DE69534381D1 - Hämatopoietisches fusionsprotein multivariantes il-3 enthaltend - Google Patents

Hämatopoietisches fusionsprotein multivariantes il-3 enthaltend

Info

Publication number
DE69534381D1
DE69534381D1 DE69534381T DE69534381T DE69534381D1 DE 69534381 D1 DE69534381 D1 DE 69534381D1 DE 69534381 T DE69534381 T DE 69534381T DE 69534381 T DE69534381 T DE 69534381T DE 69534381 D1 DE69534381 D1 DE 69534381D1
Authority
DE
Germany
Prior art keywords
fusion protein
amino acids
given
multivariant
terminus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69534381T
Other languages
English (en)
Other versions
DE69534381T2 (de
Inventor
Christopher S Bauer
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Marie Helena Caparon
Alan Michael Easton
Barbara Kure Klein
Kearn John Patrick Mc
Peter O Olins
Kumnan Paik
John Warren Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE69534381D1 publication Critical patent/DE69534381D1/de
Publication of DE69534381T2 publication Critical patent/DE69534381T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69534381T 1994-02-04 1995-02-02 Hämatopoetisches fusionsprotein multivariantes il-3 enthaltend Expired - Fee Related DE69534381T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/192,325 US6057133A (en) 1992-11-24 1994-02-04 Multivariant human IL-3 fusion proteins and their recombinant production
US192325 1994-02-04
PCT/US1995/001185 WO1995021254A1 (en) 1994-02-04 1995-02-02 Multivariant il-3 hematopoiesis fusion protein

Publications (2)

Publication Number Publication Date
DE69534381D1 true DE69534381D1 (de) 2005-09-22
DE69534381T2 DE69534381T2 (de) 2006-11-23

Family

ID=22709185

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69534381T Expired - Fee Related DE69534381T2 (de) 1994-02-04 1995-02-02 Hämatopoetisches fusionsprotein multivariantes il-3 enthaltend

Country Status (17)

Country Link
US (3) US6057133A (de)
EP (2) EP1482044A3 (de)
JP (1) JPH10502801A (de)
KR (1) KR100370264B1 (de)
CN (1) CN1227604A (de)
AT (1) ATE302275T1 (de)
BR (1) BR9506733A (de)
CA (1) CA2182484A1 (de)
CZ (1) CZ289904B6 (de)
DE (1) DE69534381T2 (de)
FI (1) FI963072A0 (de)
MX (1) MX9603205A (de)
NO (1) NO963225L (de)
NZ (2) NZ281421A (de)
PL (1) PL315791A1 (de)
RO (1) RO118016B1 (de)
WO (1) WO1995021254A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
WO1996023888A1 (en) * 1995-02-03 1996-08-08 G.D. Searle & Co. NOVEL c-MPL LIGANDS
US6066318A (en) 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
JP2000510684A (ja) * 1995-10-05 2000-08-22 ジー．ディー．サール アンド カンパニー インターロイキン−３（ｉｌ−３）受容体アゴニスト
JPH11510062A (ja) * 1995-10-05 1999-09-07 ジー．ディー．サール アンド カンパニー 多機能性造血受容体アゴニスト
CA2213512A1 (en) * 1995-12-22 1997-07-03 Toray Industries, Inc. Method for producing bioactive fusion protein
RO120919B1 (ro) * 1996-10-25 2006-09-29 G.D. Searle & Co. Proteină hematopoietină, moleculă de acid nucleiccare o codifică, compoziţie farmaceutică şi utilizarea proteinei
US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
DE19900743A1 (de) * 1999-01-12 2000-07-13 Aventis Pharma Gmbh Neue komplexbildende Proteine
AR025984A1 (es) * 1999-10-07 2002-12-26 Maxygen Aps Polipeptidos oligomericos de cadena simple
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
AU2001289307A1 (en) * 2000-04-06 2001-10-23 Pharmacia Corporation Chemically-modified myelopoietin conjugates
AU2000275771B2 (en) 2000-09-11 2006-06-29 Therapro Technologies, Inc. Thionin as an antineoplastic and immunostimulant
AU2002325819B2 (en) * 2001-07-11 2008-06-19 Maxygen, Inc. G-CSF Conjugates
EP1567641B1 (de) 2001-08-24 2012-05-23 UVic Industry Partnerships Inc. Proaerolysin enthaltende proteaseaktivierungssequenzen und verfahren zur anwendung bei der behandlung von prostatakrebs
ATE312605T1 (de) * 2002-06-29 2005-12-15 Aquanova Ger Solubilisate Tech Isoflavonkonzentrate sowie verfahren zu ihrer herstellung
US7598224B2 (en) 2002-08-20 2009-10-06 Biosurface Engineering Technologies, Inc. Dual chain synthetic heparin-binding growth factor analogs
US7166574B2 (en) * 2002-08-20 2007-01-23 Biosurface Engineering Technologies, Inc. Synthetic heparin-binding growth factor analogs
US8227411B2 (en) * 2002-08-20 2012-07-24 BioSurface Engineering Technologies, Incle FGF growth factor analogs
US7414028B1 (en) * 2004-02-04 2008-08-19 Biosurface Engineering Technologies, Inc. Growth factor analogs
US20080227696A1 (en) * 2005-02-22 2008-09-18 Biosurface Engineering Technologies, Inc. Single branch heparin-binding growth factor analogs
US7671012B2 (en) 2004-02-10 2010-03-02 Biosurface Engineering Technologies, Inc. Formulations and methods for delivery of growth factor analogs
US20060024347A1 (en) * 2004-02-10 2006-02-02 Biosurface Engineering Technologies, Inc. Bioactive peptide coatings
US7528105B1 (en) 2004-02-10 2009-05-05 Biosurface Engineering Technologies Heterodimeric chain synthetic heparin-binding growth factor analogs
JP4895826B2 (ja) 2004-02-20 2012-03-14 バイオサーフェス エンジニアリング テクノロジーズ，インク． 骨形成蛋白−２の正のモジュレーター
CN1993460A (zh) * 2004-07-12 2007-07-04 索林集团意大利有限公司 用于培养人细胞的装置和方法
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
CA2607844C (en) 2005-06-01 2012-07-10 Maxygen Holdings Ltd. Pegylated g-csf polypeptides and methods of producing same
EP1960523A4 (de) 2005-11-21 2009-03-11 Protox Therapeutics Inc Modifizierte porenformende proteintoxine und verwendung davon
US7820172B1 (en) 2006-06-01 2010-10-26 Biosurface Engineering Technologies, Inc. Laminin-derived multi-domain peptides
JP2009541358A (ja) * 2006-06-22 2009-11-26 バイオサーフェス エンジニアリング テクノロジーズ，インク． 骨形成を強化するためにｂｍｐ−２増幅因子／共活性化因子を送達するための組成物および方法
CN101139399B (zh) * 2007-08-13 2011-01-26 重庆医科大学附属第二医院 重组靶向杀伤白血病细胞的融合蛋白及其制备方法和用途
US8815229B2 (en) 2009-10-12 2014-08-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Granulysin in immunotherapy
CN102906108B (zh) 2010-03-04 2016-01-20 菲尼克斯公司 用于无变性制备可溶性重组干扰素蛋白的方法
PL2552949T3 (pl) 2010-04-01 2017-01-31 Pfenex Inc. Sposoby wytwarzania G-CSF w komórce gospodarza Pseudomonas
CA3037175C (en) 2011-09-23 2020-04-07 Olivier NEGRE Improved gene therapy methods
CA3078434A1 (en) 2017-10-10 2019-04-18 Medicenna Therapeutics, Inc. Il-4-fusion formulations for treatment of central nervous system (cns) tumors
JP2021532796A (ja) * 2018-07-30 2021-12-02 晋宇 張 タンパク質ヘテロ二量体およびその使用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5591427A (en) * 1979-10-07 1997-01-07 Medvet Science Pty. Ltd. Human Interleukin-3(Il-3) variants and their use to promote or antagonize IL-3-mediated processes
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
IL75725A (en) * 1984-07-06 1993-02-21 Sandoz Ag Recombinant human gm-csf
AU588819B2 (en) * 1984-10-29 1989-09-28 Immunex Corporation Cloning of human granulocyte-macrophage colony stimulating factor gene
US4810643A (en) * 1985-08-23 1989-03-07 Kirin- Amgen Inc. Production of pluripotent granulocyte colony-stimulating factor
JPS63500636A (ja) * 1985-08-23 1988-03-10 麒麟麦酒株式会社 多分化能性顆粒球コロニー刺激因子をコードするｄｎａ
US4877729A (en) * 1986-07-14 1989-10-31 Genetics Institute, Inc. Recombinant DNA encoding novel family of primate hematopoietic growth factors
US5032395A (en) * 1986-07-14 1991-07-16 Genetics Institute, Inc. Method of inducing leukocytosis with a combination of IL-3 and GM-CSF
US4959455A (en) * 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
EP0790307A1 (de) * 1986-12-16 1997-08-20 Gist-Brocades B.V. Molekulare Klonierung und Expression von menschlichem IL-3
JPH02501925A (ja) * 1987-01-20 1990-06-28 イミュネックス・コーポレーション ヒト　インターロイキン‐３　蛋白質
JPH04500508A (ja) * 1988-07-20 1992-01-30 イミュネックス・コーポレーション 非グリコシル化　ヒト　インターロイキン―３　組成物
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
WO1990012877A1 (en) * 1989-04-19 1990-11-01 Cetus Corporation Multifunctional m-csf proteins and genes encoding therefor
DE69030937T2 (de) * 1989-08-14 1997-10-09 Gist Brocades Nv Mutanten von Interleukin-3
US5516512A (en) * 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
DE69007975T2 (de) * 1989-08-22 1994-07-21 Immunex Corp Fusionsprotein bestehend aus gm-csf und il-3.
US5108910A (en) * 1989-08-22 1992-04-28 Immunex Corporation DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
US5073627A (en) * 1989-08-22 1991-12-17 Immunex Corporation Fusion proteins comprising GM-CSF and IL-3
DE3939703C2 (de) * 1989-12-01 1998-07-02 Boehringer Ingelheim Kg Verbesserte transdermale Applikation von pharmakologisch aktiven Verbindungen
JPH0463595A (ja) * 1990-04-03 1992-02-28 Kirin Brewery Co Ltd ヒトインターロイキン３誘導体
DK0546124T4 (da) * 1990-08-29 2003-05-19 Inst Genetics Llc Hæmatopoiese-stimulatorer med flere domæner
WO1992006116A1 (en) * 1990-09-28 1992-04-16 Ortho Pharmaceutical Corporation Hybrid growth factors
DE4030850A1 (de) * 1990-09-29 1992-04-02 Henkel Kgaa Bleichmittelzubereitung
US5199942A (en) * 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5376367A (en) * 1991-11-22 1994-12-27 Immunex Corporation Fusion proteins comprising MGF and IL-3
EP1283264A3 (de) * 1992-11-24 2004-03-10 G.D. Searle & Co. Interleukin-3 (iL-3) mutanten Polypeptide
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same

Also Published As

Publication number Publication date
FI963072A (fi) 1996-08-02
ATE302275T1 (de) 2005-09-15
DE69534381T2 (de) 2006-11-23
BR9506733A (pt) 1997-09-23
MX9603205A (es) 1997-03-29
RO118016B1 (ro) 2002-12-30
EP0742826B1 (de) 2005-08-17
US6022535A (en) 2000-02-08
PL315791A1 (en) 1996-12-09
KR100370264B1 (ko) 2003-05-09
WO1995021254A1 (en) 1995-08-10
NZ281421A (en) 1998-05-27
CN1227604A (zh) 1999-09-01
AU1835695A (en) 1995-08-21
KR970700766A (ko) 1997-02-12
EP1482044A3 (de) 2005-05-18
JPH10502801A (ja) 1998-03-17
US6030812A (en) 2000-02-29
FI963072A0 (fi) 1996-08-02
NO963225D0 (no) 1996-08-01
EP0742826A1 (de) 1996-11-20
NZ330060A (en) 1999-11-29
CA2182484A1 (en) 1995-08-10
AU697433B2 (en) 1998-10-08
CZ229896A3 (en) 1996-12-11
US6057133A (en) 2000-05-02
NO963225L (no) 1996-09-25
CZ289904B6 (cs) 2002-04-17
EP1482044A2 (de) 2004-12-01

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee