DE69838916T2 - Neuartige exendin agonisten - Google Patents
Neuartige exendin agonisten Download PDFInfo
- Publication number
- DE69838916T2 DE69838916T2 DE69838916T DE69838916T DE69838916T2 DE 69838916 T2 DE69838916 T2 DE 69838916T2 DE 69838916 T DE69838916 T DE 69838916T DE 69838916 T DE69838916 T DE 69838916T DE 69838916 T2 DE69838916 T2 DE 69838916T2
- Authority
- DE
- Germany
- Prior art keywords
- seq
- connection
- exendin
- peptide
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 239000000203 mixture Substances 0.000 claims description 24
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- 238000002360 preparation method Methods 0.000 claims description 17
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6544297P | 1997-11-14 | 1997-11-14 | |
| US65442P | 1997-11-14 | ||
| PCT/US1998/024210 WO1999025727A2 (en) | 1997-11-14 | 1998-11-13 | Novel exendin agonist compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69838916D1 DE69838916D1 (de) | 2008-02-07 |
| DE69838916T2 true DE69838916T2 (de) | 2008-12-18 |
Family
ID=22062753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69838916T Expired - Lifetime DE69838916T2 (de) | 1997-11-14 | 1998-11-13 | Neuartige exendin agonisten |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7696161B2 (https=) |
| EP (1) | EP1066314B1 (https=) |
| JP (1) | JP2003522721A (https=) |
| AT (1) | ATE381939T1 (https=) |
| AU (1) | AU757748B2 (https=) |
| BR (1) | BR9815670A (https=) |
| CA (1) | CA2310097C (https=) |
| DE (1) | DE69838916T2 (https=) |
| ES (1) | ES2294822T3 (https=) |
| MX (1) | MXPA00004670A (https=) |
| NZ (1) | NZ504258A (https=) |
| WO (1) | WO1999025727A2 (https=) |
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| MX2019015544A (es) | 2017-06-21 | 2020-07-28 | Amgen Inc | Metodo para tratar o mejorar trastornos metabolicos con proteinas de fusion de agonistas del receptor de glp-1/proteinas de union antagonistas para el receptor peptidico inhibidor gastrico (gipr). |
| EP3774838B9 (en) | 2018-04-10 | 2025-12-10 | Sanofi-Aventis Deutschland GmbH | Lixisenatide synthesis with capping |
| MX2020010716A (es) | 2018-04-10 | 2021-03-09 | Sanofi Aventis Deutschland | Metodo para escindir de la fase solida peptidos unidos a una fase solida. |
| EP3934679A1 (en) | 2019-03-08 | 2022-01-12 | Amgen Inc. | Growth differentiation factor 15 combination therapy |
| WO2024123812A1 (en) | 2022-12-05 | 2024-06-13 | Shattuck Labs, Inc. | Fusion proteins for the treatment of cardiometabolic diseases |
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| US5120712A (en) | 1986-05-05 | 1992-06-09 | The General Hospital Corporation | Insulinotropic hormone |
| US5118666A (en) | 1986-05-05 | 1992-06-02 | The General Hospital Corporation | Insulinotropic hormone |
| JPH04504246A (ja) | 1989-03-20 | 1992-07-30 | ザ・ジェネラル・ホスピタル・コーポレーション | インシュリン刺激ホルモン |
| ATE164852T1 (de) | 1990-01-24 | 1998-04-15 | Douglas I Buckley | Glp-1-analoga verwendbar in der diabetesbehandlung |
| US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
| DK36392D0 (da) | 1992-03-19 | 1992-03-19 | Novo Nordisk As | Anvendelse af kemisk forbindelse |
| SK155694A3 (en) | 1992-06-15 | 1995-05-10 | Pfizer | Glucagon-like peptide, insulinotropin derivatives, method of their preparation, pharmaceutical agent containing and using these matters |
| US5424286A (en) * | 1993-05-24 | 1995-06-13 | Eng; John | Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same |
| US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| US5574008A (en) | 1994-08-30 | 1996-11-12 | Eli Lilly And Company | Biologically active fragments of glucagon-like insulinotropic peptide |
| US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
| DE59712555D1 (de) * | 1996-06-05 | 2006-04-06 | Roche Diagnostics Gmbh | Exendin-analoga, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| US5686511A (en) | 1996-06-28 | 1997-11-11 | The Valspar Corporation | Esterifying epoxy resin with carboxyl polymer and quenching |
| WO1998005351A1 (en) * | 1996-08-08 | 1998-02-12 | Amylin Pharmaceuticals, Inc. | Methods for regulating gastrointestinal motility |
| UA65549C2 (uk) | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| EP0996459B1 (en) | 1997-01-07 | 2005-09-21 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the reduction of food intake |
| US5846937A (en) | 1997-03-03 | 1998-12-08 | 1149336 Ontario Inc. | Method of using exendin and GLP-1 to affect the central nervous system |
| CA2299425A1 (en) * | 1997-08-08 | 1999-02-18 | Amylin Pharmaceuticals, Inc. | Novel exendin agonist compounds |
| US7220721B1 (en) * | 1997-11-14 | 2007-05-22 | Amylin Pharmaceuticals, Inc. | Exendin agonist peptides |
| US7223725B1 (en) * | 1997-11-14 | 2007-05-29 | Amylin Pharmaceuticals, Inc. | Exendin agonist compounds |
| US6506724B1 (en) | 1999-06-01 | 2003-01-14 | Amylin Pharmaceuticals, Inc. | Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus |
| DE60007592T2 (de) | 1999-09-30 | 2004-09-16 | Pfizer Products Inc., Groton | Bicyclische Pyrrolylamide als Glycogenphosphorylase-Inhibitoren |
-
1998
- 1998-11-13 WO PCT/US1998/024210 patent/WO1999025727A2/en not_active Ceased
- 1998-11-13 AT AT98957897T patent/ATE381939T1/de not_active IP Right Cessation
- 1998-11-13 EP EP98957897A patent/EP1066314B1/en not_active Expired - Lifetime
- 1998-11-13 NZ NZ504258A patent/NZ504258A/xx not_active IP Right Cessation
- 1998-11-13 AU AU14046/99A patent/AU757748B2/en not_active Ceased
- 1998-11-13 DE DE69838916T patent/DE69838916T2/de not_active Expired - Lifetime
- 1998-11-13 ES ES98957897T patent/ES2294822T3/es not_active Expired - Lifetime
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- 1998-11-13 MX MXPA00004670A patent/MXPA00004670A/es active IP Right Grant
- 1998-11-13 BR BR9815670-5A patent/BR9815670A/pt not_active IP Right Cessation
- 1998-11-13 JP JP2000521107A patent/JP2003522721A/ja active Pending
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2007
- 2007-05-25 US US11/807,031 patent/US7696161B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ504258A (en) | 2002-12-20 |
| US7696161B2 (en) | 2010-04-13 |
| AU1404699A (en) | 1999-06-07 |
| ES2294822T3 (es) | 2008-04-01 |
| EP1066314B1 (en) | 2007-12-26 |
| EP1066314A4 (en) | 2002-04-10 |
| ATE381939T1 (de) | 2008-01-15 |
| WO1999025727A2 (en) | 1999-05-27 |
| JP2003522721A (ja) | 2003-07-29 |
| US20080119393A1 (en) | 2008-05-22 |
| BR9815670A (pt) | 2000-10-17 |
| AU757748B2 (en) | 2003-03-06 |
| DE69838916D1 (de) | 2008-02-07 |
| EP1066314A1 (en) | 2001-01-10 |
| CA2310097A1 (en) | 1999-05-27 |
| CA2310097C (en) | 2014-07-29 |
| MXPA00004670A (es) | 2003-07-14 |
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