PT1009743E - Certos antagonistas da endotelina a base de dioxido de benzotiazina e processos para a sua preparacao - Google Patents

Certos antagonistas da endotelina a base de dioxido de benzotiazina e processos para a sua preparacao

Info

Publication number
PT1009743E
PT1009743E PT98942061T PT98942061T PT1009743E PT 1009743 E PT1009743 E PT 1009743E PT 98942061 T PT98942061 T PT 98942061T PT 98942061 T PT98942061 T PT 98942061T PT 1009743 E PT1009743 E PT 1009743E
Authority
PT
Portugal
Prior art keywords
benzotiazine
dioxide
processes
preparation
certain
Prior art date
Application number
PT98942061T
Other languages
English (en)
Inventor
Joseph Thomas Repine
Jeremy John Edmunds
Xue-Min Cheng
Chitase Lee
Annette Marian Doherty
Amy Mae Bunker
Richard Skeean
Gerald David Kanter
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PT1009743E publication Critical patent/PT1009743E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D279/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/021,2-Thiazines; Hydrogenated 1,2-thiazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT98942061T 1997-09-05 1998-08-13 Certos antagonistas da endotelina a base de dioxido de benzotiazina e processos para a sua preparacao PT1009743E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5811197P 1997-09-05 1997-09-05
US9232698P 1998-07-09 1998-07-09

Publications (1)

Publication Number Publication Date
PT1009743E true PT1009743E (pt) 2004-09-30

Family

ID=26737251

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98942061T PT1009743E (pt) 1997-09-05 1998-08-13 Certos antagonistas da endotelina a base de dioxido de benzotiazina e processos para a sua preparacao

Country Status (24)

Country Link
US (5) US6265399B1 (pt)
EP (1) EP1009743B1 (pt)
JP (1) JP2001515893A (pt)
KR (1) KR20010023686A (pt)
AR (1) AR017056A1 (pt)
AT (1) ATE270281T1 (pt)
AU (1) AU759169B2 (pt)
BR (1) BR9812431A (pt)
CA (1) CA2296358A1 (pt)
CO (1) CO4970725A1 (pt)
DE (1) DE69824863T2 (pt)
ES (1) ES2221191T3 (pt)
HU (1) HUP0003689A3 (pt)
IL (1) IL134057A0 (pt)
IS (1) IS5356A (pt)
MY (1) MY116277A (pt)
NO (1) NO20001078D0 (pt)
NZ (1) NZ502670A (pt)
PE (1) PE116699A1 (pt)
PL (1) PL338983A1 (pt)
PT (1) PT1009743E (pt)
TW (1) TW508355B (pt)
UY (1) UY25168A1 (pt)
WO (1) WO1999012916A1 (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU759169B2 (en) 1997-09-05 2003-04-10 Warner-Lambert Company Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
WO2001083431A1 (fr) * 2000-04-28 2001-11-08 Shionogi & Co., Ltd. Inhibiteurs de mmp-12
MXPA02010764A (es) * 2000-05-31 2003-03-10 Warner Lambert Co Combinaciones de un antagonista del receptor endotelina y un compuesto antiepileptico que tiene propiedades para aliviar el dolor o analgesico.
US20020115661A1 (en) * 2000-12-07 2002-08-22 Keller Laurence Harvey Method for treating chronic obstructive pulmonary disease
WO2005051298A2 (en) 2003-11-19 2005-06-09 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
FR2874011B1 (fr) 2004-08-03 2007-06-15 Sanofi Synthelabo Derives de sulfonamides, leur preparation et leur application en therapeutique
DE102008026894A1 (de) * 2008-06-05 2009-12-10 Evonik Degussa Gmbh Ink Jet Tinte
CA2969756A1 (en) * 2014-12-05 2016-06-09 Aquinnah Pharmaceuticals, Inc. Sulfonamide derivatives, compositions and methods of use in the treatment of neurodegenerative diseases
CN108727176B (zh) * 2018-07-26 2021-05-18 荆楚理工学院 一种制备5-卤-2,3-二羟基苯甲醛的方法
CN113214299A (zh) * 2021-03-01 2021-08-06 重庆西南制药二厂有限责任公司 γ-联苯双酯中间体及合成方法及γ-联苯双酯合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960856A (en) * 1975-06-20 1976-06-01 Warner-Lambert Company Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide
IN159273B (pt) * 1981-10-05 1987-04-25 Pfizer
JPH0495057A (ja) * 1990-08-08 1992-03-27 Taisho Pharmaceut Co Ltd N―置換スルホンアニリド化合物
US5389620A (en) 1993-08-18 1995-02-14 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
EP0714897B1 (en) * 1993-08-18 2001-02-14 Banyu Pharmaceutical Co., Ltd. Fused heteroaromatic cyclopentene derivative having endothelin-antagonist activity
JPH0912562A (ja) 1995-06-22 1997-01-14 Suntory Ltd 置換ベンゾチアジン誘導体
CA2156849A1 (en) 1993-12-24 1995-07-06 Akira Mizuno Benzothiazine derivative
US5482960A (en) 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
US5599811A (en) * 1995-02-21 1997-02-04 Warner-Lambert Company Benzothiazine dioxides as endothelin antagonists
CA2190708A1 (en) 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
AU759169B2 (en) 1997-09-05 2003-04-10 Warner-Lambert Company Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

Also Published As

Publication number Publication date
CA2296358A1 (en) 1999-03-18
US6440962B2 (en) 2002-08-27
US20020094980A1 (en) 2002-07-18
DE69824863T2 (de) 2005-06-30
CO4970725A1 (es) 2000-11-07
HUP0003689A3 (en) 2003-05-28
MY116277A (en) 2003-12-31
EP1009743B1 (en) 2004-06-30
US6252070B1 (en) 2001-06-26
US20030073684A1 (en) 2003-04-17
AR017056A1 (es) 2001-08-22
ES2221191T3 (es) 2004-12-16
UY25168A1 (es) 1999-05-14
NZ502670A (en) 2003-01-31
IS5356A (is) 2000-01-21
AU759169B2 (en) 2003-04-10
PL338983A1 (en) 2000-12-04
JP2001515893A (ja) 2001-09-25
US20010036944A1 (en) 2001-11-01
DE69824863D1 (de) 2004-08-05
WO1999012916A1 (en) 1999-03-18
US6545150B2 (en) 2003-04-08
BR9812431A (pt) 2000-09-19
IL134057A0 (en) 2001-04-30
EP1009743A1 (en) 2000-06-21
HUP0003689A2 (hu) 2001-09-28
KR20010023686A (ko) 2001-03-26
US6265399B1 (en) 2001-07-24
NO20001078L (no) 2000-03-02
PE116699A1 (es) 1999-12-19
ATE270281T1 (de) 2004-07-15
AU9019698A (en) 1999-03-29
TW508355B (en) 2002-11-01
NO20001078D0 (no) 2000-03-02

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