CA2201944A1 - Analogs of keratinocyte growth factor having enhanced temperature stability - Google Patents
Analogs of keratinocyte growth factor having enhanced temperature stabilityInfo
- Publication number
- CA2201944A1 CA2201944A1 CA002201944A CA2201944A CA2201944A1 CA 2201944 A1 CA2201944 A1 CA 2201944A1 CA 002201944 A CA002201944 A CA 002201944A CA 2201944 A CA2201944 A CA 2201944A CA 2201944 A1 CA2201944 A1 CA 2201944A1
- Authority
- CA
- Canada
- Prior art keywords
- analogs
- growth factor
- temperature stability
- keratinocyte growth
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003972 Fibroblast growth factor 7 Human genes 0.000 title 1
- 108090000385 Fibroblast growth factor 7 Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Analogs of proteins in the FGF family are provided in accordance with the present invention. These analogs are more stable than the corresponding naturally occurring proteins. Enhanced stability may be achieved by substituting at least one amino acid having a higher loop-forming potential for an amino acid residue having a lower loop-forming potential in an identified loop-forming region in the amino acid sequence of the protein. The analogs of the present invention are especially useful in therapeutic applications.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32347394A | 1994-10-13 | 1994-10-13 | |
US08/323,473 | 1994-10-13 | ||
PCT/US1995/012907 WO1996022369A1 (en) | 1994-10-13 | 1995-10-12 | Analogs of acidic fibroblast growth factor having enhanced stability and biological activity |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2201944A1 true CA2201944A1 (en) | 1996-07-25 |
CA2201944C CA2201944C (en) | 2002-12-31 |
Family
ID=23259345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002201944A Expired - Lifetime CA2201944C (en) | 1994-10-13 | 1995-10-12 | Analogs of keratinocyte growth factor having enhanced temperature stability |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0786000A1 (en) |
JP (1) | JPH10507929A (en) |
CN (1) | CN1169158A (en) |
AU (1) | AU3828195A (en) |
CA (1) | CA2201944C (en) |
CZ (1) | CZ98097A3 (en) |
HU (1) | HUT77746A (en) |
NO (1) | NO971508L (en) |
SK (1) | SK43297A3 (en) |
WO (1) | WO1996022369A1 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0785949B1 (en) * | 1994-10-13 | 2003-05-02 | Amgen Inc. | Method for purifying keratinocyte growth factors |
US6693077B1 (en) | 1995-02-14 | 2004-02-17 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
US6077692A (en) | 1995-02-14 | 2000-06-20 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
US7232667B2 (en) | 1995-02-14 | 2007-06-19 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 polynucleotides |
US6743422B1 (en) | 1996-10-15 | 2004-06-01 | Amgen, Inc. | Keratinocyte growth factor-2 products |
WO1998039436A2 (en) * | 1997-03-03 | 1998-09-11 | Eisai Co., Ltd. | Fibroblast growth factor mutein compositions and methods of use therefor |
US6869927B1 (en) | 1997-12-22 | 2005-03-22 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 formulations |
US6238888B1 (en) | 1997-12-22 | 2001-05-29 | Human Genone Sciences, Inc. | Keratinocyte growth factor-2 formulations |
US6274712B1 (en) | 1997-12-23 | 2001-08-14 | 3-Dimensional Pharmaceuticals, Inc. | Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137 |
IL139380A0 (en) * | 2000-10-31 | 2001-11-25 | Prochon Biotech Ltd | Active variants of fibroblast growth factor |
TWI634898B (en) * | 2013-10-07 | 2018-09-11 | 雅祥生技醫藥股份有限公司 | Modified acidic fibroblast growth factors and composition thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2098484A1 (en) * | 1990-12-18 | 1992-06-19 | Tsutomu Arakawa | Analogs of acidic fibroblast growth factor having enhanced stability and biological activity |
-
1995
- 1995-10-12 EP EP95936275A patent/EP0786000A1/en not_active Withdrawn
- 1995-10-12 HU HU9800740A patent/HUT77746A/en unknown
- 1995-10-12 CZ CZ97980A patent/CZ98097A3/en unknown
- 1995-10-12 JP JP8517875A patent/JPH10507929A/en not_active Withdrawn
- 1995-10-12 CA CA002201944A patent/CA2201944C/en not_active Expired - Lifetime
- 1995-10-12 CN CN95196717A patent/CN1169158A/en active Pending
- 1995-10-12 SK SK432-97A patent/SK43297A3/en unknown
- 1995-10-12 AU AU38281/95A patent/AU3828195A/en not_active Abandoned
- 1995-10-12 WO PCT/US1995/012907 patent/WO1996022369A1/en not_active Application Discontinuation
-
1997
- 1997-04-03 NO NO971508A patent/NO971508L/en unknown
Also Published As
Publication number | Publication date |
---|---|
HUT77746A (en) | 1998-07-28 |
CA2201944C (en) | 2002-12-31 |
NO971508L (en) | 1997-06-13 |
WO1996022369A1 (en) | 1996-07-25 |
CN1169158A (en) | 1997-12-31 |
JPH10507929A (en) | 1998-08-04 |
AU3828195A (en) | 1996-08-07 |
CZ98097A3 (en) | 1997-12-17 |
SK43297A3 (en) | 1998-01-14 |
EP0786000A1 (en) | 1997-07-30 |
NO971508D0 (en) | 1997-04-03 |
MX9702475A (en) | 1997-07-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20151013 |