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Agentes ansioliticos y antidepresivos bis-aza-biciclicos.

Abstract

ANXIOLITICO O ANTIDEPRESIVO QUE ES UN COMPUESTO RACEMICO U OPTICAMENTE ACTIVO DE LA FORMULA O UNA SAL DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLE, EN DONDE X ES N O CH; Y ES Z ES SCH2, OCH2, -Y1(CH2)N O Y1(CH2)N SUSTITUIDO EN CARBONO CON HASTA 2 GRUPOS METILICOS; N ES 1 O 2; Y Y1 ES CH2, NH O NCH3.

Classifications

C07D471/04 Ortho-condensed systems
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Health & Medical Sciences Organic Chemistry
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ES2053094T3

Spain

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Other languages
English
Inventor
Kishor Amratral Desai
Gene Michael Bright
Current Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Worldwide applications
1989 MX WO HU WO RO IS 1990 EP DK AT ES DE IL BG MY AR NZ CA EG KR ZA MA CZ PL DD IE PT YU AU SK AP CN OA JP 1991 US RU FI NO 1993 GR 1998 BA
Application ES90300362T events
1990-01-12
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL
1994-07-16
Application granted
1994-07-16
Publication of ES2053094T3
2010-01-12
Anticipated expiration
Status
Expired - Lifetime
Info
Patent citations (12)
Cited by (29)
Legal events
Similar documents
Priority and Related Applications
External links
Espacenet
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Discuss

Patent Citations (12)

Publication number Priority date Publication date Assignee Title
Family To Family Citations
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US4182763A * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4339579A * 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A * 1982-05-25 1983-11-08 American Home Products Corporation 4-Substituted-piperidino carboxamides
US4517187A * 1982-10-18 1985-05-14 Pennwalt Corporation 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
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IT1204803B * 1986-02-17 1989-03-10 Acraf Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
JP2668259B2 * 1988-02-18 1997-10-27 塩野義製薬株式会社 複素環化合物および抗潰瘍剤
MX19222A * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
* Cited by examiner, † Cited by third party

Cited By (29)

Publication number Priority date Publication date Assignee Title
Family To Family Citations
MX19222A * 1989-01-23 1993-12-01 Pfizer Agentes ansioliticos bis-aza-biciclicos
WO1992000075A1 * 1990-06-29 1992-01-09 Pfizer Inc. Pyridopyrazine derivatives for treating substance abuse and addiction
JP2609410B2 * 1991-01-31 1997-05-14 ファイザー・インコーポレーテッド （７Ｓ，トランス）−２−（２−ピリミジニル）−７−（ヒドロキシメチル）オクタヒドロ−２Ｈ−ピリド［１，２−ａ］ピラジンの製造
US5157034A * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
US5185449A * 1991-02-27 1993-02-09 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
CA2195622C * 1991-02-27 1999-08-17 Frank J. Urban Process for preparing trans-piperidine-2,5-dicarboxylates
US5311195A * 1991-08-30 1994-05-10 Etak, Inc. Combined relative and absolute positioning method and apparatus
PL170889B1 * 1991-09-25 1997-02-28 Pfizer S posób wytwarzania nowej (7S,9aS)-2-(benzo[d]izoksazoliio-3) perhydro-7-{2-[(2aS)-2a- hydroksy-3,3- czterometylenogluta-rimido]etyio}-1H-pirydo[1,2-a] pirazyny i nowej(7S,9aS)-2-(benzo[d]izoksazolilo-3) perhydro-7-{2[(2aR)-2a-hydroksy-3,3- czterometylenoglutarimido]-etylo}-1 H-pirydo[1,2-a] pirazyny PL PL
JP2753146B2 * 1992-06-16 1998-05-18 ファイザー・インコーポレーテッド ビス−アザー二環式抗不安薬の製法および中間体
AU5291793A * 1992-09-24 1994-04-12 National Institutes Of Health Aralkyl diazabicycloalkane derivatives for cns disorders
IL104506A * 1993-01-25 1997-11-20 Israel State Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A * 1993-08-20 1997-06-10 Pfizer Inc. Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A * 1993-10-13 1995-10-03 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A * 1993-11-01 1999-06-20 Israel State Controlled cryogenic contact system
HUT77354A * 1994-09-30 1998-03-30 Pfizer Inc. 2,7-Szubsztituált oktahidro-1H-pirido[1,2-a]pirazin-származékok, ezeket tartalmazó gyógyszerkészítmények és intermedierek
US6231833B1 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
WO1996010570A1 * 1994-09-30 1996-04-11 Pfizer Inc. NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
CA2240594C * 1995-12-21 2001-07-24 Pfizer Limited 2,7-substituted octahydro-pyrrolo¬1,2-a|pyrazine derivatives
TR199802743T2 * 1996-07-01 1999-03-22 Pfizer Inc. (7S, trans)-2-(2-Primidinil)-7- (hidroksimetil) oktahidro-2H- pirido $1,2-A] pirazin'in haz�rlan���.
PA8469101A1 * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1
US6251893B1 * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A * 1998-09-21 2000-11-11 Pfizer Prod Inc Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US20020016334A1 * 2000-07-31 2002-02-07 Coe Jotham Wadsworth Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
UA78437C2 * 2003-03-12 2007-03-15 Pfizer Prod Inc Azabicyclic derivatives of pyridyloxymethyl and benzisoxazole
EP1633756B1 2003-04-09 2008-12-24 Biogen Idec MA Inc. A2a adenosine receptor antagonists
ES2347152T3 * 2003-11-26 2010-10-26 Pfizer Products Inc. Derivados de aminopirazol como inhibidores de gsk-3.
BRPI0511529A * 2004-05-27 2008-01-02 Warner Lambert Co combinação terapêutica para distúrbios de hiperatividade/déficit de atenção
US7658206B2 2006-12-05 2010-02-09 Kohler Co. Plumbing valve with stick control handle
* Cited by examiner, † Cited by third party, ‡ Family to family citation

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Priority And Related Applications

Applications Claiming Priority (2)

Application Filing date Title
PCT/US1989/000275 1989-01-23 Bis-aza-bicyclic anxiolytic agents
PCT/US1989/003811 1989-09-01 Bis-aza-bicyclic anxiolytic agents

Legal Events

Date Code Title Description
1994-07-16 FG2A Definitive protection

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Concepts

machine-extracted
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Name Image Sections Count Query match
Carbon abstract 1 0.000
METHYL GROUPS abstract 1 0.000
Streptomyces halstedii sch2 gene abstract 1 0.000
acidificating effect abstract 1 0.000
anti-depressive effect abstract 1 0.000
antidepressant agent abstract 1 0.000
antidepressants abstract 1 0.000
anxiolytic agent abstract 1 0.000
anxiolytic effect abstract 1 0.000
carbon abstract 1 0.000
compounds abstract 1 0.000
salts abstract 1 0.000
Show all concepts from the description section
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