MX9603205A - Proteina de fusion de hematopoyesis de il-3, multivariante. - Google Patents

Proteina de fusion de hematopoyesis de il-3, multivariante.

Info

Publication number
MX9603205A
MX9603205A MX9603205A MX9603205A MX9603205A MX 9603205 A MX9603205 A MX 9603205A MX 9603205 A MX9603205 A MX 9603205A MX 9603205 A MX9603205 A MX 9603205A MX 9603205 A MX9603205 A MX 9603205A
Authority
MX
Mexico
Prior art keywords
multivariant
hematopoiesis
fusion protein
muteins
lymphokines
Prior art date
Application number
MX9603205A
Other languages
English (en)
Inventor
S Bauer Christopher
Mark Allen Abrams
Sarah Ruth Braford Goldberg
Marie Helena Caparon
Alan Michael Easton
Barbara Kure Klein
John Patrick Mc Kearn
Peter O Olins
Kumnan Paik
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of MX9603205A publication Critical patent/MX9603205A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La presente invencion se refiere a una variante de interleuquina-3 humana (hIL-3) o proteínas mutantes (muteinas) fundidas con otros factores estimuladores de colonia (FEC). Citoquinas, linfoquinas, interleuquinas, factores de desarrollo hematopoyetico o variantes de IL-3.
MX9603205A 1994-02-04 1995-02-02 Proteina de fusion de hematopoyesis de il-3, multivariante. MX9603205A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/192,325 US6057133A (en) 1992-11-24 1994-02-04 Multivariant human IL-3 fusion proteins and their recombinant production
PCT/US1995/001185 WO1995021254A1 (en) 1994-02-04 1995-02-02 Multivariant il-3 hematopoiesis fusion protein

Publications (1)

Publication Number Publication Date
MX9603205A true MX9603205A (es) 1997-03-29

Family

ID=22709185

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9603205A MX9603205A (es) 1994-02-04 1995-02-02 Proteina de fusion de hematopoyesis de il-3, multivariante.

Country Status (17)

Country Link
US (3) US6057133A (es)
EP (2) EP0742826B1 (es)
JP (1) JPH10502801A (es)
KR (1) KR100370264B1 (es)
CN (1) CN1227604A (es)
AT (1) ATE302275T1 (es)
BR (1) BR9506733A (es)
CA (1) CA2182484A1 (es)
CZ (1) CZ289904B6 (es)
DE (1) DE69534381T2 (es)
FI (1) FI963072A0 (es)
MX (1) MX9603205A (es)
NO (1) NO963225L (es)
NZ (2) NZ330060A (es)
PL (1) PL315791A1 (es)
RO (1) RO118016B1 (es)
WO (1) WO1995021254A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
JPH11500308A (ja) * 1995-02-03 1999-01-12 ジー．ディー．サール アンド カンパニー 新規ｃ−ＭＰＬリガンド
CA2234045A1 (en) * 1995-10-05 1997-04-10 G.D. Searle & Co. Interleuken-3 (il-3) receptor agonists
EP0854928A2 (en) * 1995-10-05 1998-07-29 G.D. Searle & Co. Multi-functional hematopoietic receptor agonists
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
WO1997023639A1 (fr) * 1995-12-22 1997-07-03 Toray Industries, Inc. Procede de production de proteines fusionnees biologiquement actives
AU725547B2 (en) * 1996-10-25 2000-10-12 G.D. Searle & Co. Multi-functional chimeric hematopoietic receptor agonists
US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
DE19900743A1 (de) * 1999-01-12 2000-07-13 Aventis Pharma Gmbh Neue komplexbildende Proteine
WO2001025277A1 (en) * 1999-10-07 2001-04-12 Maxygen Aps Single-chain antagonist polypeptides
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
WO2001076639A2 (en) * 2000-04-06 2001-10-18 Pharmacia Corporation Chemically-modified myelopoietin conjugates
US7572436B1 (en) 2000-09-11 2009-08-11 Therapro Technologies, Inc. Thionin as an antineoplastic and immunostimulant
PL371781A1 (en) 2001-07-11 2005-06-27 Maxygen Holdings, Ltd. G-csf conjugates
ES2542888T3 (es) 2001-08-24 2015-08-12 Uvic Industry Partnerships Inc. Proaerolisina que contiene secuencias de activación de proteasa y métodos de uso para el tratamiento del cáncer de próstata
EP1450786B1 (de) * 2002-06-29 2005-12-14 AQUANOVA German Solubilisate Technologies (AGT) GmbH Isoflavonkonzentrate sowie verfahren zu ihrer herstellung
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US7166574B2 (en) * 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US7414028B1 (en) 2004-02-04 2008-08-19 Biosurface Engineering Technologies, Inc. Growth factor analogs
US20060024347A1 (en) * 2004-02-10 2006-02-02 Biosurface Engineering Technologies, Inc. Bioactive peptide coatings
US7671012B2 (en) 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
US7528105B1 (en) 2004-02-10 2009-05-05 Biosurface Engineering Technologies Heterodimeric chain synthetic heparin-binding growth factor analogs
JP4895826B2 (ja) * 2004-02-20 2012-03-14 バイオサーフェス エンジニアリング テクノロジーズ，インク． 骨形成蛋白−２の正のモジュレーター
CN1993460A (zh) * 2004-07-12 2007-07-04 索林集团意大利有限公司 用于培养人细胞的装置和方法
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
US7381805B2 (en) 2005-06-01 2008-06-03 Maxygen Holdings, Ltd. Compositions comprising mixtures of positional PEG isomers of PEGylated G-CSF
US20090016988A1 (en) 2005-11-21 2009-01-15 Buckley J Thomas Modified Pore-Forming Protein Toxins and Use Thereof
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
EP2046350A4 (en) 2006-06-22 2011-09-14 Biosurface Eng Tech Inc COMPOSITIONS AND METHOD FOR THE RELEASE OF A BMP-2 AMPLIFIER / COACTIVATOR FOR REINFORCED OSTEOGENESIS
CN101139399B (zh) * 2007-08-13 2011-01-26 重庆医科大学附属第二医院 重组靶向杀伤白血病细胞的融合蛋白及其制备方法和用途
WO2011046832A2 (en) 2009-10-12 2011-04-21 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Granulysin in immunotherapy
MX2012010148A (es) 2010-03-04 2013-01-22 Pfenex Inc Metodo para producir proteinas de interferon recombinantes solubles sin desnaturalizacion.
WO2011123570A2 (en) 2010-04-01 2011-10-06 Pfenex Inc. Methods for g-csf production in a pseudomonas host cell
AU2011377617B2 (en) 2011-09-23 2018-03-08 Bluebird Bio, Inc. Improved gene therapy methods
AU2018347796A1 (en) 2017-10-10 2020-05-07 Medicenna Therapeutics, Inc. IL-4-fusion formulations for treatment of central nervous system (CNS) tumors
CN112513276B (zh) 2018-07-30 2024-03-15 张晋宇 蛋白质异二聚体及其用途

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591427A (en) * 1979-10-07 1997-01-07 Medvet Science Pty. Ltd. Human Interleukin-3(Il-3) variants and their use to promote or antagonize IL-3-mediated processes
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
NZ228031A (en) * 1984-07-06 1991-12-23 Sandoz Ltd Primate gm-csf and method of extraction
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (ja) * 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ
US5032395A (en) * 1986-07-14 1991-07-16 Genetics Institute, Inc. Method of inducing leukocytosis with a combination of IL-3 and GM-CSF
US4959455A (en) * 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US4877729A (en) * 1986-07-14 1989-10-31 Genetics Institute, Inc. Recombinant DNA encoding novel family of primate hematopoietic growth factors
EP0790307A1 (en) * 1986-12-16 1997-08-20 Gist-Brocades B.V. Molecular cloning and expression of human IL-3
EP0342206A4 (en) * 1987-01-20 1990-09-19 Immunex Corporation Human interleukin-3 proteins
AU3864089A (en) * 1988-07-20 1990-02-19 Immunex Corporation Nonglycosylated human interleukin-3 compositions
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
DE69030937T2 (de) * 1989-08-14 1997-10-09 Gist Brocades Nv Mutanten von Interleukin-3
US5516512A (en) * 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
US5073627A (en) * 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
US5108910A (en) * 1989-08-22 1992-04-28 Immunex Corporation DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
EP0489116B1 (en) * 1989-08-22 1994-04-06 Immunex Corporation Fusion proteins comprising gm-csf and il-3
DE3939703C2 (de) * 1989-12-01 1998-07-02 Boehringer Ingelheim Kg Verbesserte transdermale Applikation von pharmakologisch aktiven Verbindungen
JPH0463595A (ja) * 1990-04-03 1992-02-28 Kirin Brewery Co Ltd ヒトインターロイキン３誘導体
ATE167896T1 (de) * 1990-08-29 1998-07-15 Genetics Inst Aus mehreren domänen bestehende hämatopoese- stimulatoren
AU8735991A (en) * 1990-09-28 1992-04-28 Ortho Pharmaceutical Corporation Hybrid growth factors
DE4030850A1 (de) * 1990-09-29 1992-04-02 Henkel Kgaa Bleichmittelzubereitung
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
JPH08503489A (ja) * 1992-11-24 1996-04-16 ジー．ディー．サール アンド カンパニー インターロイキン−３（ｉｌ−３）突然変異ポリペプチド
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same

Also Published As

Publication number Publication date
AU1835695A (en) 1995-08-21
CZ229896A3 (en) 1996-12-11
NZ330060A (en) 1999-11-29
EP1482044A2 (en) 2004-12-01
EP0742826A1 (en) 1996-11-20
ATE302275T1 (de) 2005-09-15
DE69534381T2 (de) 2006-11-23
KR100370264B1 (ko) 2003-05-09
AU697433B2 (en) 1998-10-08
NO963225D0 (no) 1996-08-01
CN1227604A (zh) 1999-09-01
US6057133A (en) 2000-05-02
US6030812A (en) 2000-02-29
CZ289904B6 (cs) 2002-04-17
BR9506733A (pt) 1997-09-23
DE69534381D1 (de) 2005-09-22
NO963225L (no) 1996-09-25
RO118016B1 (ro) 2002-12-30
PL315791A1 (en) 1996-12-09
CA2182484A1 (en) 1995-08-10
JPH10502801A (ja) 1998-03-17
NZ281421A (en) 1998-05-27
FI963072A (fi) 1996-08-02
KR970700766A (ko) 1997-02-12
FI963072A0 (fi) 1996-08-02
US6022535A (en) 2000-02-08
EP1482044A3 (en) 2005-05-18
EP0742826B1 (en) 2005-08-17
WO1995021254A1 (en) 1995-08-10

Similar Documents

Publication Publication Date Title
MX9603205A (es) Proteina de fusion de hematopoyesis de il-3, multivariante.
ES2180624T3 (es) Co-administracion de mutantes de interleuquina-3 con factores estimulantes de colonias.
HK1013655A1 (en) Il-3 variant hematopoiesis fusion protein
AU7087891A (en) Modified hil-6
WO1988003173A3 (en) New forms of colony stimulating factor-1
AU635296B2 (en) Human gp130 protein
EE200100223A (et) Interferoon-beetaga sulandatud valgud ja nende kasutamine
FI864016A (fi) Med rekombinant-dna-teknik erhaollen kolonistimulerande faktor-1.
AU7169481A (en) Unglycosylated interferon
IT8421436A1 (it) Un plasmide ricombinante, un microorganismo trasformante, un segmento di polideossiribonucleotide, un procedimento per produrre una proteina biologicamente attiva e la proteina così prodotta
AU637139B2 (en) Gm-csf protein, its derivatives, the preparation of proteins of this type, and their use
EP0810285A3 (en) Mutants of human Interleukin-3
AU1909995A (en) Co-administration of interleukin-3 mutant polypeptides with csf's for multi-lineage hematopoietic cell production
MX9702341A (es) Citoquina designada lerk-6.
ES2012283A6 (es) Procedimiento de obtencion de una proteina de endotoxina de efecto insecticida.
EP0669933A4 (en) CLEANING FUSION PROTEINS CONTAINING GM-CSF AND IL-3.
ATE291629T1 (de) Expressionssystem für die sekretion von bioaktivem, menschlichem granulozyt-makrophagem koloniestimulierungsfaktor (gm-csf) und anderen heterologen proteinen aus streptomyces
AU571460B2 (en) Alpha interferon dna, recombinant plasmid, engineered organism and alpha interferon polypeptide
MY134493A (en) Thrombopoietin peptides, fragments, nucleic acids encoding the same, and method
MY114223A (en) Fusion proteins comprising gm-csf and il-3
MX9702475A (es) Analogos del factor de crecimiento acido de fibroblasto que tienen estabilidad y acticidad biologica mejoradas.

Legal Events

Date Code Title Description
FG Grant or registration
MM Annulment or lapse due to non-payment of fees