FR2829136B1 - Derives lipidiques d'aminoglycosides - Google Patents

Derives lipidiques d'aminoglycosides

Info

Publication number
FR2829136B1
FR2829136B1 FR0111199A FR0111199A FR2829136B1 FR 2829136 B1 FR2829136 B1 FR 2829136B1 FR 0111199 A FR0111199 A FR 0111199A FR 0111199 A FR0111199 A FR 0111199A FR 2829136 B1 FR2829136 B1 FR 2829136B1
Authority
FR
France
Prior art keywords
aminoglycosides
lipid derivatives
lipid
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR0111199A
Other languages
English (en)
Other versions
FR2829136A1 (fr
Inventor
Jean Marie Lehn
Pierre Lehn
Jean Pierre Vigneron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to FR0111199A priority Critical patent/FR2829136B1/fr
Priority to US10/228,959 priority patent/US7772003B2/en
Priority to PCT/FR2002/002959 priority patent/WO2003018603A1/fr
Priority to AT02796324T priority patent/ATE430758T1/de
Priority to JP2003523262A priority patent/JP4629333B2/ja
Priority to EP02796324A priority patent/EP1430074B1/fr
Priority to DE60232258T priority patent/DE60232258D1/de
Priority to AU2002334051A priority patent/AU2002334051B2/en
Priority to CA2458626A priority patent/CA2458626C/fr
Publication of FR2829136A1 publication Critical patent/FR2829136A1/fr
Application granted granted Critical
Publication of FR2829136B1 publication Critical patent/FR2829136B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR0111199A 2001-08-29 2001-08-29 Derives lipidiques d'aminoglycosides Expired - Lifetime FR2829136B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR0111199A FR2829136B1 (fr) 2001-08-29 2001-08-29 Derives lipidiques d'aminoglycosides
US10/228,959 US7772003B2 (en) 2001-08-29 2002-08-28 Lipid derivatives of aminoglycosides
AT02796324T ATE430758T1 (de) 2001-08-29 2002-08-29 Lipid-aminoglykosid konjugate zur transfektion
JP2003523262A JP4629333B2 (ja) 2001-08-29 2002-08-29 アミノグリコシドの脂質誘導体
PCT/FR2002/002959 WO2003018603A1 (fr) 2001-08-29 2002-08-29 Derives lipidiques d'aminoglycosides_pour la transfection
EP02796324A EP1430074B1 (fr) 2001-08-29 2002-08-29 Derives lipidiques d'aminoglycosides-pour la transfection
DE60232258T DE60232258D1 (de) 2001-08-29 2002-08-29 Lipid-aminoglykosid konjugate zur transfektion
AU2002334051A AU2002334051B2 (en) 2001-08-29 2002-08-29 Aminoglycoside lipid derivatives for transfection
CA2458626A CA2458626C (fr) 2001-08-29 2002-08-29 Derives lipidiques d'aminoglycosides pour la transfection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0111199A FR2829136B1 (fr) 2001-08-29 2001-08-29 Derives lipidiques d'aminoglycosides

Publications (2)

Publication Number Publication Date
FR2829136A1 FR2829136A1 (fr) 2003-03-07
FR2829136B1 true FR2829136B1 (fr) 2006-11-17

Family

ID=8866791

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0111199A Expired - Lifetime FR2829136B1 (fr) 2001-08-29 2001-08-29 Derives lipidiques d'aminoglycosides

Country Status (2)

Country Link
US (1) US7772003B2 (fr)
FR (1) FR2829136B1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006125165A2 (fr) * 2005-05-19 2006-11-23 Clemson University Methodes et compositions pour faciliter l'entree de composes dans des cellules
WO2008040792A2 (fr) 2006-10-04 2008-04-10 Centre National De La Recherche Scientifique (Cnrs) COMPOSITIONS INCLUANT UN siARN ET DES DÉRIVÉS LIPIDIQUES D'AMINOGLYCOSIDE À NOYAU 2-DÉSOXYSTREPTAMINE 4,5-DISUBSTITUÉE ET LEURS UTILISATIONS
WO2010004433A2 (fr) * 2008-07-09 2010-01-14 University Of Manitoba Aminoglycosides améliorés au plan de l'hydrophobicité
US20130053337A1 (en) * 2010-03-05 2013-02-28 University Of Manitoba Guanidinylated aminoglycoside-lipid conjugates

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3293128A (en) * 1961-11-24 1966-12-20 Lilly Co Eli Anthelmintic hygromycin b derivatives and process of using same
BE758942A (fr) * 1969-11-15 1971-04-16 Abbou Richard Medicament pour le traitement d'affections infectieuses et/ou inflammatoires
US4400375A (en) * 1981-11-23 1983-08-23 Eli Lilly And Company Tobramycin-double stranded RNA complex suitable for inducing interferon
DE3486053T3 (de) 1983-10-20 2004-01-08 The Research Foundation Of State University Of New York Regulierung von Gen-Expression durch Translationshemmung unter Verwendung von m-RNS hinderndem Komplementär-RNS.
US6696420B1 (en) * 1984-11-20 2004-02-24 Institut Pasteur Adenoviral vector with a deletion in the E1A coding region expressing a hetorologous protein
FR2573436B1 (fr) 1984-11-20 1989-02-17 Pasteur Institut Adn recombinant comportant une sequence nucleotidique codant pour un polypeptide determine sous le controle d'un promoteur d'adenovirus, vecteurs contenant cet adn recombinant, cellules eucaryotes transformees par cet adn recombinant, produits d'excretion de ces cellules transformees et leurs applications, notamment a la constitution de vaccins
FR2602790B1 (fr) 1986-08-13 1990-06-01 Transgene Sa Expression d'un antigene specifique de tumeur par un virus vecteur recombinant et utilisation de celui-ci pour le traitement preventif ou curatif de la tumeur correspondante
US5744133A (en) * 1986-08-13 1998-04-28 Transgene S.A. Expression of a tumor-specific antigen by a recombinant vector virus and use thereof in preventitive or curative treatment of the corresponding tumor
AR243935A1 (es) 1987-12-15 1993-09-30 Gene Shears Pty Ltd Compuesto oligonucleotidico de aplicacion biologica en plantas y excluyendo su uso farmaceutico, metodo para prepararlo y composicion que lo comprende.
US5543389A (en) * 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization Covalent polar lipid-peptide conjugates for use in salves
US6743623B2 (en) 1991-09-27 2004-06-01 Centre National De La Recherche Scientifique Viral recombinant vectors for expression in muscle cells
FR2681786A1 (fr) 1991-09-27 1993-04-02 Centre Nat Rech Scient Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires.
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
FR2704234B1 (fr) 1993-04-22 1995-07-21 Centre Nat Rech Scient Virus recombinants, preparation et utilisation en therapie genique.
FR2704556B1 (fr) * 1993-04-30 1995-07-13 Rhone Poulenc Rorer Sa Virus recombinants et leur utilisation en thérapie génique.
US6015686A (en) * 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
AU4923696A (en) * 1995-02-10 1996-08-27 Nexstar Pharmaceuticals, Inc. Lipid constructs for cytoplasmic delivery of agents
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
FR2739292B1 (fr) 1995-09-28 1997-10-31 Rhone Poulenc Rorer Sa Composition pharmaceutique utile pour la transfection d'acides nucleiques et ses utilisations
FR2741066B1 (fr) 1995-11-14 1997-12-12 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
HU228072B1 (en) 1996-03-01 2012-09-28 Centre Nat Rech Scient New cholesterol amidinium derivatives, pharmaceutical compositions containing same, and uses thereof
ES2392246T3 (es) * 1996-11-12 2012-12-07 The Regents Of The University Of California Preparación de formulaciones estables de complejos de lípido-ácido nucleico para el suministro eficaz in vivo
FR2764304B1 (fr) * 1997-06-06 1999-07-16 Rhone Poulenc Rorer Sa Nouvelle classe d'agents transfectants cationiques des acides nucleiques
WO1999012945A2 (fr) * 1997-09-08 1999-03-18 Valentis,Inc. Derives de glycosylamine hydrophobes, compositions a base de ces derives et procedes d'utilisation
IL127773A0 (en) * 1998-12-28 1999-10-28 Yeda Res & Dev Saccharide conjugates and pharmaceutical compositions comprising them
AU2600100A (en) * 1999-01-05 2000-07-24 Valentis, Inc. Methods and compositions for delivering nucleic acids
GB9930533D0 (en) * 1999-12-23 2000-02-16 Mitsubishi Tokyo Pharm Inc Nucleic acid delivery

Also Published As

Publication number Publication date
US20030054556A1 (en) 2003-03-20
US7772003B2 (en) 2010-08-10
FR2829136A1 (fr) 2003-03-07

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