DE69824863T2 - Benzothiazindioxid-endothelin antagonisten und verfahren zu ihrer herstellung - Google Patents

Benzothiazindioxid-endothelin antagonisten und verfahren zu ihrer herstellung Download PDF

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Publication number
DE69824863T2
DE69824863T2 DE69824863T DE69824863T DE69824863T2 DE 69824863 T2 DE69824863 T2 DE 69824863T2 DE 69824863 T DE69824863 T DE 69824863T DE 69824863 T DE69824863 T DE 69824863T DE 69824863 T2 DE69824863 T2 DE 69824863T2
Authority
DE
Germany
Prior art keywords
benzo
dihydro
dioxo
thiazine
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69824863T
Other languages
German (de)
English (en)
Other versions
DE69824863D1 (de
Inventor
Mae Amy BUNKER
Xue-Min Cheng
Marian Annette DOHERTY
Chitase Lee
Thomas Joseph REPINE
Richard Skeean
John Jeremy EDMUNDS
David Gerald KANTER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of DE69824863D1 publication Critical patent/DE69824863D1/de
Publication of DE69824863T2 publication Critical patent/DE69824863T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69824863T 1997-09-05 1998-08-13 Benzothiazindioxid-endothelin antagonisten und verfahren zu ihrer herstellung Expired - Fee Related DE69824863T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5811197P 1997-09-05 1997-09-05
US58111P 1997-09-05
US9232698P 1998-07-09 1998-07-09
US92326P 1998-07-09
PCT/US1998/016856 WO1999012916A1 (en) 1997-09-05 1998-08-13 Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

Publications (2)

Publication Number Publication Date
DE69824863D1 DE69824863D1 (de) 2004-08-05
DE69824863T2 true DE69824863T2 (de) 2005-06-30

Family

ID=26737251

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69824863T Expired - Fee Related DE69824863T2 (de) 1997-09-05 1998-08-13 Benzothiazindioxid-endothelin antagonisten und verfahren zu ihrer herstellung

Country Status (24)

Country Link
US (5) US6265399B1 (https=)
EP (1) EP1009743B1 (https=)
JP (1) JP2001515893A (https=)
KR (1) KR20010023686A (https=)
AR (1) AR017056A1 (https=)
AT (1) ATE270281T1 (https=)
AU (1) AU759169B2 (https=)
BR (1) BR9812431A (https=)
CA (1) CA2296358A1 (https=)
CO (1) CO4970725A1 (https=)
DE (1) DE69824863T2 (https=)
ES (1) ES2221191T3 (https=)
HU (1) HUP0003689A3 (https=)
IL (1) IL134057A0 (https=)
IS (1) IS5356A (https=)
MY (1) MY116277A (https=)
NO (1) NO20001078L (https=)
NZ (1) NZ502670A (https=)
PE (1) PE116699A1 (https=)
PL (1) PL338983A1 (https=)
PT (1) PT1009743E (https=)
TW (1) TW508355B (https=)
UY (1) UY25168A1 (https=)
WO (1) WO1999012916A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU759169B2 (en) 1997-09-05 2003-04-10 Warner-Lambert Company Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
EP1288199A4 (en) 2000-04-28 2005-10-12 Shionogi & Co INHIBITORS OF MMP-12
WO2001091736A2 (en) * 2000-05-31 2001-12-06 Warner-Lambert Company Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
US20020115661A1 (en) * 2000-12-07 2002-08-22 Keller Laurence Harvey Method for treating chronic obstructive pulmonary disease
CN1882327A (zh) 2003-11-19 2006-12-20 症变治疗公司 含磷的新的拟甲状腺素药
FR2874011B1 (fr) * 2004-08-03 2007-06-15 Sanofi Synthelabo Derives de sulfonamides, leur preparation et leur application en therapeutique
DE102008026894A1 (de) * 2008-06-05 2009-12-10 Evonik Degussa Gmbh Ink Jet Tinte
CA2969756A1 (en) * 2014-12-05 2016-06-09 Aquinnah Pharmaceuticals, Inc. Sulfonamide derivatives, compositions and methods of use in the treatment of neurodegenerative diseases
CN108727176B (zh) * 2018-07-26 2021-05-18 荆楚理工学院 一种制备5-卤-2,3-二羟基苯甲醛的方法
CN113214299A (zh) * 2021-03-01 2021-08-06 重庆西南制药二厂有限责任公司 γ-联苯双酯中间体及合成方法及γ-联苯双酯合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960856A (en) * 1975-06-20 1976-06-01 Warner-Lambert Company Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide
IN159273B (https=) * 1981-10-05 1987-04-25 Pfizer
JPH0495057A (ja) * 1990-08-08 1992-03-27 Taisho Pharmaceut Co Ltd Ｎ―置換スルホンアニリド化合物
AU675870B2 (en) * 1993-08-18 1997-02-20 Msd K.K. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
US5389620A (en) 1993-08-18 1995-02-14 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
CA2156849A1 (en) 1993-12-24 1995-07-06 Akira Mizuno Benzothiazine derivative
JPH0912562A (ja) 1995-06-22 1997-01-14 Suntory Ltd 置換ベンゾチアジン誘導体
US5482960A (en) 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
US5599811A (en) * 1995-02-21 1997-02-04 Warner-Lambert Company Benzothiazine dioxides as endothelin antagonists
CA2190708A1 (en) 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
AU759169B2 (en) 1997-09-05 2003-04-10 Warner-Lambert Company Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

Also Published As

Publication number Publication date
AR017056A1 (es) 2001-08-22
PE116699A1 (es) 1999-12-19
HUP0003689A2 (hu) 2001-09-28
US20030073684A1 (en) 2003-04-17
BR9812431A (pt) 2000-09-19
JP2001515893A (ja) 2001-09-25
NO20001078D0 (no) 2000-03-02
US6440962B2 (en) 2002-08-27
US6265399B1 (en) 2001-07-24
UY25168A1 (es) 1999-05-14
MY116277A (en) 2003-12-31
US6252070B1 (en) 2001-06-26
ES2221191T3 (es) 2004-12-16
PL338983A1 (en) 2000-12-04
AU759169B2 (en) 2003-04-10
HUP0003689A3 (en) 2003-05-28
WO1999012916A1 (en) 1999-03-18
IS5356A (is) 2000-01-21
EP1009743A1 (en) 2000-06-21
IL134057A0 (en) 2001-04-30
US20020094980A1 (en) 2002-07-18
EP1009743B1 (en) 2004-06-30
DE69824863D1 (de) 2004-08-05
US6545150B2 (en) 2003-04-08
KR20010023686A (ko) 2001-03-26
CA2296358A1 (en) 1999-03-18
NO20001078L (no) 2000-03-02
AU9019698A (en) 1999-03-29
US20010036944A1 (en) 2001-11-01
PT1009743E (pt) 2004-09-30
TW508355B (en) 2002-11-01
CO4970725A1 (es) 2000-11-07
NZ502670A (en) 2003-01-31
ATE270281T1 (de) 2004-07-15

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee