DE69704561D1 - Stabile nichthygroskopische salze von l(-)carnitin und alkanoyl-l(-)carnitinen, verfahren zu ihrer herstellung und feste, oral verabreichbare zusammensetzungen,die sie enthalten - Google Patents
Stabile nichthygroskopische salze von l(-)carnitin und alkanoyl-l(-)carnitinen, verfahren zu ihrer herstellung und feste, oral verabreichbare zusammensetzungen,die sie enthaltenInfo
- Publication number
- DE69704561D1 DE69704561D1 DE69704561T DE69704561T DE69704561D1 DE 69704561 D1 DE69704561 D1 DE 69704561D1 DE 69704561 T DE69704561 T DE 69704561T DE 69704561 T DE69704561 T DE 69704561T DE 69704561 D1 DE69704561 D1 DE 69704561D1
- Authority
- DE
- Germany
- Prior art keywords
- salts
- carnitines
- alkanoyl
- solid
- thygroscopic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/285—Polyhydroxy dicarboxylic acids having five or more carbon atoms, e.g. saccharic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI961116 IT1283086B1 (it) | 1996-05-31 | 1996-05-31 | Sali stabili e non igroscopici di l-carnitina e di alcanoil l-carnitine |
IT97MI000409A IT1289974B1 (it) | 1997-02-25 | 1997-02-25 | Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine |
PCT/EP1997/002693 WO1997046512A1 (en) | 1996-05-31 | 1997-05-26 | Stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69704561D1 true DE69704561D1 (de) | 2001-05-17 |
DE69704561T2 DE69704561T2 (de) | 2001-08-09 |
Family
ID=26331398
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69704561T Expired - Lifetime DE69704561T2 (de) | 1996-05-31 | 1997-05-26 | Stabile nicht-hygroskopische salze von l(-)carnitin und alkanoyl-l(-)carnitinen,ein verfahren zu deren herstellung und feste, oral verabreichbare zusammensetzungen, die solche salze enthalten |
Country Status (24)
Country | Link |
---|---|
US (1) | US5952379A (de) |
EP (1) | EP0914315B1 (de) |
JP (1) | JP4160634B2 (de) |
CN (1) | CN1177807C (de) |
AT (1) | ATE200479T1 (de) |
AU (1) | AU718308B2 (de) |
BR (1) | BR9709627A (de) |
CZ (1) | CZ290902B6 (de) |
DE (1) | DE69704561T2 (de) |
DK (1) | DK0914315T3 (de) |
EE (1) | EE03604B1 (de) |
ES (1) | ES2156381T3 (de) |
GR (1) | GR3035969T3 (de) |
HK (1) | HK1024463A1 (de) |
HU (1) | HU228008B1 (de) |
IL (1) | IL127266A (de) |
IS (1) | IS2085B (de) |
NO (1) | NO323593B1 (de) |
NZ (1) | NZ333061A (de) |
PL (1) | PL188558B1 (de) |
PT (1) | PT914315E (de) |
SK (1) | SK283105B6 (de) |
TR (1) | TR199802492T2 (de) |
WO (1) | WO1997046512A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1289974B1 (it) * | 1997-02-25 | 1998-10-19 | Aldo Fassi | Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine |
IT1312018B1 (it) * | 1999-03-19 | 2002-04-04 | Fassi Aldo | Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina. |
MXPA02002327A (es) * | 1999-09-03 | 2004-07-16 | Sigma Tau Healthscience Spa | L-carnitina ultrafina, metodos para preparar la misma, composiciones que contienen la misma y metodos para usar la misma. |
IT1316988B1 (it) * | 2000-02-10 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Procedimento migliorato di preparazione industriale di mucati dellal-carnitina e di alcanoil l-carnitine. |
US8252309B2 (en) * | 2000-04-04 | 2012-08-28 | Sigma-Tau Industrie Farmaceutiche Riunite Spa | Dietary supplement energy-providing to skeletal muscles |
ITRM20010030A1 (it) * | 2001-01-23 | 2002-07-23 | Aldo Fassi | Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr |
ITRM20010029A1 (it) * | 2001-01-23 | 2002-07-23 | Aldo Fassi | Sali metallici di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per |
ITRM20010044A1 (it) * | 2001-01-29 | 2002-07-29 | Sigma Tau Healthscience Spa | Integratore alimentare ad effetto dimagrante. |
DE10133200A1 (de) * | 2001-07-07 | 2003-01-23 | Beiersdorf Ag | Carnitin enthaltende kosmetische und dermatologische Zubereitungen zur Behandlung und aktiven Prävention trockener Haut und anderer negativer Veränderungen der physiologischen Homöostase der gesunden Haut |
ITRM20020055A1 (it) * | 2002-02-04 | 2003-08-04 | Aldo Fassi | Sali metallici di carnitine, integratori dietetici/nutritivi che li contengono e kit dietetici per contrastare disturbi sessuali in soggetti |
JP2006111550A (ja) * | 2004-10-13 | 2006-04-27 | Nisshin Pharma Inc | カルニチン含有製品 |
EP1901715B1 (de) * | 2005-07-05 | 2012-05-02 | Lonza AG | Sprühtrockenverfahren zur herstellung eines trockenen carnitin-pulvers oder -granulats |
CN101209975B (zh) | 2006-12-29 | 2010-12-01 | 沈阳科硕营养科技有限公司 | 左旋肉碱富马酸钙及其制备方法与用途 |
EP2425834A1 (de) * | 2010-09-06 | 2012-03-07 | Lonza Ltd. | Verfahren zur Herstellung von L-Carnitin-Tartrat |
CN102911068A (zh) * | 2011-08-04 | 2013-02-06 | 广州市奥海生物科技有限公司 | 左旋肉碱l-苹果酸盐及其制备方法与用途 |
CN102911067A (zh) * | 2011-08-04 | 2013-02-06 | 广州市奥海生物科技有限公司 | 左旋肉碱丙酮酸盐及其制备方法与用途 |
BR112015026841A8 (pt) * | 2013-04-26 | 2019-12-24 | Sanofi Sa | sal de l-tartarato de [(s)-2-[metil-3-(2-oxo-pirrolidin-1-il)- benzenossulfonilamino]-3-(4-metil-piperazin-1-il)-3-oxopropril] amida de ácido 5-cloro-tiofeno-2-carboxílico, processo de preparação do mesmo, seu uso, medicamento e composição farmacêutica |
CN103664667A (zh) * | 2013-12-16 | 2014-03-26 | 天津天成制药有限公司 | 乙酰左旋肉碱硝酸盐的制备方法 |
CN106045919B (zh) * | 2016-07-07 | 2022-08-09 | 湖北楚维药业有限公司 | 一种左旋肉碱乳清酸盐的制备方法 |
CN106748845B (zh) * | 2016-12-23 | 2018-11-20 | 东北制药集团股份有限公司 | 一种左旋肉碱盐微粉的制备方法 |
CN112250588B (zh) * | 2020-11-06 | 2023-03-31 | 哈尔滨工业大学(深圳) | 一种左旋肉碱离子液体及其制备方法、应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR5656M (de) * | 1965-10-12 | 1967-12-26 | ||
EP0150688B1 (de) * | 1983-12-28 | 1987-04-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Salze von L-Carnitin und Alkanoyl-L-Carnitinen sowie Verfahren zur Herstellung derselben |
US5073376A (en) * | 1989-12-22 | 1991-12-17 | Lonza Ltd. | Preparations containing l-carnitine |
IT1258370B (it) * | 1992-03-02 | 1996-02-26 | Sigma Tau Ind Farmaceuti | Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono. |
IT1261808B (it) * | 1993-07-06 | 1996-06-03 | Impiego di l-carnitina o acido l-carnitine e valproato nel trattamentodei disosrdini convulsivi |
-
1997
- 1997-05-26 WO PCT/EP1997/002693 patent/WO1997046512A1/en active IP Right Grant
- 1997-05-26 EP EP97924007A patent/EP0914315B1/de not_active Expired - Lifetime
- 1997-05-26 PL PL97330189A patent/PL188558B1/pl unknown
- 1997-05-26 US US09/194,608 patent/US5952379A/en not_active Expired - Lifetime
- 1997-05-26 CN CNB971951454A patent/CN1177807C/zh not_active Expired - Lifetime
- 1997-05-26 DE DE69704561T patent/DE69704561T2/de not_active Expired - Lifetime
- 1997-05-26 TR TR1998/02492T patent/TR199802492T2/xx unknown
- 1997-05-26 AU AU29612/97A patent/AU718308B2/en not_active Expired
- 1997-05-26 NZ NZ333061A patent/NZ333061A/xx not_active IP Right Cessation
- 1997-05-26 HU HU9903455A patent/HU228008B1/hu unknown
- 1997-05-26 PT PT97924007T patent/PT914315E/pt unknown
- 1997-05-26 SK SK1649-98A patent/SK283105B6/sk not_active IP Right Cessation
- 1997-05-26 BR BR9709627A patent/BR9709627A/pt not_active IP Right Cessation
- 1997-05-26 DK DK97924007T patent/DK0914315T3/da active
- 1997-05-26 JP JP50017398A patent/JP4160634B2/ja not_active Expired - Lifetime
- 1997-05-26 IL IL12726697A patent/IL127266A/en not_active IP Right Cessation
- 1997-05-26 EE EE9800422A patent/EE03604B1/xx unknown
- 1997-05-26 AT AT97924007T patent/ATE200479T1/de active
- 1997-05-26 CZ CZ19983915A patent/CZ290902B6/cs not_active IP Right Cessation
- 1997-05-26 ES ES97924007T patent/ES2156381T3/es not_active Expired - Lifetime
-
1998
- 1998-11-27 NO NO19985562A patent/NO323593B1/no not_active IP Right Cessation
- 1998-11-30 IS IS4914A patent/IS2085B/is unknown
-
2000
- 2000-06-21 HK HK00103735A patent/HK1024463A1/xx not_active IP Right Cessation
-
2001
- 2001-05-31 GR GR20010400820T patent/GR3035969T3/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69704561D1 (de) | Stabile nichthygroskopische salze von l(-)carnitin und alkanoyl-l(-)carnitinen, verfahren zu ihrer herstellung und feste, oral verabreichbare zusammensetzungen,die sie enthalten | |
TW324028B (en) | A cleaner composition used in the process of producing semiconductor device | |
ES8801920A1 (es) | Procedimiento para la obtencio de enaminas | |
DE69625699D1 (de) | Aminsäure-salzverbindungen und ein verfahren zu ihrer herstellung | |
HUT40126A (en) | Process for producing 6,7-disubstituted-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtiridine-3-carboxylic acid derivatives and pharmaceutical compositions and food additives containing them | |
CA2281630A1 (en) | Process for the preparation of stable, non-hygroscopic salts of l(-)carnitine | |
ATE224379T1 (de) | Ein verfahren zur herstellung von 1,4,7,10- tetraazacyclododecan-1,4,7-triessigsäure und deren derivaten | |
ES8607218A1 (es) | Un procedimiento para preparar compuestos de amidina | |
ATE70837T1 (de) | Allylmercaptoacetyl-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung. | |
ATE122335T1 (de) | Verfahren zur herstellung von 2,5-di- (phenylamino)-terephthalsäure und ihrer dialkylester in hoher reinheit. | |
DE58900439D1 (de) | N-substituierte-n-nitroso-aminoacetonitrile, verfahren zu ihrer herstellung und ihre verwendung. | |
IT1277339B1 (it) | Processo per la produzione di agenti contrastografici iodurati | |
DE69737376D1 (de) | Verfahren zur Synthese einer Oxonolverbindung | |
DE3668451D1 (de) | Neue imidazolylverbindungen und verfahren zu ihrer herstellung. | |
BG60209B2 (bg) | Метод за получаване на производни на дихидро- пиримидотиазин | |
AU2859792A (en) | 5,6-dihydro-dibenz(b,e)azepine-6,11-dione-11-oximes | |
DE3684908D1 (de) | Verfahren zur herstellung von 6beta-halopenicillansaeuren und deren salzen. | |
CA2256712A1 (en) | Stable, non-hygroscopic salts of l(-)carnitine and alkanoyl l(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts | |
DE69612237D1 (de) | Verfahren zur Herstellung von alpha-Methyl-2-thiophenessigsäure-Derivaten | |
MY112938A (en) | New highly selective process for the preparation of enantiomerically pure phenyl-substituted 1, 4- dihydropyridine-3,5-dicarboxylic acid derivatives | |
ATE73455T1 (de) | 4,4-dimethyltetrahydropyr-2-on-derivate, verfahren zu ihrer herstellung und ihre verwendung zur synthese von pyretrinverbindungen. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |