DE69609982D1 - Lipopolyamine als transfectionsmittel und ihre pharmazeutischen anwendungen - Google Patents

Lipopolyamine als transfectionsmittel und ihre pharmazeutischen anwendungen

Info

Publication number
DE69609982D1
DE69609982D1 DE69609982T DE69609982T DE69609982D1 DE 69609982 D1 DE69609982 D1 DE 69609982D1 DE 69609982 T DE69609982 T DE 69609982T DE 69609982 T DE69609982 T DE 69609982T DE 69609982 D1 DE69609982 D1 DE 69609982D1
Authority
DE
Germany
Prior art keywords
lipopolyamine
pharmaceutical applications
transfection agent
transfection
lipopolyamines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69609982T
Other languages
English (en)
Other versions
DE69609982T2 (de
Inventor
Gerardo Byk
Daniel Scherman
Bertrand Schwartz
Catherine Dubertret
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of DE69609982D1 publication Critical patent/DE69609982D1/de
Application granted granted Critical
Publication of DE69609982T2 publication Critical patent/DE69609982T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B19/00—Driving, starting, stopping record carriers not specifically of filamentary or web form, or of supports therefor; Control thereof; Control of operating function ; Driving both disc and head
    • G11B19/02—Control of operating function, e.g. switching from recording to reproducing
    • G11B19/04—Arrangements for preventing, inhibiting, or warning against double recording on the same blank or against other recording or reproducing malfunctions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B20/00—Signal processing not specific to the method of recording or reproducing; Circuits therefor
    • G11B20/10—Digital recording or reproducing
    • G11B20/18—Error detection or correction; Testing, e.g. of drop-outs
    • G11B20/1816—Testing
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B20/00—Signal processing not specific to the method of recording or reproducing; Circuits therefor
    • G11B20/10—Digital recording or reproducing
    • G11B20/18—Error detection or correction; Testing, e.g. of drop-outs
    • G11B20/1866—Error detection or correction; Testing, e.g. of drop-outs by interleaving
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B20/00—Signal processing not specific to the method of recording or reproducing; Circuits therefor
    • G11B20/24—Signal processing not specific to the method of recording or reproducing; Circuits therefor for reducing noise
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B20/00—Signal processing not specific to the method of recording or reproducing; Circuits therefor
    • G11B20/10—Digital recording or reproducing
    • G11B20/10009—Improvement or modification of read or write signals
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B20/00—Signal processing not specific to the method of recording or reproducing; Circuits therefor
    • G11B20/10—Digital recording or reproducing
    • G11B20/12—Formatting, e.g. arrangement of data block or words on the record carriers
    • G11B20/1217—Formatting, e.g. arrangement of data block or words on the record carriers on discs
    • G11B20/1258—Formatting, e.g. arrangement of data block or words on the record carriers on discs where blocks are arranged within multiple radial zones, e.g. Zone Bit Recording or Constant Density Recording discs, MCAV discs, MCLV discs
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B20/00—Signal processing not specific to the method of recording or reproducing; Circuits therefor
    • G11B20/10—Digital recording or reproducing
    • G11B20/14—Digital recording or reproducing using self-clocking codes
    • G11B20/1403—Digital recording or reproducing using self-clocking codes characterised by the use of two levels
    • G11B2020/1476—Synchronisation patterns; Coping with defects thereof
    • G—PHYSICS
    • G11—INFORMATION STORAGE
    • G11B—INFORMATION STORAGE BASED ON RELATIVE MOVEMENT BETWEEN RECORD CARRIER AND TRANSDUCER
    • G11B20/00—Signal processing not specific to the method of recording or reproducing; Circuits therefor
    • G11B20/10—Digital recording or reproducing
    • G11B20/18—Error detection or correction; Testing, e.g. of drop-outs
    • G11B20/1816—Testing
    • G11B2020/183—Testing wherein at least one additional attempt is made to read or write the data when a first attempt is unsuccessful

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Signal Processing (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
DE69609982T 1995-11-14 1996-11-08 Lipopolyamine als transfectionsmittel und ihre pharmazeutischen anwendungen Expired - Lifetime DE69609982T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9513490A FR2741066B1 (fr) 1995-11-14 1995-11-14 Nouveaux agents de transfection et leurs applications pharmaceutiques
PCT/FR1996/001774 WO1997018185A1 (fr) 1995-11-14 1996-11-08 Lipopolymamines comme agents de transfection et leurs applications pharmaceutiques

Publications (2)

Publication Number Publication Date
DE69609982D1 true DE69609982D1 (de) 2000-09-28
DE69609982T2 DE69609982T2 (de) 2001-01-25

Family

ID=9484558

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69609982T Expired - Lifetime DE69609982T2 (de) 1995-11-14 1996-11-08 Lipopolyamine als transfectionsmittel und ihre pharmazeutischen anwendungen

Country Status (23)

Country Link
US (1) US6171612B1 (de)
EP (1) EP0861228B1 (de)
JP (2) JP4176831B2 (de)
KR (1) KR19990067552A (de)
AT (1) ATE195721T1 (de)
AU (1) AU718568B2 (de)
BR (1) BR9611533A (de)
CA (1) CA2235721C (de)
CZ (1) CZ147398A3 (de)
DE (1) DE69609982T2 (de)
DK (1) DK0861228T3 (de)
ES (1) ES2151185T3 (de)
FR (1) FR2741066B1 (de)
GR (1) GR3034204T3 (de)
HU (1) HUP9900605A3 (de)
IL (1) IL124411A (de)
MX (1) MX9803761A (de)
NO (1) NO981944D0 (de)
PT (1) PT861228E (de)
SI (1) SI0861228T1 (de)
SK (1) SK282173B6 (de)
WO (1) WO1997018185A1 (de)
ZA (1) ZA969489B (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2756491B1 (fr) * 1996-11-29 1999-01-08 Rhone Poulenc Rorer Sa Composition transfectante utile en therapie genique associan t a un virus recombinant incorporant un acide nucleique exog ene, un agent de transfection non viral et non plasmidique
FR2750704B1 (fr) 1996-07-04 1998-09-25 Rhone Poulenc Rorer Sa Procede de production d'adn therapeutique
US6884430B1 (en) * 1997-02-10 2005-04-26 Aventis Pharma S.A. Formulation of stabilized cationic transfection agent(s) /nucleic acid particles
FR2763943B1 (fr) * 1997-05-28 1999-07-09 Rhone Poulenc Rorer Sa Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules
US20020058795A1 (en) * 1997-09-08 2002-05-16 Russ J. Mumper Hydrophobic glycosylamine derivatives, compositions, and methods for use
WO1999038821A2 (fr) * 1998-01-30 1999-08-05 Aventis Pharma S.A. Composes transfectants sensibles aux conditions reductrices, compositions pharmaceutiques les contenant, et leurs applications
FR2774394B1 (fr) * 1998-01-30 2002-04-26 Rhone Poulenc Rorer Sa Composes transfectants sensibles aux conditions reductrices, compositions pharmaceutiques les contenant, et leurs applications
FR2777017B1 (fr) * 1998-04-02 2002-08-23 Rhone Poulenc Rorer Sa Nouveaux agents de transfert d'acides nucleiques, compositions les contenant et leurs applications
KR20010042318A (ko) * 1998-04-02 2001-05-25 아방티 파르마 소시에테 아노님 신규 핵산 전달제, 이를 함유하는 조성물 및 용도
AU768542C (en) * 1998-04-08 2004-06-17 Celltech R & D Limited Lipids
GB9914045D0 (en) * 1999-06-16 1999-08-18 Smithkline Beecham Plc Novel compounds
GB9918670D0 (en) 1999-08-06 1999-10-13 Celltech Therapeutics Ltd Biological product
GB9919338D0 (en) * 1999-08-16 1999-10-20 Celltech Therapeutics Ltd Biological products
US20020091242A1 (en) 2000-10-11 2002-07-11 Michel Bessodes Acid-sensitive compounds, their preparation and uses
CA2441484A1 (en) * 2001-03-23 2002-10-03 Napro Biotherapeutics, Inc. Molecular conjugates for use in treatment of cancer
JP4276439B2 (ja) * 2001-05-14 2009-06-10 サントリオン ポリチオ尿素の脂質誘導体
FR2824557B1 (fr) * 2001-05-14 2003-08-29 Aventis Pharma Sa Derives lipidiques de polythiouree
AUPR621501A0 (en) 2001-07-06 2001-08-02 Commonwealth Scientific And Industrial Research Organisation Delivery of ds rna
FR2829136B1 (fr) 2001-08-29 2006-11-17 Aventis Pharma Sa Derives lipidiques d'aminoglycosides
JP4629333B2 (ja) * 2001-08-29 2011-02-09 アベンティス・ファーマ・ソシエテ・アノニム アミノグリコシドの脂質誘導体
EP1479985B1 (de) 2002-01-17 2017-06-14 Alfa Laval Corporate AB Getauchter Verdampfer umfassend einen Plattenwärmetauscher und ein zylindrisches Gehäuse in dem der Plattenwärmetauscher angeordnet ist
WO2003099225A2 (en) * 2002-05-24 2003-12-04 Mirus Corporation Compositions for delivering nucleic acids to cells
US20060211004A1 (en) 2005-02-15 2006-09-21 Ilsley Diane D Methods and compositions for determining non-specific cytotoxicity of a transfection agent
AU2006259415B2 (en) * 2005-06-15 2012-08-30 Massachusetts Institute Of Technology Amine-containing lipids and uses thereof
US20100035974A1 (en) * 2006-10-04 2010-02-11 Centre National De La Recherche Scientifique (Cnrs Compositions comprising a sirna and lipidic 4,5-disubstituted 2-deoxystreptamine ring aminoglycoside derivatives and uses thereof
WO2008137470A1 (en) * 2007-05-01 2008-11-13 Pgr-Solutions Multi-chain lipophilic polyamines
US8790664B2 (en) 2008-09-05 2014-07-29 Institut National De La Sante Et De La Recherche Medicale (Inserm) Multimodular assembly useful for intracellular delivery
MX353900B (es) 2008-11-07 2018-02-01 Massachusetts Inst Technology Lipidoides de aminoalcohol y usos de los mismos.
FR2941152B1 (fr) 2009-01-20 2013-10-18 Centre Nat Rech Scient Vecteurs comprenant une macromolecule anionique et un lipide cationique pour l'administration de petits acides nucleiques.
CN103380113B (zh) * 2010-11-15 2018-03-30 生命科技公司 含胺的转染试剂及其制备和使用方法
PL2691443T3 (pl) 2011-03-28 2021-08-30 Massachusetts Institute Of Technology Sprzężone lipomery i ich zastosowania
WO2013016058A1 (en) * 2011-07-22 2013-01-31 Merck Sharp & Dohme Corp. Novel bis-nitrogen containing cationic lipids for oligonucleotide delivery
WO2013051718A1 (ja) 2011-10-07 2013-04-11 国立大学法人三重大学 キメラ抗原受容体
CA3119789A1 (en) 2011-10-27 2013-05-02 Massachusetts Institute Of Technology Amino acid derivatives functionalized on the n-terminal capable of forming drug encapsulating microspheres
CZ303963B6 (cs) * 2012-01-13 2013-07-17 Ústav organické chemie a biochemie Akademie ved CR, v.v.i. Lipopolyaminy sperminového typu pro konstrukci liposomálních transfekcních systému
US9840479B2 (en) 2014-07-02 2017-12-12 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
JP6800410B2 (ja) 2015-06-19 2020-12-16 マサチューセッツ インスティテュート オブ テクノロジー アルケニル置換２，５−ピペラジンジオン、および、対象または細胞に剤を送達するための組成物におけるそれらの使用
WO2017024318A1 (en) 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses
US11052111B2 (en) 2015-12-08 2021-07-06 Chimera Bioengineering, Inc. Smart CAR devices and DE CAR polypeptides for treating disease and methods for enhancing immune responses
CN112481217A (zh) 2016-09-01 2021-03-12 嵌合体生物工程公司 Gold优化的car t-细胞
CN111386263A (zh) 2017-02-08 2020-07-07 达纳-法伯癌症研究所有限公司 调节嵌合抗原受体
EP3790896A1 (de) 2018-05-07 2021-03-17 Children's Hospital Medical Center Chimere polypeptide, nukleinsäuremoleküle, zellen und verwandte verfahren
WO2020213724A1 (ja) 2019-04-19 2020-10-22 中外製薬株式会社 抗体改変部位認識キメラ受容体
JPWO2020246563A1 (de) 2019-06-05 2020-12-10
CN116194124A (zh) 2020-07-31 2023-05-30 中外制药株式会社 包含表达嵌合受体的细胞的药物组合物
CA3212343A1 (en) 2021-03-17 2022-09-22 Kazunori YOSHIKIYO Gene encoding a chimeric receptor for an anti-acetylcholine receptor autoantibody
WO2022214887A1 (en) 2021-04-08 2022-10-13 Phosphogam, Llc Methods and compositions for enhancing the cytotoxicity of gamma/delta-t cells

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3211692A (en) * 1961-11-06 1965-10-12 Gulf Oil Corp Ethylene polymeric compositions containing substituted ureas
US3965015A (en) * 1972-08-01 1976-06-22 Colgate-Palmolive Company Bleach-resistant fabric softener
DE2355026A1 (de) * 1973-11-03 1975-05-15 Henkel & Cie Gmbh Neue omega-amino-carbonsaeureamide, deren herstellung, sowie verwendung als antimikrobielle mittel
FR2369837A1 (fr) * 1976-11-04 1978-06-02 Labaz Derives actifs de l'uree, leur procede de preparation ainsi que les compositions therapeutiques les contenant
JPS60123451A (ja) * 1983-12-07 1985-07-02 Eisai Co Ltd ポリプレニル系化合物およびその製造方法ならびにそれを含有する医薬
CA1280414C (en) * 1985-03-15 1991-02-19 Saichi Matsumoto Isoprenoidamine derivatives and antiulcer agents
US4828982A (en) * 1985-05-28 1989-05-09 Becton, Dickinson & Company Vesticles and use thereof in an enzyme assay
EP0233101A1 (de) * 1986-01-13 1987-08-19 Ire-Celltarg S.A. Vinblastin-Derivate und diese enthaltende Arzneimittel
JPS6480282A (en) * 1987-09-22 1989-03-27 Nippon Oils & Fats Co Ltd Nonaqueous highly active enzyme
DK523288A (da) * 1987-10-06 1989-04-07 Hoffmann La Roche Aminosyrederivater
JP2720167B2 (ja) * 1988-04-11 1998-02-25 日本ケミファ株式会社 アルキレンジアミン誘導体
FR2645866B1 (fr) 1989-04-17 1991-07-05 Centre Nat Rech Scient Nouvelles lipopolyamines, leur preparation et leur emploi
ES2066050T3 (es) * 1989-07-28 1995-03-01 Chemie Linz Gmbh Procedimiento para la obtencion de ureas asimetricamente substituidas, carbamatos, tiocarbamatos e isocianatos substituidos.
JP2620727B2 (ja) * 1990-10-26 1997-06-18 富士写真フイルム株式会社 ペプチド脂質
US5334761A (en) * 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
FR2714830B1 (fr) * 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition contenant des acides nucléiques, préparation et utilisations.
US5837533A (en) * 1994-09-28 1998-11-17 American Home Products Corporation Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations

Also Published As

Publication number Publication date
FR2741066B1 (fr) 1997-12-12
GR3034204T3 (en) 2000-11-30
AU718568B2 (en) 2000-04-13
MX9803761A (es) 1998-09-30
SK282173B6 (sk) 2001-11-06
AU7576896A (en) 1997-06-05
JP2000501383A (ja) 2000-02-08
US6171612B1 (en) 2001-01-09
KR19990067552A (ko) 1999-08-25
JP2009029790A (ja) 2009-02-12
PT861228E (pt) 2001-02-28
SI0861228T1 (en) 2000-12-31
JP4176831B2 (ja) 2008-11-05
EP0861228A1 (de) 1998-09-02
CA2235721C (fr) 2009-07-14
JP4999784B2 (ja) 2012-08-15
EP0861228B1 (de) 2000-08-23
NO981944L (no) 1998-04-29
SK63198A3 (en) 1998-11-04
HUP9900605A2 (hu) 1999-06-28
HUP9900605A3 (en) 1999-11-29
NO981944D0 (no) 1998-04-29
DE69609982T2 (de) 2001-01-25
DK0861228T3 (da) 2000-10-23
CA2235721A1 (fr) 1997-05-22
BR9611533A (pt) 1999-07-13
ATE195721T1 (de) 2000-09-15
CZ147398A3 (cs) 1998-08-12
IL124411A (en) 2001-09-13
WO1997018185A1 (fr) 1997-05-22
IL124411A0 (en) 1998-12-06
FR2741066A1 (fr) 1997-05-16
ZA969489B (en) 1997-06-02
ES2151185T3 (es) 2000-12-16

Similar Documents

Publication Publication Date Title
DE69609982D1 (de) Lipopolyamine als transfectionsmittel und ihre pharmazeutischen anwendungen
DK1033981T3 (da) Formuleringer og fremgangsmåder til nedsættelse af antineoplastiske midlers toksicitet
BR0208338A (pt) Derivados de piridina
TR200200785T2 (tr) 8-Fenil-6,9-dihidro-[1,2,4] triazolo [3,4-i] purin-5-on türevleri
DE69620877T2 (de) Arzneimittelformulierungen für il-12
ME00907B (me) Farmaceutske formulacije koje sadrže vorikonazol
NO962841D0 (no) Anvendelse av 2-hydroksy-5-fenylazobenzosyrederivater som colon cancer kjemopreventativer og kjemoterapeutiske midler
TR199802344A2 (xx) �kame edilmi� imidazolidin t�revleri
TR199801861T2 (xx) Farmas�tik olarak yararl� bile�imler.
BR9709845B1 (pt) preparaÇço aquosa de insulina, formulaÇço farmacÊutica parenteral, e, processso para aumentar a estabilidade quÍmica de uma preparaÇço de insulina.
IT1314185B1 (it) Composizione farmaceutica per somministrazione di sostanze attivescarsamente solubili in mezzi acquosi
ATE375359T1 (de) Aminosterolderivate und ihre verwendungen
ATE479657T1 (de) N-(aryl)-2-arylethensulfonamide und ihre therapeutischen anwendungen
MY120683A (en) New phenylamidine derivatives, processes for their preparation and their use as pharmaceuticals.
TR200000291T2 (tr) Taşikinin reseptör antagonistleri olarak 2-asilaminopropanaminler.
DE69624308D1 (de) Bernsteinsäurederivate als abbaubare Chelatbildner, ihre Verwendungen und Zusammensetzungen
RS49772B (sr) Farmaceutske kompozicije
DE69602886T2 (de) Im kardiovaskulären System aktive seco-D-Steroide und diese enthaltende pharmazeutische Zubereitungen
PT1017681E (pt) Derivados de hidrazono-benzazuleno composicoes farmaceuticas e intermediarios
BR9814188A (pt) "agonistas de 5-ht1f"
TR200100801T2 (tr) Benzoilguanidin türevleri, imalatlarına yönelik yöntemler, ilaç yapımında kullanımı
BR0308201A (pt) Derivados de quinolina
ATE204286T1 (de) Modifizierte alpha-d-glcp-(1,2)-alpha-d-glcp-(1, 3)-alpha-d-glcp-analoge
DK1105388T3 (da) N-substituerede azabicycloheptan-derivater, fremstilling og anvendelse heraf

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC