AU3828195A - Analogs of acidic fibroblast growth factor having enhanced stability and biological activity - Google Patents

Analogs of acidic fibroblast growth factor having enhanced stability and biological activity

Info

Publication number
AU3828195A
AU3828195A AU38281/95A AU3828195A AU3828195A AU 3828195 A AU3828195 A AU 3828195A AU 38281/95 A AU38281/95 A AU 38281/95A AU 3828195 A AU3828195 A AU 3828195A AU 3828195 A AU3828195 A AU 3828195A
Authority
AU
Australia
Prior art keywords
analogs
growth factor
biological activity
fibroblast growth
enhanced stability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU38281/95A
Other languages
English (en)
Inventor
Tsutomu Arakawa
Gary Michael Fox
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of AU3828195A publication Critical patent/AU3828195A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU38281/95A 1994-10-13 1995-10-12 Analogs of acidic fibroblast growth factor having enhanced stability and biological activity Abandoned AU3828195A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US323473 1989-03-14
US32347394A 1994-10-13 1994-10-13
PCT/US1995/012907 WO1996022369A1 (fr) 1994-10-13 1995-10-12 Analogues de facteur de croissance du fibroblaste acide a stabilite et activite biologique renforcees

Publications (1)

Publication Number Publication Date
AU3828195A true AU3828195A (en) 1996-08-07

Family

ID=23259345

Family Applications (1)

Application Number Title Priority Date Filing Date
AU38281/95A Abandoned AU3828195A (en) 1994-10-13 1995-10-12 Analogs of acidic fibroblast growth factor having enhanced stability and biological activity

Country Status (10)

Country Link
EP (1) EP0786000A1 (fr)
JP (1) JPH10507929A (fr)
CN (1) CN1169158A (fr)
AU (1) AU3828195A (fr)
CA (1) CA2201944C (fr)
CZ (1) CZ98097A3 (fr)
HU (1) HUT77746A (fr)
NO (1) NO971508L (fr)
SK (1) SK43297A3 (fr)
WO (1) WO1996022369A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0785949T3 (da) * 1994-10-13 2003-08-18 Amgen Inc Fremgangsmåde til oprensning af keratinocytvækstfaktorer
US7232667B2 (en) 1995-02-14 2007-06-19 Human Genome Sciences, Inc. Keratinocyte growth factor-2 polynucleotides
US6077692A (en) * 1995-02-14 2000-06-20 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6693077B1 (en) 1995-02-14 2004-02-17 Human Genome Sciences, Inc. Keratinocyte growth factor-2
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
WO1998039436A2 (fr) * 1997-03-03 1998-09-11 Eisai Co., Ltd. Compositions de muteine du facteur de croissance des fibroblastes, et procedes d'utilisation de ces compositions
US6869927B1 (en) 1997-12-22 2005-03-22 Human Genome Sciences, Inc. Keratinocyte growth factor-2 formulations
JP2001526239A (ja) 1997-12-22 2001-12-18 ヒューマン・ジェノム・サイエンシズ・インコーポレイテッド 角質細胞増殖因子−２製剤
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
IL139380A0 (en) * 2000-10-31 2001-11-25 Prochon Biotech Ltd Active variants of fibroblast growth factor
TWI634898B (zh) * 2013-10-07 2018-09-11 雅祥生技醫藥股份有限公司 經修飾之人類酸性纖維母細胞生長因子及其組合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ241021A (en) * 1990-12-18 1993-12-23 Amgen Inc Analogues of acidic fibroblast growth factor and pharmaceutical

Also Published As

Publication number Publication date
SK43297A3 (en) 1998-01-14
MX9702475A (es) 1997-07-31
EP0786000A1 (fr) 1997-07-30
CA2201944C (fr) 2002-12-31
HUT77746A (hu) 1998-07-28
WO1996022369A1 (fr) 1996-07-25
JPH10507929A (ja) 1998-08-04
CA2201944A1 (fr) 1996-07-25
NO971508D0 (no) 1997-04-03
CN1169158A (zh) 1997-12-31
NO971508L (no) 1997-06-13
CZ98097A3 (en) 1997-12-17

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