DK0742720T3 - Co-indgivelse af interleukin-3-mutantpolypeptider med CSF'er til produktion af hæmatopoietiske celler med multi-afstamning - Google Patents

Co-indgivelse af interleukin-3-mutantpolypeptider med CSF'er til produktion af hæmatopoietiske celler med multi-afstamning

Info

Publication number
DK0742720T3
DK0742720T3 DK95911589T DK95911589T DK0742720T3 DK 0742720 T3 DK0742720 T3 DK 0742720T3 DK 95911589 T DK95911589 T DK 95911589T DK 95911589 T DK95911589 T DK 95911589T DK 0742720 T3 DK0742720 T3 DK 0742720T3
Authority
DK
Denmark
Prior art keywords
interleukin
csfs
administration
hematopoietic cells
mutant polypeptides
Prior art date
Application number
DK95911589T
Other languages
English (en)
Inventor
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Kumnan Paik
Mark Allen Abrams
Barbara Kure Klein
Christopher S Bauer
John Patrick Mckearn
Peter O Olins
John Warren Thomas
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0742720T3 publication Critical patent/DK0742720T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK95911589T 1994-02-04 1995-02-02 Co-indgivelse af interleukin-3-mutantpolypeptider med CSF'er til produktion af hæmatopoietiske celler med multi-afstamning DK0742720T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/193,373 US6153183A (en) 1992-11-24 1994-02-04 Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
PCT/US1995/001184 WO1995020977A1 (en) 1994-02-04 1995-02-02 Co-administration of interleukin-3 mutant polypeptides with csf's for multi-lineage hematopoietic cell production

Publications (1)

Publication Number Publication Date
DK0742720T3 true DK0742720T3 (da) 2003-08-25

Family

ID=22713377

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95911589T DK0742720T3 (da) 1994-02-04 1995-02-02 Co-indgivelse af interleukin-3-mutantpolypeptider med CSF'er til produktion af hæmatopoietiske celler med multi-afstamning

Country Status (10)

Country Link
US (4) US6153183A (da)
EP (1) EP0742720B1 (da)
AT (1) ATE239496T1 (da)
AU (1) AU1909995A (da)
CA (1) CA2182474A1 (da)
DE (1) DE69530676T2 (da)
DK (1) DK0742720T3 (da)
ES (1) ES2199242T3 (da)
PT (1) PT742720E (da)
WO (1) WO1995020977A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) * 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
WO1999041382A2 (en) * 1998-02-17 1999-08-19 Hyseq, Inc. A novel interleukin-3 and uses thereof
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
JP4444652B2 (ja) 2001-07-11 2010-03-31 マキシゲン・ホールディングズ・リミテッド Ｇ−ｃｓｆ結合体
US20050054054A1 (en) * 2002-11-12 2005-03-10 Foss Francine M. Interleukin-7 molecules with altered biological properties
CN1993460A (zh) * 2004-07-12 2007-07-04 索林集团意大利有限公司 用于培养人细胞的装置和方法
JP5137821B2 (ja) 2005-06-01 2013-02-06 マキシジェン， インコーポレイテッド Ｐｅｇ化されたｇ−ｃｓｆポリペプチドおよびその製造方法
US8226162B2 (en) * 2009-09-11 2012-07-24 Campbell Corey A Child safety seat

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WO1993007171A1 (en) * 1991-10-07 1993-04-15 Medvet Science Pty. Ltd. Human il-3 variants
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
EP0188479B1 (en) * 1984-07-06 1991-09-11 Sandoz Ag Lymphokine production and purification
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (ja) * 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5032395A (en) * 1986-07-14 1991-07-16 Genetics Institute, Inc. Method of inducing leukocytosis with a combination of IL-3 and GM-CSF
US4959455A (en) * 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
GR871029B (en) 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors
US4877729A (en) * 1986-07-14 1989-10-31 Genetics Institute, Inc. Recombinant DNA encoding novel family of primate hematopoietic growth factors
EP0790307A1 (en) * 1986-12-16 1997-08-20 Gist-Brocades B.V. Molecular cloning and expression of human IL-3
WO1988005469A1 (en) * 1987-01-20 1988-07-28 Immunex Corporation Human interleukin-3 proteins
WO1988006116A1 (en) * 1987-02-12 1988-08-25 Peter Herbrig Bathing platform for boats
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".
AU3864089A (en) * 1988-07-20 1990-02-19 Immunex Corporation Nonglycosylated human interleukin-3 compositions
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
US5166322A (en) 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5128450A (en) * 1989-06-30 1992-07-07 Urdal David L Nonglycosylated human interleukin-3 analog proteins
US5516512A (en) * 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
DE69030937T2 (de) * 1989-08-14 1997-10-09 Gist Brocades Nv Mutanten von Interleukin-3
IL96477A0 (en) * 1989-12-01 1991-08-16 Amgen Inc Megakaryocyte production
JPH0463595A (ja) * 1990-04-03 1992-02-28 Kirin Brewery Co Ltd ヒトインターロイキン３誘導体
EP0503050A4 (en) 1990-09-28 1994-07-06 Ortho Pharma Corp Hybrid growth factors
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
DE69332908T2 (de) * 1992-11-24 2003-12-24 G.D. Searle & Co., Chicago Interleukin-3 (il-3)-polypeptide mith mehreren mutationen
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same

Also Published As

Publication number Publication date
EP0742720A1 (en) 1996-11-20
CA2182474A1 (en) 1995-08-10
US6093395A (en) 2000-07-25
WO1995020977A1 (en) 1995-08-10
US6060047A (en) 2000-05-09
ATE239496T1 (de) 2003-05-15
DE69530676T2 (de) 2004-03-18
US6379662B1 (en) 2002-04-30
EP0742720B1 (en) 2003-05-07
US6153183A (en) 2000-11-28
ES2199242T3 (es) 2004-02-16
AU1909995A (en) 1995-08-21
DE69530676D1 (de) 2003-06-12
PT742720E (pt) 2003-09-30

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