CZ157998A3 - Chinolinové deriváty, způsob jejich přípravy, farmaceutický prostředek a použití - Google Patents

Chinolinové deriváty, způsob jejich přípravy, farmaceutický prostředek a použití Download PDF

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Publication number
CZ157998A3
CZ157998A3 CZ981579A CZ157998A CZ157998A3 CZ 157998 A3 CZ157998 A3 CZ 157998A3 CZ 981579 A CZ981579 A CZ 981579A CZ 157998 A CZ157998 A CZ 157998A CZ 157998 A3 CZ157998 A3 CZ 157998A3
Authority
CZ
Czechia
Prior art keywords
group
alkyl
compound
formula
amino
Prior art date
Application number
CZ981579A
Other languages
Czech (cs)
English (en)
Inventor
Giuseppe Arnaldo Maria Giardina
Mario Grugni
Luca Francesco Raveglia
Carlo Farina
Original Assignee
Smithkline Beecham S. P. A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT95MI002461 external-priority patent/IT1276170B1/it
Priority claimed from ITMI961689 external-priority patent/IT1307331B1/it
Application filed by Smithkline Beecham S. P. A. filed Critical Smithkline Beecham S. P. A.
Publication of CZ157998A3 publication Critical patent/CZ157998A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CZ981579A 1995-11-24 1996-11-22 Chinolinové deriváty, způsob jejich přípravy, farmaceutický prostředek a použití CZ157998A3 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI002461 IT1276170B1 (it) 1995-11-24 1995-11-24 Derivati chinolinici
ITMI961689 IT1307331B1 (it) 1996-08-02 1996-08-02 Derivati chinolinici

Publications (1)

Publication Number Publication Date
CZ157998A3 true CZ157998A3 (cs) 1998-12-16

Family

ID=26331326

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ981579A CZ157998A3 (cs) 1995-11-24 1996-11-22 Chinolinové deriváty, způsob jejich přípravy, farmaceutický prostředek a použití

Country Status (26)

Country Link
US (1) US6277862B1 (OSRAM)
EP (1) EP0876347B1 (OSRAM)
JP (1) JP2000501104A (OSRAM)
KR (1) KR19990071597A (OSRAM)
CN (1) CN1207730A (OSRAM)
AP (1) AP9801237A0 (OSRAM)
AR (1) AR004972A1 (OSRAM)
AT (1) ATE289994T1 (OSRAM)
BG (1) BG102558A (OSRAM)
BR (1) BR9611820A (OSRAM)
CA (1) CA2238298A1 (OSRAM)
CZ (1) CZ157998A3 (OSRAM)
DE (1) DE69634416T2 (OSRAM)
EA (1) EA002124B1 (OSRAM)
ES (1) ES2236757T3 (OSRAM)
IL (1) IL124522A0 (OSRAM)
MX (1) MX9804107A (OSRAM)
NO (1) NO311212B1 (OSRAM)
NZ (1) NZ323387A (OSRAM)
OA (1) OA11010A (OSRAM)
PL (1) PL326967A1 (OSRAM)
SK (1) SK66798A3 (OSRAM)
TR (1) TR199800924T2 (OSRAM)
TW (1) TW353066B (OSRAM)
UY (1) UY24733A1 (OSRAM)
WO (1) WO1997021680A1 (OSRAM)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK44894A3 (en) * 1991-10-18 1995-04-12 Monsanto Co Trisubstituted aromatic compounds, method of their preparation and fungicidal agents
SE9703407D0 (sv) * 1997-09-19 1997-09-19 Astra Ab New use
SE9802073D0 (sv) 1998-06-11 1998-06-11 Astra Ab New use
GB9825554D0 (en) * 1998-11-20 1999-01-13 Smithkline Beecham Spa Novel Compounds
US7037922B1 (en) 2000-03-10 2006-05-02 Neurogen Corporation Aryl fused 2,4-disubstituted pyridines: NK3 receptor ligands
EP1165542B1 (en) 1999-03-29 2003-08-20 Neurogen Corporation 4-substituted quinoline derivatives as nk-3 and/or gaba(a) receptor ligands
AU4802500A (en) 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
JP2004525184A (ja) * 2001-04-11 2004-08-19 グラクソスミスクライン・ソシエタ・ペル・アチオニ Ｎｋ−３およびｎｋ−２受容体アンタゴニストとしての３−置換キノリン−４−カルボキサミド誘導体
AU2002259147A1 (en) * 2001-05-08 2002-11-18 Schering Corporation Use of neurokinin receptor antagonists to treat androgen-dependent diseases
PT2246360E (pt) 2003-01-28 2012-08-31 Ironwood Pharmaceuticals Inc Composições para o tratamento de desordens gastrointestinais
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0303086D0 (en) 2003-02-11 2003-03-19 Merck Sharp & Dohme New compounds
GB0419192D0 (en) 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
MX2007005590A (es) * 2004-11-09 2007-05-24 Smithkline Beecham Corp Compuestos del inhibidor glicogeno fosforilasa y sus composiciones farmaceuticas.
GB0425077D0 (en) * 2004-11-12 2004-12-15 Smithkline Beecham Corp Novel compounds
GB0515580D0 (en) 2005-07-29 2005-09-07 Merck Sharp & Dohme Therapeutic compounds
EP1915361A1 (en) * 2005-08-11 2008-04-30 AstraZeneca AB Alkylpyridyl quinolines as nk3 receptor modulators
AR057130A1 (es) 2005-09-21 2007-11-14 Astrazeneca Ab Quinolinas de alquilsulfoxido y una composicion farmaceutica
TW200804288A (en) 2005-12-12 2008-01-16 Astrazeneca Ab Alkylsulphonamide quinolines
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2195287A1 (en) * 2007-09-28 2010-06-16 GlaxoSmithKline LLC Glycogen phosphorylase inhibitor compound and pharmaceutical composition thereof
MX2010003442A (es) * 2007-09-28 2010-04-21 Glaxosmithkline Llc Compuesto inhibidor de fosforilasa de glicogeno y composicion farmaceutica del mismo.
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3351248B1 (en) 2008-12-31 2021-06-09 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
EP2887964B1 (en) 2012-08-21 2019-07-03 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
RU2675364C2 (ru) 2013-04-12 2018-12-19 Арделикс, Инк Nhe3-связывающие соединения и способы ингибирования транспорта фосфатов
CA2909752A1 (en) 2013-04-19 2014-10-23 Astrazeneca Ab A nk3 receptor antagonist compound (nk3ra) for use in a method for the treatment of polycystic ovary syndrome (pcos)
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
WO2017072629A1 (en) 2015-10-29 2017-05-04 Cadila Healthcare Limited Pharmaceutical combination of nk3 receptor antagonist and biguanides
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
WO2018129552A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2538388B1 (fr) * 1982-12-24 1985-06-21 Pharmuka Lab Nouveaux derives de naphtalene- ou azanaphtalenecarboxamide, leurs procedes de preparation et leur utilisation comme medicaments
JPS6399057A (ja) * 1986-06-27 1988-04-30 Nippon Shinyaku Co Ltd グリシン誘導体
ES2227769T3 (es) * 1994-05-27 2005-04-01 Glaxosmithkline S.P.A. Derivados de quinolina como antagonistas del receptor nk3 de taquiquinina.
IT1270615B (it) * 1994-07-14 1997-05-07 Smithkline Beecham Farma Uso di derivati di chinolina

Also Published As

Publication number Publication date
NO311212B1 (no) 2001-10-29
NO982331D0 (no) 1998-05-22
ES2236757T3 (es) 2005-07-16
WO1997021680A1 (en) 1997-06-19
CN1207730A (zh) 1999-02-10
EP0876347B1 (en) 2005-03-02
JP2000501104A (ja) 2000-02-02
IL124522A0 (en) 1998-12-06
TW353066B (en) 1999-02-21
MX9804107A (es) 1998-09-30
BG102558A (bg) 1999-03-31
SK66798A3 (en) 1999-01-11
UY24733A1 (es) 2001-08-27
DE69634416D1 (de) 2005-04-07
KR19990071597A (ko) 1999-09-27
EA002124B1 (ru) 2001-12-24
ATE289994T1 (de) 2005-03-15
BR9611820A (pt) 1999-07-13
EA199800477A1 (ru) 1998-12-24
DE69634416T2 (de) 2005-12-29
AR004972A1 (es) 1999-04-07
NO982331L (no) 1998-07-22
EP0876347A1 (en) 1998-11-11
NZ323387A (en) 2000-02-28
OA11010A (en) 2003-03-06
AP9801237A0 (en) 1998-06-30
PL326967A1 (en) 1998-11-09
CA2238298A1 (en) 1997-06-19
TR199800924T2 (xx) 1998-08-21
US6277862B1 (en) 2001-08-21

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic