DE69723429T3 - Verfahren zur verbesserten funktionellen Erholung der motorischen Koordination, der Sprache oder Sinneswahrnehmung nach Trauma oder Ischämie des ZNS - Google Patents
Verfahren zur verbesserten funktionellen Erholung der motorischen Koordination, der Sprache oder Sinneswahrnehmung nach Trauma oder Ischämie des ZNS Download PDFInfo
- Publication number
- DE69723429T3 DE69723429T3 DE69723429T DE69723429T DE69723429T3 DE 69723429 T3 DE69723429 T3 DE 69723429T3 DE 69723429 T DE69723429 T DE 69723429T DE 69723429 T DE69723429 T DE 69723429T DE 69723429 T3 DE69723429 T3 DE 69723429T3
- Authority
- DE
- Germany
- Prior art keywords
- bmp
- res
- xaa
- morphogen
- gdf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Control Of Electric Motors In General (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- Protection Of Generators And Motors (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62044496A | 1996-03-22 | 1996-03-22 | |
| US620444 | 1996-03-22 | ||
| PCT/US1997/004177 WO1997034626A1 (en) | 1996-03-22 | 1997-03-21 | Methods for enhancing functional recovery following central nervous system ischemia or trauma |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE69723429D1 DE69723429D1 (de) | 2003-08-14 |
| DE69723429T2 DE69723429T2 (de) | 2004-04-22 |
| DE69723429T3 true DE69723429T3 (de) | 2007-09-20 |
Family
ID=24485972
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69723429T Expired - Lifetime DE69723429T3 (de) | 1996-03-22 | 1997-03-21 | Verfahren zur verbesserten funktionellen Erholung der motorischen Koordination, der Sprache oder Sinneswahrnehmung nach Trauma oder Ischämie des ZNS |
| DE69740089T Expired - Lifetime DE69740089D1 (de) | 1996-03-22 | 1997-03-21 | Verfahren zur verbesserten funktionellen Erholung der motorischen Koordiination, der Sprache oder der Sinneswahrnehmung nach Trauma oder Ischämie des ZNS |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69740089T Expired - Lifetime DE69740089D1 (de) | 1996-03-22 | 1997-03-21 | Verfahren zur verbesserten funktionellen Erholung der motorischen Koordiination, der Sprache oder der Sinneswahrnehmung nach Trauma oder Ischämie des ZNS |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US6214796B1 (enExample) |
| EP (3) | EP0894004B2 (enExample) |
| JP (2) | JP4847634B2 (enExample) |
| KR (1) | KR20000064752A (enExample) |
| CN (1) | CN1181885C (enExample) |
| AT (2) | ATE493141T1 (enExample) |
| AU (2) | AU725341B2 (enExample) |
| CA (2) | CA2249368A1 (enExample) |
| DE (2) | DE69723429T3 (enExample) |
| ES (1) | ES2201287T5 (enExample) |
| WO (2) | WO1997034626A1 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
| DK0698094T3 (da) | 1993-05-12 | 2004-05-03 | Inst Genetics Llc | BMP-11-sammensætninger |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| DE69434651T2 (de) | 1993-12-07 | 2007-03-08 | Genetics Institute, Inc., Cambridge | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| US6498142B1 (en) * | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
| AU5244998A (en) * | 1996-11-15 | 1998-06-03 | Creative Biomolecules, Inc. | Morphogen-induced regeneration of sense perceptory tissues |
| WO1998050060A1 (en) * | 1997-05-05 | 1998-11-12 | Creative Biomolecules, Inc. | Therapies for acute renal failure |
| CA2291514C (en) * | 1997-05-30 | 2011-07-12 | Mariel Therapeutics, Inc. | Methods for evaluating tissue morphogenesis and activity |
| EP1037910A2 (en) * | 1997-12-04 | 2000-09-27 | Curis, Inc. | Maintenance of smooth muscle integrity by morphogenic proteins |
| US20030170213A1 (en) * | 1998-01-23 | 2003-09-11 | Marc F. Charette | Methods and compositions for enhancing cognitive function using morphogenic proteins |
| US7147839B2 (en) | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
| DE19837230A1 (de) * | 1998-08-17 | 2000-03-09 | Jean Krutmann | Neurotrophin-4 zur Behandlung von Tumoren neuroektodermalen Ursprungs |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| US6749850B1 (en) | 1999-08-18 | 2004-06-15 | The General Hospital Corporation | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
| IL148175A0 (en) * | 1999-08-18 | 2002-09-12 | Gen Hospital Corp | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
| ATE271886T1 (de) | 1999-10-15 | 2004-08-15 | Inst Genetics Llc | Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine |
| US7060676B2 (en) * | 1999-12-20 | 2006-06-13 | Trustees Of Tufts College | T. cruzi-derived neurotrophic agents and methods of use therefor |
| US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US6855690B2 (en) | 2000-06-01 | 2005-02-15 | Children's Medical Center Corporation | Methods and compositions for treating ocular disorders |
| AU2001268147B2 (en) * | 2000-06-01 | 2006-05-04 | Children's Medical Center Corporation | Methods and compositions for producing a neurosalutary effect in a subject |
| TWI329129B (en) | 2001-02-08 | 2010-08-21 | Wyeth Corp | Modified and stabilized gdf propeptides and uses thereof |
| US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
| WO2002099037A2 (en) | 2001-06-01 | 2002-12-12 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| KR20040048379A (ko) * | 2001-06-01 | 2004-06-09 | 싸이트 테라피스 인코포레이티드 | T 세포 유도된 조직 복구 및 재생 |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| US20060259014A1 (en) | 2002-05-22 | 2006-11-16 | Surgimark, Inc. | Aspirator sleeve and suction handle |
| BR0316560A (pt) | 2002-11-26 | 2005-10-04 | Nobex Corp | Conjugado de composto natriurético, formulação farmacêutica, método de tratar uma condição, método de preparação do conjugado de composto natriurético, conjugado de peptìdeo pró-polinatriurético modificado, análogo de peptìdeo natriurético, análogo de hbnp, composto, e, método de preparar um composto |
| US20040229292A1 (en) * | 2002-11-26 | 2004-11-18 | Sebastiano Cavallaro | Use of FGF-18 in the diagnosis and treatment of memory disorders |
| DE60334250D1 (de) | 2003-05-08 | 2010-10-28 | Life Technologies Corp | Erzeugung und isolierung antigenspezifischer t-zellen |
| CA2897218A1 (en) | 2004-06-17 | 2006-01-26 | Thrasos Innovation, Inc. | Tdf-related compounds and analogs thereof |
| DK1766077T3 (da) | 2004-06-21 | 2012-07-16 | Univ Leland Stanford Junior | Differentielt udtrykte gener og veje i bipolar forstyrrelse og/eller alvorlig depressiv forstyrrelse |
| WO2006012365A2 (en) * | 2004-07-20 | 2006-02-02 | University Of Maryland | Protease inhibitor |
| EP1782821A4 (en) * | 2004-07-29 | 2009-11-11 | Anges Mg Inc | MEDICAMENT AND METHOD FOR IMPROVING BRAIN FUNCTION |
| US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
| GB0425625D0 (en) * | 2004-11-22 | 2004-12-22 | Royal College Of Surgeons Ie | Treatment of disease |
| PT2497780E (pt) | 2005-09-20 | 2015-08-20 | Thrasos Innovation Inc | Compostos relacionados com tdf e seus análogos |
| EP1951908B1 (en) | 2005-11-12 | 2013-08-07 | The Board of Trustees of The Leland Stanford Junior University | Fgf2-related methods for diagnosing and treating depression |
| AU2007234612B2 (en) * | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| SI2121142T1 (sl) * | 2007-01-25 | 2012-12-31 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Uporaba GDF-5 za izboljšanje ali vzdrževanje videza kože |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| WO2009020744A1 (en) | 2007-08-07 | 2009-02-12 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations comprising gdf-5 in aqueous acidic solution |
| BRPI0911048A2 (pt) * | 2008-04-14 | 2015-12-29 | Atrm Llc | formulações líquidas tamponadas de gdf-5 |
| US20100204124A1 (en) * | 2009-02-12 | 2010-08-12 | Mary Elizabeth Pecquet Goad | Compositions and Methods for Minimally-Invasive Systemic Delivery of Proteins Including TGF-Beta Superfamily Members |
| WO2010093925A2 (en) * | 2009-02-12 | 2010-08-19 | Stryker Corporation | PERIPHERAL ADMINISTRATION OF PROTEINS INCLUDING TGF-β SUPERFAMILY MEMBERS FOR TREATMENT OF SYSTEMIC DISORDERS AND DISEASE |
| AU2010223268B2 (en) | 2009-03-12 | 2015-04-23 | Haase Investments Gmbh | Bone morphogenetic protein 2 (BMP2 ) variants with reduced BMP antagonist sensitivity |
| WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
| US20110224410A1 (en) | 2009-09-17 | 2011-09-15 | Hile David | Buffers for Controlling the pH of Bone Morphogenetic Proteins |
| CA2785038A1 (en) | 2009-12-22 | 2011-07-21 | Stryker Corporation | Bmp-7 variants with reduced immunogenicity |
| CN101822815A (zh) * | 2010-04-29 | 2010-09-08 | 广东八加一医药有限公司 | 系列多肽小分子在制备防治缺血性脑血管疾病药物中的应用 |
| US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| WO2012023113A2 (en) | 2010-08-20 | 2012-02-23 | Wyeth Llc | Designer osteogenic proteins |
| US9700596B2 (en) | 2011-03-04 | 2017-07-11 | The Regents Of The University Of California | Locally released growth factors to mediate motor recovery after stroke |
| KR101274930B1 (ko) * | 2011-06-03 | 2013-06-17 | 전남대학교산학협력단 | 골 형성 또는 혈관신생 촉진용 펩타이드 bfp 4 및 이의 용도 |
| US20140057831A1 (en) * | 2011-07-19 | 2014-02-27 | Thrasos Innovation, Inc. | Anti-fibrotic peptides and their use in methods for treating diseases and disorders characterized by fibrosis |
| EP2784083A1 (en) | 2013-03-28 | 2014-10-01 | Charité - Universitätsmedizin Berlin | Bone Morphogenetic Protein (BMP) variants with highly reduced antagonist sensitivity and enhanced specific biological activity |
| HUE052232T2 (hu) | 2013-05-06 | 2021-04-28 | Scholar Rock Inc | Készítmények és eljárások növekedési faktor modulálására |
| EP3007719B1 (en) * | 2013-06-11 | 2021-03-17 | President and Fellows of Harvard College | Methods and compositions for increasing neurogenesis and angiogenesis |
| WO2016131052A1 (en) | 2015-02-13 | 2016-08-18 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| IL308824A (en) | 2016-08-17 | 2024-01-01 | Factor Bioscience Inc | Nucleic acid products and methods of administration thereof |
| JP2021529835A (ja) * | 2018-07-03 | 2021-11-04 | ベンチュリス セラピューティクス, インク.Venturis Therapeutics, Inc. | 脳卒中を治療するための組成物及び方法 |
| WO2021165465A1 (en) * | 2020-02-20 | 2021-08-26 | Universiteit Maastricht | Detection method of circulating bmp10 (bone morphogenetic protein 10) |
| US20230263860A1 (en) * | 2020-05-19 | 2023-08-24 | Elevian, Inc. | Methods And Compositions For Treating Stroke |
| WO2024259004A1 (en) * | 2023-06-13 | 2024-12-19 | Bedford Research Foundation | Systems and methods of cell transport at ambient temperature |
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-
1997
- 1997-03-21 DE DE69723429T patent/DE69723429T3/de not_active Expired - Lifetime
- 1997-03-21 WO PCT/US1997/004177 patent/WO1997034626A1/en not_active Ceased
- 1997-03-21 JP JP53358397A patent/JP4847634B2/ja not_active Expired - Fee Related
- 1997-03-21 JP JP9533791A patent/JP2000507939A/ja not_active Withdrawn
- 1997-03-21 AU AU25823/97A patent/AU725341B2/en not_active Ceased
- 1997-03-21 EP EP97917532A patent/EP0894004B2/en not_active Expired - Lifetime
- 1997-03-21 EP EP97917091A patent/EP0904093A4/en not_active Withdrawn
- 1997-03-21 AT AT03010945T patent/ATE493141T1/de not_active IP Right Cessation
- 1997-03-21 KR KR1019980707507A patent/KR20000064752A/ko not_active Ceased
- 1997-03-21 EP EP03010945A patent/EP1364655B1/en not_active Expired - Lifetime
- 1997-03-21 US US08/822,455 patent/US6214796B1/en not_active Expired - Fee Related
- 1997-03-21 AU AU25529/97A patent/AU734312B2/en not_active Ceased
- 1997-03-21 DE DE69740089T patent/DE69740089D1/de not_active Expired - Lifetime
- 1997-03-21 US US08/828,281 patent/US6407060B1/en not_active Expired - Lifetime
- 1997-03-21 CA CA002249368A patent/CA2249368A1/en not_active Abandoned
- 1997-03-21 AT AT97917532T patent/ATE244574T1/de not_active IP Right Cessation
- 1997-03-21 CA CA2249596A patent/CA2249596C/en not_active Expired - Fee Related
- 1997-03-21 CN CNB97194749XA patent/CN1181885C/zh not_active Expired - Fee Related
- 1997-03-21 ES ES97917532T patent/ES2201287T5/es not_active Expired - Lifetime
- 1997-03-21 WO PCT/US1997/005071 patent/WO1997034618A1/en not_active Ceased
-
2001
- 2001-04-10 US US09/833,096 patent/US20010039261A1/en not_active Abandoned
-
2002
- 2002-02-01 US US10/062,370 patent/US20030022830A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1219133A (zh) | 1999-06-09 |
| CA2249596A1 (en) | 1997-09-25 |
| ATE244574T1 (de) | 2003-07-15 |
| AU2582397A (en) | 1997-10-10 |
| AU725341B2 (en) | 2000-10-12 |
| WO1997034626A1 (en) | 1997-09-25 |
| CN1181885C (zh) | 2004-12-29 |
| ES2201287T5 (es) | 2007-10-16 |
| WO1997034618A1 (en) | 1997-09-25 |
| US6214796B1 (en) | 2001-04-10 |
| CA2249368A1 (en) | 1997-09-25 |
| EP1364655B1 (en) | 2010-12-29 |
| KR20000064752A (ko) | 2000-11-06 |
| ATE493141T1 (de) | 2011-01-15 |
| DE69723429D1 (de) | 2003-08-14 |
| EP1364655A1 (en) | 2003-11-26 |
| CA2249596C (en) | 2011-11-08 |
| EP0904093A4 (en) | 2004-11-17 |
| US20010039261A1 (en) | 2001-11-08 |
| EP0894004B2 (en) | 2007-02-21 |
| EP0894004A1 (en) | 1999-02-03 |
| JP2000506894A (ja) | 2000-06-06 |
| DE69740089D1 (de) | 2011-02-10 |
| ES2201287T3 (es) | 2004-03-16 |
| DE69723429T2 (de) | 2004-04-22 |
| US6407060B1 (en) | 2002-06-18 |
| US20030022830A1 (en) | 2003-01-30 |
| AU734312B2 (en) | 2001-06-07 |
| AU2552997A (en) | 1997-10-10 |
| JP4847634B2 (ja) | 2011-12-28 |
| EP0894004B1 (en) | 2003-07-09 |
| EP0904093A1 (en) | 1999-03-31 |
| JP2000507939A (ja) | 2000-06-27 |
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| 8363 | Opposition against the patent | ||
| 8366 | Restricted maintained after opposition proceedings | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: STRYKER CORP., KALAMAZOO, MICH., US Owner name: THE GENERAL HOSPITAL CORP., BOSTON, MASS., US |