HUP0100456A1 - IFNAR2/IFN komplex, alkalmazásai és a komplexet tartalmazó készítmények - Google Patents

IFNAR2/IFN komplex, alkalmazásai és a komplexet tartalmazó készítmények

Info

Publication number
HUP0100456A1
HUP0100456A1 HU0100456A HUP0100456A HUP0100456A1 HU P0100456 A1 HUP0100456 A1 HU P0100456A1 HU 0100456 A HU0100456 A HU 0100456A HU P0100456 A HUP0100456 A HU P0100456A HU P0100456 A1 HUP0100456 A1 HU P0100456A1
Authority
HU
Hungary
Prior art keywords
ifn
interferon
complex
type
ifnar
Prior art date
Application number
HU0100456A
Other languages
English (en)
Inventor
Mark Cunningham
Nabil El Tayar
Sean Mckenna
David Sherris
Mark Tepper
Original Assignee
Applied Research Systems Ars Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.
Publication of HUP0100456A1 publication Critical patent/HUP0100456A1/hu
Publication of HUP0100456A3 publication Critical patent/HUP0100456A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A találmány tárgya I. típusú interferont (IFN) és a humán eredetűinterferon a/<-receptor (IFNAR) I. típusú interferonhoz kötődni képesalegységének komplexét tartalmazó molekula és az azt tartalmazógyógyászati készítmény. A találmány szerinti komplex előnyösen fúziósfehérje. ═gy a találmány tárgya a fúziós fehérjét kódoló DNS és az azttartalmazó gazdasejt. A találmány tárgyát képezi továbbá eljárás I.típusú interferon tárolhatóságának javítására, valamint humán eredetűinterferon a/<-receptor (IFNAR) alkalmazása I. típusú interferon (IFN)biológai hatásainak meghosszabítását szolgáló gyógyszerelőállításában. A találmány szerinti komplex meghosszabbítja az IFNhatását, megjavítja stabilitását és megnöveli a hatásosságát. Akomplex lehet kovalens vagy nem kovalens, előbbi esetben az IFN és azIFNAR között peptidkapocs is alkalmazható. Az IFN komplex formábantörténő tárolása megjavítja az IFN tárolhatóságát és lehetővé teszi atárolást enyhe körülmények között. Ó
HU0100456A 1997-12-19 1998-12-18 Ifnar2/ifn complex HUP0100456A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6829597P 1997-12-19 1997-12-19
PCT/US1998/026926 WO1999032141A1 (en) 1997-12-19 1998-12-18 Ifnar2/ifn complex

Publications (2)

Publication Number Publication Date
HUP0100456A1 true HUP0100456A1 (hu) 2001-06-28
HUP0100456A3 HUP0100456A3 (en) 2003-09-29

Family

ID=22081665

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100456A HUP0100456A3 (en) 1997-12-19 1998-12-18 Ifnar2/ifn complex

Country Status (28)

Country Link
US (1) US6372207B1 (hu)
EP (1) EP1037658B1 (hu)
JP (1) JP4601163B2 (hu)
KR (1) KR100593981B1 (hu)
CN (1) CN1241638C (hu)
AR (1) AR020315A1 (hu)
AT (1) ATE218362T1 (hu)
AU (1) AU755078B2 (hu)
BG (1) BG64920B1 (hu)
BR (1) BR9813753A (hu)
CA (1) CA2311648C (hu)
DE (1) DE69805844T2 (hu)
DK (1) DK1037658T3 (hu)
EA (1) EA003635B1 (hu)
EE (1) EE200000355A (hu)
ES (1) ES2174530T3 (hu)
HK (1) HK1032914A1 (hu)
HU (1) HUP0100456A3 (hu)
IL (2) IL136855A0 (hu)
NO (1) NO20002691L (hu)
NZ (1) NZ504771A (hu)
PL (1) PL197568B1 (hu)
PT (1) PT1037658E (hu)
SK (1) SK9222000A3 (hu)
TR (1) TR200001961T2 (hu)
UA (1) UA74132C2 (hu)
WO (1) WO1999032141A1 (hu)
ZA (1) ZA9811634B (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL122818A0 (en) * 1997-07-10 1998-08-16 Yeda Res & Dev Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
AUPP670698A0 (en) * 1998-10-23 1998-11-19 Monash University A method of regulation
US7138379B2 (en) * 2000-07-26 2006-11-21 Schering Aktiengesellschaft Use of the interferon receptor 2c polypeptide chain to enhance the anti-growth effects of type I interferons
IL147414A0 (en) * 2001-12-31 2002-08-14 Yeda Res & Dev Ifnar2 mutants, their production and use
US20040175359A1 (en) * 2002-11-12 2004-09-09 Desjarlais John Rudolph Novel proteins with antiviral, antineoplastic, and/or immunomodulatory activity
CN100519581C (zh) * 2003-08-25 2009-07-29 东丽株式会社 干扰素-β复合物
CN100400664C (zh) * 2005-09-06 2008-07-09 中国人民解放军第四军医大学 肿瘤血管导向肽与人干扰素α-2b的融合蛋白的制备方法
EP2091568A2 (en) * 2006-10-31 2009-08-26 East Carolina University Fusion proteins comprising a anti-inflammatory cytokine and an antigen for treatment of immune disorders
GB0715383D0 (en) * 2007-08-08 2007-09-19 Asterion Ltd Interferon
GB0815216D0 (en) * 2008-08-21 2008-09-24 Asterion Ltd Interleukin
EP3348275A3 (en) 2009-03-31 2018-10-24 East Carolina University Cytokines and neuroantigens for treatment of immune disorders
KR101293363B1 (ko) * 2011-02-28 2013-08-05 성균관대학교산학협력단 인터페론 수용체 유전자를 포함하는 조류독감 예방용 조성물
EA038502B1 (ru) * 2013-03-15 2021-09-07 Янссен Байотек, Инк. Антитела-антагонисты к интерферону альфа и интерферону омега
LT6164B (lt) 2013-10-15 2015-06-25 Uab Biotechnologinės Farmacijos Centras "Biotechpharma" Sulieti interferono-alfa 5 baltymai su kitu citokinu ir jų gamybos būdas
KR20200015742A (ko) * 2017-06-20 2020-02-12 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 암 치료를 위한 인터페론 전구약물
US10947295B2 (en) 2017-08-22 2021-03-16 Sanabio, Llc Heterodimers of soluble interferon receptors and uses thereof
CN112646783B (zh) * 2020-12-30 2023-12-01 广州医科大学附属市八医院 表达基因、经基因修饰的受精卵的构建方法和小鼠模型的构建方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821078A (en) 1992-09-03 1998-10-13 Yeda Research And Development Co. Ltd. Nucleic acid encoding interferon-α/β binding protein
IL106591A (en) 1992-09-03 2008-03-20 Yeda Res & Dev Interferon alpha/beta binding protein, its preparation and pharmaceutical compositions containing it
IL107378A (en) * 1993-10-24 2005-05-17 Yeda Res & Dev SOLUBLE INTERFERON alpha-RECEPTOR, ITS PREPARATION AND USE

Also Published As

Publication number Publication date
AU755078B2 (en) 2002-12-05
BG104539A (en) 2001-04-30
SK9222000A3 (en) 2001-01-18
KR100593981B1 (ko) 2006-06-30
KR20010032836A (ko) 2001-04-25
EA200000685A1 (ru) 2000-12-25
BR9813753A (pt) 2000-10-10
PL197568B1 (pl) 2008-04-30
PT1037658E (pt) 2002-10-31
EP1037658B1 (en) 2002-06-05
WO1999032141A1 (en) 1999-07-01
IL136855A (en) 2007-07-24
TR200001961T2 (tr) 2000-11-21
IL136855A0 (en) 2001-06-14
AR020315A1 (es) 2002-05-08
PL341423A1 (en) 2001-04-09
JP4601163B2 (ja) 2010-12-22
NO20002691L (no) 2000-08-18
EA003635B1 (ru) 2003-08-28
DK1037658T3 (da) 2002-09-30
CA2311648A1 (en) 1999-07-01
BG64920B1 (bg) 2006-09-29
NO20002691D0 (no) 2000-05-25
CN1241638C (zh) 2006-02-15
DE69805844T2 (de) 2002-10-24
AU1926999A (en) 1999-07-12
DE69805844D1 (de) 2002-07-11
US6372207B1 (en) 2002-04-16
EE200000355A (et) 2001-10-15
ES2174530T3 (es) 2002-11-01
CA2311648C (en) 2010-11-16
HK1032914A1 (en) 2001-08-10
ZA9811634B (en) 1999-06-22
CN1282255A (zh) 2001-01-31
EP1037658A1 (en) 2000-09-27
UA74132C2 (uk) 2005-11-15
ATE218362T1 (de) 2002-06-15
JP2001526242A (ja) 2001-12-18
HUP0100456A3 (en) 2003-09-29
NZ504771A (en) 2002-09-27

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Legal Events

Date Code Title Description
FD9A Lapse of provisional protection due to non-payment of fees