MX9702475A - Analogos del factor de crecimiento acido de fibroblasto que tienen estabilidad y acticidad biologica mejoradas. - Google Patents

Analogos del factor de crecimiento acido de fibroblasto que tienen estabilidad y acticidad biologica mejoradas.

Info

Publication number
MX9702475A
MX9702475A MX9702475A MX9702475A MX9702475A MX 9702475 A MX9702475 A MX 9702475A MX 9702475 A MX9702475 A MX 9702475A MX 9702475 A MX9702475 A MX 9702475A MX 9702475 A MX9702475 A MX 9702475A
Authority
MX
Mexico
Prior art keywords
analogs
enhanced stability
growth factor
biological activity
fibroblast growth
Prior art date
Application number
MX9702475A
Other languages
English (en)
Other versions
MXPA97002475A (es
Inventor
Tsutomu Arakawa
Gary Michael Fox
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX9702475A publication Critical patent/MX9702475A/es
Publication of MXPA97002475A publication Critical patent/MXPA97002475A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invencion describe análogos de proteínas en la familia de FGF. Estos análogos son más estables que las proteínas correspondientes que existen naturalmente. Las estabilidad mejorada puede ser lograda substituyendo al menos un amino ácido que tiene un potencial de formacion de bucle más alto por un residuo de amino ácido que tiene un menor potencial de formacion de bucle en la region de formacion de bucle identificada en la secuencia de amino ácidos de la proteína. Los análogos de la presente invencion son especialmente utiles en aplicaciones terapéuticas.
MXPA/A/1997/002475A 1994-10-13 1997-04-04 Analogos del factor de crecimiento acido de fibroblasto que tienen estabilidad y acticidad biologica mejoradas MXPA97002475A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32347394A 1994-10-13 1994-10-13
US323473 1994-10-13
PCT/US1995/012907 WO1996022369A1 (en) 1994-10-13 1995-10-12 Analogs of acidic fibroblast growth factor having enhanced stability and biological activity

Publications (2)

Publication Number Publication Date
MX9702475A true MX9702475A (es) 1997-07-31
MXPA97002475A MXPA97002475A (es) 1997-12-01

Family

ID=

Also Published As

Publication number Publication date
CA2201944A1 (en) 1996-07-25
CA2201944C (en) 2002-12-31
CZ98097A3 (en) 1997-12-17
SK43297A3 (en) 1998-01-14
HUT77746A (hu) 1998-07-28
NO971508L (no) 1997-06-13
AU3828195A (en) 1996-08-07
NO971508D0 (no) 1997-04-03
EP0786000A1 (en) 1997-07-30
JPH10507929A (ja) 1998-08-04
CN1169158A (zh) 1997-12-31
WO1996022369A1 (en) 1996-07-25

Similar Documents

Publication Publication Date Title
ATE402957T1 (de) Analoge des menschlichen interferon-alpha mit niedriger toxizität
EE200100223A (et) Interferoon-beetaga sulandatud valgud ja nende kasutamine
NZ503850A (en) April - a novel protein with growth effects
EP0607297A4 (en) Hormone analogs with multiple ctp extensions.
DK0792287T3 (da) Peptidanaloger af humant basisk myelinprotein
GR3026554T3 (en) Human CNP gene and precursor protein
ATE189475T1 (de) Wachstums-differenzierungsfaktor der tgf-b familie
DE69823046D1 (de) Praktische in vitro sialylierung von rekombinanten glykpproteinen
ATE177757T1 (de) Verbesserte immunogene zusammensetzung gegen mensliches gastrin 17
GR3032775T3 (en) Modified protein and peptide pharmaceuticals
HU9200548D0 (en) Improved activity process of recombined proteins
AU6020099A (en) Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
HK1001004A1 (en) Bpc peptides their preparation and use
MX9203879A (es) Muteina de il-6 con cisteina parcialmente suprimida.
CA2201944A1 (en) Analogs of keratinocyte growth factor having enhanced temperature stability
ZA896980B (en) Peptide compounds
ES2087337T3 (es) Composiciones de implantes que contienen una proteina, peptido o polipeptido biologicamente activos.
ES2142840T3 (es) Proteina que se une al interferon alfa/beta, su preparacion y las composiciones farmaceuticas que la contienen.
EP1074264A4 (en) NEOVASCULARIZATION INHIBITORS
ATE145939T1 (de) Mitogen für die glatte muskulatur und dessen kodierende dns
DE60138885D1 (de) Polypeptide mit aktivität der stimulierung von neutrophilen
NZ329156A (en) A method of treating harmful effects of an endogenous HGF using a modified HGf which in non-glycosylated
ATE207496T1 (de) Neue peptide und nootroper wirkstoff
RU97105853A (ru) Аналоги кислого фактора роста фибробластов