DE69513976T2 - Entzündungshemmende verbindungen - Google Patents
Entzündungshemmende verbindungenInfo
- Publication number
- DE69513976T2 DE69513976T2 DE69513976T DE69513976T DE69513976T2 DE 69513976 T2 DE69513976 T2 DE 69513976T2 DE 69513976 T DE69513976 T DE 69513976T DE 69513976 T DE69513976 T DE 69513976T DE 69513976 T2 DE69513976 T2 DE 69513976T2
- Authority
- DE
- Germany
- Prior art keywords
- inflammation
- connections
- inflammation connections
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/252,716 US5470882A (en) | 1994-06-02 | 1994-06-02 | Anti-inflammatory compounds |
PCT/US1995/006677 WO1995033712A1 (en) | 1994-06-02 | 1995-06-02 | Anti-inflammatory compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69513976D1 DE69513976D1 (de) | 2000-01-20 |
DE69513976T2 true DE69513976T2 (de) | 2000-06-15 |
Family
ID=22957219
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69513976T Expired - Fee Related DE69513976T2 (de) | 1994-06-02 | 1995-06-02 | Entzündungshemmende verbindungen |
Country Status (5)
Country | Link |
---|---|
US (2) | US5470882A (de) |
EP (1) | EP0765305B1 (de) |
JP (1) | JPH10506092A (de) |
DE (1) | DE69513976T2 (de) |
WO (1) | WO1995033712A1 (de) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6461593B1 (en) * | 1992-02-19 | 2002-10-08 | Biomedical And Clinical Research | Therapy with coenzyme Q10 to reduce subgingival microorganisms in patients with periodontal disease |
US5470882A (en) * | 1994-06-02 | 1995-11-28 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
EP0809492A4 (de) * | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | Il-8 rezeptor antagonisten |
US5780483A (en) * | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
EP0841910A4 (de) * | 1995-07-25 | 2006-09-13 | Smithkline Beecham Corp | HEMMUNG EINER CoA-UNABHÄNGIGEN TRANSACYLASE UND DER APOPTOSE |
US6005008A (en) * | 1996-02-16 | 1999-12-21 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
US6211373B1 (en) | 1996-03-20 | 2001-04-03 | Smithkline Beecham Corporation | Phenyl urea antagonists of the IL-8 receptor |
US6262113B1 (en) | 1996-03-20 | 2001-07-17 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
KR20000022274A (ko) * | 1996-06-27 | 2000-04-25 | 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 | Il-8 수용체 길항제 |
CZ425698A3 (cs) | 1996-06-27 | 1999-06-16 | Smithkline Beecham Corporation | Antagonista IL-8 receptoru |
US5925672A (en) * | 1996-12-06 | 1999-07-20 | Neurosciences Research Foundation, Inc. | Methods of treating mental diseases, inflammation and pain |
US6344476B1 (en) * | 1997-05-23 | 2002-02-05 | Bayer Corporation | Inhibition of p38 kinase activity by aryl ureas |
US7329670B1 (en) * | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
US7517880B2 (en) | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
EP1049664B1 (de) * | 1997-12-22 | 2005-03-16 | Bayer Pharmaceuticals Corporation | Hemmung der raf-kinase unter verwendung von symmetrisch und unsymmetrisch substituierten harnstoffen |
EP1158985B1 (de) | 1999-01-13 | 2011-12-28 | Bayer HealthCare LLC | GAMMA CARBOXYARYLSUBSTITUIERTE DIPHENYLHARNSTOFFVERBINDUNGEN ALS p38 KINASEHEMMER |
RU2319693C9 (ru) | 1999-01-13 | 2008-08-20 | Байер Копэрейшн | Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты) |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
EP1140840B1 (de) | 1999-01-13 | 2006-03-22 | Bayer Pharmaceuticals Corp. | -g(v)-carboxyaryl substituierte diphenyl harnstoffe als raf kinase inhibitoren |
US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
US6800298B1 (en) | 2000-05-11 | 2004-10-05 | Clemson University | Biological lubricant composition and method of applying lubricant composition |
US7235576B1 (en) * | 2001-01-12 | 2007-06-26 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US7371763B2 (en) | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
SI1478358T1 (sl) | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
AU2003209119A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
ATE529406T1 (de) | 2002-02-11 | 2011-11-15 | Bayer Healthcare Llc | Aryl-harnstoffe als kinase inhibitoren |
US20030232097A1 (en) * | 2002-06-17 | 2003-12-18 | Strides Inc. | Oily wax matrix suspension formulation comprising ibuprofen free acid and potassium salt of ibuprofen |
US20050113445A1 (en) * | 2003-02-20 | 2005-05-26 | Daniele Piomelli | Methods of treating mental diseases, inflammation and pain |
UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
DK1636585T3 (da) | 2003-05-20 | 2008-05-26 | Bayer Pharmaceuticals Corp | Diarylurinstoffer med kinasehæmmende aktivitet |
CL2004001834A1 (es) | 2003-07-23 | 2005-06-03 | Bayer Pharmaceuticals Corp | Compuesto 4-{4-[3-(4-cloro-3-trifluorometilfenil)-ureido]-3-fluorofenoxi}-piridin-2-metilamida, inhibidor de la raf, vegfr, p38 y pdgfr quinasas, sus sales; composiicon farmaceutica; combinacion farmaceutica; y su uso para tratar trastornos hiperprol |
US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
US8338648B2 (en) * | 2004-06-12 | 2012-12-25 | Signum Biosciences, Inc. | Topical compositions and methods for epithelial-related conditions |
KR100703955B1 (ko) * | 2005-08-26 | 2007-04-06 | 주식회사 엘지에스 | 면광원장치 |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2119882A (en) * | 1934-10-03 | 1938-06-07 | Gen Aniline Works Inc | Aminotrifluoromethyl-aryl-sulphonic acids and process of preparing them |
US2141893A (en) * | 1935-08-17 | 1938-12-27 | Gen Aniline Works Inc | Trifluoromethyl-aryl-sulphonic acids and a process of preparing them |
CH215294A (de) * | 1938-06-16 | 1941-06-15 | Geigy Ag J R | Verfahren zur Herstellung eines Harnstoffderivates. |
CH215322A (de) * | 1938-06-16 | 1941-06-15 | Geigy Ag J R | Verfahren zur Herstellung eines Harnstoffderivates. |
US2311062A (en) * | 1938-06-16 | 1943-02-16 | Geigy Ag J R | Halogen substituted acylamino sulphonic acids |
CH215328A (de) * | 1938-06-16 | 1941-06-15 | Geigy Ag J R | Verfahren zur Herstellung eines Harnstoffderivates. |
US2363074A (en) * | 1938-06-16 | 1944-11-21 | Geigy Ag J R | Halogen substituted acylamino sulphonic acids of the aromatic series and their manufacture |
CH215293A (de) * | 1938-06-16 | 1941-06-15 | Geigy Ag J R | Verfahren zur Herstellung eines Harnstoffderivates. |
CH215320A (de) * | 1938-06-16 | 1941-06-15 | Geigy Ag J R | Verfahren zur Herstellung eines Harnstoffderivates. |
US2424477A (en) * | 1938-12-24 | 1947-07-22 | Geigy Ag J R | Preparation of halogen substituted aminoarylsulphonic acid derivatives |
US2328159A (en) * | 1938-12-24 | 1943-08-31 | Geigy Ag J R | Preparation of halogen substituted aminoarylsulphonic acid derivatives |
US2299834A (en) * | 1939-12-14 | 1942-10-27 | Firm Of J R Geigy A G | Halogen containing acylaminosulphonic acids and their manufacture |
CH304968A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304263A (de) * | 1950-04-29 | 1954-12-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH305318A (de) * | 1950-04-29 | 1955-02-15 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304949A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304953A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304979A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304946A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
DE925476C (de) * | 1950-04-29 | 1955-03-21 | Variapat Ag | Verfahren zur Herstellung von farblosen, wasserloeslichen, trifluormethyl- und sulfonsaeuregruppenhaltigen, aliphatischen oder aromatischen Carbonsaeure- bzw. Sulfonsaeurearyliden |
CH304945A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304942A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH305317A (de) * | 1950-04-29 | 1955-02-15 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH305322A (de) * | 1950-04-29 | 1955-02-15 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304980A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304950A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304268A (de) * | 1950-04-29 | 1954-12-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304954A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304981A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
CH304956A (de) * | 1950-04-29 | 1955-01-31 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
US2715643A (en) * | 1950-12-26 | 1955-08-16 | Variapat Ag | Process for preparing n-[2'-(4'-chloro-2"-sulfophenoxy)-5'-chlorophenyl]-n'-[3, 4-dichlorophenyl]-urea |
CH305314A (de) * | 1950-12-26 | 1955-02-15 | Ag Variapat | Verfahren zur Herstellung eines Kondensationsproduktes. |
US2722544A (en) * | 1950-12-26 | 1955-11-01 | Variapat Ag | Trifluoromethyl halogenated diphenylcarbamide sulfonic acids and their preparation |
US2707183A (en) * | 1952-10-16 | 1955-04-26 | Geigy Ag J R | Metallizable trisazo dyestuffs |
US2833744A (en) * | 1953-08-27 | 1958-05-06 | Ciba Pharm Prod Inc | Polyureas and process of preparing same |
US2760958A (en) * | 1953-12-09 | 1956-08-28 | Geigy Ag J R | Disazo dyestuffs |
US3055930A (en) * | 1959-02-26 | 1962-09-25 | Geigy Chem Corp | New benzophenone sulphonic acid amides |
DE1493513C3 (de) * | 1962-03-09 | 1975-09-11 | Ciba-Geigy Ag, Basel (Schweiz) | Sulfamylanthranilsäuren, deren therapeutisch verwendbare Salze, Verfahren zu ihrer Herstellung und diese enthaltenden pharmazeutischen Präparate |
US3369042A (en) * | 1964-04-07 | 1968-02-13 | Parke Davis & Co | N-(substituted phenyl)anthranilic acids, salts, and esters thereof |
US3700773A (en) * | 1969-06-25 | 1972-10-24 | Merck & Co Inc | Substituted phenylsulfamyl salicyclic acids and derivatives thereof in the treatment of inflammation |
US4005141A (en) * | 1972-07-03 | 1977-01-25 | Minnesota Mining And Manufacturing Company | Perfluoroalkylsulfonamidoaryl compounds |
US3927093A (en) * | 1972-10-10 | 1975-12-16 | Squibb & Sons Inc | 2-(O-aminophenylthio)benzyl alcohols |
US4250192A (en) * | 1977-05-11 | 1981-02-10 | Ciba-Geigy Corporation | Novel substituted phenylacetic acid amide compounds |
US4280835A (en) * | 1977-12-13 | 1981-07-28 | Sumitomo Chemical Company, Limited | Herbicidal N-phenyl-N-methylurea derivatives |
JPS54122252A (en) * | 1978-03-13 | 1979-09-21 | Sumitomo Chem Co Ltd | Substitued phenylurea derivative, its preparation, and herbicide containing the same |
US4221816A (en) * | 1979-04-16 | 1980-09-09 | American Cyanamid Company | Method for the control of phytopathogenic fungi using p-(alkoxyalkyl)urea compounds |
DE3120359A1 (de) * | 1981-05-22 | 1982-12-16 | Celamerck Gmbh & Co Kg, 6507 Ingelheim | Harnstoffderivate, ihre herstellung und verwendung |
US4528392A (en) * | 1984-04-18 | 1985-07-09 | American Home Products Corporation | Aromatic compounds as antiallergic agents |
US4897397A (en) * | 1988-12-16 | 1990-01-30 | Schering Corporation | Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents |
US5470882A (en) * | 1994-06-02 | 1995-11-28 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
-
1994
- 1994-06-02 US US08/252,716 patent/US5470882A/en not_active Expired - Fee Related
-
1995
- 1995-06-02 WO PCT/US1995/006677 patent/WO1995033712A1/en active IP Right Grant
- 1995-06-02 JP JP8501061A patent/JPH10506092A/ja not_active Ceased
- 1995-06-02 US US08/737,650 patent/US5912270A/en not_active Expired - Fee Related
- 1995-06-02 EP EP95922898A patent/EP0765305B1/de not_active Expired - Lifetime
- 1995-06-02 DE DE69513976T patent/DE69513976T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO1995033712A1 (en) | 1995-12-14 |
JPH10506092A (ja) | 1998-06-16 |
EP0765305A4 (de) | 1997-09-03 |
DE69513976D1 (de) | 2000-01-20 |
EP0765305B1 (de) | 1999-12-15 |
US5470882A (en) | 1995-11-28 |
US5912270A (en) | 1999-06-15 |
EP0765305A1 (de) | 1997-04-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |