AU3812993A - Refolding and purification of insulin-like growth factor I - Google Patents

Refolding and purification of insulin-like growth factor I

Info

Publication number
AU3812993A
AU3812993A AU38129/93A AU3812993A AU3812993A AU 3812993 A AU3812993 A AU 3812993A AU 38129/93 A AU38129/93 A AU 38129/93A AU 3812993 A AU3812993 A AU 3812993A AU 3812993 A AU3812993 A AU 3812993A
Authority
AU
Australia
Prior art keywords
refolding
insulin
purification
growth factor
growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU38129/93A
Inventor
George N. Cox
Tom M Gleason
Martin J McDermott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Boulder Inc
Original Assignee
Synergen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synergen Inc filed Critical Synergen Inc
Publication of AU3812993A publication Critical patent/AU3812993A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
AU38129/93A 1992-03-24 1993-03-19 Refolding and purification of insulin-like growth factor I Abandoned AU3812993A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85816692A 1992-03-24 1992-03-24
US858161 1992-03-24

Publications (1)

Publication Number Publication Date
AU3812993A true AU3812993A (en) 1993-10-21

Family

ID=25327654

Family Applications (1)

Application Number Title Priority Date Filing Date
AU38129/93A Abandoned AU3812993A (en) 1992-03-24 1993-03-19 Refolding and purification of insulin-like growth factor I

Country Status (4)

Country Link
EP (1) EP0586667A1 (en)
AU (1) AU3812993A (en)
CA (1) CA2109820A1 (en)
WO (1) WO1993019084A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663304A (en) * 1993-08-20 1997-09-02 Genentech, Inc. Refolding of misfolded insulin-like growth factor-I
SE9303784D0 (en) * 1993-11-16 1993-11-16 Kabi Pharmacia Ab IGF
US6756484B1 (en) 1995-04-14 2004-06-29 Cephalon, Inc. IGF-I purification process
US5650496A (en) 1995-04-14 1997-07-22 Cephalon, Inc. IGF-I purification process
US7071313B1 (en) 1995-06-07 2006-07-04 Cephalon, Inc. Methods of purifying authentic IGF from yeast hosts
US5789547A (en) * 1995-06-07 1998-08-04 Celtrix Pharmaceuticals, Inc. Method of producing insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) with correct folding and disulfide bonding
JP2002514890A (en) * 1995-06-07 2002-05-21 カイロン コーポレイション Methods for purifying authentic IGF from yeast hosts
US7193042B1 (en) 1995-06-07 2007-03-20 Chiron Corporation Methods for purifying authentic IGF from yeast hosts
US6008013A (en) * 1996-07-05 1999-12-28 University Of Rochester Chondrocyte proteins
KR20020074749A (en) * 2001-03-21 2002-10-04 한국생명공학연구원 Large scale production of recombinant human insulin like growth factor-1
EP1988154B1 (en) * 2007-04-30 2013-08-21 Ajinomoto Co., Inc. Method for producing human insulin-like growth factor I

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8303626D0 (en) * 1983-06-23 1983-06-23 Kabigen Ab A RECOMBINANT PLASMID AND A TRANSFORMANT MICROORGANISM, A POLYDOXYREBONUCLEOTIDE SEGMENT, A PROCESS FOR PRODUCING A BIOLOGICALLY ACTIVE PROTEIN, AND THE PROTEIN THUS PRODUCED
WO1985000831A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of insulin-like growth factor
DE3537708A1 (en) * 1985-10-23 1987-04-23 Boehringer Mannheim Gmbh METHOD FOR ACTIVATING T-PA AFTER EXPRESSION IN PROKARYONTS
ATE86496T1 (en) * 1988-02-05 1993-03-15 Ciba Geigy Ag USE OF IGF I IN THE MANUFACTURE OF A PREPARATION FOR THE TREATMENT OF KIDNEY DISEASES.
WO1990002815A1 (en) * 1988-09-13 1990-03-22 The General Hospital Corporation Isolation, purification, and characterization of the aminopeptidases: mas ii and mas iii
DE3835350A1 (en) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh ACTIVATION OF GENETICALLY MANUFACTURED ANTIBODY EXPRESSED IN PROKARYONS

Also Published As

Publication number Publication date
WO1993019084A1 (en) 1993-09-30
EP0586667A1 (en) 1994-03-16
CA2109820A1 (en) 1993-09-30

Similar Documents

Publication Publication Date Title
AU4953793A (en) Multicistronic expression units and their use
AU4840293A (en) Cloning and expression of pur protein
AU2082492A (en) Keratoprosthesis and method of producing the same
AU4214193A (en) Bioadhesive treatment compositions and method of use
AU5433494A (en) Injector and use of the same
AU4683589A (en) Cloning and expression of transforming growth factor beta-2
AU5044393A (en) Stereoselective reduction of ketones
AU8011694A (en) Casket and method of making same
AU652321B1 (en) Purification of pentafluoroethane
AU8806491A (en) Active fragments of fibroblast growth factor
AU4233593A (en) Moving harness and method of use
AU3812993A (en) Refolding and purification of insulin-like growth factor I
AU7254894A (en) Activated human factor viii and method of preparation
AU3474095A (en) Use of insulin-like growth factors (i) and (ii) for inhibition of inflammatory response
AU3574593A (en) Hair growth and restoration promoter
AU7065694A (en) Catheter and method of use thereof
AU4086793A (en) Biofiltration of gases
AU1393295A (en) Purification of natural gas
AU6723294A (en) Use of simmondsine
AU4243389A (en) Antimicrobial composition and method of use
AU1942995A (en) New use of growth hormone
AU4220193A (en) Deazaaminopterins for treatment of inflammation
AU4560493A (en) Series of gear units
AU7476494A (en) Use of n-methyl-aspartic acid for enhancing growth and altering body composition
AU7859391A (en) Crystals of factor d