CA2201944A1 - Analogs of keratinocyte growth factor having enhanced temperature stability - Google Patents

Analogs of keratinocyte growth factor having enhanced temperature stability

Info

Publication number
CA2201944A1
CA2201944A1 CA002201944A CA2201944A CA2201944A1 CA 2201944 A1 CA2201944 A1 CA 2201944A1 CA 002201944 A CA002201944 A CA 002201944A CA 2201944 A CA2201944 A CA 2201944A CA 2201944 A1 CA2201944 A1 CA 2201944A1
Authority
CA
Canada
Prior art keywords
analogs
growth factor
temperature stability
keratinocyte growth
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002201944A
Other languages
French (fr)
Other versions
CA2201944C (en
Inventor
Tsutomu Arakawa
Gary Michael Fox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2201944A1 publication Critical patent/CA2201944A1/en
Application granted granted Critical
Publication of CA2201944C publication Critical patent/CA2201944C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Analogs of proteins in the FGF family are provided in accordance with the present invention. These analogs are more stable than the corresponding naturally occurring proteins. Enhanced stability may be achieved by substituting at least one amino acid having a higher loop-forming potential for an amino acid residue having a lower loop-forming potential in an identified loop-forming region in the amino acid sequence of the protein. The analogs of the present invention are especially useful in therapeutic applications.
CA002201944A 1994-10-13 1995-10-12 Analogs of keratinocyte growth factor having enhanced temperature stability Expired - Lifetime CA2201944C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32347394A 1994-10-13 1994-10-13
US08/323,473 1994-10-13
PCT/US1995/012907 WO1996022369A1 (en) 1994-10-13 1995-10-12 Analogs of acidic fibroblast growth factor having enhanced stability and biological activity

Publications (2)

Publication Number Publication Date
CA2201944A1 true CA2201944A1 (en) 1996-07-25
CA2201944C CA2201944C (en) 2002-12-31

Family

ID=23259345

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002201944A Expired - Lifetime CA2201944C (en) 1994-10-13 1995-10-12 Analogs of keratinocyte growth factor having enhanced temperature stability

Country Status (10)

Country Link
EP (1) EP0786000A1 (en)
JP (1) JPH10507929A (en)
CN (1) CN1169158A (en)
AU (1) AU3828195A (en)
CA (1) CA2201944C (en)
CZ (1) CZ98097A3 (en)
HU (1) HUT77746A (en)
NO (1) NO971508L (en)
SK (1) SK43297A3 (en)
WO (1) WO1996022369A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0785949B1 (en) * 1994-10-13 2003-05-02 Amgen Inc. Method for purifying keratinocyte growth factors
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6077692A (en) 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
WO1998039436A2 (en) * 1997-03-03 1998-09-11 Eisai Co., Ltd. Fibroblast growth factor mutein compositions and methods of use therefor
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
US6238888B1 (en) 1997-12-22 2001-05-29 Human Genone Sciences, Inc. Keratinocyte growth factor-2 formulations
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
IL139380A0 (en) * 2000-10-31 2001-11-25 Prochon Biotech Ltd Active variants of fibroblast growth factor
TWI634898B (en) * 2013-10-07 2018-09-11 雅祥生技醫藥股份有限公司 Modified acidic fibroblast growth factors and composition thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2098484A1 (en) * 1990-12-18 1992-06-19 Tsutomu Arakawa Analogs of acidic fibroblast growth factor having enhanced stability and biological activity

Also Published As

Publication number Publication date
HUT77746A (en) 1998-07-28
CA2201944C (en) 2002-12-31
NO971508L (en) 1997-06-13
WO1996022369A1 (en) 1996-07-25
CN1169158A (en) 1997-12-31
JPH10507929A (en) 1998-08-04
AU3828195A (en) 1996-08-07
CZ98097A3 (en) 1997-12-17
SK43297A3 (en) 1998-01-14
EP0786000A1 (en) 1997-07-30
NO971508D0 (en) 1997-04-03
MX9702475A (en) 1997-07-31

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Effective date: 20151013