IS5356A - Viss bensóþíasíndíoxíð-mótlyf gegn endóþelíni og ferli til að smíða þau - Google Patents
Viss bensóþíasíndíoxíð-mótlyf gegn endóþelíni og ferli til að smíða þauInfo
- Publication number
- IS5356A IS5356A IS5356A IS5356A IS5356A IS 5356 A IS5356 A IS 5356A IS 5356 A IS5356 A IS 5356A IS 5356 A IS5356 A IS 5356A IS 5356 A IS5356 A IS 5356A
- Authority
- IS
- Iceland
- Prior art keywords
- making
- certain
- antagonists against
- against endothelin
- benzothiazine dioxide
- Prior art date
Links
- GHNLJDPNIAIWOQ-UHFFFAOYSA-N 2h-1$l^{6},2-benzothiazine 1,1-dioxide Chemical compound C1=CC=C2S(=O)(=O)NC=CC2=C1 GHNLJDPNIAIWOQ-UHFFFAOYSA-N 0.000 title 1
- 102000002045 Endothelin Human genes 0.000 title 1
- 108050009340 Endothelin Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5811197P | 1997-09-05 | 1997-09-05 | |
| US9232698P | 1998-07-09 | 1998-07-09 | |
| PCT/US1998/016856 WO1999012916A1 (en) | 1997-09-05 | 1998-08-13 | Certain benzothiazine dioxide endothelin antagonists and processes for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS5356A true IS5356A (is) | 2000-01-21 |
Family
ID=26737251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS5356A IS5356A (is) | 1997-09-05 | 2000-01-21 | Viss bensóþíasíndíoxíð-mótlyf gegn endóþelíni og ferli til að smíða þau |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US6265399B1 (is) |
| EP (1) | EP1009743B1 (is) |
| JP (1) | JP2001515893A (is) |
| KR (1) | KR20010023686A (is) |
| AR (1) | AR017056A1 (is) |
| AT (1) | ATE270281T1 (is) |
| AU (1) | AU759169B2 (is) |
| BR (1) | BR9812431A (is) |
| CA (1) | CA2296358A1 (is) |
| CO (1) | CO4970725A1 (is) |
| DE (1) | DE69824863T2 (is) |
| ES (1) | ES2221191T3 (is) |
| HU (1) | HUP0003689A3 (is) |
| IL (1) | IL134057A0 (is) |
| IS (1) | IS5356A (is) |
| MY (1) | MY116277A (is) |
| NO (1) | NO20001078L (is) |
| NZ (1) | NZ502670A (is) |
| PE (1) | PE116699A1 (is) |
| PL (1) | PL338983A1 (is) |
| PT (1) | PT1009743E (is) |
| TW (1) | TW508355B (is) |
| UY (1) | UY25168A1 (is) |
| WO (1) | WO1999012916A1 (is) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001515893A (ja) | 1997-09-05 | 2001-09-25 | ワーナー−ランバート・カンパニー | 特定のベンゾチアジンジオキシドエンドセリンアンタゴニスト類およびその製造方法 |
| US6897237B2 (en) | 2000-04-28 | 2005-05-24 | Shionogi & Co. Ltd. | MMP-12 inhibitors |
| CA2409927A1 (en) * | 2000-05-31 | 2001-12-06 | Warner-Lambert Company | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic |
| US20020115661A1 (en) * | 2000-12-07 | 2002-08-22 | Keller Laurence Harvey | Method for treating chronic obstructive pulmonary disease |
| EP2428516A1 (en) | 2003-11-19 | 2012-03-14 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| FR2874011B1 (fr) * | 2004-08-03 | 2007-06-15 | Sanofi Synthelabo | Derives de sulfonamides, leur preparation et leur application en therapeutique |
| DE102008026894A1 (de) * | 2008-06-05 | 2009-12-10 | Evonik Degussa Gmbh | Ink Jet Tinte |
| US20170360726A1 (en) * | 2014-12-05 | 2017-12-21 | Aquinnah Pharmaceuticals, Inc. | Compounds, compositions and methods of use |
| CN108727176B (zh) * | 2018-07-26 | 2021-05-18 | 荆楚理工学院 | 一种制备5-卤-2,3-二羟基苯甲醛的方法 |
| CN113214299A (zh) * | 2021-03-01 | 2021-08-06 | 重庆西南制药二厂有限责任公司 | γ-联苯双酯中间体及合成方法及γ-联苯双酯合成方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3960856A (en) * | 1975-06-20 | 1976-06-01 | Warner-Lambert Company | Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide |
| IN159273B (is) * | 1981-10-05 | 1987-04-25 | Pfizer | |
| JPH0495057A (ja) * | 1990-08-08 | 1992-03-27 | Taisho Pharmaceut Co Ltd | Ｎ―置換スルホンアニリド化合物 |
| US5389620A (en) | 1993-08-18 | 1995-02-14 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives |
| DE69426698T2 (de) * | 1993-08-18 | 2001-08-16 | Banyu Pharmaceutical Co., Ltd. | Kondensierte heteroaromatische cyclopentenderivate mit endothelin-antagonistischer aktivität |
| JPH0912562A (ja) | 1995-06-22 | 1997-01-14 | Suntory Ltd | 置換ベンゾチアジン誘導体 |
| CA2156849A1 (en) | 1993-12-24 | 1995-07-06 | Akira Mizuno | Benzothiazine derivative |
| US5482960A (en) | 1994-11-14 | 1996-01-09 | Warner-Lambert Company | Nonpeptide endothelin antagonists |
| US5599811A (en) * | 1995-02-21 | 1997-02-04 | Warner-Lambert Company | Benzothiazine dioxides as endothelin antagonists |
| CA2190708A1 (en) | 1995-12-08 | 1997-06-09 | Johannes Aebi | Aminoalkyl substituted benzo-heterocyclic compounds |
| JP2001515893A (ja) | 1997-09-05 | 2001-09-25 | ワーナー−ランバート・カンパニー | 特定のベンゾチアジンジオキシドエンドセリンアンタゴニスト類およびその製造方法 |
-
1998
- 1998-08-13 JP JP2000510724A patent/JP2001515893A/ja not_active Abandoned
- 1998-08-13 PL PL98338983A patent/PL338983A1/xx unknown
- 1998-08-13 AU AU90196/98A patent/AU759169B2/en not_active Ceased
- 1998-08-13 BR BR9812431-5A patent/BR9812431A/pt not_active Application Discontinuation
- 1998-08-13 HU HU0003689A patent/HUP0003689A3/hu unknown
- 1998-08-13 KR KR1020007002339A patent/KR20010023686A/ko not_active Withdrawn
- 1998-08-13 WO PCT/US1998/016856 patent/WO1999012916A1/en active IP Right Grant
- 1998-08-13 NZ NZ502670A patent/NZ502670A/xx unknown
- 1998-08-13 IL IL13405798A patent/IL134057A0/xx unknown
- 1998-08-13 US US09/445,504 patent/US6265399B1/en not_active Expired - Fee Related
- 1998-08-13 PT PT98942061T patent/PT1009743E/pt unknown
- 1998-08-13 DE DE69824863T patent/DE69824863T2/de not_active Expired - Fee Related
- 1998-08-13 AT AT98942061T patent/ATE270281T1/de not_active IP Right Cessation
- 1998-08-13 ES ES98942061T patent/ES2221191T3/es not_active Expired - Lifetime
- 1998-08-13 EP EP98942061A patent/EP1009743B1/en not_active Expired - Lifetime
- 1998-08-13 CA CA002296358A patent/CA2296358A1/en not_active Abandoned
- 1998-09-03 MY MYPI98004024A patent/MY116277A/en unknown
- 1998-09-04 AR ARP980104414A patent/AR017056A1/es unknown
- 1998-09-04 PE PE1998000822A patent/PE116699A1/es not_active Application Discontinuation
- 1998-09-04 CO CO98050781A patent/CO4970725A1/es unknown
- 1998-09-04 UY UY25168A patent/UY25168A1/es not_active IP Right Cessation
- 1998-10-28 TW TW087114760A patent/TW508355B/zh not_active IP Right Cessation
-
2000
- 2000-01-21 IS IS5356A patent/IS5356A/is unknown
- 2000-03-02 NO NO20001078A patent/NO20001078L/no unknown
- 2000-08-07 US US09/633,720 patent/US6252070B1/en not_active Expired - Fee Related
-
2001
- 2001-03-27 US US09/818,394 patent/US6440962B2/en not_active Expired - Fee Related
- 2001-12-05 US US10/006,589 patent/US6545150B2/en not_active Expired - Fee Related
-
2002
- 2002-06-03 US US10/161,569 patent/US20030073684A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69824863D1 (de) | 2004-08-05 |
| CA2296358A1 (en) | 1999-03-18 |
| UY25168A1 (es) | 1999-05-14 |
| TW508355B (en) | 2002-11-01 |
| PT1009743E (pt) | 2004-09-30 |
| HUP0003689A2 (hu) | 2001-09-28 |
| US6545150B2 (en) | 2003-04-08 |
| PE116699A1 (es) | 1999-12-19 |
| EP1009743A1 (en) | 2000-06-21 |
| ATE270281T1 (de) | 2004-07-15 |
| NO20001078D0 (no) | 2000-03-02 |
| US20020094980A1 (en) | 2002-07-18 |
| WO1999012916A1 (en) | 1999-03-18 |
| US20010036944A1 (en) | 2001-11-01 |
| NZ502670A (en) | 2003-01-31 |
| CO4970725A1 (es) | 2000-11-07 |
| IL134057A0 (en) | 2001-04-30 |
| DE69824863T2 (de) | 2005-06-30 |
| US6252070B1 (en) | 2001-06-26 |
| AU759169B2 (en) | 2003-04-10 |
| US6440962B2 (en) | 2002-08-27 |
| NO20001078L (no) | 2000-03-02 |
| AR017056A1 (es) | 2001-08-22 |
| JP2001515893A (ja) | 2001-09-25 |
| HUP0003689A3 (en) | 2003-05-28 |
| US20030073684A1 (en) | 2003-04-17 |
| MY116277A (en) | 2003-12-31 |
| BR9812431A (pt) | 2000-09-19 |
| EP1009743B1 (en) | 2004-06-30 |
| AU9019698A (en) | 1999-03-29 |
| US6265399B1 (en) | 2001-07-24 |
| ES2221191T3 (es) | 2004-12-16 |
| PL338983A1 (en) | 2000-12-04 |
| KR20010023686A (ko) | 2001-03-26 |
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