KR20000064752A - 중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법 - Google Patents
중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법 Download PDFInfo
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Control Of Electric Motors In General (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Protection Of Generators And Motors (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
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| PCT/US1997/005071 WO1997034618A1 (en) | 1996-03-22 | 1997-03-21 | Administration of polypeptide growth factors following central nervous system ischemia or trauma |
Publications (1)
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| KR20000064752A true KR20000064752A (ko) | 2000-11-06 |
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| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
| DE69433530T2 (de) | 1993-05-12 | 2005-01-05 | Genetics Institute, LLC, Cambridge | Bmp-11 zusammensetzungen |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| PT733109E (pt) | 1993-12-07 | 2006-07-31 | Genetics Inst Llc | Proteinas morfogeneticas dos 0ss0s pmo-12 e pmo-13 e as suas composicoes para inducao de tendao |
| US6498142B1 (en) * | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
| WO1998020889A1 (en) * | 1996-11-15 | 1998-05-22 | Creative Biomolecules Inc | Morphogen peptide-induced regeneration of sense perceptory tissues |
| EP0980252B1 (en) | 1997-05-05 | 2004-10-06 | Curis, Inc. | Therapies for acute renal failure |
| EP0985149A1 (en) * | 1997-05-30 | 2000-03-15 | Creative Biomolecules, Inc. | Methods for evaluating tissue morphogenesis and activity |
| WO1999028341A2 (en) * | 1997-12-04 | 1999-06-10 | Creative Biomolecules, Inc. | Maintenance of smooth muscle integrity by morphogenic proteins |
| US20030170213A1 (en) * | 1998-01-23 | 2003-09-11 | Marc F. Charette | Methods and compositions for enhancing cognitive function using morphogenic proteins |
| US7147839B2 (en) | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
| DE19837230A1 (de) * | 1998-08-17 | 2000-03-09 | Jean Krutmann | Neurotrophin-4 zur Behandlung von Tumoren neuroektodermalen Ursprungs |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| US6749850B1 (en) | 1999-08-18 | 2004-06-15 | The General Hospital Corporation | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
| AU6790300A (en) * | 1999-08-18 | 2001-03-13 | Children's Medical Center Corporation | Methods, compositions and kits for promoting recovery from damage to the central nervous system |
| AU774427B2 (en) | 1999-10-15 | 2004-06-24 | Fidia Advanced Biopolymers S.R.L. | Formulations of hyaluronic acid for delivery of osteogenic proteins |
| US7060676B2 (en) * | 1999-12-20 | 2006-06-13 | Trustees Of Tufts College | T. cruzi-derived neurotrophic agents and methods of use therefor |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| US7541184B2 (en) | 2000-02-24 | 2009-06-02 | Invitrogen Corporation | Activation and expansion of cells |
| CA2411666A1 (en) | 2000-06-01 | 2001-12-06 | Children's Medical Center Corporation | Methods and compositions for producing a neurosalutary effect in a subject |
| US6855690B2 (en) | 2000-06-01 | 2005-02-15 | Children's Medical Center Corporation | Methods and compositions for treating ocular disorders |
| TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
| US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
| CA2449008A1 (en) | 2001-06-01 | 2002-12-12 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| JP2004528042A (ja) * | 2001-06-01 | 2004-09-16 | エクサイト セラピーズ， インコーポレイテッド | Ｔ細胞誘導性組織修復および再生 |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| US20060259014A1 (en) | 2002-05-22 | 2006-11-16 | Surgimark, Inc. | Aspirator sleeve and suction handle |
| BR0316560A (pt) | 2002-11-26 | 2005-10-04 | Nobex Corp | Conjugado de composto natriurético, formulação farmacêutica, método de tratar uma condição, método de preparação do conjugado de composto natriurético, conjugado de peptìdeo pró-polinatriurético modificado, análogo de peptìdeo natriurético, análogo de hbnp, composto, e, método de preparar um composto |
| US20040229292A1 (en) * | 2002-11-26 | 2004-11-18 | Sebastiano Cavallaro | Use of FGF-18 in the diagnosis and treatment of memory disorders |
| EP1623017B1 (en) | 2003-05-08 | 2010-09-15 | Life Technologies Corporation | Generation and isolation of antigen-specific t cells |
| EP2789342A1 (en) | 2004-06-17 | 2014-10-15 | Thrasos Innovation, Inc. | TDF-related compounds and analogs thereof |
| DK2453024T3 (en) | 2004-06-21 | 2018-02-12 | Univ Leland Stanford Junior | Genes and conduits that are differentially expressed in bipolar disorder and / or major depressive disorder |
| WO2006012365A2 (en) * | 2004-07-20 | 2006-02-02 | University Of Maryland | Protease inhibitor |
| EP1782821A4 (en) * | 2004-07-29 | 2009-11-11 | Anges Mg Inc | MEDICAMENT AND METHOD FOR IMPROVING BRAIN FUNCTION |
| US8697139B2 (en) | 2004-09-21 | 2014-04-15 | Frank M. Phillips | Method of intervertebral disc treatment using articular chondrocyte cells |
| GB0425625D0 (en) * | 2004-11-22 | 2004-12-22 | Royal College Of Surgeons Ie | Treatment of disease |
| US8299212B2 (en) | 2005-09-20 | 2012-10-30 | Thrasos Therapeutics, Inc. | TDF-related compounds and analogs thereof, analogs and bioactive fragments |
| AU2006315562C1 (en) | 2005-11-12 | 2013-10-03 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating depression using NCAM peptide mimetics |
| AU2007234612B2 (en) * | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| HRP20120698T1 (hr) * | 2007-01-25 | 2013-09-30 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Uporaba dgf-5 za poboljšanje ili održavanje izgleda kože |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| CN101801405A (zh) | 2007-08-07 | 2010-08-11 | 先进科技及再生医学有限责任公司 | 包含于酸性水溶液中的gdf-5的蛋白质配方 |
| WO2009129101A1 (en) * | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
| EP2396026A2 (en) * | 2009-02-12 | 2011-12-21 | Stryker Corporation | Compositions and methods for minimally-invasive systemic delivery of proteins including tgf- superfamily members |
| CN102369016A (zh) * | 2009-02-12 | 2012-03-07 | 史赛克公司 | 用于治疗系统性病症和疾病的包含TGF-β超家族成员的蛋白质的外周施用 |
| EP2406281B1 (en) | 2009-03-12 | 2016-02-17 | Haase Investments UG | Bone morphogenetic protein 2 (bmp2) variants with reduced bmp antagonist sensitivity |
| WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
| CA2774024A1 (en) | 2009-09-17 | 2011-03-24 | Stryker Corporation | Buffers for controlling the ph of bone morphogenetic proteins |
| JP2013514811A (ja) | 2009-12-22 | 2013-05-02 | ストライカー コーポレイション | 免疫原性が抑制されたｂｍｐ−７変異体 |
| CN101822815A (zh) * | 2010-04-29 | 2010-09-08 | 广东八加一医药有限公司 | 系列多肽小分子在制备防治缺血性脑血管疾病药物中的应用 |
| US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| CA2807343C (en) | 2010-08-20 | 2018-05-22 | Wyeth Llc | Designer osteogenic proteins |
| AU2012225784B2 (en) * | 2011-03-04 | 2016-03-17 | The Regents Of The University Of California | Locally released growth factors to mediate motor recovery after stroke |
| KR101274930B1 (ko) * | 2011-06-03 | 2013-06-17 | 전남대학교산학협력단 | 골 형성 또는 혈관신생 촉진용 펩타이드 ｂｆｐ 4 및 이의 용도 |
| WO2013013085A2 (en) * | 2011-07-19 | 2013-01-24 | Thrasos Innovation, Inc. | Anti-fibrotic peptides and their use in methods for treating diseases and disorders characterized by fibrosis |
| EP2784083A1 (en) | 2013-03-28 | 2014-10-01 | Charité - Universitätsmedizin Berlin | Bone Morphogenetic Protein (BMP) variants with highly reduced antagonist sensitivity and enhanced specific biological activity |
| HRP20251426T1 (hr) | 2013-05-06 | 2026-01-02 | Scholar Rock, Inc. | Sastavi i postupci za modulaciju faktora rasta |
| WO2014201143A1 (en) * | 2013-06-11 | 2014-12-18 | President And Fellows Of Harvard College | Methods and compositions for increasing neurogenesis and angiogenesis |
| CA2976376A1 (en) | 2015-02-13 | 2016-08-18 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| JP2019528284A (ja) | 2016-08-17 | 2019-10-10 | ファクター バイオサイエンス インコーポレイテッド | 核酸産物およびその投与方法 |
| JP2021529835A (ja) * | 2018-07-03 | 2021-11-04 | ベンチュリス セラピューティクス， インク．Ｖｅｎｔｕｒｉｓ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | 脳卒中を治療するための組成物及び方法 |
| EP4528281A3 (en) * | 2020-02-20 | 2025-06-18 | Universiteit Maastricht | Detection method of circulating bmp10 (bone morphogenetic protein 10) |
| EP4154001A4 (en) * | 2020-05-19 | 2024-06-05 | Elevian, Inc. | METHODS AND COMPOSITIONS FOR THE TREATMENT OF STROKE |
| WO2024259004A1 (en) * | 2023-06-13 | 2024-12-19 | Bedford Research Foundation | Systems and methods of cell transport at ambient temperature |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440860A (en) | 1980-01-18 | 1984-04-03 | The Children's Medical Center Corporation | Stimulating cell growth |
| US4378347A (en) * | 1980-06-30 | 1983-03-29 | Franco Wayne P | Composition for treating the heart for myocardial infarction |
| US4296100A (en) | 1980-06-30 | 1981-10-20 | Franco Wayne P | Method of treating the heart for myocardial infarction |
| DE3110560A1 (de) | 1981-03-18 | 1982-10-14 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | "angiotropine der leukozyten und des entzuendungsgewebes: eine neue klasse natuerlicher chemotropischer mitogene fuer das richtungswachstum von blutgefaessen und zur neovaskularisierung von geweben" |
| EP0105014B1 (en) | 1982-09-24 | 1992-05-20 | THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce | Repair of tissue in animals |
| US4971952A (en) | 1986-03-06 | 1990-11-20 | Collagen Corporation | Method of treating inflammation with cartilage inducing factor |
| US4806523A (en) | 1985-08-06 | 1989-02-21 | Collagen Corporation | Method of treating inflammation |
| US4994559A (en) | 1985-12-17 | 1991-02-19 | Synergen, Inc. | Human basic fibroblast growth factor |
| IL83003A (en) | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
| US4801575A (en) | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| CA1322714C (en) | 1986-11-14 | 1993-10-05 | Harry N. Antoniades | Wound healing and bone regeneration |
| EP0269408A3 (en) | 1986-11-26 | 1989-08-30 | Genentech, Inc. | Tgf-beta in the treatment of inflammatory disorders |
| US4797277A (en) | 1987-09-22 | 1989-01-10 | Pharmacia Ab | Method for reperfusion therapy |
| US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| US5108753A (en) | 1988-04-08 | 1992-04-28 | Creative Biomolecules | Osteogenic devices |
| JPH0262829A (ja) | 1988-05-18 | 1990-03-02 | Nippon Kayaku Co Ltd | 虚血に基づく傷害の予防及び治療剤 |
| US4983581A (en) | 1988-05-20 | 1991-01-08 | Institute Of Molecular Biology, Inc. | Wound healing composition of IGF-I and TGF-β |
| HU201095B (en) | 1988-06-14 | 1990-09-28 | Richter Gedeon Vegyeszet | New peptides inhibiting the activity of the immune system and pharmaceutical compositions comprising same, as well as process for producing these peptides and compositions |
| WO1990000619A1 (en) | 1988-07-08 | 1990-01-25 | University College London | Analysis of cell modifying substances |
| AU4056089A (en) | 1988-07-20 | 1990-02-19 | Amgen, Inc. | Method of treating inflammatory disorders by reducing phagocyte activation |
| US5057494A (en) | 1988-08-03 | 1991-10-15 | Ethicon, Inc. | Method for preventing tissue damage after an ischemic episode |
| US5106626A (en) | 1988-10-11 | 1992-04-21 | International Genetic Engineering, Inc. | Osteogenic factors |
| US5135915A (en) | 1988-10-14 | 1992-08-04 | Genentech, Inc. | Method for the treatment of grafts prior to transplantation using TGF-.beta. |
| US5011914A (en) | 1989-01-05 | 1991-04-30 | Collins Franklin D | Purified ciliary neurotrophic factor |
| US5002965A (en) | 1989-05-09 | 1991-03-26 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Use of ginkgolides to prevent reperfusion injury in organ transplantation |
| US5118791A (en) | 1989-05-25 | 1992-06-02 | Genentech, Inc. | Biologically active polypeptides based on transforming growth factor-β |
| IL97365A0 (en) | 1991-02-27 | 1992-05-25 | Yeda Res & Dev | Pharmaceutical compositions comprising a lymphokine |
| US5158934A (en) | 1989-09-01 | 1992-10-27 | Genentech, Inc. | Method of inducing bone growth using TGF-β |
| DE69032424T2 (de) | 1989-10-17 | 1999-02-04 | Stryker Corp., Kalamazoo, Mich. | Osteogene vorrichtungen |
| US5108989A (en) | 1990-04-04 | 1992-04-28 | Genentech, Inc. | Method of predisposing mammals to accelerated tissue repair |
| WO1992000382A1 (en) | 1990-06-15 | 1992-01-09 | Carnegie Institution Of Washington | Gdf-1 |
| DE69133338T2 (de) | 1990-09-26 | 2004-04-15 | Genetics Institute, LLC, Cambridge | Bmp-5-derivate |
| WO1992007073A1 (en) | 1990-10-18 | 1992-04-30 | Creative Biomolecules, Inc. | Osteogenic peptides |
| DE69132275T2 (de) | 1990-11-16 | 2001-01-25 | Celtrix Pharmaceuticals, Inc. | Beta-type ähnlicher transformierender wachstumfaktor |
| EP1142581A3 (en) | 1990-11-27 | 2002-09-11 | American National Red Cross | Tissue sealant and growth factor containing compositions that promote accelerated wound healing |
| AU651421B2 (en) | 1990-11-30 | 1994-07-21 | Celtrix Pharmaceuticals, Inc. | Use of a bone morphogenetic protein in synergistic combination with TGF-beta for bone repair |
| DE69231946T2 (de) * | 1991-03-11 | 2002-04-04 | Curis, Inc. | Protein-induzierende morphogenese |
| US5118667A (en) | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
| JPH06500574A (ja) | 1991-05-10 | 1994-01-20 | ザ ソーク インスティテュート フォア バイオロジカル スタディーズ | アクチビン／ＴＧＦ―βスーパーファミリーのレセプターのクローニングおよび組換えによる産生 |
| JPH07500315A (ja) | 1991-05-10 | 1995-01-12 | セルトリックス ファーマシューティカルズ，インコーポレイテッド | 骨成長因子の標的送達 |
| ES2094359T3 (es) | 1991-06-21 | 1997-01-16 | Genetics Inst | Formulaciones farmaceuticas de proteinas osteogenicas. |
| ATE175441T1 (de) | 1991-06-25 | 1999-01-15 | Genetics Inst | Bmp-9 zusammensetzungen |
| CA2116562C (en) * | 1991-08-30 | 1999-04-13 | Thangavel Kuberasampath | Morphogen-induced modulation of inflammatory response |
| EP0825442A3 (en) | 1991-08-30 | 2004-02-11 | Curis, Inc. | Morphogenic protein screening method |
| JP4235689B2 (ja) | 1991-08-30 | 2009-03-11 | ストライカー・コーポレーション | 骨疾患を処置するための骨形成タンパク質 |
| WO1993009229A1 (en) | 1991-11-04 | 1993-05-13 | Genetics Institute, Inc. | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
| WO1993008828A1 (en) * | 1991-11-08 | 1993-05-13 | Syntex-Synergen Neuroscience Joint Venture | Methods for the treatment of neuronal damage associated with ischemia, hypoxia or neurodegeneration |
| JP4101284B2 (ja) * | 1991-11-22 | 2008-06-18 | ジェネンテック・インコーポレーテッド | 神経損傷を改善するｔｇｆ−ｂｅｔａ |
| DE19525416A1 (de) † | 1995-07-12 | 1997-01-16 | Bioph Biotech Entw Pharm Gmbh | Verwendung von MP52 zur Behandlung und Prävention von Erkrankungen des Nervensystems |
| JP4344012B2 (ja) | 1992-07-31 | 2009-10-14 | ストライカー・コーポレーション | 組織形成因子誘導による神経の再生と修復 |
| ES2061380B1 (es) * | 1992-11-23 | 1995-07-01 | Boehringer Ingelheim Espana | Empleo del factor de crecimiento fibroblastico y sus derivados como neuroprotectores y neuromoduladores. |
| CA2169191C (en) | 1993-08-26 | 2008-01-15 | Elizabeth A. Wang | Neural regeneration using human bone morphogenetic proteins |
| WO1995006656A1 (en) | 1993-09-03 | 1995-03-09 | The Regents Of The University Of California | Neural tissue affecting factor and compositions |
| ATE355369T1 (de) | 1993-10-14 | 2006-03-15 | Harvard College | Verfahren zur induzierung und zur erhaltung neuronalen zellen |
| WO1995024474A1 (en) | 1994-03-10 | 1995-09-14 | Human Genome Sciences, Inc. | Bone morphogenic protein-10 |
| WO1998020889A1 (en) * | 1996-11-15 | 1998-05-22 | Creative Biomolecules Inc | Morphogen peptide-induced regeneration of sense perceptory tissues |
-
1997
- 1997-03-21 JP JP9533791A patent/JP2000507939A/ja not_active Withdrawn
- 1997-03-21 JP JP53358397A patent/JP4847634B2/ja not_active Expired - Fee Related
- 1997-03-21 AT AT03010945T patent/ATE493141T1/de not_active IP Right Cessation
- 1997-03-21 EP EP03010945A patent/EP1364655B1/en not_active Expired - Lifetime
- 1997-03-21 DE DE69740089T patent/DE69740089D1/de not_active Expired - Lifetime
- 1997-03-21 CA CA002249368A patent/CA2249368A1/en not_active Abandoned
- 1997-03-21 CN CNB97194749XA patent/CN1181885C/zh not_active Expired - Fee Related
- 1997-03-21 EP EP97917091A patent/EP0904093A4/en not_active Withdrawn
- 1997-03-21 WO PCT/US1997/005071 patent/WO1997034618A1/en not_active Ceased
- 1997-03-21 KR KR1019980707507A patent/KR20000064752A/ko not_active Ceased
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- 2001-04-10 US US09/833,096 patent/US20010039261A1/en not_active Abandoned
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| US6214796B1 (en) | 2001-04-10 |
| DE69723429T2 (de) | 2004-04-22 |
| DE69723429D1 (de) | 2003-08-14 |
| JP2000506894A (ja) | 2000-06-06 |
| CN1219133A (zh) | 1999-06-09 |
| DE69723429T3 (de) | 2007-09-20 |
| ATE244574T1 (de) | 2003-07-15 |
| CA2249368A1 (en) | 1997-09-25 |
| US6407060B1 (en) | 2002-06-18 |
| CN1181885C (zh) | 2004-12-29 |
| EP0904093A1 (en) | 1999-03-31 |
| WO1997034618A1 (en) | 1997-09-25 |
| ES2201287T3 (es) | 2004-03-16 |
| AU2552997A (en) | 1997-10-10 |
| AU734312B2 (en) | 2001-06-07 |
| JP4847634B2 (ja) | 2011-12-28 |
| EP1364655B1 (en) | 2010-12-29 |
| ATE493141T1 (de) | 2011-01-15 |
| DE69740089D1 (de) | 2011-02-10 |
| EP1364655A1 (en) | 2003-11-26 |
| EP0904093A4 (en) | 2004-11-17 |
| CA2249596C (en) | 2011-11-08 |
| EP0894004B2 (en) | 2007-02-21 |
| EP0894004A1 (en) | 1999-02-03 |
| JP2000507939A (ja) | 2000-06-27 |
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