DE69530374D1 - Blutbildendes fusionprotein mit il-3 varianten - Google Patents

Blutbildendes fusionprotein mit il-3 varianten

Info

Publication number
DE69530374D1
DE69530374D1 DE69530374T DE69530374T DE69530374D1 DE 69530374 D1 DE69530374 D1 DE 69530374D1 DE 69530374 T DE69530374 T DE 69530374T DE 69530374 T DE69530374 T DE 69530374T DE 69530374 D1 DE69530374 D1 DE 69530374D1
Authority
DE
Germany
Prior art keywords
variants
blooding
fusion protein
hil
variant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69530374T
Other languages
English (en)
Other versions
DE69530374T2 (de
Inventor
Christopher S Bauer
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Barbara Kure Klein
Kearn John Patrick Mc
Peter O Olins
Kumnan Paik
John Warren Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE69530374D1 publication Critical patent/DE69530374D1/de
Publication of DE69530374T2 publication Critical patent/DE69530374T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin
DE69530374T 1994-02-04 1995-01-25 Blutbildendes fusionprotein mit il-3 varianten Expired - Fee Related DE69530374T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/192,299 US5738849A (en) 1992-11-24 1994-02-04 Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
PCT/US1995/000549 WO1995021197A1 (en) 1994-02-04 1995-01-25 Il-3 variant hematopoiesis fusion protein

Publications (2)

Publication Number Publication Date
DE69530374D1 true DE69530374D1 (de) 2003-05-22
DE69530374T2 DE69530374T2 (de) 2003-12-18

Family

ID=22709107

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69530374T Expired - Fee Related DE69530374T2 (de) 1994-02-04 1995-01-25 Blutbildendes fusionprotein mit il-3 varianten

Country Status (13)

Country Link
US (4) US5738849A (de)
EP (2) EP0742796B1 (de)
JP (1) JPH09508524A (de)
AT (1) ATE237641T1 (de)
AU (1) AU700220B2 (de)
CA (1) CA2182483C (de)
DE (1) DE69530374T2 (de)
DK (1) DK0742796T3 (de)
ES (1) ES2197191T3 (de)
HK (1) HK1013655A1 (de)
NZ (1) NZ279624A (de)
PT (1) PT742796E (de)
WO (1) WO1995021197A1 (de)

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KR100456212B1 (ko) * 1995-10-05 2005-01-15 지.디. 썰 엘엘씨 다기능성조혈수용체아고니스트
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US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
IL129565A0 (en) * 1996-10-25 2000-02-29 Searle & Co Multi-functional chimeric hematopoietic receptor agonists
AU721196B2 (en) * 1996-10-25 2000-06-29 G.D. Searle & Co. Circularly permuted erythropoietin receptor agonists
US6165476A (en) * 1997-07-10 2000-12-26 Beth Israel Deaconess Medical Center Fusion proteins with an immunoglobulin hinge region linker
DE69824039T2 (de) 1997-12-08 2005-08-18 Lexigen Pharmaceuticals Corp., Lexington Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung
US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
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US7067110B1 (en) 1999-07-21 2006-06-27 Emd Lexigen Research Center Corp. Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
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WO2001027621A2 (en) * 1999-10-07 2001-04-19 Pharmacia Corporation Competitive inhibition elisa for antibody detection
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US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
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AU2001289307A1 (en) * 2000-04-06 2001-10-23 Pharmacia Corporation Chemically-modified myelopoietin conjugates
EP1268794A2 (de) * 2000-04-07 2003-01-02 Heska Corporation Zusammensetzungen und verfahren die an igg aus dem hund und il-13 rezeptoren aus dem hund relatiert sind
DE60129695T2 (de) * 2000-06-29 2008-06-05 Merck Patent Gmbh Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme
US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
RU2003109746A (ru) * 2000-09-08 2005-01-27 Грифон Терапьютикс, Инк. (Us) Синтетические белки, стимулирующие эритропоэз
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US6992174B2 (en) * 2001-03-30 2006-01-31 Emd Lexigen Research Center Corp. Reducing the immunogenicity of fusion proteins
DE60239454D1 (de) * 2001-05-03 2011-04-28 Merck Patent Gmbh Rekombinanter, tumorspezifischer antikörper und dessen verwendung
NZ530545A (en) * 2001-07-11 2006-10-27 Maxygen Holdings Ltd Specific conjugates comprising a polypeptide exhibiting G-CSF activity and a non-polypeptide moiety
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US7048922B2 (en) * 2002-05-29 2006-05-23 Demao Yang Stimulation of hematopoiesis by ex vivo activated immune cells
US7332158B2 (en) * 2002-05-29 2008-02-19 Demao Yang Compositions and treatments for myelosuppression by ex vivo activated immune cells
JP4494977B2 (ja) * 2002-12-17 2010-06-30 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｇｄ２に結合するマウス１４．１８抗体のヒト化抗体（ｈ１４．１８）およびそのｉｌ−２融合タンパク質
EP1702069A2 (de) * 2004-01-05 2006-09-20 EMD Lexigen Research Center Corp. Auf onkofötales fibronectin gerichtetes interleukin-12
WO2006005360A1 (en) * 2004-07-12 2006-01-19 Sorin Group Italia S.R.L. Devices and methods for growing human cells
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
BRPI0611221A2 (pt) 2005-06-01 2010-08-24 Maxygen Holdings Ltd polipeptÍdeos de g-csf peguilados e mÉtodos de produÇço dos mesmos
KR101435420B1 (ko) * 2005-08-02 2014-09-25 플래닛 바이오테크놀로지, 인코포레이티드 개선된 키메라 독소 수용체 단백질 및 탄저병의 예방 및치료를 위한 키메라 독소 수용체 단백질
PT1966238E (pt) 2005-12-30 2012-07-31 Merck Patent Gmbh Uso de hsp70 como um regulador de atividade enzimática
WO2008036374A2 (en) * 2006-09-21 2008-03-27 Medistem Laboratories, Inc. Allogeneic stem cell transplants in non-conditioned recipients
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Also Published As

Publication number Publication date
DE69530374T2 (de) 2003-12-18
JPH09508524A (ja) 1997-09-02
ES2197191T3 (es) 2004-01-01
US5738849A (en) 1998-04-14
PT742796E (pt) 2003-08-29
EP1323737A3 (de) 2003-10-15
DK0742796T3 (da) 2003-08-11
EP0742796A1 (de) 1996-11-20
US6074639A (en) 2000-06-13
AU1680595A (en) 1995-08-21
EP1323737A2 (de) 2003-07-02
NZ279624A (en) 1998-05-27
EP0742796B1 (de) 2003-04-16
ATE237641T1 (de) 2003-05-15
CA2182483A1 (en) 1995-08-10
HK1013655A1 (en) 1999-09-03
CA2182483C (en) 2002-04-02
AU700220B2 (en) 1998-12-24
US5858347A (en) 1999-01-12
US6132991A (en) 2000-10-17
WO1995021197A1 (en) 1995-08-10

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee