DE69131580T2 - GDF-1 und UOG1 Proteine - Google Patents

GDF-1 und UOG1 Proteine

Info

Publication number
DE69131580T2
DE69131580T2 DE69131580T DE69131580T DE69131580T2 DE 69131580 T2 DE69131580 T2 DE 69131580T2 DE 69131580 T DE69131580 T DE 69131580T DE 69131580 T DE69131580 T DE 69131580T DE 69131580 T2 DE69131580 T2 DE 69131580T2
Authority
DE
Germany
Prior art keywords
gdf
protein
uog1
proteins
mammalian
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69131580T
Other languages
English (en)
Other versions
DE69131580D1 (de
Inventor
Se-Jin Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carnegie Institution of Washington
Original Assignee
Carnegie Institution of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carnegie Institution of Washington filed Critical Carnegie Institution of Washington
Application granted granted Critical
Publication of DE69131580D1 publication Critical patent/DE69131580D1/de
Publication of DE69131580T2 publication Critical patent/DE69131580T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69131580T 1990-06-15 1991-06-14 GDF-1 und UOG1 Proteine Expired - Fee Related DE69131580T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53837290A 1990-06-15 1990-06-15
US61445290A 1990-11-16 1990-11-16
PCT/US1991/004096 WO1992000382A1 (en) 1990-06-15 1991-06-14 Gdf-1

Publications (2)

Publication Number Publication Date
DE69131580D1 DE69131580D1 (de) 1999-10-07
DE69131580T2 true DE69131580T2 (de) 2000-01-13

Family

ID=27065793

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69131580T Expired - Fee Related DE69131580T2 (de) 1990-06-15 1991-06-14 GDF-1 und UOG1 Proteine

Country Status (10)

Country Link
US (2) US20040039162A1 (de)
EP (1) EP0652951B1 (de)
JP (1) JPH06500466A (de)
AT (1) ATE184052T1 (de)
AU (1) AU666291B2 (de)
CA (1) CA2085134C (de)
DE (1) DE69131580T2 (de)
ES (1) ES2137931T3 (de)
HK (1) HK1013847A1 (de)
WO (1) WO1992000382A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6949505B1 (en) 1991-03-11 2005-09-27 Curis, Inc. Morphogen-induced dendritic growth
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
CA2104678C (en) 1991-03-11 2002-05-14 Charles M. Cohen Protein-induced morphogenesis
EP0601135B1 (de) * 1991-08-30 2005-11-02 Curis, Inc. Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten
ATE242639T1 (de) * 1992-07-31 2003-06-15 Curis Inc Morphogen induzierte nerven wiederherstellung und wiedergutmachung.
US5821056A (en) 1993-01-12 1998-10-13 The Johns Hopkins University School Of Medicine Growth differentiation factor-9
CA2153654A1 (en) * 1993-01-12 1994-07-21 Se-Jin Lee Growth differentiation factor-5
EP0717633A4 (de) 1993-07-09 1998-05-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-7
EP0804214A4 (de) * 1993-07-09 1998-05-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-6
US20030167492A1 (en) 1994-07-08 2003-09-04 Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same
ATE305036T1 (de) * 1994-07-08 2005-10-15 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-11
US5831054A (en) * 1994-07-13 1998-11-03 The Johns Hopkins University School Of Medicine Polynucleotide encoding growth differentiation factor-12
ATE244574T1 (de) 1996-03-22 2003-07-15 Curis Inc Verfahren zur verbesserten funktionelle erholung der motorische koordiination, der sprache oder der sinneswahrnehmung nach trauma oder ischämie des zns
US6524802B1 (en) * 1996-03-29 2003-02-25 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-14
ATE239514T1 (de) 1997-02-07 2003-05-15 Stryker Corp Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
EP2309261A1 (de) 1997-05-30 2011-04-13 Stryker Corporation Verfahren zur Beurteilung von Gewebemorphogenese und- aktivität
WO1999058671A2 (en) * 1998-05-08 1999-11-18 Research Corporation Technologies, Inc. Human and nematode homologues of the yeast longevity assurance gene lag1
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US6872698B2 (en) * 1998-07-06 2005-03-29 Scion Pharmaceuticals, Inc. Methods for treating neurological injuries and disorders
CA2336718A1 (en) * 1998-07-06 2000-01-13 Cambridge Neuroscience, Inc. Methods for treating neurological injuries and disorders
PL1737734T3 (pl) 2004-03-10 2011-02-28 Scil Tech Gmbh Powlekane implanty, ich wytwarzanie i zastosowanie
AU2005247871A1 (en) 2004-04-27 2005-12-08 Research Development Foundation Antagonism of TGF-beta superfamily receptor signaling
AU2005247440B2 (en) 2004-05-25 2011-09-29 Stryker Corporation Use of morphogenic proteins for treating cartilage defects
JP5362554B2 (ja) 2006-05-17 2013-12-11 ストライカー コーポレイション 軟骨の欠損を処置するための可溶性形態形成タンパク質の使用
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
EP2120859B1 (de) 2006-12-21 2013-11-20 Stryker Corporation Formulierungen mit verzögerter freisetzung mit kristallen von bmp-7
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
JP5323832B2 (ja) 2007-08-07 2013-10-23 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー 酸性水溶液中にｇｄｆ−５を含むタンパク質製剤
WO2009102966A2 (en) 2008-02-13 2009-08-20 Keith Hruska Method of treating vascular sclerosis
CA2720845A1 (en) 2008-04-14 2009-10-22 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered gdf-5 formulations
EP2396025A2 (de) 2009-02-12 2011-12-21 Stryker Corporation Periphere verabreichung von proteinen einschliesslich mitglieder der tgf-beta-superfamilie zur systemischen behandlung von störungen und erkrankungen
US20120148539A1 (en) 2009-03-24 2012-06-14 Moulay Hicham Alaoui-Ismaili Methods and Compositions for Tissue Engineering
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
US20110224138A1 (en) 2009-09-09 2011-09-15 Julie Krop Methods for treating pain induced by injuries and diseases of an articular joint
US20110224410A1 (en) 2009-09-17 2011-09-15 Hile David Buffers for Controlling the pH of Bone Morphogenetic Proteins
JP2013514811A (ja) 2009-12-22 2013-05-02 ストライカー コーポレイション 免疫原性が抑制されたｂｍｐ−７変異体
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
EP2949338B1 (de) 2010-08-20 2017-10-25 Wyeth LLC Osteogene designerproteine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886747A (en) * 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses

Also Published As

Publication number Publication date
EP0652951A1 (de) 1995-05-17
US20030040611A1 (en) 2003-02-27
ATE184052T1 (de) 1999-09-15
HK1013847A1 (en) 1999-12-10
AU666291B2 (en) 1996-02-08
ES2137931T3 (es) 2000-01-01
EP0652951B1 (de) 1999-09-01
WO1992000382A1 (en) 1992-01-09
US20040039162A1 (en) 2004-02-26
EP0652951A4 (de) 1993-08-16
DE69131580D1 (de) 1999-10-07
CA2085134C (en) 2003-03-18
AU8496491A (en) 1992-01-23
JPH06500466A (ja) 1994-01-20
CA2085134A1 (en) 1991-12-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee