CA2201944A1 - Analogues du facteur de croissance des keratinocytes ayant une stabilite de temperature amelioree - Google Patents

Analogues du facteur de croissance des keratinocytes ayant une stabilite de temperature amelioree

Info

Publication number
CA2201944A1
CA2201944A1 CA002201944A CA2201944A CA2201944A1 CA 2201944 A1 CA2201944 A1 CA 2201944A1 CA 002201944 A CA002201944 A CA 002201944A CA 2201944 A CA2201944 A CA 2201944A CA 2201944 A1 CA2201944 A1 CA 2201944A1
Authority
CA
Canada
Prior art keywords
analogs
growth factor
temperature stability
keratinocyte growth
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002201944A
Other languages
English (en)
Other versions
CA2201944C (fr
Inventor
Tsutomu Arakawa
Gary Michael Fox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2201944A1 publication Critical patent/CA2201944A1/fr
Application granted granted Critical
Publication of CA2201944C publication Critical patent/CA2201944C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002201944A 1994-10-13 1995-10-12 Analogues du facteur de croissance des keratinocytes ayant une stabilite de temperature amelioree Expired - Lifetime CA2201944C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32347394A 1994-10-13 1994-10-13
US08/323,473 1994-10-13
PCT/US1995/012907 WO1996022369A1 (fr) 1994-10-13 1995-10-12 Analogues de facteur de croissance du fibroblaste acide a stabilite et activite biologique renforcees

Publications (2)

Publication Number Publication Date
CA2201944A1 true CA2201944A1 (fr) 1996-07-25
CA2201944C CA2201944C (fr) 2002-12-31

Family

ID=23259345

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002201944A Expired - Lifetime CA2201944C (fr) 1994-10-13 1995-10-12 Analogues du facteur de croissance des keratinocytes ayant une stabilite de temperature amelioree

Country Status (10)

Country Link
EP (1) EP0786000A1 (fr)
JP (1) JPH10507929A (fr)
CN (1) CN1169158A (fr)
AU (1) AU3828195A (fr)
CA (1) CA2201944C (fr)
CZ (1) CZ98097A3 (fr)
HU (1) HUT77746A (fr)
NO (1) NO971508L (fr)
SK (1) SK43297A3 (fr)
WO (1) WO1996022369A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2197926T3 (es) * 1994-10-13 2004-01-16 Amgen Inc. Metodo para purificar factores de crecimiento de queratinocitos.
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6077692A (en) * 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
WO1998039436A2 (fr) * 1997-03-03 1998-09-11 Eisai Co., Ltd. Compositions de muteine du facteur de croissance des fibroblastes, et procedes d'utilisation de ces compositions
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
CA2316015A1 (fr) 1997-12-22 1999-07-01 Human Genome Sciences, Inc. Formulations du facteur-2 de croissance des keratinocytes
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
IL139380A0 (en) * 2000-10-31 2001-11-25 Prochon Biotech Ltd Active variants of fibroblast growth factor
TWI634898B (zh) * 2013-10-07 2018-09-11 雅祥生技醫藥股份有限公司 經修飾之人類酸性纖維母細胞生長因子及其組合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06503962A (ja) * 1990-12-18 1994-05-12 アムジエン・インコーポレーテツド 増強された安定性及び生物学的活性を有する酸性線維芽細胞成長因子の類似体

Also Published As

Publication number Publication date
EP0786000A1 (fr) 1997-07-30
WO1996022369A1 (fr) 1996-07-25
CA2201944C (fr) 2002-12-31
CN1169158A (zh) 1997-12-31
NO971508L (no) 1997-06-13
NO971508D0 (no) 1997-04-03
SK43297A3 (en) 1998-01-14
JPH10507929A (ja) 1998-08-04
CZ98097A3 (en) 1997-12-17
HUT77746A (hu) 1998-07-28
MX9702475A (es) 1997-07-31
AU3828195A (en) 1996-08-07

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Legal Events

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Effective date: 20151013