JP2002531497A5 - - Google Patents
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- Publication number
- JP2002531497A5 JP2002531497A5 JP2000586326A JP2000586326A JP2002531497A5 JP 2002531497 A5 JP2002531497 A5 JP 2002531497A5 JP 2000586326 A JP2000586326 A JP 2000586326A JP 2000586326 A JP2000586326 A JP 2000586326A JP 2002531497 A5 JP2002531497 A5 JP 2002531497A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- bpheid
- pharmaceutical composition
- reagent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 description 43
- 108010013121 palladium-bacteriopheophorbide Proteins 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 13
- 238000000034 method Methods 0.000 description 11
- 239000008194 pharmaceutical composition Substances 0.000 description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 125000001189 phytyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])C([H])([H])[C@@](C([H])([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])[C@@](C([H])([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])C([H])([H])[H] 0.000 description 7
- 125000000217 alkyl group Chemical group 0.000 description 5
- 125000002686 geranylgeranyl group Chemical group [H]C([*])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])/C([H])=C(C([H])([H])[H])/C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 5
- 230000007062 hydrolysis Effects 0.000 description 5
- 238000006460 hydrolysis reaction Methods 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 4
- 238000007324 demetalation reaction Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 108010070075 Bacteriochlorophyll A Proteins 0.000 description 3
- ZSERVQBSOBTXFV-DHHJBRQQSA-M bacteriochlorophyll a Chemical compound C1([C@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC([C@@H](CC)[C@@H]3C)=[N+]4C3=CC3=C(C(C)=O)C(C)=C5N3[Mg]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ZSERVQBSOBTXFV-DHHJBRQQSA-M 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229910052793 cadmium Inorganic materials 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 206010061289 metastatic neoplasm Diseases 0.000 description 2
- 238000002428 photodynamic therapy Methods 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 229930045534 Me ester-Cyclohexaneundecanoic acid Natural products 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007071 enzymatic hydrolysis Effects 0.000 description 1
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000002960 lipid emulsion Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000001465 metallisation Methods 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 125000002072 seryl group Chemical group 0.000 description 1
- -1 seryl methyl ester Chemical class 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 238000006478 transmetalation reaction Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98403110.4 | 1998-12-09 | ||
| EP98403110 | 1998-12-09 | ||
| PCT/IL1999/000673 WO2000033833A1 (en) | 1998-12-09 | 1999-12-09 | Palladium-substituted bacteriochlorophyll derivatives and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002531497A JP2002531497A (ja) | 2002-09-24 |
| JP2002531497A5 true JP2002531497A5 (enExample) | 2007-01-18 |
| JP4796227B2 JP4796227B2 (ja) | 2011-10-19 |
Family
ID=8235584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000586326A Expired - Lifetime JP4796227B2 (ja) | 1998-12-09 | 1999-12-09 | パラジウム置換バクテリオクロロフィル誘導体およびその用途 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6569846B1 (enExample) |
| EP (1) | EP1137411B1 (enExample) |
| JP (1) | JP4796227B2 (enExample) |
| CN (1) | CN1160069C (enExample) |
| AT (1) | ATE347554T1 (enExample) |
| AU (1) | AU771292B2 (enExample) |
| BR (1) | BRPI9916096B8 (enExample) |
| CA (1) | CA2353554C (enExample) |
| CY (1) | CY1106450T1 (enExample) |
| DE (1) | DE69934328T2 (enExample) |
| DK (1) | DK1137411T3 (enExample) |
| ES (1) | ES2277454T3 (enExample) |
| HK (1) | HK1040638B (enExample) |
| HU (1) | HU228208B1 (enExample) |
| IL (1) | IL143591A0 (enExample) |
| NO (1) | NO331426B1 (enExample) |
| NZ (1) | NZ512093A (enExample) |
| PL (1) | PL201172B1 (enExample) |
| PT (1) | PT1137411E (enExample) |
| RU (1) | RU2234508C2 (enExample) |
| SI (1) | SI1137411T1 (enExample) |
| WO (1) | WO2000033833A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7897140B2 (en) * | 1999-12-23 | 2011-03-01 | Health Research, Inc. | Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents |
| WO2002013820A1 (en) * | 2000-08-11 | 2002-02-21 | Ceramoptec Industries, Inc. | Photosensitizing ointment |
| EP1277470A1 (fr) * | 2001-07-17 | 2003-01-22 | Steba Biotech N.V. | Formulation galénique injectable pour utilisation dans un diagnostic ou une thérapie photodynamique et son procédé de préparation |
| CA2485224A1 (en) | 2002-05-08 | 2003-11-20 | Yeda Research And Development Co. Ltd. | Sensitized online bold-mri imaging method |
| JP4529344B2 (ja) * | 2002-06-03 | 2010-08-25 | ニプロ株式会社 | 腫瘍組織の酸素濃度を上昇させるためのポルフィリン酸素輸液製剤 |
| AU2003248747A1 (en) | 2002-06-27 | 2004-01-19 | Health Research, Inc. | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy |
| EP1606291A2 (en) * | 2002-07-02 | 2005-12-21 | Health Research, Inc. | Efficient synthesis of pyropheophorbide a and its dervatives |
| IL152900A0 (en) | 2002-11-17 | 2003-06-24 | Yeda Res & Dev | Water-soluble bacteriochlorophyll derivatives and their pharmaceutical uses |
| RU2257898C1 (ru) * | 2004-03-22 | 2005-08-10 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Фотосенсибилизатор, липосомальная форма фотосенсибилизатора и способ проведения фотодинамической терапии |
| CN1980661B (zh) | 2004-06-07 | 2011-09-28 | 耶达研究及发展有限公司 | 阳离子细菌叶绿素衍生物及其用途 |
| GB2415372A (en) * | 2004-06-23 | 2005-12-28 | Destiny Pharma Ltd | Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent |
| US20060222592A1 (en) * | 2005-04-05 | 2006-10-05 | Clemens Burda | Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications |
| EP2244787A1 (en) * | 2008-01-28 | 2010-11-03 | Yeda Research And Development Company Ltd. | Endoscopic imaging photodynamic therapy system and methods of use |
| MX2010009530A (es) | 2008-02-27 | 2010-11-30 | Yeda Res & Dev | Conjugados de rgd-(bacterio) clorofila para terapia fotodinámica y formación de imágenes de tumores necróticos. |
| US20120034155A1 (en) * | 2010-08-03 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Artificial cells |
| GB0819594D0 (en) | 2008-10-24 | 2008-12-03 | Univ Coimbrra | Process |
| EP2425873A1 (fr) | 2010-09-07 | 2012-03-07 | Steba Maor SA | Modélisation de l'action d'une fibre optique dans un traitement par therapie photodynamique, et assistance à la planification d'un tel traitement |
| CN103405769A (zh) * | 2013-03-07 | 2013-11-27 | 北京亿仁赛博医疗科技研发中心有限公司 | 光敏剂在制备治疗疾病的病毒灭活药物中的应用 |
| CN105358702B (zh) | 2013-03-11 | 2020-12-29 | Tookad Ip有限责任公司 | 细菌叶绿素a的生产方法 |
| RU2682674C2 (ru) | 2013-03-15 | 2019-03-20 | Шерри Энн МАКФАРЛЭНД | Координационные комплексы на основе металлов в качестве фотодинамических соединений и их применение |
| EP3442582A1 (en) | 2016-04-10 | 2019-02-20 | Yeda Research and Development Co. Ltd | Combinational therapies for treatment of cancer comprising a bacteriochlorophyll derivative |
| US10933134B2 (en) | 2017-03-16 | 2021-03-02 | Memorial Sloan Kettering Cancer Center | Combination therapies for treatment of cancer |
| IL311461A (en) * | 2024-03-13 | 2025-10-01 | Impact Biotech Ltd | Process for preparing bacteriophophorbid derivatives and their alkali metal salts |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002962A (en) * | 1988-07-20 | 1991-03-26 | Health Research, Inc. | Photosensitizing agents |
| US5171741A (en) * | 1989-04-21 | 1992-12-15 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
| IL102645A (en) * | 1992-07-26 | 1998-02-22 | Yeda Res & Dev | Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them |
| RU2063971C1 (ru) * | 1993-11-05 | 1996-07-20 | Московская государственная академия тонкой химической технологии им.М.В.Ломоносова | Способ получения производного гематопорфирина |
| IL115744A (en) * | 1994-10-27 | 2000-07-16 | Akzo Nobel Nv | Peptides comprising a subsequence of human cartilage glycoprotein - 39 |
| IL116126A0 (en) * | 1995-11-24 | 1996-01-31 | Yeda Res & Dev | Process for the preparation of bacteriochlorophyllis some novel compounds of this type and pharmaceutical compositions comprising them |
-
1999
- 1999-12-09 PT PT99958470T patent/PT1137411E/pt unknown
- 1999-12-09 JP JP2000586326A patent/JP4796227B2/ja not_active Expired - Lifetime
- 1999-12-09 CA CA2353554A patent/CA2353554C/en not_active Expired - Lifetime
- 1999-12-09 US US09/857,772 patent/US6569846B1/en not_active Expired - Lifetime
- 1999-12-09 AU AU15834/00A patent/AU771292B2/en not_active Expired
- 1999-12-09 RU RU2001118842/04A patent/RU2234508C2/ru active
- 1999-12-09 HU HU0105411A patent/HU228208B1/hu unknown
- 1999-12-09 CN CNB99816058XA patent/CN1160069C/zh not_active Expired - Lifetime
- 1999-12-09 WO PCT/IL1999/000673 patent/WO2000033833A1/en not_active Ceased
- 1999-12-09 EP EP99958470A patent/EP1137411B1/en not_active Expired - Lifetime
- 1999-12-09 SI SI9930949T patent/SI1137411T1/sl unknown
- 1999-12-09 BR BRPI9916096A patent/BRPI9916096B8/pt not_active IP Right Cessation
- 1999-12-09 NZ NZ512093A patent/NZ512093A/xx unknown
- 1999-12-09 ES ES99958470T patent/ES2277454T3/es not_active Expired - Lifetime
- 1999-12-09 PL PL348201A patent/PL201172B1/pl unknown
- 1999-12-09 HK HK02102403.5A patent/HK1040638B/en unknown
- 1999-12-09 IL IL14359199A patent/IL143591A0/xx active IP Right Grant
- 1999-12-09 AT AT99958470T patent/ATE347554T1/de active
- 1999-12-09 DE DE69934328T patent/DE69934328T2/de not_active Expired - Lifetime
- 1999-12-09 DK DK99958470T patent/DK1137411T3/da active
-
2001
- 2001-06-07 NO NO20012807A patent/NO331426B1/no not_active IP Right Cessation
-
2007
- 2007-02-15 CY CY20071100207T patent/CY1106450T1/el unknown
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