PT742796E - Proteina de fusao hematopoietica variante da il-3 - Google Patents

Proteina de fusao hematopoietica variante da il-3

Info

Publication number
PT742796E
PT742796E PT95908514T PT95908514T PT742796E PT 742796 E PT742796 E PT 742796E PT 95908514 T PT95908514 T PT 95908514T PT 95908514 T PT95908514 T PT 95908514T PT 742796 E PT742796 E PT 742796E
Authority
PT
Portugal
Prior art keywords
variant
fusion protein
hil
amino acid
relates
Prior art date
Application number
PT95908514T
Other languages
English (en)
Inventor
Mark Allen Abrams
Sarah Ruth Braford-Goldberg
Maire Helena Caparon
Alan Michael Easton
Barbara Kure Klein
Peter O Olins
Kumnan Paik
John Warren Thomas
Christopher S Bauer
John Patrick Mc Kearn
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of PT742796E publication Critical patent/PT742796E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/14—Lymphokine; related peptides
    • Y10S930/141—Interleukin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PT95908514T 1994-02-04 1995-01-25 Proteina de fusao hematopoietica variante da il-3 PT742796E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/192,299 US5738849A (en) 1992-11-24 1994-02-04 Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them

Publications (1)

Publication Number Publication Date
PT742796E true PT742796E (pt) 2003-08-29

Family

ID=22709107

Family Applications (1)

Application Number Title Priority Date Filing Date
PT95908514T PT742796E (pt) 1994-02-04 1995-01-25 Proteina de fusao hematopoietica variante da il-3

Country Status (13)

Country Link
US (4) US5738849A (pt)
EP (2) EP0742796B1 (pt)
JP (1) JPH09508524A (pt)
AT (1) ATE237641T1 (pt)
AU (1) AU700220B2 (pt)
CA (1) CA2182483C (pt)
DE (1) DE69530374T2 (pt)
DK (1) DK0742796T3 (pt)
ES (1) ES2197191T3 (pt)
HK (1) HK1013655A1 (pt)
NZ (1) NZ279624A (pt)
PT (1) PT742796E (pt)
WO (1) WO1995021197A1 (pt)

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US6967092B1 (en) 1996-10-25 2005-11-22 Mc Kearn John P Multi-functional chimeric hematopoietic receptor agonists
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US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
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US7067110B1 (en) 1999-07-21 2006-06-27 Emd Lexigen Research Center Corp. Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
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WO2001027621A2 (en) * 1999-10-07 2001-04-19 Pharmacia Corporation Competitive inhibition elisa for antibody detection
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US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
CA2399832C (en) 2000-02-11 2011-09-20 Stephen D. Gillies Enhancing the circulating half-life of antibody-based fusion proteins
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WO2002079415A2 (en) * 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
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MXPA04000231A (es) * 2001-07-11 2004-05-04 Maxygen Holdings Ltd Conjugados del factor de estimulacion de colonias de granulocitos.
EP2354791A1 (en) * 2001-12-04 2011-08-10 Merck Patent GmbH Immunocytokines with modulated selectivity
US7332158B2 (en) * 2002-05-29 2008-02-19 Demao Yang Compositions and treatments for myelosuppression by ex vivo activated immune cells
US7048922B2 (en) * 2002-05-29 2006-05-23 Demao Yang Stimulation of hematopoiesis by ex vivo activated immune cells
BRPI0317376B8 (pt) * 2002-12-17 2021-05-25 Merck Patent Gmbh proteína de fusão de anticorpo-il2 designada como hu14.18-il2, usos da mesma, vetor e composição farmacêutica
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PL1966238T3 (pl) * 2005-12-30 2012-09-28 Merck Patent Gmbh Warianty interleukiny-12p40 o polepszonej stabilności
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Also Published As

Publication number Publication date
US6132991A (en) 2000-10-17
ES2197191T3 (es) 2004-01-01
DE69530374D1 (de) 2003-05-22
CA2182483A1 (en) 1995-08-10
ATE237641T1 (de) 2003-05-15
JPH09508524A (ja) 1997-09-02
CA2182483C (en) 2002-04-02
US6074639A (en) 2000-06-13
EP1323737A3 (en) 2003-10-15
AU1680595A (en) 1995-08-21
EP0742796B1 (en) 2003-04-16
WO1995021197A1 (en) 1995-08-10
DE69530374T2 (de) 2003-12-18
HK1013655A1 (en) 1999-09-03
AU700220B2 (en) 1998-12-24
EP0742796A1 (en) 1996-11-20
NZ279624A (en) 1998-05-27
US5738849A (en) 1998-04-14
DK0742796T3 (da) 2003-08-11
EP1323737A2 (en) 2003-07-02
US5858347A (en) 1999-01-12

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