DE69704561T2 - Stabile nicht-hygroskopische salze von l(-)carnitin und alkanoyl-l(-)carnitinen,ein verfahren zu deren herstellung und feste, oral verabreichbare zusammensetzungen, die solche salze enthalten - Google Patents

Stabile nicht-hygroskopische salze von l(-)carnitin und alkanoyl-l(-)carnitinen,ein verfahren zu deren herstellung und feste, oral verabreichbare zusammensetzungen, die solche salze enthalten

Info

Publication number
DE69704561T2
DE69704561T2 DE69704561T DE69704561T DE69704561T2 DE 69704561 T2 DE69704561 T2 DE 69704561T2 DE 69704561 T DE69704561 T DE 69704561T DE 69704561 T DE69704561 T DE 69704561T DE 69704561 T2 DE69704561 T2 DE 69704561T2
Authority
DE
Germany
Prior art keywords
carnitine
salt
alkanoyl
salts
dryer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69704561T
Other languages
German (de)
English (en)
Other versions
DE69704561D1 (de
Inventor
Aldo Fassi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ITMI961116 external-priority patent/IT1283086B1/it
Priority claimed from IT97MI000409A external-priority patent/IT1289974B1/it
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of DE69704561D1 publication Critical patent/DE69704561D1/de
Publication of DE69704561T2 publication Critical patent/DE69704561T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69704561T 1996-05-31 1997-05-26 Stabile nicht-hygroskopische salze von l(-)carnitin und alkanoyl-l(-)carnitinen,ein verfahren zu deren herstellung und feste, oral verabreichbare zusammensetzungen, die solche salze enthalten Expired - Lifetime DE69704561T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI961116 IT1283086B1 (it) 1996-05-31 1996-05-31 Sali stabili e non igroscopici di l-carnitina e di alcanoil l-carnitine
IT97MI000409A IT1289974B1 (it) 1997-02-25 1997-02-25 Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
PCT/EP1997/002693 WO1997046512A1 (en) 1996-05-31 1997-05-26 Stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts

Publications (2)

Publication Number Publication Date
DE69704561D1 DE69704561D1 (de) 2001-05-17
DE69704561T2 true DE69704561T2 (de) 2001-08-09

Family

ID=26331398

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69704561T Expired - Lifetime DE69704561T2 (de) 1996-05-31 1997-05-26 Stabile nicht-hygroskopische salze von l(-)carnitin und alkanoyl-l(-)carnitinen,ein verfahren zu deren herstellung und feste, oral verabreichbare zusammensetzungen, die solche salze enthalten

Country Status (23)

Country Link
US (1) US5952379A (show.php)
EP (1) EP0914315B1 (show.php)
JP (1) JP4160634B2 (show.php)
CN (1) CN1177807C (show.php)
AT (1) ATE200479T1 (show.php)
AU (1) AU718308B2 (show.php)
BR (1) BR9709627A (show.php)
CZ (1) CZ290902B6 (show.php)
DE (1) DE69704561T2 (show.php)
DK (1) DK0914315T3 (show.php)
EE (1) EE03604B1 (show.php)
ES (1) ES2156381T3 (show.php)
GR (1) GR3035969T3 (show.php)
HU (1) HU228008B1 (show.php)
IL (1) IL127266A (show.php)
IS (1) IS2085B (show.php)
NO (1) NO323593B1 (show.php)
NZ (1) NZ333061A (show.php)
PL (1) PL188558B1 (show.php)
PT (1) PT914315E (show.php)
SK (1) SK283105B6 (show.php)
TR (1) TR199802492T2 (show.php)
WO (1) WO1997046512A1 (show.php)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
IT1312018B1 (it) * 1999-03-19 2002-04-04 Fassi Aldo Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina.
MXPA02002327A (es) * 1999-09-03 2004-07-16 Sigma Tau Healthscience Spa L-carnitina ultrafina, metodos para preparar la misma, composiciones que contienen la misma y metodos para usar la misma.
IT1316988B1 (it) * 2000-02-10 2003-05-26 Sigma Tau Ind Farmaceuti Procedimento migliorato di preparazione industriale di mucati dellal-carnitina e di alcanoil l-carnitine.
US8252309B2 (en) * 2000-04-04 2012-08-28 Sigma-Tau Industrie Farmaceutiche Riunite Spa Dietary supplement energy-providing to skeletal muscles
ITRM20010030A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr
ITRM20010029A1 (it) * 2001-01-23 2002-07-23 Aldo Fassi Sali metallici di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per
ITRM20010044A1 (it) * 2001-01-29 2002-07-29 Sigma Tau Healthscience Spa Integratore alimentare ad effetto dimagrante.
DE10133200A1 (de) * 2001-07-07 2003-01-23 Beiersdorf Ag Carnitin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut
ITRM20020055A1 (it) * 2002-02-04 2003-08-04 Aldo Fassi Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti
JP2006111550A (ja) * 2004-10-13 2006-04-27 Nisshin Pharma Inc カルニチン含有製品
CN101212956A (zh) * 2005-07-05 2008-07-02 隆萨股份公司 生产干肉碱粉末或颗粒的喷雾干燥法
CN101209975B (zh) 2006-12-29 2010-12-01 沈阳科硕营养科技有限公司 左旋肉碱富马酸钙及其制备方法与用途
EP2425834A1 (en) * 2010-09-06 2012-03-07 Lonza Ltd. Process for the production of l-carnitine tartrate
CN102911068A (zh) * 2011-08-04 2013-02-06 广州市奥海生物科技有限公司 左旋肉碱l-苹果酸盐及其制备方法与用途
CN102911067A (zh) * 2011-08-04 2013-02-06 广州市奥海生物科技有限公司 左旋肉碱丙酮酸盐及其制备方法与用途
RU2664538C2 (ru) * 2013-04-26 2018-08-20 Санофи Тартратная соль [(s)-2-[метил-3-(2-оксо-пирролидин-1-ил)-бензолсульфониламино]-3-(4-метил-пиперазин-1-ил)-3-оксо-пропил]амида 5-хлор-тиофен-2-карбоновой кислоты
CN103664667A (zh) * 2013-12-16 2014-03-26 天津天成制药有限公司 乙酰左旋肉碱硝酸盐的制备方法
CN106045919B (zh) * 2016-07-07 2022-08-09 湖北楚维药业有限公司 一种左旋肉碱乳清酸盐的制备方法
CN106748845B (zh) * 2016-12-23 2018-11-20 东北制药集团股份有限公司 一种左旋肉碱盐微粉的制备方法
CN112250588B (zh) * 2020-11-06 2023-03-31 哈尔滨工业大学（深圳） 一种左旋肉碱离子液体及其制备方法、应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5656M (show.php) * 1965-10-12 1967-12-26
DE3463261D1 (en) * 1983-12-28 1987-05-27 Sigma Tau Ind Farmaceuti Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
US5073376A (en) * 1989-12-22 1991-12-17 Lonza Ltd. Preparations containing l-carnitine
IT1258370B (it) * 1992-03-02 1996-02-26 Sigma Tau Ind Farmaceuti Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.
IT1261808B (it) * 1993-07-06 1996-06-03 Impiego di l-carnitina o acido l-carnitine e valproato nel trattamentodei disosrdini convulsivi

Also Published As

Publication number Publication date
TR199802492T2 (xx) 1999-02-22
IL127266A (en) 2002-09-12
IS2085B (is) 2006-02-15
HUP9903455A2 (hu) 2000-03-28
AU718308B2 (en) 2000-04-13
GR3035969T3 (en) 2001-08-31
CN1244191A (zh) 2000-02-09
PL330189A1 (en) 1999-04-26
EP0914315A1 (en) 1999-05-12
NO985562D0 (no) 1998-11-27
ES2156381T3 (es) 2001-06-16
EE9800422A (et) 1999-06-15
JP4160634B2 (ja) 2008-10-01
EE03604B1 (et) 2002-02-15
CN1177807C (zh) 2004-12-01
NO985562L (no) 1999-01-05
JP2000514413A (ja) 2000-10-31
CZ290902B6 (cs) 2002-11-13
DK0914315T3 (da) 2001-06-05
PL188558B1 (pl) 2005-02-28
IL127266A0 (en) 1999-09-22
HU228008B1 (en) 2012-08-28
CZ391598A3 (cs) 1999-04-14
WO1997046512A1 (en) 1997-12-11
IS4914A (is) 1998-11-30
SK164998A3 (en) 1999-05-07
US5952379A (en) 1999-09-14
NZ333061A (en) 1999-05-28
AU2961297A (en) 1998-01-05
BR9709627A (pt) 1999-08-10
PT914315E (pt) 2001-07-31
SK283105B6 (sk) 2003-02-04
HUP9903455A3 (en) 2001-01-29
DE69704561D1 (de) 2001-05-17
NO323593B1 (no) 2007-06-11
EP0914315B1 (en) 2001-04-11
HK1024463A1 (en) 2000-10-13
ATE200479T1 (de) 2001-04-15

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