KR20010023686A - 특정 벤조티아진 다이옥사이드 엔도텔린 길항제 및 이의제조 방법 - Google Patents

특정 벤조티아진 다이옥사이드 엔도텔린 길항제 및 이의제조 방법 Download PDF

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Publication number
KR20010023686A
KR20010023686A KR1020007002339A KR20007002339A KR20010023686A KR 20010023686 A KR20010023686 A KR 20010023686A KR 1020007002339 A KR1020007002339 A KR 1020007002339A KR 20007002339 A KR20007002339 A KR 20007002339A KR 20010023686 A KR20010023686 A KR 20010023686A
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South Korea
Prior art keywords
benzo
phenyl
dioxo
dihydro
formula
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KR1020007002339A
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English (en)
Korean (ko)
Inventor
에이미 메이 벙커
슈-민 쳉
아네트 마리안 도어티
치타세 리
조셉 토마스 레핀
리차드 스키안
제레미 존 에드먼드
제랄드 데이비드 캔터
Original Assignee
로즈 암스트롱, 크리스틴 에이. 트러트웨인
워너-램버트 캄파니
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Application filed by 로즈 암스트롱, 크리스틴 에이. 트러트웨인, 워너-램버트 캄파니 filed Critical 로즈 암스트롱, 크리스틴 에이. 트러트웨인
Publication of KR20010023686A publication Critical patent/KR20010023686A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020007002339A 1997-09-05 1998-08-13 특정 벤조티아진 다이옥사이드 엔도텔린 길항제 및 이의제조 방법 Withdrawn KR20010023686A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5811197P 1997-09-05 1997-09-05
US60/058,111 1997-09-05
US9232698P 1998-07-09 1998-07-09
US60/092,326 1998-07-09
PCT/US1998/016856 WO1999012916A1 (en) 1997-09-05 1998-08-13 Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

Publications (1)

Publication Number Publication Date
KR20010023686A true KR20010023686A (ko) 2001-03-26

Family

ID=26737251

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007002339A Withdrawn KR20010023686A (ko) 1997-09-05 1998-08-13 특정 벤조티아진 다이옥사이드 엔도텔린 길항제 및 이의제조 방법

Country Status (24)

Country Link
US (5) US6265399B1 (https=)
EP (1) EP1009743B1 (https=)
JP (1) JP2001515893A (https=)
KR (1) KR20010023686A (https=)
AR (1) AR017056A1 (https=)
AT (1) ATE270281T1 (https=)
AU (1) AU759169B2 (https=)
BR (1) BR9812431A (https=)
CA (1) CA2296358A1 (https=)
CO (1) CO4970725A1 (https=)
DE (1) DE69824863T2 (https=)
ES (1) ES2221191T3 (https=)
HU (1) HUP0003689A3 (https=)
IL (1) IL134057A0 (https=)
IS (1) IS5356A (https=)
MY (1) MY116277A (https=)
NO (1) NO20001078L (https=)
NZ (1) NZ502670A (https=)
PE (1) PE116699A1 (https=)
PL (1) PL338983A1 (https=)
PT (1) PT1009743E (https=)
TW (1) TW508355B (https=)
UY (1) UY25168A1 (https=)
WO (1) WO1999012916A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU759169B2 (en) 1997-09-05 2003-04-10 Warner-Lambert Company Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
EP1288199A4 (en) 2000-04-28 2005-10-12 Shionogi & Co INHIBITORS OF MMP-12
WO2001091736A2 (en) * 2000-05-31 2001-12-06 Warner-Lambert Company Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
US20020115661A1 (en) * 2000-12-07 2002-08-22 Keller Laurence Harvey Method for treating chronic obstructive pulmonary disease
CN1882327A (zh) 2003-11-19 2006-12-20 症变治疗公司 含磷的新的拟甲状腺素药
FR2874011B1 (fr) * 2004-08-03 2007-06-15 Sanofi Synthelabo Derives de sulfonamides, leur preparation et leur application en therapeutique
DE102008026894A1 (de) * 2008-06-05 2009-12-10 Evonik Degussa Gmbh Ink Jet Tinte
CA2969756A1 (en) * 2014-12-05 2016-06-09 Aquinnah Pharmaceuticals, Inc. Sulfonamide derivatives, compositions and methods of use in the treatment of neurodegenerative diseases
CN108727176B (zh) * 2018-07-26 2021-05-18 荆楚理工学院 一种制备5-卤-2,3-二羟基苯甲醛的方法
CN113214299A (zh) * 2021-03-01 2021-08-06 重庆西南制药二厂有限责任公司 γ-联苯双酯中间体及合成方法及γ-联苯双酯合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960856A (en) * 1975-06-20 1976-06-01 Warner-Lambert Company Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide
IN159273B (https=) * 1981-10-05 1987-04-25 Pfizer
JPH0495057A (ja) * 1990-08-08 1992-03-27 Taisho Pharmaceut Co Ltd Ｎ―置換スルホンアニリド化合物
AU675870B2 (en) * 1993-08-18 1997-02-20 Msd K.K. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
US5389620A (en) 1993-08-18 1995-02-14 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
CA2156849A1 (en) 1993-12-24 1995-07-06 Akira Mizuno Benzothiazine derivative
JPH0912562A (ja) 1995-06-22 1997-01-14 Suntory Ltd 置換ベンゾチアジン誘導体
US5482960A (en) 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
US5599811A (en) * 1995-02-21 1997-02-04 Warner-Lambert Company Benzothiazine dioxides as endothelin antagonists
CA2190708A1 (en) 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
AU759169B2 (en) 1997-09-05 2003-04-10 Warner-Lambert Company Certain benzothiazine dioxide endothelin antagonists and processes for their preparation

Also Published As

Publication number Publication date
AR017056A1 (es) 2001-08-22
PE116699A1 (es) 1999-12-19
HUP0003689A2 (hu) 2001-09-28
US20030073684A1 (en) 2003-04-17
DE69824863T2 (de) 2005-06-30
BR9812431A (pt) 2000-09-19
JP2001515893A (ja) 2001-09-25
NO20001078D0 (no) 2000-03-02
US6440962B2 (en) 2002-08-27
US6265399B1 (en) 2001-07-24
UY25168A1 (es) 1999-05-14
MY116277A (en) 2003-12-31
US6252070B1 (en) 2001-06-26
ES2221191T3 (es) 2004-12-16
PL338983A1 (en) 2000-12-04
AU759169B2 (en) 2003-04-10
HUP0003689A3 (en) 2003-05-28
WO1999012916A1 (en) 1999-03-18
IS5356A (is) 2000-01-21
EP1009743A1 (en) 2000-06-21
IL134057A0 (en) 2001-04-30
US20020094980A1 (en) 2002-07-18
EP1009743B1 (en) 2004-06-30
DE69824863D1 (de) 2004-08-05
US6545150B2 (en) 2003-04-08
CA2296358A1 (en) 1999-03-18
NO20001078L (no) 2000-03-02
AU9019698A (en) 1999-03-29
US20010036944A1 (en) 2001-11-01
PT1009743E (pt) 2004-09-30
TW508355B (en) 2002-11-01
CO4970725A1 (es) 2000-11-07
NZ502670A (en) 2003-01-31
ATE270281T1 (de) 2004-07-15

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PA0105 International application

Patent event date: 20000304

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid