DE69831409T2 - Chalcon-derivate mit antiproliferativer aktivität - Google Patents

Chalcon-derivate mit antiproliferativer aktivität Download PDF

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Publication number
DE69831409T2
DE69831409T2 DE69831409T DE69831409T DE69831409T2 DE 69831409 T2 DE69831409 T2 DE 69831409T2 DE 69831409 T DE69831409 T DE 69831409T DE 69831409 T DE69831409 T DE 69831409T DE 69831409 T2 DE69831409 T2 DE 69831409T2
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DE
Germany
Prior art keywords
phenyl
hydroxy
propen
pyridyl
cme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69831409T
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German (de)
English (en)
Other versions
DE69831409D1 (de
Inventor
Ezio Bombardelli
Piero Valenti
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Indena SpA
Original Assignee
Indena SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA filed Critical Indena SpA
Application granted granted Critical
Publication of DE69831409D1 publication Critical patent/DE69831409D1/de
Publication of DE69831409T2 publication Critical patent/DE69831409T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/22—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69831409T 1997-06-19 1998-06-12 Chalcon-derivate mit antiproliferativer aktivität Expired - Lifetime DE69831409T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9712966 1997-06-19
GBGB9712966.2A GB9712966D0 (en) 1997-06-19 1997-06-19 Novel chalcones
PCT/EP1998/003558 WO1998058913A1 (en) 1997-06-19 1998-06-12 Chalcones having antiproliferative activity

Publications (2)

Publication Number Publication Date
DE69831409D1 DE69831409D1 (de) 2005-10-06
DE69831409T2 true DE69831409T2 (de) 2006-06-08

Family

ID=10814591

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69831409T Expired - Lifetime DE69831409T2 (de) 1997-06-19 1998-06-12 Chalcon-derivate mit antiproliferativer aktivität

Country Status (22)

Country Link
US (1) US6147082A (no)
EP (1) EP0989973B1 (no)
JP (1) JP4064471B2 (no)
KR (1) KR20010013603A (no)
CN (1) CN1198802C (no)
AT (1) ATE303362T1 (no)
AU (1) AU742784C (no)
CA (1) CA2294278C (no)
CZ (1) CZ294976B6 (no)
DE (1) DE69831409T2 (no)
DK (1) DK0989973T3 (no)
ES (1) ES2244075T3 (no)
GB (1) GB9712966D0 (no)
HK (1) HK1023770A1 (no)
HU (1) HU227628B1 (no)
NO (1) NO314802B1 (no)
PL (1) PL190495B1 (no)
PT (1) PT989973E (no)
RU (1) RU2203883C2 (no)
SI (1) SI0989973T1 (no)
SK (1) SK283077B6 (no)
WO (1) WO1998058913A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE409028T1 (de) * 2000-01-27 2008-10-15 Takara Bio Inc Arzneien zur behandlung von nervenerkrankungen
KR100377514B1 (ko) * 2000-05-23 2003-03-26 신국현 찰콘 유도체, 그의 제조방법 및 그를 포함하는 약학적조성물
DE10060677A1 (de) 2000-12-05 2002-06-20 Aventis Pharma Gmbh Klainetine und ihre Derivate, Verfahren zu ihrer Herstellung und Verwendung derselben
US7514579B2 (en) * 2002-06-13 2009-04-07 Johns Hopkins University Boronic chalcone derivatives and uses thereof
CA2500527A1 (en) * 2002-10-01 2004-04-15 Takara Bio Inc. Remedies
CA2567813C (en) * 2004-05-23 2015-11-24 Gerard M. Housey Theramutein modulators
CN100336797C (zh) * 2005-08-19 2007-09-12 浙江大学 四取代查耳酮衍生物及制备方法和用途
CN102060792B (zh) * 2010-12-24 2016-08-03 西南大学 2′-胺基查尔酮唑类化合物及其吡唑啉和环丙基唑类衍生物、制备方法与用途
ES2540457B2 (es) * 2013-06-19 2015-12-28 Universidad De Sevilla Procedimiento de obtención de extractos de hojas de Corema album y su aplicación terapéutica
CN103360338B (zh) * 2013-07-30 2015-04-01 中国科学院新疆理化技术研究所 一种查尔酮苯并噻唑酰胺类衍生物的制备方法和用途
CN103896932A (zh) * 2014-04-18 2014-07-02 山东药品食品职业学院 异恶唑基芳基查尔酮衍生物及其制备方法和应用
CN103910691A (zh) * 2014-04-18 2014-07-09 山东药品食品职业学院 卤代苯基查尔酮衍生物及其制备方法和应用
CZ307046B6 (cs) * 2015-09-02 2017-12-13 Univerzita PalackĂ©ho v Olomouci Komplexy mědi s deriváty (E)-1-(2´-hydroxyfenyl)-3-fenylprop-2-en-1-onu a jejich použití jako léčiv v protinádorové terapii
WO2017103637A1 (en) 2015-12-18 2017-06-22 Blirt S.A. Diphenylpropane compounds and their cytotoxic activity
CN106279082B (zh) * 2016-08-02 2019-02-01 浙江大学 取代的呋喃查耳酮类衍生物及其制备方法
CN111138264B (zh) * 2019-11-29 2023-08-04 温州医科大学 一种丁香醛衍生物及其在制备抗妇科肿瘤药物中的应用
KR102496887B1 (ko) * 2020-10-15 2023-02-06 경상국립대학교산학협력단 부테인 유도체 또는 이의 약학적으로 허용가능한 염을 포함하는 유방암의 예방, 개선 또는 치료용 조성물

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05509078A (ja) * 1990-05-17 1993-12-16 ベイラー カレッジ オブ メディシン 成長抑制因とガンおよび細胞増殖性疾患措置法
IT1271301B (it) * 1994-12-20 1997-05-27 Indena Spa Calconi naturali e sintetici e loro esteri ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno e formulazioni che li contengono

Also Published As

Publication number Publication date
AU742784C (en) 2005-08-18
WO1998058913A1 (en) 1998-12-30
CN1198802C (zh) 2005-04-27
SK283077B6 (sk) 2003-02-04
GB9712966D0 (en) 1997-08-27
HUP0003068A2 (hu) 2001-01-29
JP2002506439A (ja) 2002-02-26
ATE303362T1 (de) 2005-09-15
AU742784B2 (en) 2002-01-10
HU227628B1 (en) 2011-10-28
CZ294976B6 (cs) 2005-04-13
CZ459999A3 (cs) 2000-05-17
JP4064471B2 (ja) 2008-03-19
KR20010013603A (ko) 2001-02-26
NO314802B1 (no) 2003-05-26
NO996287L (no) 2000-02-21
HUP0003068A3 (en) 2002-02-28
SK179599A3 (en) 2000-06-12
US6147082A (en) 2000-11-14
RU2203883C2 (ru) 2003-05-10
DK0989973T3 (da) 2005-10-17
ES2244075T3 (es) 2005-12-01
PL190495B1 (pl) 2005-12-30
HK1023770A1 (en) 2000-09-22
EP0989973B1 (en) 2005-08-31
AU8537598A (en) 1999-01-04
SI0989973T1 (sl) 2006-02-28
PT989973E (pt) 2005-11-30
EP0989973A1 (en) 2000-04-05
DE69831409D1 (de) 2005-10-06
NO996287D0 (no) 1999-12-17
CN1261349A (zh) 2000-07-26
CA2294278A1 (en) 1998-12-30
PL337361A1 (en) 2000-08-14
CA2294278C (en) 2007-09-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC