DE69923315T2 - Verfahren zur herstellung von liposomen - Google Patents
Verfahren zur herstellung von liposomen Download PDFInfo
- Publication number
- DE69923315T2 DE69923315T2 DE69923315T DE69923315T DE69923315T2 DE 69923315 T2 DE69923315 T2 DE 69923315T2 DE 69923315 T DE69923315 T DE 69923315T DE 69923315 T DE69923315 T DE 69923315T DE 69923315 T2 DE69923315 T2 DE 69923315T2
- Authority
- DE
- Germany
- Prior art keywords
- liposomes
- sucrose
- sugar
- size
- drying
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 238000002360 preparation method Methods 0.000 title description 21
- 229930006000 Sucrose Natural products 0.000 claims abstract description 56
- 239000005720 sucrose Substances 0.000 claims abstract description 56
- 235000000346 sugar Nutrition 0.000 claims abstract description 37
- 239000000203 mixture Substances 0.000 claims abstract description 31
- 238000004519 manufacturing process Methods 0.000 claims abstract description 13
- 238000001035 drying Methods 0.000 claims abstract description 11
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 150000002632 lipids Chemical class 0.000 claims description 31
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- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9813100.6A GB9813100D0 (en) | 1998-06-18 | 1998-06-18 | Method of forming liposomes |
| GB9813100 | 1998-06-18 | ||
| PCT/GB1999/001911 WO1999065465A1 (en) | 1998-06-18 | 1999-06-16 | Method of forming liposomes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69923315D1 DE69923315D1 (de) | 2005-02-24 |
| DE69923315T2 true DE69923315T2 (de) | 2006-04-06 |
Family
ID=10833946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69923315T Expired - Lifetime DE69923315T2 (de) | 1998-06-18 | 1999-06-16 | Verfahren zur herstellung von liposomen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9675554B1 (enExample) |
| EP (1) | EP1087754B1 (enExample) |
| JP (1) | JP4567882B2 (enExample) |
| KR (1) | KR100658956B1 (enExample) |
| CN (1) | CN1312707A (enExample) |
| AT (1) | ATE287258T1 (enExample) |
| AU (1) | AU749499B2 (enExample) |
| CA (1) | CA2335183A1 (enExample) |
| DE (1) | DE69923315T2 (enExample) |
| GB (2) | GB9813100D0 (enExample) |
| NO (1) | NO20006442L (enExample) |
| NZ (1) | NZ508960A (enExample) |
| RU (1) | RU2216315C2 (enExample) |
| WO (1) | WO1999065465A1 (enExample) |
| ZA (1) | ZA200007507B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE341310T1 (de) * | 2000-02-04 | 2006-10-15 | Lipoxen Technologies Ltd | Dehydratisierungs-/rehydratisierungsverfahren zur herstellung von liposome |
| WO2002038128A1 (fr) * | 2000-11-10 | 2002-05-16 | Japan Science And Technology Corporation | Procede de preparation d'une dispersion de microsome |
| AU3652602A (en) * | 2000-11-15 | 2002-05-27 | Us Gov Health & Human Serv | Sol-fusin: use of gp64-6his to catalyze membrane fusion |
| BRPI0105509B8 (pt) | 2001-11-05 | 2021-05-25 | Univ Minas Gerais | formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga |
| US7285289B2 (en) * | 2002-04-12 | 2007-10-23 | Nagy Jon O | Nanoparticle vaccines |
| KR100482355B1 (ko) * | 2002-05-02 | 2005-04-14 | 주식회사 알로에마임 | 디팔미토일하이드록시프롤린과 소이이소플라본을 함유한리포좀 또는 나노에멀젼 및 이를 함유한 화장료 조성물 및그 제조방법 |
| SI2108362T1 (sl) * | 2002-06-26 | 2013-08-30 | Medigene Ag | Kationski nosilni sistem, ki vsebuje taksan |
| ES2331791T5 (es) | 2002-06-26 | 2016-01-21 | Medigene Ag | Método de producción de una preparación catiónica de liposomas que comprende un compuesto lipófilo |
| US20050175683A1 (en) * | 2003-10-24 | 2005-08-11 | Yuanpeng Zhang | Preparation of lipid particles |
| KR101462825B1 (ko) | 2004-05-03 | 2014-11-21 | 헤르메스 바이오사이언스, 인코포레이티드 | 약물 전달에 유용한 리포좀 |
| ATE454884T1 (de) * | 2004-10-18 | 2010-01-15 | Polymun Scient Immunbio Forsch | Liposomale zusammensetzung einen wirkstoff zur relaxierung glatter muskulatur enthaltend, die herstellung dieser zusammensetzung und deren therapeutische verwendung |
| JP2009510032A (ja) | 2005-09-30 | 2009-03-12 | リポクセン テクノロジーズ リミテッド | 多糖抗原及びタンパク質アジュバントを含む多価リポソームワクチン組成物 |
| RU2300369C1 (ru) * | 2005-12-27 | 2007-06-10 | Наталья Ивановна Ларионова | Способ получения полиэлектролитных микрочастиц, содержащих инкапсулируемое вещество, чувствительных к изменению состава окружающей среды |
| EP2492278A1 (en) | 2006-09-18 | 2012-08-29 | Compugen Ltd. | Antibodies against an agonist of G-protein coupled receptors and its use indiagnosis and therapy |
| CA2693651A1 (en) | 2007-07-12 | 2009-01-15 | Ronen Shemesh | Bioactive peptides and method of using same |
| JP5362998B2 (ja) * | 2008-01-10 | 2013-12-11 | 第一ファインケミカル株式会社 | 乾燥リポソーム製剤 |
| US9445975B2 (en) | 2008-10-03 | 2016-09-20 | Access Business Group International, Llc | Composition and method for preparing stable unilamellar liposomal suspension |
| WO2010041255A2 (en) | 2008-10-07 | 2010-04-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. | Liposomal systems comprising sphingomyelin |
| EP2184054A1 (en) | 2008-11-08 | 2010-05-12 | Lipoxen Technologies Limited | Small Interfering RNA Delivery |
| WO2010140377A1 (ja) | 2009-06-04 | 2010-12-09 | 独立行政法人産業技術総合研究所 | マイコプラズマ感染症用ワクチン |
| RU2409668C1 (ru) * | 2009-09-02 | 2011-01-20 | Александр Анатольевич Ярославов | Способ получения иммобилизованных бислойных везикул |
| KR20110068831A (ko) | 2009-12-16 | 2011-06-22 | 재단법인 전라남도생물산업진흥재단 | 리포좀 조성물, 그 제조방법, 및 폐렴 백신으로서의 그 용도 |
| FR2958851B1 (fr) * | 2010-04-16 | 2012-06-29 | Xeda International | Nouvelles formulations d'ingredient(s) actif(s) d'origine vegetale ou leurs analogues synthetiques ou d'extrait(s) d'origine vegetale les contenant, et de lecithine |
| BR112013017267B1 (pt) | 2011-01-04 | 2021-06-22 | Archivel Farma, Sl | Formulação de lipossomas, suspensão e composição farmacêutica |
| PT2768484T (pt) | 2011-10-21 | 2019-10-28 | Jazz Pharmaceuticals Res Llc | Lipossomas liofilizados |
| IN2014MN01594A (enExample) | 2012-01-12 | 2015-05-08 | Archivel Farma Sl | |
| EA023079B1 (ru) * | 2012-12-24 | 2016-04-29 | Общество С Ограниченной Ответственностью "Технология Лекарств" | Способ получения липосомальной формы иринотекана (варианты) |
| JP6866060B2 (ja) * | 2014-10-27 | 2021-04-28 | 花王株式会社 | 精製茶抽出物の製造方法 |
| KR101739208B1 (ko) * | 2014-12-30 | 2017-05-25 | (주)셀트리온 | 표피성장인자와 리포좀의 하이브리드형 다중층 나노구조체 및 그 제조방법 |
| WO2016191700A1 (en) * | 2015-05-27 | 2016-12-01 | Nuvox Pharma Llc | Treatment of acute complications of sickle cell disease |
| WO2017049132A1 (en) * | 2015-09-18 | 2017-03-23 | DNARx | Systems and methods for nucleic acid expression in vivo |
| ES3036518T3 (en) | 2015-10-16 | 2025-09-19 | Ipsen Biopharm Ltd | Stabilizing camptothecin pharmaceutical compositions |
| EP3600428A4 (en) | 2017-03-23 | 2020-08-26 | Dnarx | SYSTEMS AND METHODS FOR THE EXPRESSION OF NUCLEIC ACIDS IN VIVO |
| GB201707700D0 (en) | 2017-05-12 | 2017-06-28 | Glaxosmithkline Biologicals Sa | Dried composition |
| RU2697802C1 (ru) * | 2018-08-23 | 2019-08-20 | Федеральное Государственное Бюджетное Учреждение Науки Институт Биохимической Физики Им. Н.М. Эмануэля Российской Академии Наук (Ибхф Ран) | Способ получения магнитных липосом |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880635B1 (en) * | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
| US4857319A (en) * | 1985-01-11 | 1989-08-15 | The Regents Of The University Of California | Method for preserving liposomes |
| EP0208764A4 (en) * | 1985-01-11 | 1987-10-08 | Univ California | METHOD FOR PRESERVING LIPOSOMES. |
| CA1256372A (en) * | 1985-04-11 | 1989-06-27 | Koichiro Miyazima | Process for producing liposome composition |
| US5094785A (en) * | 1986-12-10 | 1992-03-10 | Ciba Corning Diagnostics Corp. | Process for stabilizing liposomes |
| AU612631B2 (en) * | 1987-02-24 | 1991-07-18 | Vestar, Inc. | Dehydrating vesicule preparations for long-term storage |
| US5089181A (en) * | 1987-02-24 | 1992-02-18 | Vestar, Inc. | Method of dehydrating vesicle preparations for long term storage |
| MX9203808A (es) * | 1987-03-05 | 1992-07-01 | Liposome Co Inc | Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos. |
| JP2780755B2 (ja) * | 1987-05-22 | 1998-07-30 | ザ リポソーム カンパニー，インコーポレイテッド | プロスタグランジン‐脂質製剤 |
| DE68916439T2 (de) * | 1988-10-05 | 1994-10-20 | Vestar Inc | Verfahren zur herstellung von liposomen mit verbesserter stabilität während des trocknens. |
| RU2014071C1 (ru) * | 1991-03-26 | 1994-06-15 | Научно-производственный центр медицинской биотехнологии | Способ получения липосом, содержащих водорастворимые низкомолекулярные соединения |
| US5958881A (en) * | 1991-04-25 | 1999-09-28 | Korman; Louis Y. | Composition containing VIP for injection and a method of enhancing visualization of tissues during medical procedures |
| WO1993020802A1 (en) * | 1992-04-09 | 1993-10-28 | Northwestern University | Acoustically reflective liposomes and methods to make and use the same |
| DK0678017T3 (da) * | 1993-11-05 | 1998-10-19 | Amgen Inc | Liposomfremstilling og materialeindkapslingsfremgangsmåde |
| EP0914094A4 (en) * | 1996-03-28 | 2000-03-01 | Univ Illinois | MATERIALS AND METHOD FOR PRODUCING IMPROVED LIPOSOMAL AGENTS |
| CA2202103C (en) * | 1996-04-11 | 2007-01-09 | Toshiaki Tagawa | Method for preparing closed vesicles |
| JP3693209B2 (ja) * | 1996-04-11 | 2005-09-07 | 三菱化学株式会社 | 閉鎖小胞の製造方法 |
| RU2123328C1 (ru) * | 1996-04-19 | 1998-12-20 | Государственный научный центр вирусологии и биотехнологии "Вектор" | Липосомальное противовирусное лекарственное средство для перорального применения |
| NZ332666A (en) * | 1996-05-08 | 2000-05-26 | Nika Health Products Ltd | Cationic virosomes having a positively charged lipid bilayer membrane with an integrated viral fusogenic peptide as genetic transfer systems for use in gene therapy |
-
1998
- 1998-06-18 GB GBGB9813100.6A patent/GB9813100D0/en not_active Ceased
-
1999
- 1999-06-16 RU RU2001101910/14A patent/RU2216315C2/ru active
- 1999-06-16 CA CA002335183A patent/CA2335183A1/en not_active Abandoned
- 1999-06-16 US US09/719,795 patent/US9675554B1/en not_active Expired - Fee Related
- 1999-06-16 GB GB0030767A patent/GB2354166B/en not_active Expired - Lifetime
- 1999-06-16 AT AT99928051T patent/ATE287258T1/de not_active IP Right Cessation
- 1999-06-16 AU AU45180/99A patent/AU749499B2/en not_active Expired
- 1999-06-16 NZ NZ508960A patent/NZ508960A/xx unknown
- 1999-06-16 JP JP2000554345A patent/JP4567882B2/ja not_active Expired - Lifetime
- 1999-06-16 EP EP99928051A patent/EP1087754B1/en not_active Expired - Lifetime
- 1999-06-16 WO PCT/GB1999/001911 patent/WO1999065465A1/en not_active Ceased
- 1999-06-16 CN CN99809563A patent/CN1312707A/zh active Pending
- 1999-06-16 KR KR1020007014404A patent/KR100658956B1/ko not_active Expired - Lifetime
- 1999-06-16 DE DE69923315T patent/DE69923315T2/de not_active Expired - Lifetime
-
2000
- 2000-12-14 ZA ZA200007505A patent/ZA200007507B/en unknown
- 2000-12-15 NO NO20006442A patent/NO20006442L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2216315C2 (ru) | 2003-11-20 |
| NZ508960A (en) | 2002-11-26 |
| CN1312707A (zh) | 2001-09-12 |
| NO20006442D0 (no) | 2000-12-15 |
| GB2354166B (en) | 2003-09-10 |
| NO20006442L (no) | 2001-02-15 |
| ATE287258T1 (de) | 2005-02-15 |
| GB9813100D0 (en) | 1998-08-19 |
| KR20010053006A (ko) | 2001-06-25 |
| US9675554B1 (en) | 2017-06-13 |
| JP2003513003A (ja) | 2003-04-08 |
| EP1087754B1 (en) | 2005-01-19 |
| KR100658956B1 (ko) | 2006-12-21 |
| AU749499B2 (en) | 2002-06-27 |
| GB0030767D0 (en) | 2001-01-31 |
| EP1087754A1 (en) | 2001-04-04 |
| DE69923315D1 (de) | 2005-02-24 |
| ZA200007507B (en) | 2002-03-14 |
| GB2354166A (en) | 2001-03-21 |
| WO1999065465A1 (en) | 1999-12-23 |
| CA2335183A1 (en) | 1999-12-23 |
| AU4518099A (en) | 2000-01-05 |
| JP4567882B2 (ja) | 2010-10-20 |
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| 8364 | No opposition during term of opposition |