DE69708100D1 - Konjugate von cis-docosahexaensäure und paclitaxel - Google Patents

Konjugate von cis-docosahexaensäure und paclitaxel

Info

Publication number
DE69708100D1
DE69708100D1 DE69708100T DE69708100T DE69708100D1 DE 69708100 D1 DE69708100 D1 DE 69708100D1 DE 69708100 T DE69708100 T DE 69708100T DE 69708100 T DE69708100 T DE 69708100T DE 69708100 D1 DE69708100 D1 DE 69708100D1
Authority
DE
Germany
Prior art keywords
conjugates
paclitaxel
cis
acid
docosahexaic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69708100T
Other languages
English (en)
Other versions
DE69708100T2 (de
Inventor
O Bradley
E Shashoua
L Webb
S Swindell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American Regent Inc
Original Assignee
Protarga Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protarga Inc filed Critical Protarga Inc
Publication of DE69708100D1 publication Critical patent/DE69708100D1/de
Application granted granted Critical
Publication of DE69708100T2 publication Critical patent/DE69708100T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicinal Preparation (AREA)
DE69708100T 1996-05-22 1997-05-22 Konjugate von cis-docosahexaensäure und paclitaxel Expired - Lifetime DE69708100T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/653,951 US5919815A (en) 1996-05-22 1996-05-22 Taxane compounds and compositions
PCT/US1997/008792 WO1997044336A1 (en) 1996-05-22 1997-05-22 Conjugates of cis-docosahexaenoic acid and paclitaxel

Publications (2)

Publication Number Publication Date
DE69708100D1 true DE69708100D1 (de) 2001-12-13
DE69708100T2 DE69708100T2 (de) 2002-04-11

Family

ID=24622927

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69708100T Expired - Lifetime DE69708100T2 (de) 1996-05-22 1997-05-22 Konjugate von cis-docosahexaensäure und paclitaxel

Country Status (11)

Country Link
US (1) US5919815A (de)
EP (1) EP0912535B1 (de)
JP (1) JP4172725B2 (de)
AT (1) ATE208382T1 (de)
AU (1) AU720704B2 (de)
CA (1) CA2255637C (de)
DE (1) DE69708100T2 (de)
DK (1) DK0912535T3 (de)
ES (1) ES2162681T3 (de)
HK (1) HK1022301A1 (de)
WO (1) WO1997044336A1 (de)

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HK1022301A1 (en) 2000-08-04
CA2255637A1 (en) 1997-11-27
EP0912535A1 (de) 1999-05-06
JP4172725B2 (ja) 2008-10-29
DE69708100T2 (de) 2002-04-11
ATE208382T1 (de) 2001-11-15
US5919815A (en) 1999-07-06
DK0912535T3 (da) 2002-02-25
ES2162681T3 (es) 2002-01-01
AU720704B2 (en) 2000-06-08
JP2000511187A (ja) 2000-08-29
WO1997044336A1 (en) 1997-11-27
AU3473497A (en) 1997-12-09
EP0912535B1 (de) 2001-11-07
CA2255637C (en) 2005-01-04

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