ATE184052T1 - Gdf-1 und uog1 proteine - Google Patents

Gdf-1 und uog1 proteine

Info

Publication number
ATE184052T1
ATE184052T1 AT91915864T AT91915864T ATE184052T1 AT E184052 T1 ATE184052 T1 AT E184052T1 AT 91915864 T AT91915864 T AT 91915864T AT 91915864 T AT91915864 T AT 91915864T AT E184052 T1 ATE184052 T1 AT E184052T1
Authority
AT
Austria
Prior art keywords
gdf
protein
uog1
proteins
mammalian
Prior art date
Application number
AT91915864T
Other languages
English (en)
Inventor
Se-Jin Lee
Original Assignee
Carnegie Inst Of Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carnegie Inst Of Washington filed Critical Carnegie Inst Of Washington
Application granted granted Critical
Publication of ATE184052T1 publication Critical patent/ATE184052T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
AT91915864T 1990-06-15 1991-06-14 Gdf-1 und uog1 proteine ATE184052T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53837290A 1990-06-15 1990-06-15
US61445290A 1990-11-16 1990-11-16

Publications (1)

Publication Number Publication Date
ATE184052T1 true ATE184052T1 (de) 1999-09-15

Family

ID=27065793

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91915864T ATE184052T1 (de) 1990-06-15 1991-06-14 Gdf-1 und uog1 proteine

Country Status (9)

Country Link
US (2) US20040039162A1 (de)
EP (1) EP0652951B1 (de)
JP (1) JPH06500466A (de)
AT (1) ATE184052T1 (de)
AU (1) AU666291B2 (de)
CA (1) CA2085134C (de)
DE (1) DE69131580T2 (de)
ES (1) ES2137931T3 (de)
WO (1) WO1992000382A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
CA2104678C (en) 1991-03-11 2002-05-14 Charles M. Cohen Protein-induced morphogenesis
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6949505B1 (en) 1991-03-11 2005-09-27 Curis, Inc. Morphogen-induced dendritic growth
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
DE69233559T2 (de) * 1991-08-30 2006-08-31 Curis, Inc., Cambridge Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten
JP4344012B2 (ja) * 1992-07-31 2009-10-14 ストライカー・コーポレーション 組織形成因子誘導による神経の再生と修復
EP0690871A4 (de) * 1993-01-12 1999-10-20 Univ Johns Hopkins Med Wachstums-differenzierungsfaktor-5
US5821056A (en) 1993-01-12 1998-10-13 The Johns Hopkins University School Of Medicine Growth differentiation factor-9
WO1995001802A1 (en) * 1993-07-09 1995-01-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-7
WO1995001801A1 (en) * 1993-07-09 1995-01-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-6
US20030167492A1 (en) 1994-07-08 2003-09-04 Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same
DK0776337T3 (da) * 1994-07-08 2005-12-12 Univ Johns Hopkins Med Vækstdifferentieringsfaktor-11
US5831054A (en) * 1994-07-13 1998-11-03 The Johns Hopkins University School Of Medicine Polynucleotide encoding growth differentiation factor-12
KR20000064752A (ko) 1996-03-22 2000-11-06 더 제네랄 호스피탈 코포레이션 중추신경계허혈또는외상의발현후폴리펩티드성장인자를투여하는방법
US6524802B1 (en) * 1996-03-29 2003-02-25 The Johns Hopkins University School Of Medicine Methods of detecting growth differentiation factor-14
US6281195B1 (en) 1997-02-07 2001-08-28 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
EP0985149A1 (de) 1997-05-30 2000-03-15 Creative Biomolecules, Inc. Verfahren zur bestimmung der gewebemorphogenese und morphogenesische tätigkeit
WO1999058671A2 (en) * 1998-05-08 1999-11-18 Research Corporation Technologies, Inc. Human and nematode homologues of the yeast longevity assurance gene lag1
US7147839B2 (en) 1998-05-29 2006-12-12 Curis, Inc. Methods for evaluating tissue morphogenesis and activity
US6872698B2 (en) * 1998-07-06 2005-03-29 Scion Pharmaceuticals, Inc. Methods for treating neurological injuries and disorders
JP2002519394A (ja) * 1998-07-06 2002-07-02 スネス ファーマシューティカルズ インコーポレイテッド 神経損傷および障害を治療するための方法
ATE478008T1 (de) 2004-03-10 2010-09-15 Scil Technology Gmbh Überzogene implantate, ihre herstellung und verwendung davon
US7575751B2 (en) 2004-04-27 2009-08-18 Research Development Foundation Activin-A mutants
ATE515268T1 (de) 2004-05-25 2011-07-15 Stryker Corp Verwendung von op-1 zur behandlung von knorpeldefekten
AU2007257208B2 (en) 2006-05-17 2013-05-02 Stryker Corporation Use of a soluble morphogenic protein complex for treating cartilage defects
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
WO2008082563A2 (en) 2006-12-21 2008-07-10 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
US8058237B2 (en) 2007-08-07 2011-11-15 Advanced Technologies & Regenerative Medicine, LLC Stable composition of GDF-5 and method of storage
EP2268302B1 (de) 2008-02-13 2014-04-09 Keith Hruska Bmp-7 zur behandlung von neointimaler hyperplasie
CN102026619A (zh) 2008-04-14 2011-04-20 先进科技及再生医学有限责任公司 液体缓冲的gdf-5制剂
SG173632A1 (en) 2009-02-12 2011-09-29 Stryker Corp Peripheral administration of proteins including tgf-beta superfamily members for systemic treatment of disorders and disease
WO2010110974A1 (en) 2009-03-24 2010-09-30 Stryker Corporation Methods and compositions for tissue engineering
WO2010144696A1 (en) 2009-06-11 2010-12-16 Burnham Institute For Medical Research Directed differentiation of stem cells
WO2011031856A1 (en) 2009-09-09 2011-03-17 Stryker Corporation Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
AU2010295509A1 (en) 2009-09-17 2012-04-19 Stryker Corporation Buffers for controlling the pH of bone morphogenetic proteins
EP2516456A1 (de) 2009-12-22 2012-10-31 Stryker Corporation Bmp-7-varianten mit reduzierter immunogenität
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
CA2807343C (en) 2010-08-20 2018-05-22 Wyeth Llc Designer osteogenic proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886747A (en) * 1985-03-22 1989-12-12 Genentech, Inc. Nucleic acid encoding TGF-β and its uses

Also Published As

Publication number Publication date
ES2137931T3 (es) 2000-01-01
JPH06500466A (ja) 1994-01-20
AU8496491A (en) 1992-01-23
EP0652951B1 (de) 1999-09-01
US20030040611A1 (en) 2003-02-27
EP0652951A1 (de) 1995-05-17
DE69131580D1 (de) 1999-10-07
CA2085134C (en) 2003-03-18
HK1013847A1 (en) 1999-12-10
AU666291B2 (en) 1996-02-08
CA2085134A1 (en) 1991-12-16
WO1992000382A1 (en) 1992-01-09
EP0652951A4 (de) 1993-08-16
DE69131580T2 (de) 2000-01-13
US20040039162A1 (en) 2004-02-26

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