DE69634416T2 - Chinolin-derivate - Google Patents

Chinolin-derivate Download PDF

Info

Publication number
DE69634416T2
DE69634416T2 DE69634416T DE69634416T DE69634416T2 DE 69634416 T2 DE69634416 T2 DE 69634416T2 DE 69634416 T DE69634416 T DE 69634416T DE 69634416 T DE69634416 T DE 69634416T DE 69634416 T2 DE69634416 T2 DE 69634416T2
Authority
DE
Germany
Prior art keywords
compound
formula
pharmaceutically acceptable
alkyl
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69634416T
Other languages
German (de)
English (en)
Other versions
DE69634416D1 (de
Inventor
Giuseppe Arnaldo Maria Giardina
Mario Grugni
Luca Francesco Raveglia
Carlo Farino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
GlaxoSmithKline SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT95MI002461 external-priority patent/IT1276170B1/it
Priority claimed from ITMI961689 external-priority patent/IT1307331B1/it
Application filed by GlaxoSmithKline SpA filed Critical GlaxoSmithKline SpA
Publication of DE69634416D1 publication Critical patent/DE69634416D1/de
Application granted granted Critical
Publication of DE69634416T2 publication Critical patent/DE69634416T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69634416T 1995-11-24 1996-11-22 Chinolin-derivate Expired - Fee Related DE69634416T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IT95MI002461 IT1276170B1 (it) 1995-11-24 1995-11-24 Derivati chinolinici
ITMI952461 1995-11-24
ITMI961689 IT1307331B1 (it) 1996-08-02 1996-08-02 Derivati chinolinici
ITMI961689 1996-08-02
PCT/EP1996/005203 WO1997021680A1 (en) 1995-11-24 1996-11-22 Quinoline derivatives

Publications (2)

Publication Number Publication Date
DE69634416D1 DE69634416D1 (de) 2005-04-07
DE69634416T2 true DE69634416T2 (de) 2005-12-29

Family

ID=26331326

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69634416T Expired - Fee Related DE69634416T2 (de) 1995-11-24 1996-11-22 Chinolin-derivate

Country Status (26)

Country Link
US (1) US6277862B1 (OSRAM)
EP (1) EP0876347B1 (OSRAM)
JP (1) JP2000501104A (OSRAM)
KR (1) KR19990071597A (OSRAM)
CN (1) CN1207730A (OSRAM)
AP (1) AP9801237A0 (OSRAM)
AR (1) AR004972A1 (OSRAM)
AT (1) ATE289994T1 (OSRAM)
BG (1) BG102558A (OSRAM)
BR (1) BR9611820A (OSRAM)
CA (1) CA2238298A1 (OSRAM)
CZ (1) CZ157998A3 (OSRAM)
DE (1) DE69634416T2 (OSRAM)
EA (1) EA002124B1 (OSRAM)
ES (1) ES2236757T3 (OSRAM)
IL (1) IL124522A0 (OSRAM)
MX (1) MX9804107A (OSRAM)
NO (1) NO311212B1 (OSRAM)
NZ (1) NZ323387A (OSRAM)
OA (1) OA11010A (OSRAM)
PL (1) PL326967A1 (OSRAM)
SK (1) SK66798A3 (OSRAM)
TR (1) TR199800924T2 (OSRAM)
TW (1) TW353066B (OSRAM)
UY (1) UY24733A1 (OSRAM)
WO (1) WO1997021680A1 (OSRAM)

Families Citing this family (38)

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AU664392B2 (en) * 1991-10-18 1995-11-16 Monsanto Technology Llc Fungicides for the control of take-all disease of plants
SE9703407D0 (sv) * 1997-09-19 1997-09-19 Astra Ab New use
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
GB9825554D0 (en) * 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
US7037922B1 (en) * 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
EP1165542B1 (en) 1999-03-29 2003-08-20 Neurogen Corporation 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands
WO2000064877A1 (en) * 1999-04-26 2000-11-02 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
JP2004525184A (ja) * 2001-04-11 2004-08-19 グラクソスミスクライン・ソシエタ・ペル・アチオニ Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしての３−置換キノリン−４−カルボキサミド誘導体
WO2002089802A2 (en) * 2001-05-08 2002-11-14 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
ATE477268T1 (de) 2003-01-28 2010-08-15 Ironwood Pharmaceuticals Inc Zusammensetzungen zur behandlung von magen-darm- störungen
GB0303086D0 (en) 2003-02-11 2003-03-19 Merck Sharp & Dohme New compounds
GB0419192D0 (en) 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
WO2006052722A1 (en) * 2004-11-09 2006-05-18 Smithkline Beecham Corporation Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
EP1915361A1 (en) * 2005-08-11 2008-04-30 AstraZeneca AB Alkylpyridyl quinolines as nk3 receptor modulators
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW201018662A (en) * 2005-12-12 2010-05-16 Astrazeneca Ab Alkylsulphonamide quinolines
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP5546451B2 (ja) 2007-06-04 2014-07-09 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
MX2010003440A (es) * 2007-09-28 2010-04-21 Glaxosmithkline Llc Compuesto inhibidor de glicogeno fosforilasa y composicion farmaceutica del mismo.
JP2010540553A (ja) * 2007-09-28 2010-12-24 グラクソスミスクライン エルエルシー グリコーゲンホスホリラーゼ阻害剤化合物及びその医薬組成物
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
JP5502106B2 (ja) 2008-12-31 2014-05-28 アーデリクス，インコーポレーテッド 体液貯留または塩分過負荷と関連する障害および消化管障害の治療におけるｎｈｅ媒介性アンチポートを阻害するための組成物および方法
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
KR102138390B1 (ko) 2012-08-21 2020-07-27 알데릭스, 인코포레이티드 체액 저류 또는 염 과부하와 연관된 장애 및 위장관 장애의 치료에서 ｎｈｅ-매개된 역수송 저해를 위한 화합물 및 방법
HK1220696A1 (zh) 2013-03-15 2017-05-12 Bausch Health Ireland Limited 鸟苷酸环化酶激动剂及其用途
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
KR102287207B1 (ko) 2013-04-12 2021-08-09 알데릭스, 인코포레이티드 Nhe3-결합 화합물 및 포스페이트 수송을 저해하는 방법
AU2014255512A1 (en) 2013-04-19 2015-11-12 Astrazeneca Ab A NK3 receptor antagonist compound (NK3RA) for use in a method for the treatment of polycystic ovary syndrome (PCOS)
EP4424697A3 (en) 2013-06-05 2024-12-25 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2017072629A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical combination of nk3 receptor antagonist and biguanides
CA3049679A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Inhibitors of nhe-mediated antiport
UA126283C2 (uk) 2017-01-09 2022-09-14 Арделікс, Інк. Сполуки, придатні для лікування розладів шлунково-кишкового тракту

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
JPS63119455A (ja) * 1986-06-27 1988-05-24 Nippon Shinyaku Co Ltd グリシン誘導体
CA2191352C (en) * 1994-05-27 2001-01-30 Carlo Farina Quinoline derivatives as tachykinin nk3 receptor antagonists
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina

Also Published As

Publication number Publication date
NO311212B1 (no) 2001-10-29
CZ157998A3 (cs) 1998-12-16
SK66798A3 (en) 1999-01-11
EP0876347A1 (en) 1998-11-11
NZ323387A (en) 2000-02-28
BG102558A (bg) 1999-03-31
DE69634416D1 (de) 2005-04-07
WO1997021680A1 (en) 1997-06-19
NO982331L (no) 1998-07-22
TW353066B (en) 1999-02-21
JP2000501104A (ja) 2000-02-02
ES2236757T3 (es) 2005-07-16
BR9611820A (pt) 1999-07-13
TR199800924T2 (xx) 1998-08-21
AR004972A1 (es) 1999-04-07
KR19990071597A (ko) 1999-09-27
PL326967A1 (en) 1998-11-09
UY24733A1 (es) 2001-08-27
NO982331D0 (no) 1998-05-22
IL124522A0 (en) 1998-12-06
AP9801237A0 (en) 1998-06-30
EP0876347B1 (en) 2005-03-02
OA11010A (en) 2003-03-06
ATE289994T1 (de) 2005-03-15
US6277862B1 (en) 2001-08-21
EA199800477A1 (ru) 1998-12-24
CA2238298A1 (en) 1997-06-19
EA002124B1 (ru) 2001-12-24
MX9804107A (es) 1998-09-30
CN1207730A (zh) 1999-02-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee