JPS574913A - Urokinase preparation for oral administration - Google Patents

Urokinase preparation for oral administration

Info

Publication number
JPS574913A
JPS574913A JP7883480A JP7883480A JPS574913A JP S574913 A JPS574913 A JP S574913A JP 7883480 A JP7883480 A JP 7883480A JP 7883480 A JP7883480 A JP 7883480A JP S574913 A JPS574913 A JP S574913A
Authority
JP
Japan
Prior art keywords
lipid
urokinase
solvent
preparation
denaturation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7883480A
Other languages
Japanese (ja)
Inventor
Tsunekazu Fukushima
Tadakazu Suyama
Satoru Funakoshi
Kazumasa Yokoyama
Takashi Shoji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Priority to JP7883480A priority Critical patent/JPS574913A/en
Publication of JPS574913A publication Critical patent/JPS574913A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

PURPOSE:The titled preparation that is made by confining urokinase in spaces in fine lipid particles, thus removing bad influences caused by parenteral administration and making it possible to keep prolonged activity in blood. CONSTITUTION:A solution of a lipid, e.g., phospholipid such as lecithin or phosphatidylcholine, in a solvent that causes no denaturation of the lipid such as ethanol is treated to remove the solvent. Then, the lipid is made into films. At this time, cholesterol or phosphatidic acid may be added as a stabilizer. Another solution of urokinase in a solvent that causes no denaturation of the lipid such as a phosphoric acid buffer solution of 6-8pH is added to the film and they are vigorously stirred. Preferably, they are treated with ultrasonic waves to disperse the film uniformly, resulting in the inclusion of urokinase in spaces of the lipid. The addition of a high- molecular stabilizer such as albumin gives the preparation with highly increased stability.
JP7883480A 1980-06-11 1980-06-11 Urokinase preparation for oral administration Pending JPS574913A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7883480A JPS574913A (en) 1980-06-11 1980-06-11 Urokinase preparation for oral administration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7883480A JPS574913A (en) 1980-06-11 1980-06-11 Urokinase preparation for oral administration

Publications (1)

Publication Number Publication Date
JPS574913A true JPS574913A (en) 1982-01-11

Family

ID=13672851

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7883480A Pending JPS574913A (en) 1980-06-11 1980-06-11 Urokinase preparation for oral administration

Country Status (1)

Country Link
JP (1) JPS574913A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002076A1 (en) * 1982-11-26 1984-06-07 Fluidcarbon International Ab Method of preparing controlled-release preparations for biologically active materials and resulting compositions
JPS6056918A (en) * 1983-08-03 1985-04-02 ビオメデイカ・フオスカマ・インデユストリア・キミコ−フアルマチエウテイカ・エツセ・ピ・ア Liposome containing frustose-1,6-diphosphoric acid
JPS6242733A (en) * 1985-08-07 1987-02-24 スミスクライン・ビーチャム・コーポレイション Liposome forming composition and formation of liposome
EP0395765A1 (en) * 1988-01-13 1990-11-07 Dainippon Pharmaceutical Co., Ltd. Oozing-proof liposome preparation
EP0437479A1 (en) * 1988-10-05 1991-07-24 Vestar Inc Method of making liposomes with improved stability during drying.
JPH05501855A (en) * 1989-05-17 1993-04-08 リサーチ、コーポレーション、テクノロジーズ、インコーポレーテッド Methods and compositions for treating thrombosis in mammals
JPH0818973B2 (en) * 1984-08-08 1996-02-28 ザ リポソ−ム，カムパニ−，インコ−ポレ−テツド Dehydration liposome
WO1996017594A1 (en) * 1994-12-09 1996-06-13 Cortecs Limited Sequestration agents

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984002076A1 (en) * 1982-11-26 1984-06-07 Fluidcarbon International Ab Method of preparing controlled-release preparations for biologically active materials and resulting compositions
JPS6056918A (en) * 1983-08-03 1985-04-02 ビオメデイカ・フオスカマ・インデユストリア・キミコ−フアルマチエウテイカ・エツセ・ピ・ア Liposome containing frustose-1,6-diphosphoric acid
US5578320A (en) * 1984-08-08 1996-11-26 The Liposome Company, Inc. Method of dehydrating liposomes using protective sugars
JPH0818973B2 (en) * 1984-08-08 1996-02-28 ザ リポソ−ム，カムパニ−，インコ−ポレ−テツド Dehydration liposome
US5837279A (en) * 1984-08-08 1998-11-17 The Lipsome Company, Inc. Encapsulation of ionizable agents in liposomes
US5922350A (en) * 1984-08-08 1999-07-13 The Liposome Company, Inc. Methods of dehydrating, storing and rehydrating liposomes
JPS6242733A (en) * 1985-08-07 1987-02-24 スミスクライン・ビーチャム・コーポレイション Liposome forming composition and formation of liposome
EP0395765A1 (en) * 1988-01-13 1990-11-07 Dainippon Pharmaceutical Co., Ltd. Oozing-proof liposome preparation
EP0437479A1 (en) * 1988-10-05 1991-07-24 Vestar Inc Method of making liposomes with improved stability during drying.
US5817334A (en) * 1988-10-05 1998-10-06 Nexstar Pharmaceuticals, Inc. Method of making liposomes with improved stability during drying
JPH05501855A (en) * 1989-05-17 1993-04-08 リサーチ、コーポレーション、テクノロジーズ、インコーポレーテッド Methods and compositions for treating thrombosis in mammals
US5503850A (en) * 1989-05-17 1996-04-02 Research Corporation Technologies, Inc. Method and composition for the treatment of thrombosis in a mammal
WO1996017594A1 (en) * 1994-12-09 1996-06-13 Cortecs Limited Sequestration agents

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