JP4796227B2 - パラジウム置換バクテリオクロロフィル誘導体およびその用途 - Google Patents

パラジウム置換バクテリオクロロフィル誘導体およびその用途 Download PDF

Info

Publication number
JP4796227B2
JP4796227B2 JP2000586326A JP2000586326A JP4796227B2 JP 4796227 B2 JP4796227 B2 JP 4796227B2 JP 2000586326 A JP2000586326 A JP 2000586326A JP 2000586326 A JP2000586326 A JP 2000586326A JP 4796227 B2 JP4796227 B2 JP 4796227B2
Authority
JP
Japan
Prior art keywords
bpheid
compound
formula
cells
pdt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2000586326A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002531497A5 (enExample
JP2002531497A (ja
Inventor
シェルズ、アビグドル
サロモン、ヨラム
ブランディス、アレクサンデル
シェール、フーゴ
Original Assignee
イエダ・リサーチ・アンド・デベロツプメント・カンパニー・リミテツド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by イエダ・リサーチ・アンド・デベロツプメント・カンパニー・リミテツド filed Critical イエダ・リサーチ・アンド・デベロツプメント・カンパニー・リミテツド
Publication of JP2002531497A publication Critical patent/JP2002531497A/ja
Publication of JP2002531497A5 publication Critical patent/JP2002531497A5/ja
Application granted granted Critical
Publication of JP4796227B2 publication Critical patent/JP4796227B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2000586326A 1998-12-09 1999-12-09 パラジウム置換バクテリオクロロフィル誘導体およびその用途 Expired - Lifetime JP4796227B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98403110 1998-12-09
EP98403110.4 1998-12-09
PCT/IL1999/000673 WO2000033833A1 (en) 1998-12-09 1999-12-09 Palladium-substituted bacteriochlorophyll derivatives and use thereof

Publications (3)

Publication Number Publication Date
JP2002531497A JP2002531497A (ja) 2002-09-24
JP2002531497A5 JP2002531497A5 (enExample) 2007-01-18
JP4796227B2 true JP4796227B2 (ja) 2011-10-19

Family

ID=8235584

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000586326A Expired - Lifetime JP4796227B2 (ja) 1998-12-09 1999-12-09 パラジウム置換バクテリオクロロフィル誘導体およびその用途

Country Status (22)

Country Link
US (1) US6569846B1 (enExample)
EP (1) EP1137411B1 (enExample)
JP (1) JP4796227B2 (enExample)
CN (1) CN1160069C (enExample)
AT (1) ATE347554T1 (enExample)
AU (1) AU771292B2 (enExample)
BR (1) BRPI9916096B8 (enExample)
CA (1) CA2353554C (enExample)
CY (1) CY1106450T1 (enExample)
DE (1) DE69934328T2 (enExample)
DK (1) DK1137411T3 (enExample)
ES (1) ES2277454T3 (enExample)
HK (1) HK1040638B (enExample)
HU (1) HU228208B1 (enExample)
IL (1) IL143591A0 (enExample)
NO (1) NO331426B1 (enExample)
NZ (1) NZ512093A (enExample)
PL (1) PL201172B1 (enExample)
PT (1) PT1137411E (enExample)
RU (1) RU2234508C2 (enExample)
SI (1) SI1137411T1 (enExample)
WO (1) WO2000033833A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
WO2002013820A1 (en) * 2000-08-11 2002-02-21 Ceramoptec Industries, Inc. Photosensitizing ointment
EP1277470A1 (fr) * 2001-07-17 2003-01-22 Steba Biotech N.V. Formulation galénique injectable pour utilisation dans un diagnostic ou une thérapie photodynamique et son procédé de préparation
US7715901B2 (en) * 2002-05-08 2010-05-11 Yeda Research And Development Co. Ltd. Sensitized online BOLD-MRI imaging method
JP4529344B2 (ja) * 2002-06-03 2010-08-25 ニプロ株式会社 腫瘍組織の酸素濃度を上昇させるためのポルフィリン酸素輸液製剤
AU2003248747A1 (en) 2002-06-27 2004-01-19 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
WO2004005289A2 (en) * 2002-07-02 2004-01-15 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
IL152900A0 (en) * 2002-11-17 2003-06-24 Yeda Res & Dev Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses
RU2257898C1 (ru) * 2004-03-22 2005-08-10 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Фотосенсибилизатор, липосомальная форма фотосенсибилизатора и способ проведения фотодинамической терапии
CN1980661B (zh) * 2004-06-07 2011-09-28 耶达研究及发展有限公司 阳离子细菌叶绿素衍生物及其用途
GB2415372A (en) * 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
US20060222592A1 (en) * 2005-04-05 2006-10-05 Clemens Burda Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications
CN101925382A (zh) * 2008-01-28 2010-12-22 耶达研究及发展有限公司 内窥镜成像光动力学治疗系统及其使用方法
DK2257309T3 (da) 2008-02-27 2020-01-20 Yeda Res And Development Company Ltd Rgd-(bakterie)chlorophyl-konjugater til anvendelse ved diagnose af tumorer, der omfatter nekrotiske domæner
US20120034155A1 (en) * 2010-08-03 2012-02-09 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Artificial cells
GB0819594D0 (en) 2008-10-24 2008-12-03 Univ Coimbrra Process
EP2425873A1 (fr) 2010-09-07 2012-03-07 Steba Maor SA Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement
CN103405769A (zh) * 2013-03-07 2013-11-27 北京亿仁赛博医疗科技研发中心有限公司 光敏剂在制备治疗疾病的病毒灭活药物中的应用
JP6517158B2 (ja) 2013-03-11 2019-05-22 トーカド イーペー エスアーエールエル バクテリオクロロフィルａの生成方法
WO2014145428A2 (en) 2013-03-15 2014-09-18 Mcfarland Sherri Ann Metal-based coordination complexes as photodynamic compounds and their use
EP3442582A1 (en) 2016-04-10 2019-02-20 Yeda Research and Development Co. Ltd Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative
US10933134B2 (en) 2017-03-16 2021-03-02 Memorial Sloan Kettering Cancer Center Combination therapies for treatment of cancer
IL311461B2 (en) * 2024-03-13 2026-05-01 Impact Biotech Ltd Process for preparing palladium-bacteriophophorbide derivatives and their alkali metal salts

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019081A1 (en) * 1995-11-24 1997-05-29 Yeda Research And Development Co. Ltd. Synthetic metal-substituted bacteriochlorophyll derivatives and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002962A (en) * 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US5171741A (en) * 1989-04-21 1992-12-15 Health Research, Inc. Bacteriochlorophyll-a derivatives useful in photodynamic therapy
IL102645A (en) 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
RU2063971C1 (ru) * 1993-11-05 1996-07-20 Московская государственная академия тонкой химической технологии им.М.В.Ломоносова Способ получения производного гематопорфирина
IL115744A (en) * 1994-10-27 2000-07-16 Akzo Nobel Nv Peptides comprising a subsequence of human cartilage glycoprotein - 39

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997019081A1 (en) * 1995-11-24 1997-05-29 Yeda Research And Development Co. Ltd. Synthetic metal-substituted bacteriochlorophyll derivatives and use thereof

Also Published As

Publication number Publication date
HK1040638A1 (en) 2002-06-21
CN1334728A (zh) 2002-02-06
DE69934328D1 (de) 2007-01-18
DK1137411T3 (da) 2007-03-26
EP1137411A1 (en) 2001-10-04
PL201172B1 (pl) 2009-03-31
BRPI9916096B8 (pt) 2021-05-25
ATE347554T1 (de) 2006-12-15
NO331426B1 (no) 2011-12-27
HUP0105411A2 (hu) 2002-04-29
IL143591A0 (en) 2002-04-21
CY1106450T1 (el) 2011-10-12
NO20012807L (no) 2001-08-08
US6569846B1 (en) 2003-05-27
ES2277454T3 (es) 2007-07-01
BR9916096A (pt) 2001-11-13
NZ512093A (en) 2003-04-29
RU2234508C2 (ru) 2004-08-20
WO2000033833A1 (en) 2000-06-15
AU1583400A (en) 2000-06-26
HUP0105411A3 (en) 2003-12-29
AU771292B2 (en) 2004-03-18
CN1160069C (zh) 2004-08-04
BR9916096B1 (pt) 2013-11-19
DE69934328T2 (de) 2007-07-19
HK1040638B (en) 2007-06-15
EP1137411B1 (en) 2006-12-06
HU228208B1 (en) 2013-01-28
CA2353554C (en) 2011-04-26
PL348201A1 (en) 2002-05-06
SI1137411T1 (sl) 2007-10-31
EP1137411A4 (en) 2003-04-23
NO20012807D0 (no) 2001-06-07
PT1137411E (pt) 2007-02-28
CA2353554A1 (en) 2000-06-15
JP2002531497A (ja) 2002-09-24

Similar Documents

Publication Publication Date Title
US6569846B1 (en) Palladium-substituted bacteriochlorophyll derivatives and use thereof
JP5567024B2 (ja) クロリンの製造方法、及びその医薬としての使用
JP5555659B2 (ja) 水溶性陰イオン性バクテリオクロロフィル誘導体及びそれらの使用
JP3184218B2 (ja) 光力学治療のためのポルフィセン化合物
EP1246826B1 (en) Chlorophyll and bacteriochlorophyll esters, their preparation and pharmaceutical compositions comprising them
CA2440650C (en) Photosensitizer and method for production thereof
WO2000061584A1 (en) IMPROVED β,β,-DIHYDROXY MESO-SUBSTITUTED CHLORINS, ISOBACTERIOCHLORINS, AND BACTERIOCHLORINS
US7022843B1 (en) β,β′-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins
US7045117B2 (en) Method for tumor diagnosis comprising administering of palladium-substituted bacteriochlorophyll derivatives
MXPA01005855A (es) Derivados de bacterioclorofila sustituidos con paladio y uso de los mismos
IL143591A (en) Palladium-substituted bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
KR950013563B1 (ko) 10-히드록시 페오피틴 에이(Pheophytin a)
RU2340615C1 (ru) Алкилтиозамещенные фталоцианины, их лекарственные формы и способ проведения фотодинамической терапии
HK1081858B (en) Water-soluble anionic bacteriochlorophyll derivatives and their uses
Hui Evaluation of 151-Hydroxypurpurin-7-Lactone (G2) Derivatives, Boron Dipyrromethene (Bodipy) and Rosamine Analogues as Photosensitisers for Photodynamic Cancer Therapy

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061120

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20061120

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20100622

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100922

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20110705

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20110729

R150 Certificate of patent or registration of utility model

Ref document number: 4796227

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140805

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term