DE69333243D1 - Mutierte polypeptide des interleukin-3(il-3) - Google Patents

Mutierte polypeptide des interleukin-3(il-3)

Info

Publication number
DE69333243D1
DE69333243D1 DE69333243T DE69333243T DE69333243D1 DE 69333243 D1 DE69333243 D1 DE 69333243D1 DE 69333243 T DE69333243 T DE 69333243T DE 69333243 T DE69333243 T DE 69333243T DE 69333243 D1 DE69333243 D1 DE 69333243D1
Authority
DE
Germany
Prior art keywords
hil
muteins
amino acid
relates
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69333243T
Other languages
English (en)
Other versions
DE69333243T2 (de
Inventor
S Christopher Bauer
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Barbara Kure Klein
John Patrick Mckearn
Peter O Olins
Kumman Paik
Joseph O Polazzi
John Warren Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE69333243D1 publication Critical patent/DE69333243D1/de
Publication of DE69333243T2 publication Critical patent/DE69333243T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69333243T 1992-11-24 1993-11-22 Mutierte polypeptide des interleukin-3(il-3) Expired - Fee Related DE69333243T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98104492A 1992-11-24 1992-11-24
US981044 1992-11-24
PCT/US1993/011198 WO1994012639A2 (en) 1992-11-24 1993-11-22 Interleukin-3 (il-3) mutant polypeptides

Publications (2)

Publication Number Publication Date
DE69333243D1 true DE69333243D1 (de) 2003-11-13
DE69333243T2 DE69333243T2 (de) 2004-08-19

Family

ID=25528061

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69333243T Expired - Fee Related DE69333243T2 (de) 1992-11-24 1993-11-22 Mutierte polypeptide des interleukin-3(il-3)
DE69332908T Expired - Fee Related DE69332908T2 (de) 1992-11-24 1993-11-22 Interleukin-3 (il-3)-polypeptide mith mehreren mutationen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69332908T Expired - Fee Related DE69332908T2 (de) 1992-11-24 1993-11-22 Interleukin-3 (il-3)-polypeptide mith mehreren mutationen

Country Status (12)

Country Link
US (11) US5677149A (de)
EP (4) EP1283264A3 (de)
JP (3) JPH08503489A (de)
KR (1) KR100332139B1 (de)
AT (2) ATE251669T1 (de)
AU (3) AU690088B2 (de)
CA (2) CA2150116A1 (de)
DE (2) DE69333243T2 (de)
DK (2) DK0672145T3 (de)
ES (2) ES2211875T3 (de)
PT (2) PT672145E (de)
WO (2) WO1994012639A2 (de)

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US7091319B1 (en) 1992-11-24 2006-08-15 Bauer S Christopher IL-3 variant hematopoiesis fusion protein
US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
US6413509B1 (en) * 1992-11-24 2002-07-02 S. Christopher Bauer Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
US6403076B1 (en) * 1992-11-24 2002-06-11 S. Christopher Bauer Compositions for increasing hematopoiesis with interleukin-3 mutants
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6436387B1 (en) * 1992-11-24 2002-08-20 G.D. Searle & Co. Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins
US6361976B1 (en) * 1992-11-24 2002-03-26 S. Christopher Bauer Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
US6153183A (en) * 1992-11-24 2000-11-28 G. D. Searle & Company Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US5581476A (en) 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
US20050059149A1 (en) * 1993-11-22 2005-03-17 Bauer S. Christopher Methods of ex-vivo expansion of hematopoeitic cells using multivariant IL-3 hematopoiesis chimera proteins
US6465616B1 (en) 1994-04-08 2002-10-15 Bresagen Limited Interleukin-5 antagonist
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US6017523A (en) * 1995-06-06 2000-01-25 G.D. Searle & Co. Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
US6066318A (en) * 1995-10-05 2000-05-23 G.D. Searle & Co. Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6171820B1 (en) 1995-12-07 2001-01-09 Diversa Corporation Saturation mutagenesis in directed evolution
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US7153943B2 (en) 1997-07-14 2006-12-26 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins, and methods of use thereof
WO1999003887A1 (en) 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
US20080076706A1 (en) 1997-07-14 2008-03-27 Bolder Biotechnology, Inc. Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof
US7495087B2 (en) 1997-07-14 2009-02-24 Bolder Biotechnology, Inc. Cysteine muteins in the C-D loop of human interleukin-11
US8288126B2 (en) 1999-01-14 2012-10-16 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
US7270984B1 (en) * 1999-06-25 2007-09-18 Basf Aktiengesellschaft Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum
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US6646110B2 (en) * 2000-01-10 2003-11-11 Maxygen Holdings Ltd. G-CSF polypeptides and conjugates
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
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US20100209341A1 (en) * 2009-02-18 2010-08-19 Csl Limited Treatment of chronic inflammatory conditions
JP6193570B2 (ja) 2009-07-17 2017-09-13 バイオアトラ、エルエルシー 産生宿主における抗体／タンパク質パフォーマンス及び発現の同時で統合された選択及び進化
DK3435087T3 (da) 2010-07-16 2023-11-27 Bioatla Inc Hidtil ukendte fremgangsmåder til proteinevolution
WO2012048276A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
MX2019001355A (es) 2012-05-10 2023-01-17 Bioatla Llc Anticuerpos monoclonales multiespecíficos.
DE102012110664A1 (de) * 2012-11-07 2014-05-08 Henkel Ag & Co. Kgaa In Beschichtungsmitteln, Haftvermittlern oder Klebstoffen für oxidische Oberflächen einsetzbare Peptide
KR101510743B1 (ko) 2013-07-23 2015-04-10 (주)케어젠 파골 세포 분화 억제용 펩타이드 및 이의 용도
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US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
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JP3236400B2 (ja) 1993-04-07 2001-12-10 旭化成株式会社 非水二次電池

Also Published As

Publication number Publication date
US20050244372A1 (en) 2005-11-03
JPH08503706A (ja) 1996-04-23
US20030220472A1 (en) 2003-11-27
US5604116A (en) 1997-02-18
ES2198416T3 (es) 2004-02-01
US6440407B1 (en) 2002-08-27
US6051217A (en) 2000-04-18
AU5612594A (en) 1994-06-22
KR100332139B1 (ko) 2002-11-30
DE69333243T2 (de) 2004-08-19
US20030103936A1 (en) 2003-06-05
DE69332908D1 (de) 2003-05-28
DE69332908T2 (de) 2003-12-24
US5677149A (en) 1997-10-14
KR950704490A (ko) 1995-11-20
ATE238421T1 (de) 2003-05-15
JPH08503489A (ja) 1996-04-16
EP0670898B1 (de) 2003-10-08
AU5670994A (en) 1994-06-22
US5817486A (en) 1998-10-06
EP1283264A2 (de) 2003-02-12
EP1361273A3 (de) 2004-02-11
DK0670898T3 (da) 2004-02-09
WO1994012638A2 (en) 1994-06-09
AU6078398A (en) 1998-06-18
EP0670898A1 (de) 1995-09-13
US6479261B1 (en) 2002-11-12
ES2211875T3 (es) 2004-07-16
EP1283264A3 (de) 2004-03-10
DK0672145T3 (da) 2003-08-11
PT672145E (pt) 2003-08-29
WO1994012638A3 (en) 1994-09-01
AU690088B2 (en) 1998-04-23
WO1994012639A3 (en) 1994-07-21
EP0672145B1 (de) 2003-04-23
EP1361273A2 (de) 2003-11-12
US20040018618A1 (en) 2004-01-29
US6458931B1 (en) 2002-10-01
JP2003259886A (ja) 2003-09-16
EP0672145A1 (de) 1995-09-20
CA2150116A1 (en) 1994-06-09
PT670898E (pt) 2004-02-27
ATE251669T1 (de) 2003-10-15
WO1994012639A2 (en) 1994-06-09
CA2150117A1 (en) 1994-06-09

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