DE68916439T2 - Verfahren zur herstellung von liposomen mit verbesserter stabilität während des trocknens. - Google Patents

Verfahren zur herstellung von liposomen mit verbesserter stabilität während des trocknens.

Info

Publication number
DE68916439T2
DE68916439T2 DE68916439T DE68916439T DE68916439T2 DE 68916439 T2 DE68916439 T2 DE 68916439T2 DE 68916439 T DE68916439 T DE 68916439T DE 68916439 T DE68916439 T DE 68916439T DE 68916439 T2 DE68916439 T2 DE 68916439T2
Authority
DE
Germany
Prior art keywords
stability during
improved stability
during drying
producing liposomes
liposomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68916439T
Other languages
English (en)
Other versions
DE68916439D1 (de
Inventor
Paul Schmidt
Gary Fujii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nexstar Pharmaceuticals Inc
Original Assignee
Vestar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vestar Inc filed Critical Vestar Inc
Publication of DE68916439D1 publication Critical patent/DE68916439D1/de
Application granted granted Critical
Publication of DE68916439T2 publication Critical patent/DE68916439T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Cosmetics (AREA)
DE68916439T 1988-10-05 1989-10-03 Verfahren zur herstellung von liposomen mit verbesserter stabilität während des trocknens. Expired - Fee Related DE68916439T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25368088A 1988-10-05 1988-10-05
PCT/US1989/004222 WO1990003795A1 (en) 1988-10-05 1989-10-03 Method of making liposomes with improved stability during drying

Publications (2)

Publication Number Publication Date
DE68916439D1 DE68916439D1 (de) 1994-07-28
DE68916439T2 true DE68916439T2 (de) 1994-10-20

Family

ID=22961272

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68916439T Expired - Fee Related DE68916439T2 (de) 1988-10-05 1989-10-03 Verfahren zur herstellung von liposomen mit verbesserter stabilität während des trocknens.

Country Status (13)

Country Link
US (1) US5817334A (de)
EP (1) EP0437479B1 (de)
JP (1) JP2792702B2 (de)
AT (1) ATE107502T1 (de)
AU (1) AU612285B2 (de)
CA (1) CA2000219A1 (de)
DE (1) DE68916439T2 (de)
DK (1) DK59691A (de)
FI (1) FI902249A0 (de)
IE (1) IE64559B1 (de)
IL (1) IL91901A (de)
NO (1) NO180363C (de)
WO (1) WO1990003795A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials
WO1993004672A1 (en) * 1991-09-11 1993-03-18 Pitman-Moore, Inc. Method for enhancing the immune system in a host employing liposome-encapsulated polypeptides
JP3329554B2 (ja) * 1993-03-10 2002-09-30 千葉製粉株式会社 乾燥小胞体
DE4341472A1 (de) * 1993-12-02 1995-06-08 Schering Ag Verfahren zur Erhöhung der Stabilität von hydrophile Wirkstoffe enthaltenden Liposomensuspensionen
US5589189A (en) * 1994-09-14 1996-12-31 Nexstar Pharmaceuticals, Inc. Liposome dispersion
CA2202103C (en) * 1996-04-11 2007-01-09 Toshiaki Tagawa Method for preparing closed vesicles
GB9813100D0 (en) * 1998-06-18 1998-08-19 Secr Defence Method of forming liposomes
AU775694B2 (en) * 1999-03-11 2004-08-12 Fujisawa Pharmaceutical Co., Ltd. Liposome preparations
CA2309373A1 (en) * 1999-05-27 2000-11-27 Johnson & Johnson Consumer Companies, Inc. Novel topical formulations
DE69928778T2 (de) * 1999-06-08 2006-07-06 Gentium S.P.A., Villa Guardia Anwendung von Komplexen von kationischen Liposomen und Polydeoxyribonukleotiden wie Arzneimitteln
ATE273516T1 (de) * 1999-06-23 2004-08-15 Cornell Res Foundation Inc Entwässerung/rehydratisierung von markierten liposomen auf einer prüfeinrichtung
US6576460B1 (en) 1999-10-28 2003-06-10 Cornell Research Foundation, Inc. Filtration-detection device and method of use
US20040057988A1 (en) * 2000-11-10 2004-03-25 Eishun Tsuchida Method for preparing microsome dispersion
US7125568B2 (en) 2001-08-23 2006-10-24 Sung Michael T Lipophilic drug compositions
EP1443900B1 (de) * 2001-11-13 2012-05-23 Celator Pharmaceuticals, Inc. Lipidträgerzusammensetzungen mit erhöhter blutstabilität
AU2003243348B2 (en) 2002-05-31 2009-12-03 Cornell Research Foundation, Inc. Universal biosensor and methods of use
DE10233632A1 (de) * 2002-07-24 2004-02-05 Wilex Ag Formulierungen von Phenylalanin-Derivaten
AU2003268087A1 (en) * 2002-08-23 2004-03-11 Ian Ma Liposomal gemcitabine compositions for better drug delivery
AU2003287526A1 (en) * 2002-11-06 2004-06-03 Protein-stabilized liposomal formulations of pharmaceutical agents
AU2003293195A1 (en) 2002-12-23 2004-07-29 Vical Incorporated Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes
EP1581201A4 (de) * 2002-12-23 2011-03-30 Vical Inc Verfahren zur herstellung steriler arzneimittel auf polynukleotidbasis
WO2005020893A2 (en) * 2003-08-06 2005-03-10 The Regents Of The University Of California Therapeutic platelets and methods
US7811602B2 (en) * 2004-05-17 2010-10-12 Tekmira Pharmaceuticals Corporation Liposomal formulations comprising dihydrosphingomyelin and methods of use thereof
FR2870741B1 (fr) * 2004-05-25 2008-03-14 Coletica Sa Phase lamellaires hydratees ou liposomes, contenant une monoamine grasse ou un polymere cationique favorisant la penetration intercellulaire, et composition cosmetique ou pharmaceutique la contenant.
US20060110441A1 (en) * 2004-10-28 2006-05-25 Harry Wong Lyophilized liposome formulations and method
WO2006068759A2 (en) * 2004-11-22 2006-06-29 Magellan Companies, Inc. Liposomes containing phytochemical agents and methods for making and using same
EP1932517A3 (de) * 2006-12-11 2008-07-16 Universiteit Utrecht Holding B.V. Liposomen beinhaltend Polyphenolderivaten und deren Verfahren zur Nachbeladung
US20090047336A1 (en) * 2007-08-17 2009-02-19 Hong Kong Baptist University novel formulation of dehydrated lipid vesicles for controlled release of active pharmaceutical ingredient via inhalation
US8962015B2 (en) * 2007-09-28 2015-02-24 Sdg, Inc. Orally bioavailable lipid-based constructs
CN101485629B (zh) * 2008-01-16 2013-01-23 沈阳药科大学 一种给药系统及其制备方法
EP2317981B1 (de) * 2008-07-24 2013-11-13 Amorepacific Corporation Mehrschichtiges lamellares granulat und dieses enthaltende zusammensetzung zur topischen applikation auf die haut
CA2754896C (en) * 2009-03-09 2017-11-28 Molecular Express, Inc. Methods and compositions for liposomal formulation of antigens and uses thereof
US9775819B2 (en) 2009-09-16 2017-10-03 R.P. Scherer Technologies, Llc Oral solid dosage form containing nanoparticles and process of formulating the same using fish gelatin
EP2386647A1 (de) * 2010-05-10 2011-11-16 Qiagen GmbH Verfahren zur Transfektion einer eurkaryotischen Zelle
EP2471511A1 (de) 2011-01-04 2012-07-04 Archivel Farma, SL Zur Behandlung oder Vorbeugung von Tuberkulose geeignete Liposomformulierung
CN104114156A (zh) * 2011-10-21 2014-10-22 切拉托尔制药公司 冻干脂质体
US10076496B2 (en) * 2011-11-11 2018-09-18 The Chinese University Of Hong Kong Engineering of polymer-stabilized nanoparticles for drugs with Log P values below 6 by controlled antisolvent precipitation
EA022183B1 (ru) * 2012-12-24 2015-11-30 Общество С Ограниченной Ответственностью "Технология Лекарств" Способ получения липосомальной формы цитохрома с
MX2017002271A (es) 2014-08-28 2017-05-22 Massachusetts Gen Hospital Composiciones y metodos para el tratamiento de trastornos neurologicos.
US11471401B2 (en) 2014-08-28 2022-10-18 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
US11504322B2 (en) 2014-08-28 2022-11-22 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
SG10201913504XA (en) 2016-02-26 2020-03-30 Massachusetts Gen Hospital Medical ice slurry production and delivery systems and methods
US20220273569A1 (en) * 2019-07-24 2022-09-01 The General Hospital Corporation Methods of creating a substance with different freezing points by encapsulation
CN114886785B (zh) * 2022-06-07 2023-02-03 美尚(广州)化妆品股份有限公司 一种三元冻干组合物及其在冻干制剂中的应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
CH621479A5 (de) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4460577A (en) * 1977-09-30 1984-07-17 Farmitalia Carlo Erba S.P.A. Pharmaceutical compositions consisting or consisting essentially of liposomes, and processes for making same
FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4193983A (en) * 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
US4377567A (en) * 1978-10-02 1983-03-22 The Procter & Gamble Company Lipid membrane drug delivery
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
JPS574913A (en) * 1980-06-11 1982-01-11 Green Cross Corp:The Urokinase preparation for oral administration
JPS5746921A (en) * 1980-09-02 1982-03-17 Green Cross Corp:The Oral preparation of human blood coagulation factor
US4460560A (en) * 1982-06-18 1984-07-17 University Of Southern California Drug delivery by polymeric carriers
US4568545A (en) * 1982-10-02 1986-02-04 Amano Seiyaku Kabushiki Kaisha Thrombolytic agent
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4914084A (en) * 1984-05-09 1990-04-03 Synthetic Blood Corporation Composition and method for introducing heme, hemoproteins, and/or heme-hemoprotein complexes into the body
US5008109A (en) * 1984-05-25 1991-04-16 Vestar, Inc. Vesicle stabilization
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
EP0208764A4 (de) * 1985-01-11 1987-10-08 Univ California Konservierungsverfahren für liposome.
CA1256372A (en) * 1985-04-11 1989-06-27 Koichiro Miyazima Process for producing liposome composition
US4735210A (en) * 1985-07-05 1988-04-05 Immunomedics, Inc. Lymphographic and organ imaging method and kit
US4766046A (en) * 1985-09-27 1988-08-23 Liposome Technology, Inc. Stabilized liposome/amphotericin composition and method
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
GB8604983D0 (en) * 1986-02-28 1986-04-09 Biocompatibles Ltd Protein preservation
US5089181A (en) * 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
EP0395765A4 (en) * 1988-01-13 1991-09-25 Dainippon Pharmaceutical Co., Ltd. Oozing-proof liposome preparation
JPH02273538A (ja) * 1989-04-13 1990-11-08 Fuji Photo Film Co Ltd リポソームの保存方法
US5705187A (en) * 1989-12-22 1998-01-06 Imarx Pharmaceutical Corp. Compositions of lipids and stabilizing materials

Also Published As

Publication number Publication date
FI902249A0 (fi) 1990-05-04
EP0437479A1 (de) 1991-07-24
JP2792702B2 (ja) 1998-09-03
DK59691D0 (da) 1991-04-04
AU4340089A (en) 1990-05-01
AU612285B2 (en) 1991-07-04
WO1990003795A1 (en) 1990-04-19
DE68916439D1 (de) 1994-07-28
IE893196L (en) 1990-04-05
JPH04500803A (ja) 1992-02-13
ATE107502T1 (de) 1994-07-15
NO901852L (no) 1990-08-01
CA2000219A1 (en) 1990-04-05
EP0437479A4 (en) 1991-10-16
IE64559B1 (en) 1995-08-23
EP0437479B1 (de) 1994-06-22
IL91901A (en) 1993-06-10
NO901852D0 (no) 1990-04-26
US5817334A (en) 1998-10-06
DK59691A (da) 1991-04-04
IL91901A0 (en) 1990-06-10
NO180363C (no) 1997-04-09
NO180363B (no) 1996-12-30

Similar Documents

Publication Publication Date Title
DE68916439T2 (de) Verfahren zur herstellung von liposomen mit verbesserter stabilität während des trocknens.
DE3852116T2 (de) Herstellung von Proteinen in aktiver Form.
EP0158277A3 (de) Implantierbare Zubereitungen von regulatorischen Peptiden mit gesteuerter Freisetzung und Verfahren zur ihrer Herstellung
EP0283713A3 (en) Complexes of saponins with phospholipids and pharmaceutical and cosmetic compositions containing them
DE69224622D1 (de) Herstellung von prothrombinzeit-reagenzien aus rekombinantem menschlichem gewebefaktor und sythetischen phospholipiden
FI873796A0 (fi) Foerbaettrad metod foer produktion av proteiner av faktor viii:c-typ.
CA2113995A1 (en) Use of gentisic acid or gentisyl alcohol for stabilising radiolabeled peptides and proteins
ES8106407A1 (es) Procedimiento para el tratamiento de superficies hidrofobas
DE68912657T2 (de) Verfahren zur Herstellung von 1,1,1,2-Tetrafluorethan.
IE45255L (en) Whippable composition.
ATE15901T1 (de) Lipide und proteine in teilchenform enthaltender stoff und verfahren zu seiner herstellung.
DE69001609D1 (de) Herstellung von niedrigviskosen fotografischen kleinteilchen-dispersionen in gelatine.
ES8305501A1 (es) Procedimiento para preparar un material de referencia o control de hemoglobina.
DE69029765D1 (de) Stabilisierung von hochgereinigten Proteinen
DE69001573D1 (de) Zusammensetzungen zur herstellung von in dosisformen aktiven vitaminen d3 sowie verfahren zur herstellung stabiler, in dosisformen aktiver vitamine d3 unter deren verwendung.
HUP9900506A2 (hu) Protrombinszármazékok
DE68905327T2 (de) Verfahren zur Herstellung von 1,1,1,2-tetrafluorethan.
EP0315118A3 (de) Endothelin kodierendes DNA und dessen Verwendung
KR910003095A (ko) 사람의 단백질 c변이체 및 이의 제조방법
DE58903876D1 (de) Riboflavin-4'5'-cyclo-phosphorsaeureesterchlorid, dessen herstellung und verwendung zur herstellung von riboflavin-5'-phosphat (5'-fmn) bzw. dessen natriumsalz.
DE69529750D1 (de) Verbesserungen in der herstellung von proteinen in wirtszellen
DE68922361D1 (de) Verfahren zur Herstellung von 2,6-Naphthalendicarbonsäure.
DE68913888D1 (de) Verfahren zur Herstellung von 3,5-dialkyl-4-hydroxybenzyl-substituierten Aromaten.
JPS642603A (en) Hair reinforcing method
JPS52148487A (en) Filter membrane of hollow fiber

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NEXSTAR PHARMACEUTICALS INC. (N.D.GES.D. STAATES D

8339 Ceased/non-payment of the annual fee