ES2133329T3 - Variantes de il-3 humana. - Google Patents

Variantes de il-3 humana.

Info

Publication number
ES2133329T3
ES2133329T3 ES92921235T ES92921235T ES2133329T3 ES 2133329 T3 ES2133329 T3 ES 2133329T3 ES 92921235 T ES92921235 T ES 92921235T ES 92921235 T ES92921235 T ES 92921235T ES 2133329 T3 ES2133329 T3 ES 2133329T3
Authority
ES
Spain
Prior art keywords
pct
variants
human
sec
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92921235T
Other languages
English (en)
Inventor
Mathew Alexander Vadas
Angel Francisco Lopez
Mary Frances Shannon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medvet Science Pty Ltd
Original Assignee
Medvet Science Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medvet Science Pty Ltd filed Critical Medvet Science Pty Ltd
Application granted granted Critical
Publication of ES2133329T3 publication Critical patent/ES2133329T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LOS MUTANTES O VARIANTES DEL IL-3 HUMANO SE CARACTERIZA EN QUE UNO O MAS AMINOACIDOS CONTENIDOS O ADYACENTES A LA CUARTA HELICE (ALFA) DEL HIL-3 Y/O UNO O MAS AMINOACIDOS EN LA PRIMERA HELICE (ALFA) DEL HIL-3 SE REEMPLAZAN POR OTRO AMINOACIDO. ESTOS MUTANTES O VARIANTES SON UTILES EN LA MODULACION DE LA PROLIFERACION, DIFERENCIACION O ACTIVACION FUNCIONAL DE LAS CELULAS HAEMOPOIETICAS O DE LAS CELULAS NO HAEMOPOIETICAS QUE EXPRESAN O ESTAN REALIZADAS PARA EXPRESAR EL RECEPTOR DEL IL-3.
ES92921235T 1991-10-07 1992-10-07 Variantes de il-3 humana. Expired - Lifetime ES2133329T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPK874291 1991-10-07

Publications (1)

Publication Number Publication Date
ES2133329T3 true ES2133329T3 (es) 1999-09-16

Family

ID=3775735

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92921235T Expired - Lifetime ES2133329T3 (es) 1991-10-07 1992-10-07 Variantes de il-3 humana.

Country Status (11)

Country Link
US (1) US5591427A (es)
EP (1) EP0609280B1 (es)
JP (1) JPH07501520A (es)
AT (1) ATE179211T1 (es)
AU (1) AU668364B2 (es)
CA (1) CA2120707A1 (es)
DE (1) DE69228997T2 (es)
DK (1) DK0609280T3 (es)
ES (1) ES2133329T3 (es)
GR (1) GR3030032T3 (es)
WO (1) WO1993007171A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
JPH08503489A (ja) 1992-11-24 1996-04-16 ジー．ディー．サール アンド カンパニー インターロイキン−３（ｉｌ−３）突然変異ポリペプチド
US6361977B1 (en) * 1992-11-24 2002-03-26 S. Christopher Bauer Methods of using multivariant IL-3 hematopoiesis fusion protein
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
US6153183A (en) * 1992-11-24 2000-11-28 G. D. Searle & Company Co-administration of interleukin-3 mutant polypeptides with CSF's or cytokines for multi-lineage hematopoietic cell production
US6403076B1 (en) 1992-11-24 2002-06-11 S. Christopher Bauer Compositions for increasing hematopoiesis with interleukin-3 mutants
US6436387B1 (en) * 1992-11-24 2002-08-20 G.D. Searle & Co. Methods of ex-vivo expansion of hematopoietic cells using multivariant IL-3 hematopoiesis chimera proteins
US6413509B1 (en) * 1992-11-24 2002-07-02 S. Christopher Bauer Methods of ex-vivo expansion of hematopoietic cells using interleukin-3 mutant polypeptides with other hematopoietic growth factors
US6361976B1 (en) 1992-11-24 2002-03-26 S. Christopher Bauer Co-administration of interleukin-3 mutant polypeptides with CSF'S for multi-lineage hematopoietic cell production
US6057133A (en) * 1992-11-24 2000-05-02 G. D. Searle Multivariant human IL-3 fusion proteins and their recombinant production
US7091319B1 (en) * 1992-11-24 2006-08-15 Bauer S Christopher IL-3 variant hematopoiesis fusion protein
US5772992A (en) * 1992-11-24 1998-06-30 G.D. Searle & Co. Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors
NZ269766A (en) * 1993-07-28 1998-01-26 Medvet Science Pty Ltd Haemopoietic growth factor antagonists; relates to modified forms of such factors
AU699913B2 (en) * 1993-11-10 1998-12-17 Henry M. Jackson Foundation For The Advancement Of Military Medicine Compositions and method for stimulating antibody release by B lymphocytes
US20050059149A1 (en) * 1993-11-22 2005-03-17 Bauer S. Christopher Methods of ex-vivo expansion of hematopoeitic cells using multivariant IL-3 hematopoiesis chimera proteins
WO1995024501A1 (en) 1994-03-07 1995-09-14 Cetus Oncology Corporation Compositions for the inhibition of tnf formation and uses thereof
US6465616B1 (en) 1994-04-08 2002-10-15 Bresagen Limited Interleukin-5 antagonist
US6017523A (en) * 1995-06-06 2000-01-25 G.D. Searle & Co. Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
CA2234045A1 (en) * 1995-10-05 1997-04-10 G.D. Searle & Co. Interleuken-3 (il-3) receptor agonists

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".
DE69030937T2 (de) * 1989-08-14 1997-10-09 Gist Brocades Nv Mutanten von Interleukin-3

Also Published As

Publication number Publication date
AU668364B2 (en) 1996-05-02
US5591427A (en) 1997-01-07
DE69228997D1 (de) 1999-05-27
EP0609280B1 (en) 1999-04-21
DK0609280T3 (da) 1999-10-25
AU2753892A (en) 1993-05-03
CA2120707A1 (en) 1993-04-15
JPH07501520A (ja) 1995-02-16
WO1993007171A1 (en) 1993-04-15
GR3030032T3 (en) 1999-07-30
EP0609280A4 (en) 1994-09-14
ATE179211T1 (de) 1999-05-15
DE69228997T2 (de) 1999-08-26
EP0609280A1 (en) 1994-08-10

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