HRP20041178B1 - Muteini placentalnog faktora rasta tipa 1, metode njihove pripreme i primjene - Google Patents

Muteini placentalnog faktora rasta tipa 1, metode njihove pripreme i primjene

Info

Publication number
HRP20041178B1
HRP20041178B1 HRP20041178AA HRP20041178A HRP20041178B1 HR P20041178 B1 HRP20041178 B1 HR P20041178B1 HR P20041178A A HRP20041178A A HR P20041178AA HR P20041178 A HRP20041178 A HR P20041178A HR P20041178 B1 HRP20041178 B1 HR P20041178B1
Authority
HR
Croatia
Prior art keywords
muteins
growth factor
placental growth
prepčaration
application
Prior art date
Application number
HRP20041178AA
Other languages
English (en)
Inventor
Domenico Maglione
Mauro Battisti
Ettore Conti
Giuseppe Salvia
Marina Tucci
Alberto Mion
Original Assignee
Geymonat S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11456311&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20041178(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Geymonat S.P.A. filed Critical Geymonat S.P.A.
Publication of HRP20041178A2 publication Critical patent/HRP20041178A2/hr
Publication of HRP20041178B1 publication Critical patent/HRP20041178B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/515—Angiogenesic factors; Angiogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ovaj izum odnosi se na kemijski stabilne muteine placentalnog faktora rasta tipa 1 (engl. Placental Growth Factor Type 1, PLGF-1), sa supstitucijom ili delecijom cisteinskog ostatka u aminokiselinskom slijedu divljeg tipa proteina, njihovu pripremu, njihove terapeutske i kozmetičke primjene, te farmaceutske i kozmetičke pripravke koji sadrže navedene derivate. Izum se na isti način odnosi i na proizvodnju protutijela za navedene derivate, te njihovu upotrebu u dijagnostici i liječenju tumorskih i netumorskih patologija.
HRP20041178AA 2002-05-17 2004-12-10 Muteini placentalnog faktora rasta tipa 1, metode njihove pripreme i primjene HRP20041178B1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002RM000277A ITRM20020277A1 (it) 2002-05-17 2002-05-17 Muteine del fattore di crescita placentare tipo 1, metodo di preparazione e loro applicazioni.
PCT/IT2003/000296 WO2003097688A2 (en) 2002-05-17 2003-05-19 Muteins of placental growth factor type 1, preparation method and application thereof

Publications (2)

Publication Number Publication Date
HRP20041178A2 HRP20041178A2 (en) 2005-10-31
HRP20041178B1 true HRP20041178B1 (hr) 2013-11-22

Family

ID=11456311

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20041178AA HRP20041178B1 (hr) 2002-05-17 2004-12-10 Muteini placentalnog faktora rasta tipa 1, metode njihove pripreme i primjene

Country Status (22)

Country Link
US (1) US7314734B2 (hr)
EP (1) EP1506295B1 (hr)
JP (1) JP4230450B2 (hr)
KR (1) KR101022934B1 (hr)
CN (1) CN1323167C (hr)
AT (1) ATE488590T1 (hr)
AU (1) AU2003234066B2 (hr)
BR (1) BR0309966A (hr)
CA (1) CA2485587C (hr)
CY (1) CY1111431T1 (hr)
DE (1) DE60334986D1 (hr)
DK (1) DK1506295T3 (hr)
ES (1) ES2356360T3 (hr)
HK (1) HK1079549A1 (hr)
HR (1) HRP20041178B1 (hr)
IT (1) ITRM20020277A1 (hr)
MX (1) MXPA04011405A (hr)
PL (1) PL209955B1 (hr)
PT (1) PT1506295E (hr)
RU (1) RU2344172C2 (hr)
WO (1) WO2003097688A2 (hr)
ZA (1) ZA200409943B (hr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004046722A2 (de) 2002-11-16 2004-06-03 Dade Behring Marburg Gmbh Scd40l, papp-a und plazentaler-wachstumsfaktor (pigf) als biochemische markerkombinationen bei kardiovaskulären erkrankungen
DE102005022047A1 (de) * 2005-05-09 2006-11-30 Dade Behring Marburg Gmbh Bindungspartner des Plazentalen Wachstumsfaktors insbesondere gegen den Plazentalen Wachstumsfaktor gerichtete Antikörper, ihre Herstellung und Verwendung
JP2009100680A (ja) * 2007-10-23 2009-05-14 Univ Nagoya ヒト全身性強皮症動物モデルの作製方法、ヒト全身性強皮症動物モデル及びその用途
CN101918834B (zh) 2008-01-07 2014-05-28 奥索临床诊断有限公司 用于同时分析能够彼此络合的蛋白质的校准物/对照物
CN101918839A (zh) * 2008-01-07 2010-12-15 奥索临床诊断有限公司 sFlt-1:血管生成因子络合物的测定
EP2295449A1 (en) * 2009-09-09 2011-03-16 Dompe PHA.R.MA S.p.A. PLGF-1 in homodimeric form
CN103087153B (zh) 2011-10-28 2015-05-06 上海市第一人民医院 一类新的抑制新生血管的小肽及其应用
AU2014273027B2 (en) 2013-05-31 2019-07-04 Cobiores Nv Human PlGF-2 for the prevention or treatment of heart failure
CN109134650A (zh) * 2018-09-10 2019-01-04 宁波奥丞生物科技有限公司 抗人plgf单克隆抗体的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999026975A2 (de) * 1997-11-05 1999-06-03 Gesellschaft für Biotechnologische Forschung mbH Verfahren zur gewinnung von biologisch aktiven dimeren von rekombinanten humanen wachstumsfaktoren aus der cystein-knoten-familie sowie verwendung der gewonnenen dimere
US5919899A (en) * 1990-09-27 1999-07-06 Consiglio Nazionale Delle Ricerche Human protein with angiogenesis regulative properties
WO2000075163A1 (en) * 1999-06-03 2000-12-14 Human Genome Sciences, Inc. Angiogenic proteins and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69229454T2 (de) * 1991-03-28 2000-01-05 Merck & Co Inc Untereinheit-C des vaskulären endothelialen Zellwachstumsfaktors
SE9601245D0 (sv) * 1996-03-29 1996-03-29 Pharmacia Ab Chimeric superantigens and their use
AU2001265953B2 (en) * 2000-05-12 2005-09-29 D. Collen Research Foundation Vzw Use of inhibitors of placental growth factor for the treatment of pathological angiogenesis, pathological arteriogenesis, inflammation, tumour formation and/or vascular leakage

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919899A (en) * 1990-09-27 1999-07-06 Consiglio Nazionale Delle Ricerche Human protein with angiogenesis regulative properties
WO1999026975A2 (de) * 1997-11-05 1999-06-03 Gesellschaft für Biotechnologische Forschung mbH Verfahren zur gewinnung von biologisch aktiven dimeren von rekombinanten humanen wachstumsfaktoren aus der cystein-knoten-familie sowie verwendung der gewonnenen dimere
WO2000075163A1 (en) * 1999-06-03 2000-12-14 Human Genome Sciences, Inc. Angiogenic proteins and uses thereof

Also Published As

Publication number Publication date
DK1506295T3 (da) 2011-03-07
ITRM20020277A0 (it) 2002-05-17
JP4230450B2 (ja) 2009-02-25
EP1506295A2 (en) 2005-02-16
PL372492A1 (en) 2005-07-25
US20050176634A1 (en) 2005-08-11
KR20040111639A (ko) 2004-12-31
EP1506295B1 (en) 2010-11-17
WO2003097688A9 (en) 2005-01-06
ATE488590T1 (de) 2010-12-15
KR101022934B1 (ko) 2011-03-16
CA2485587C (en) 2012-08-21
HK1079549A1 (en) 2006-04-07
US7314734B2 (en) 2008-01-01
AU2003234066B2 (en) 2009-04-23
JP2006508637A (ja) 2006-03-16
HRP20041178A2 (en) 2005-10-31
ITRM20020277A1 (it) 2003-11-17
RU2004137000A (ru) 2005-06-10
BR0309966A (pt) 2005-03-01
PT1506295E (pt) 2011-02-23
RU2344172C2 (ru) 2009-01-20
PL209955B1 (pl) 2011-11-30
DE60334986D1 (de) 2010-12-30
MXPA04011405A (es) 2005-02-14
WO2003097688A3 (en) 2004-02-26
CN1323167C (zh) 2007-06-27
WO2003097688A2 (en) 2003-11-27
ES2356360T3 (es) 2011-04-07
AU2003234066A1 (en) 2003-12-02
CY1111431T1 (el) 2015-08-05
CA2485587A1 (en) 2003-11-27
CN1653177A (zh) 2005-08-10
ZA200409943B (en) 2005-09-28

Similar Documents

Publication Publication Date Title
CY1111431T1 (el) Μεταλλαγμενες πρωτεϊνες πλακουντιου αυξητικου παραγοντα τυπου 1, μεθοδος παρασκευης και εφαρμογες αυτων
ES2163511T3 (es) Preparacion farmaceutica conteniendo glucagon.
HUP0500345A2 (hu) Készítmények és alkalmazások tüdőrák kezelésére és diagnosztizálására
DE69839340D1 (de) Mutanten DES VASKULÄREN, ENDOTHELZELLEN-SPEZIFISCHEN WACHSTUMSFAKTORS C (VEGF-C) UND DEREN VERWENDUNGEN
DE602004011770D1 (de) Fusionsproteine
HRP20050934B1 (hr) Formulacije s visokom koncentracijom antitijela i proteina
DE50004018D1 (de) Verwendung natriuretischer peptide als antibiotisch wirksame substanzen zur behandlung von bakteriellen infektionen
CY1114265T1 (el) Πρωτεϊνη συντηξης αλβουμινης
EA200800050A1 (ru) Самобуферирующиеся композиции белков
PT742796E (pt) Proteina de fusao hematopoietica variante da il-3
MEP53308A (en) Novel peptides that bind to the erythropoietin receptor
DE60125381D1 (de) Zusammensetzungen und verfahren mit analogen von g-csf
DE68929043D1 (de) Für androgen-rezeptor-protein kodierende dna
NO914541L (no) Fremgangsmaate ved fremstilling av tumor-nekrose-faktor-muteiner
DK382786A (da) Overfladeaktivt rekombinant-alveolarprotein
CY1106789T1 (el) Γενικος φορεας για στοχευση μοριων σε κυτταρα που εκφραζουν gb3 υποδοχεα
DE3871450D1 (de) Mittel zur haarbehandlung.
HUP0002427A2 (hu) Leptin mint tumorsejt proliferációt gátló hatóanyag és alkalmazása
HRP20050787A2 (en) Pharmaceutical composition comprising 5-methyl-2-2'-(chloro-6'-fluoroanilino) phenylacetic acid
HUP0100456A1 (hu) IFNAR2/IFN komplex, alkalmazásai és a komplexet tartalmazó készítmények
MXPA05008704A (es) Proteinas de fusion de muteinas de interferon alfa con propiedades mejoradas.
RU95106680A (ru) Бициклические ароматические соединения и содержащие их фармацевтические и косметические композиции
DK0823903T3 (da) Heterocykliske biarylforbindelser, farmaceutiske præparater og kosmetiske sammensætninger, der indeholder dem, og anvendelser
HUP9900506A2 (hu) Protrombinszármazékok
BR0311568A (pt) Método de tratamento de cabelo e uso de uma composição

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20150706

Year of fee payment: 13

PBON Lapse due to non-payment of renewal fee

Effective date: 20160519