NO971508L - Analogs of acidic fibroblast growth factor with increased stability and biological activity - Google Patents
Analogs of acidic fibroblast growth factor with increased stability and biological activityInfo
- Publication number
- NO971508L NO971508L NO971508A NO971508A NO971508L NO 971508 L NO971508 L NO 971508L NO 971508 A NO971508 A NO 971508A NO 971508 A NO971508 A NO 971508A NO 971508 L NO971508 L NO 971508L
- Authority
- NO
- Norway
- Prior art keywords
- analogs
- increased stability
- growth factor
- biological activity
- fibroblast growth
- Prior art date
Links
- 102000003971 Fibroblast Growth Factor 1 Human genes 0.000 title 1
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 title 1
- 230000004071 biological effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
- C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Analoger av proteiner i FGF- familien er tilveiebrakt i henhold til foreliggende oppfinnelse. Disse analogene er mer stabile enn de tilsvarende naturlig forekommende proteiner. Økt stabilitet kan oppnås ved å substituere minst én aminosyre som har et større sløyfedannende poten- siale, for en aminosyrerest som har et lavere sløyfedannende potensiale, i et identifisert sløyfedannende område i aminosyresekvensen til proteinet. Analogene ifølge foreliggende oppfin- nelse er spesielt anvendbare ved terapeutiske anvendelser.Analogues of proteins in the FGF family are provided in accordance with the present invention. These analogs are more stable than the corresponding naturally occurring proteins. Increased stability can be achieved by substituting at least one amino acid having a larger loop forming potential, for an amino acid residue having a lower loop forming potential, in an identified loop forming region in the amino acid sequence of the protein. The analogs of the present invention are particularly useful in therapeutic applications.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32347394A | 1994-10-13 | 1994-10-13 | |
| PCT/US1995/012907 WO1996022369A1 (en) | 1994-10-13 | 1995-10-12 | Analogs of acidic fibroblast growth factor having enhanced stability and biological activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO971508D0 NO971508D0 (en) | 1997-04-03 |
| NO971508L true NO971508L (en) | 1997-06-13 |
Family
ID=23259345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO971508A NO971508L (en) | 1994-10-13 | 1997-04-03 | Analogs of acidic fibroblast growth factor with increased stability and biological activity |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0786000A1 (en) |
| JP (1) | JPH10507929A (en) |
| CN (1) | CN1169158A (en) |
| AU (1) | AU3828195A (en) |
| CA (1) | CA2201944C (en) |
| CZ (1) | CZ98097A3 (en) |
| HU (1) | HUT77746A (en) |
| NO (1) | NO971508L (en) |
| SK (1) | SK43297A3 (en) |
| WO (1) | WO1996022369A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ98297A3 (en) * | 1994-10-13 | 1998-08-12 | Amgen Inc. | Purification process of keratinocytic growth factors |
| US6693077B1 (en) | 1995-02-14 | 2004-02-17 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
| US7232667B2 (en) | 1995-02-14 | 2007-06-19 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 polynucleotides |
| US6077692A (en) * | 1995-02-14 | 2000-06-20 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 |
| US6743422B1 (en) | 1996-10-15 | 2004-06-01 | Amgen, Inc. | Keratinocyte growth factor-2 products |
| WO1998039436A2 (en) * | 1997-03-03 | 1998-09-11 | Eisai Co., Ltd. | Fibroblast growth factor mutein compositions and methods of use therefor |
| CA2316015A1 (en) | 1997-12-22 | 1999-07-01 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 formulations |
| US6869927B1 (en) | 1997-12-22 | 2005-03-22 | Human Genome Sciences, Inc. | Keratinocyte growth factor-2 formulations |
| US6274712B1 (en) | 1997-12-23 | 2001-08-14 | 3-Dimensional Pharmaceuticals, Inc. | Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137 |
| IL139380A0 (en) * | 2000-10-31 | 2001-11-25 | Prochon Biotech Ltd | Active variants of fibroblast growth factor |
| TWI634898B (en) * | 2013-10-07 | 2018-09-11 | 雅祥生技醫藥股份有限公司 | Modified acidic fibroblast growth factors and composition thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU663067B2 (en) * | 1990-12-18 | 1995-09-28 | Amgen, Inc. | Analogs of acidic fibroblast growth factor having enhanced stability and biological activity |
-
1995
- 1995-10-12 JP JP8517875A patent/JPH10507929A/en not_active Withdrawn
- 1995-10-12 CZ CZ97980A patent/CZ98097A3/en unknown
- 1995-10-12 SK SK432-97A patent/SK43297A3/en unknown
- 1995-10-12 AU AU38281/95A patent/AU3828195A/en not_active Abandoned
- 1995-10-12 EP EP95936275A patent/EP0786000A1/en not_active Withdrawn
- 1995-10-12 CN CN95196717A patent/CN1169158A/en active Pending
- 1995-10-12 HU HU9800740A patent/HUT77746A/en unknown
- 1995-10-12 WO PCT/US1995/012907 patent/WO1996022369A1/en not_active Application Discontinuation
- 1995-10-12 CA CA002201944A patent/CA2201944C/en not_active Expired - Lifetime
-
1997
- 1997-04-03 NO NO971508A patent/NO971508L/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO971508D0 (en) | 1997-04-03 |
| CN1169158A (en) | 1997-12-31 |
| SK43297A3 (en) | 1998-01-14 |
| CA2201944A1 (en) | 1996-07-25 |
| MX9702475A (en) | 1997-07-31 |
| EP0786000A1 (en) | 1997-07-30 |
| CZ98097A3 (en) | 1997-12-17 |
| AU3828195A (en) | 1996-08-07 |
| WO1996022369A1 (en) | 1996-07-25 |
| HUT77746A (en) | 1998-07-28 |
| JPH10507929A (en) | 1998-08-04 |
| CA2201944C (en) | 2002-12-31 |
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