DK0672145T3 - Interleukin-3-(IL-3)-polypeptider med flere mutationer - Google Patents

Interleukin-3-(IL-3)-polypeptider med flere mutationer

Info

Publication number
DK0672145T3
DK0672145T3 DK94901584T DK94901584T DK0672145T3 DK 0672145 T3 DK0672145 T3 DK 0672145T3 DK 94901584 T DK94901584 T DK 94901584T DK 94901584 T DK94901584 T DK 94901584T DK 0672145 T3 DK0672145 T3 DK 0672145T3
Authority
DK
Denmark
Prior art keywords
hil
muteins
amino acid
relates
present
Prior art date
Application number
DK94901584T
Other languages
English (en)
Inventor
S Christopher Bauer
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Barbara Kure Klein
John Patrick Mckearn
Peter O Olins
Kumnan Paik
John Warren Thomas
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0672145T3 publication Critical patent/DK0672145T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK94901584T 1992-11-24 1993-11-22 Interleukin-3-(IL-3)-polypeptider med flere mutationer DK0672145T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98104492A 1992-11-24 1992-11-24
PCT/US1993/011197 WO1994012638A2 (en) 1992-11-24 1993-11-22 Interleukin-3 (il-3) multiple mutation polypeptides

Publications (1)

Publication Number Publication Date
DK0672145T3 true DK0672145T3 (da) 2003-08-11

Family

ID=25528061

Family Applications (2)

Application Number Title Priority Date Filing Date
DK94902293T DK0670898T3 (da) 1992-11-24 1993-11-22 Interleukin-3 (IL-3)-mutantpolypeptider
DK94901584T DK0672145T3 (da) 1992-11-24 1993-11-22 Interleukin-3-(IL-3)-polypeptider med flere mutationer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK94902293T DK0670898T3 (da) 1992-11-24 1993-11-22 Interleukin-3 (IL-3)-mutantpolypeptider

Country Status (12)

Country Link
US (11) US5604116A (da)
EP (4) EP1283264A3 (da)
JP (3) JPH08503489A (da)
KR (1) KR100332139B1 (da)
AT (2) ATE238421T1 (da)
AU (3) AU690088B2 (da)
CA (2) CA2150117A1 (da)
DE (2) DE69332908T2 (da)
DK (2) DK0670898T3 (da)
ES (2) ES2198416T3 (da)
PT (2) PT672145E (da)
WO (2) WO1994012638A2 (da)

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US6361976B1 (en) * 1992-11-24 2002-03-26 S. Christopher Bauer Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
US7091319B1 (en) 1992-11-24 2006-08-15 Bauer S Christopher IL-3 variant hematopoiesis fusion protein
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US20050059149A1 (en) * 1993-11-22 2005-03-17 Bauer S. Christopher Methods of ex-vivo expansion of hematopoeitic cells using multivariant IL-3 hematopoiesis chimera proteins
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Also Published As

Publication number Publication date
US5677149A (en) 1997-10-14
AU5670994A (en) 1994-06-22
DE69333243D1 (de) 2003-11-13
CA2150116A1 (en) 1994-06-09
JP2003259886A (ja) 2003-09-16
KR950704490A (ko) 1995-11-20
JPH08503706A (ja) 1996-04-23
EP1283264A3 (en) 2004-03-10
US20030103936A1 (en) 2003-06-05
AU6078398A (en) 1998-06-18
US20050244372A1 (en) 2005-11-03
AU690088B2 (en) 1998-04-23
AU5612594A (en) 1994-06-22
WO1994012639A3 (en) 1994-07-21
DK0670898T3 (da) 2004-02-09
DE69332908T2 (de) 2003-12-24
US20030220472A1 (en) 2003-11-27
US6051217A (en) 2000-04-18
ES2211875T3 (es) 2004-07-16
US6479261B1 (en) 2002-11-12
WO1994012638A3 (en) 1994-09-01
US5817486A (en) 1998-10-06
US6440407B1 (en) 2002-08-27
EP0672145A1 (en) 1995-09-20
ATE238421T1 (de) 2003-05-15
ES2198416T3 (es) 2004-02-01
PT670898E (pt) 2004-02-27
JPH08503489A (ja) 1996-04-16
PT672145E (pt) 2003-08-29
US5604116A (en) 1997-02-18
DE69332908D1 (de) 2003-05-28
WO1994012639A2 (en) 1994-06-09
EP1283264A2 (en) 2003-02-12
US6458931B1 (en) 2002-10-01
DE69333243T2 (de) 2004-08-19
CA2150117A1 (en) 1994-06-09
KR100332139B1 (ko) 2002-11-30
EP0672145B1 (en) 2003-04-23
EP0670898B1 (en) 2003-10-08
EP0670898A1 (en) 1995-09-13
WO1994012638A2 (en) 1994-06-09
US20040018618A1 (en) 2004-01-29
EP1361273A3 (en) 2004-02-11
ATE251669T1 (de) 2003-10-15
EP1361273A2 (en) 2003-11-12

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