | The Procter & Gamble Company | Skin care compositions comprising fatty material having a melting temperature range of 21-40 C |
FR2910320B1 (fr) | 2006-12-21 | 2009-02-13 | Galderma Res & Dev S N C Snc | Emulsion comprenant au moins un retinoide et du peroxyde de benzole |
FR2910321B1 (fr) | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
FR2931661B1 (fr) | 2008-05-30 | 2010-07-30 | Galderma Res & Dev | Nouvelles compositions depigmentantes sous forme d'une composition anhydre sans vaseline et sans elastomere comprenant un derive phenolique solubilise et un retinoide. |
FR2993562B1 (fr) * | 2012-07-23 | 2014-08-22 | Galderma Res & Dev | Nouveaux composes inhibiteurs selectifs du cyp26a1 utiles dans le traitement de pathologies. |
RU2753863C2 (ru) | 2016-02-03 | 2021-08-24 | Галдерма Ресерч Энд Девелопмент | Новые биароматические соединения пропинила, фармацевтические и косметические композиции, их содержащие, и их применение |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2767526B1 (fr) | 1997-08-21 | 2002-10-04 | Galderma Rech Dermatologique | Composes bi-aromatiques relies par un radical heteroethynylene et compositions pharmaceutiques et cosmetiques les contenant |
JPS4913326B1 (pt) * | 1970-06-20 | 1974-03-30 | ||
FR2713635B1 (fr) * | 1993-12-15 | 1996-01-05 | Cird Galderma | Nouveaux composés propynyl bi-aromatiques, compositions pharmaceutiques et cosmétiques les contenant et utilisations. |
-
1997
- 1997-08-21 FR FR9710554A patent/FR2767526B1/fr not_active Expired - Fee Related
-
1998
- 1998-08-21 KR KR10-1999-7003283A patent/KR100399992B1/ko not_active IP Right Cessation
- 1998-08-21 DK DK98942768T patent/DK0952975T3/da active
- 1998-08-21 NZ NZ335083A patent/NZ335083A/xx unknown
- 1998-08-21 TR TR1999/00872T patent/TR199900872T1/xx unknown
- 1998-08-21 WO PCT/FR1998/001835 patent/WO1999010322A1/fr active IP Right Grant
- 1998-08-21 EP EP98942768A patent/EP0952975B1/fr not_active Expired - Lifetime
- 1998-08-21 RU RU99109984/04A patent/RU2185373C2/ru not_active IP Right Cessation
- 1998-08-21 AT AT98942768T patent/ATE220393T1/de active
- 1998-08-21 US US09/269,977 patent/US6201019B1/en not_active Expired - Lifetime
- 1998-08-21 ES ES98942768T patent/ES2179529T3/es not_active Expired - Lifetime
- 1998-08-21 CA CA002268796A patent/CA2268796C/fr not_active Expired - Fee Related
- 1998-08-21 AU AU90782/98A patent/AU737628B2/en not_active Ceased
- 1998-08-21 ID IDW990214A patent/ID21353A/id unknown
- 1998-08-21 BR BR9806193-3A patent/BR9806193A/pt not_active Application Discontinuation
- 1998-08-21 PL PL98332964A patent/PL332964A1/xx not_active IP Right Cessation
- 1998-08-21 DE DE69806465T patent/DE69806465T2/de not_active Expired - Lifetime
- 1998-08-21 CN CNB988011735A patent/CN1184200C/zh not_active Expired - Fee Related
- 1998-08-21 PT PT98942768T patent/PT952975E/pt unknown
- 1998-09-21 IL IL12935998A patent/IL129359A0/xx unknown
-
1999
- 1999-04-19 NO NO991867A patent/NO991867L/no not_active Application Discontinuation
-
2001
- 2001-01-25 US US09/768,496 patent/US6441010B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FR2767526A1 (fr) | 1999-02-26 |
CN1236359A (zh) | 1999-11-24 |
EP0952975A1 (fr) | 1999-11-03 |
DE69806465T2 (de) | 2003-02-27 |
ES2179529T3 (es) | 2003-01-16 |
NZ335083A (en) | 2000-04-28 |
WO1999010322A1 (fr) | 1999-03-04 |
WO1999010322B1 (fr) | 1999-04-08 |
US20010056105A1 (en) | 2001-12-27 |
ID21353A (id) | 1999-05-27 |
FR2767526B1 (fr) | 2002-10-04 |
TR199900872T1 (xx) | 2000-02-21 |
KR100399992B1 (ko) | 2003-09-29 |
CN1184200C (zh) | 2005-01-12 |
US6441010B2 (en) | 2002-08-27 |
CA2268796A1 (fr) | 1999-03-04 |
KR20000068772A (ko) | 2000-11-25 |
JP3631499B2 (ja) | 2005-03-23 |
CA2268796C (fr) | 2006-03-14 |
ATE220393T1 (de) | 2002-07-15 |
NO991867L (no) | 1999-06-21 |
AU737628B2 (en) | 2001-08-23 |
JP2000516968A (ja) | 2000-12-19 |
RU2185373C2 (ru) | 2002-07-20 |
NO991867D0 (no) | 1999-04-19 |
IL129359A0 (en) | 2000-02-17 |
DK0952975T3 (da) | 2002-10-28 |
PT952975E (pt) | 2002-11-29 |
EP0952975B1 (fr) | 2002-07-10 |
AU9078298A (en) | 1999-03-16 |
US6201019B1 (en) | 2001-03-13 |
DE69806465D1 (de) | 2002-08-14 |
PL332964A1 (en) | 1999-10-25 |
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